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Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. PREVENT Investigators.

Abstract：

BACKGROUND:The results of angiographic studies have suggested that calcium channel-blocking agents may prevent new coronary lesion formation, the progression of minimal lesions, or both. METHODS AND RESULTS:The Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT) was a multicenter, randomized, placebo-controlled, double-masked clinical trial designed to test whether amlodipine would slow the progression of early coronary atherosclerosis in 825 patients with angiographically documented coronary artery disease. The primary outcome was the average 36-month angiographic change in mean minimal diameters of segments with a baseline diameter stenosis of 30%. A secondary hypothesis was whether amlodipine would reduce the rate of atherosclerosis in the carotid arteries as assessed with B-mode ultrasonography, which measured intimal-medial thicknesses (IMT). The rates of clinical events were also monitored. The placebo and amlodipine groups had nearly identical average 36-month reductions in the minimal diameter: 0.084 versus 0.095 mm, respectively (P:=0.38). In contrast, amlodipine had a significant effect in slowing the 36-month progression of carotid artery atherosclerosis: the placebo group experienced a 0.033-mm increase in IMT, whereas there was a 0. 0126-mm decrease in the amlodipine group (P:=0.007). There was no treatment difference in the rates of all-cause mortality or major cardiovascular events, although amlodipine use was associated with fewer cases of unstable angina and coronary revascularization. CONCLUSIONS:Amlodipine has no demonstrable effect on angiographic progression of coronary atherosclerosis or the risk of major cardiovascular events but is associated with fewer hospitalizations for unstable angina and revascularization.

journal_name

Circulation

journal_title

Circulation

authors

Pitt B,Byington RP,Furberg CD,Hunninghake DB,Mancini GB,Miller ME,Riley W

doi

10.1161/01.cir.102.13.1503

subject

Has Abstract

pub_date

2000-09-26 00:00:00

pages

1503-10

issue

eissn

0009-7322

issn

1524-4539

journal_volume

102

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. PREVENT Investigators.