Comparison of myocardial preservation with hypothermic potassium and nifedipine arrest.

abstract：BACKGROUND:Risk factors for obstructive sleep apnea (OSA) and the development of subsequent cardiovascular (CV) complications differ by sex. We hypothesize that the relationship between OSA and high-sensitivity troponin T (hs-TnT), cardiac structure, and CV outcomes differs by sex. METHODS AND RESULTS:Seven hundred fi...

journal_title：Circulation

authors： Roca GQ,Redline S,Claggett B,Bello N,Ballantyne CM,Solomon SD,Shah AM

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:Proto-oncogenes have been implicated in the pathogenesis of gene-mediated myocardial remodeling. In the human heart, however, it has not been clarified whether these proto-oncogenes are related to contractile impairment and structural alteration of the myocardium. The present study is designed to investigate...

journal_title：Circulation

authors： Taketani S,Sawa Y,Taniguchi K,Mitsuno M,Kawaguchi N,Onishi S,Matsuda H

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Cardiac Na/K-ATPase (NKA) regulates intracellular Na ([Na](i)), which in turn affects intracellular Ca and thus contractility via Na/Ca exchange. Recent evidence shows that phosphorylation of the NKA-associated small transmembrane protein phospholemman (PLM) mediates beta-adrenergic-induced NKA stimulation. ...

journal_title：Circulation

authors： Despa S,Tucker AL,Bers DM

更新日期：2008-04-08 00:00:00

abstract：BACKGROUND:Several noninvasive methods are available to investigate the severity of extracoronary atherosclerotic disease. No population-based study has yet examined whether differences exist between these measures with regard to their predictive value for myocardial infarction (MI) or whether a given measure of athero...

journal_title：Circulation

authors： van der Meer IM,Bots ML,Hofman A,del Sol AI,van der Kuip DA,Witteman JC

更新日期：2004-03-09 00:00:00

abstract：BACKGROUND:There is an inverse relationship between HDL cholesterol and coronary heart disease. Experimental studies have indicated that HDL cholesterol may exert an antiatherogenic effect by inducing regression of atherosclerotic plaques and by turning lipid-rich plaques into more fibrotic lesions. In this prospective...

journal_title：Circulation

authors： Johnsen SH,Mathiesen EB,Fosse E,Joakimsen O,Stensland-Bugge E,Njølstad I,Arnesen E

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...

journal_title：Circulation

authors： Wichter T,Borggrefe M,Haverkamp W,Chen X,Breithardt G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the prevalence of skeletal muscle atrophy and its relation to exercise intolerance and abnormal muscle metabolism in patients with heart failure (HF). METHODS AND RESULTS:Peak VO2, percent ideal body weight (% IBW), 24-hour urine creatinine (Cr), and anthropometr...

journal_title：Circulation

authors： Mancini DM,Walter G,Reichek N,Lenkinski R,McCully KK,Mullen JL,Wilson JR

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:An inverse association between height and risk of coronary heart disease (CHD) has been reported in several case-control and cohort studies, but the reasons for the association remain uncertain. We evaluated this association among 22,071 male physicians, a population homogeneous for high educational attainme...

journal_title：Circulation

authors： Hebert PR,Rich-Edwards JW,Manson JE,Ridker PM,Cook NR,O'Connor GT,Buring JE,Hennekens CH

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia is associated with endothelial dysfunction. On the basis of the hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate endothelial adhesiveness and that this phenomenon might be reversible, soluble endothelial leukocyte adhesion molecules (sELAMs) were ...

journal_title：Circulation

authors： Sampietro T,Tuoni M,Ferdeghini M,Ciardi A,Marraccini P,Prontera C,Sassi G,Taddei M,Bionda A

更新日期：1997-09-02 00:00:00

abstract：:Isovolumic relaxation time (IVRT) and events of early transmitral flow measured by Doppler echocardiography were validated against the time constant of left ventricular relaxation (tau) in open-chest dogs. During increased inotropy (by isoproterenol infusion) at constant preload, enhancement of relaxation was indicate...

journal_title：Circulation

authors： Myreng Y,Smiseth OA

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Angiotensin II (Ang II) plays a critical role in the development of vascular lesions in hypertension, atherosclerosis, and several renal diseases. Because Ang II may contribute to the leukocyte recruitment associated with these pathological states, the aim of the present study was to assess the role of Ang I...

journal_title：Circulation

authors： Piqueras L,Kubes P,Alvarez A,O'Connor E,Issekutz AC,Esplugues JV,Sanz MJ

更新日期：2000-10-24 00:00:00

abstract：BACKGROUND:Platelet-rich thrombus formation is a critical event in the onset of cardiovascular disease. Because ADP plays a significant role in platelet aggregation, its metabolism is important in the regulation of platelet activation and recruitment. Ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) is a key ...

journal_title：Circulation

authors： Furukoji E,Matsumoto M,Yamashita A,Yagi H,Sakurai Y,Marutsuka K,Hatakeyama K,Morishita K,Fujimura Y,Tamura S,Asada Y

更新日期：2005-02-15 00:00:00

abstract：:Thirty-one published reports (366 patients) and 48 consecutive patients treated for postinfarction ventricular septal defect at four institutions in northern California were reviewed. Overall hospital mortality was 43% in the reviewed group and was not affected by age, concomitant myocardial revascularization, date of...

journal_title：Circulation

authors： Hill JD,Stiles QR

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Therapy with racemic compounds produces effects that can be attributed to both (S)- and (R)-enantiomers. Here we have tested the hypothesis that an enantiomer-enantiomer interaction would modulate the effects of treatment with a racemate, the antiarrhythmic propafenone. Previous studies have shown that while...

journal_title：Circulation

authors： Kroemer HK,Fromm MF,Bühl K,Terefe H,Blaschke G,Eichelbaum M

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Mechanisms by which neutrophils are attracted to the myocardium in ischemia/reperfusion are not fully defined. Lipopolysaccharide-induced CXC chemokine (LIX), cytokine-induced neutrophil chemoattractant (KC), and macrophage inflammatory protein-2 (MIP-2) are rodent chemokines with potent neutrophil-chemotact...

journal_title：Circulation

authors： Chandrasekar B,Smith JB,Freeman GL

更新日期：2001-05-08 00:00:00

abstract：BACKGROUND:Production of NO by inducible NO synthase (iNOS) has been implicated in the pathology of spontaneous and antigen-induced autoimmune diseases, and iNOS is expressed in the myocardium of patients with heart failure. It is not clear whether inflammatory murine autoimmune heart disease, an experimental model for...

journal_title：Circulation

authors： Bachmaier K,Neu N,Pummerer C,Duncan GS,Mak TW,Matsuyama T,Penninger JM

更新日期：1997-07-15 00:00:00

abstract：:Ten subjects with normal hemodynamics were studied during elective cardiac catheterization with right and left heart multisensor micromanometry to assess hemodynamic responses to the Mueller maneuver. Simultaneous right and left circulatory hemodynamics and left ventricular, pulmonary arterial, and aortic pressures we...

journal_title：Circulation

authors： Condos WR Jr,Latham RD,Hoadley SD,Pasipoularides A

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Myocardium irreversibly injured by ischemic stress must be efficiently repaired to maintain tissue integrity and contractile performance. Macrophages play critical roles in this process. These cells transform across a spectrum of phenotypes to accomplish diverse functions ranging from mediating the initial i...

journal_title：Circulation

authors： Cao DJ,Schiattarella GG,Villalobos E,Jiang N,May HI,Li T,Chen ZJ,Gillette TG,Hill JA

更新日期：2018-06-12 00:00:00

abstract：BACKGROUND:Fingolimod, a sphingosine-1-phosphate receptor agonist, is used for the treatment of multiple sclerosis and exerts antiapoptotic properties. We hypothesized that sphingosine-1-phosphate receptor activation with fingolimod during acute myocardial infarction (MI) inhibits apoptosis, leading to increased myocar...

journal_title：Circulation

authors： Santos-Gallego CG,Vahl TP,Goliasch G,Picatoste B,Arias T,Ishikawa K,Njerve IU,Sanz J,Narula J,Sengupta PP,Hajjar RJ,Fuster V,Badimon JJ

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:Despite progress, many hypertensive patients remain uncontrolled. Defining characteristics of uncontrolled hypertensives may facilitate efforts to improve blood pressure control. METHODS AND RESULTS:Subjects included 13,375 hypertensive adults from National Health and Nutrition Examination Surveys (NHANESs)...

journal_title：Circulation

authors： Egan BM,Zhao Y,Axon RN,Brzezinski WA,Ferdinand KC

更新日期：2011-08-30 00:00:00

abstract：:Skeletal muscle ventricles were constructed from the latissimus dorsi in seven dogs. All skeletal muscle ventricles underwent a vascular delay period followed by 4-7 weeks of electrical preconditioning. In group 1 (n = 5), the skeletal muscle ventricle was used to replace native right-heart function. Venous return fro...

journal_title：Circulation

authors： Bridges CR Jr,Hammond RL,Dimeo F,Anderson WA,Stephenson LW

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Paraplegia remains a devastating complication of thoracic aortic surgery. The mechanism of the antecedent spinal cord ischemia and reperfusion injury (IR) remains poorly described. IR involves 2 injuries, an initial ischemic insult and subsequent inflammatory amplification of the injury. This mechanism is co...

journal_title：Circulation

authors： Smith PD,Puskas F,Meng X,Lee JH,Cleveland JC Jr,Weyant MJ,Fullerton DA,Reece TB

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Pulmonary arterial hypertension (PAH) is a life-threatening disease, characterized by vascular smooth muscle cell hyperproliferation. The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation. METHODS AND RESULTS:We investigated the expres...

journal_title：Circulation

authors： Schermuly RT,Pullamsetti SS,Kwapiszewska G,Dumitrascu R,Tian X,Weissmann N,Ghofrani HA,Kaulen C,Dunkern T,Schudt C,Voswinckel R,Zhou J,Samidurai A,Klepetko W,Paddenberg R,Kummer W,Seeger W,Grimminger F

更新日期：2007-05-01 00:00:00

abstract：:In studies to ascertain the basis of dynamic changes in the P wave, bipolar epicardial potentials were recorded from multiple atrial electrodes in dogs. One hundred to 120 activation times were displayed by a digital computer and used to construct atrial isotemporal activation sequence maps. Changes in heart rate or b...

journal_title：Circulation

authors： Boineau JP,Schuessler RB,Mooney CR,Wylds AC,Miller CB,Hudson RD,Borremans JM,Brockus CW

更新日期：1978-12-01 00:00:00

abstract：:Exercise trials in cardiology are often hindered by inconsistent approaches to exercise testing. These inconsistencies include the choice of exercise protocol, exercise end points, points of analysis, and absence or misuse of gas exchange data. Gas exchange techniques greatly enhance the accuracy with which cardiopulm...

journal_title：Circulation

authors： Myers J,Froelicher VF

更新日期：1990-11-01 00:00:00

abstract：:Twelve healthy men were studied by M mode echocardiography during exercise to investigate the effect of afterload reduction on left ventricular function at maximal exertion. They performed two maximal exercise bicycle tests 4 hr apart while in the semisupine position and were given 20 mg nifedipine sublingually 30 min...

journal_title：Circulation

authors： Andersen K,Vik-Mo H

更新日期：1984-03-01 00:00:00

abstract：:Diffuse coronary artery disease is frequently untreatable by coronary artery bypass or angioplasty. Many such "no-option" patients have been subjects for trials of angiogenesis using growth factor manipulation or laser injury. We think these novel revascularization strategies are limited by insufficient inflow to puta...

journal_title：Circulation

authors： Oesterle SN,Reifart N,Hauptmann E,Hayase M,Yeung AC

更新日期：2001-05-29 00:00:00

abstract：BACKGROUND:Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. METHODS:We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their rel...

journal_title：Circulation

authors： Bassand JP,Virdone S,Goldhaber SZ,Camm AJ,Fitzmaurice DA,Fox KAA,Goto S,Haas S,Hacke W,Kayani G,Mantovani LG,Misselwitz F,Pieper KS,Turpie AGG,van Eickels M,Verheugt FWA,Kakkar AK

更新日期：2019-02-05 00:00:00

abstract：BACKGROUND:Because pulmonary artery size is considered by most investigators to be a major prognosticator of outcome in patients undergoing staged Fontan reconstruction, the objective of the present study was to determine the efficacy of noninvasive measures in determining pulmonary artery size. METHODS AND RESULTS:Th...

journal_title：Circulation

authors： Fogel MA,Donofrio MT,Ramaciotti C,Hubbard AM,Weinberg PM

更新日期：1994-12-01 00:00:00

abstract：:Cardiovascular disease continues to be the leading cause of death among women in the United States. One of the barriers to improving cardiovascular disease outcomes in women is the lack of reliable, effective screening modalities. Breast arterial calcification has emerged as a potential risk stratification tool. Local...

journal_title：Circulation

authors： Bui QM,Daniels LB

更新日期：2019-02-19 00:00:00