Angiotensin II induces leukocyte-endothelial cell interactions in vivo via AT(1) and AT(2) receptor-mediated P-selectin upregulation.

abstract：:Advances in cardiovascular medicine fueled by innovative clinical trials have dramatically improved the lives of patients worldwide. Commensurate with this progress has been a decline in morbid and mortal events. Accordingly, an increased propensity to collate patient outcomes in clinical trials has emerged that combi...

journal_title：Circulation

authors： Armstrong PW,Westerhout CM

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Q waves on a 12-lead ECG are markers of a prior myocardial infarction (MI). However, they may regress or even disappear over time, and there is no specific ECG sign of a non-Q-wave MI. Fragmented QRS complexes (fQRSs), which include various RSR' patterns, without a typical bundle-branch block are markers of ...

journal_title：Circulation

authors： Das MK,Khan B,Jacob S,Kumar A,Mahenthiran J

更新日期：2006-05-30 00:00:00

abstract：BACKGROUND:Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Downstream of gp130, two signal-transducing pathways have been recognized, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway and the Ras-mitogen-activated protein kinase (MAPK) pathway. To d...

journal_title：Circulation

authors： Kunisada K,Hirota H,Fujio Y,Matsui H,Tani Y,Yamauchi-Takihara K,Kishimoto T

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:The synthetic catecholamine dobutamine increases stroke volume in normal subjects and in patients with congestive heart failure. In addition to its direct influence on myocardial contractility, dobutamine may significantly modulate vascular tone because of its alpha- and beta-adrenergic agonist activity. ME...

journal_title：Circulation

authors： Binkley PF,Murray KD,Watson KM,Myerowitz PD,Leier CV

更新日期：1991-09-01 00:00:00

abstract：:The myocardial uptake of 125I- and 131I-antimyosin monoclonal antibody Fab in experimental myocarditis in BALB/c mice induced by encephalomyocarditis virus was studied. The biodistribution of 125I-antimyosin demonstrated that the highest ratio of radioactivity appears in the heart of infected mice on day 14 (the ratio...

journal_title：Circulation

authors： Matsumori A,Ohkusa T,Matoba Y,Okada I,Yamada T,Kawai C,Tamaki N,Watanabe Y,Yonekura Y,Endo K

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Prospective data relating previous exposure to cytomegalovirus (CMV) to the risk of cardiac mortality are controversial. We investigated the effect of previous exposure to CMV infection on the risk of future cardiac disease-related death in relation to an underlying inflammatory response. METHODS AND RESULT...

journal_title：Circulation

authors： Blankenberg S,Rupprecht HJ,Bickel C,Espinola-Klein C,Rippin G,Hafner G,Ossendorf M,Steinhagen K,Meyer J

更新日期：2001-06-19 00:00:00

abstract：BACKGROUND:Patients with acute ischemic right ventricular dysfunction often develop hemodynamic compromise, yet most manifest spontaneous early clinical improvement and later recovery of global right ventricular performance. This study was designed to delineate the determinants of right ventricular performance followin...

journal_title：Circulation

authors： Laster SB,Shelton TJ,Barzilai B,Goldstein JA

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Performance of coronary artery bypass graft (CABG) during an acute coronary syndrome (ACS) is mainly used in high-risk patients. Although potentially life-saving, patients undergoing early CABG are traditionally associated with a worse outcome than those not requiring CABG. Is this really true in an unselect...

journal_title：Circulation

authors： Monteiro P,Portuguese Registry on Acute Coronary Syndromes.

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Alterations in the balance of matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is related to interstitial fibrosis or LV dysfunction in patients with chronic pressure overload-induced LV hypertrophy, howev...

journal_title：Circulation

authors： Heymans S,Schroen B,Vermeersch P,Milting H,Gao F,Kassner A,Gillijns H,Herijgers P,Flameng W,Carmeliet P,Van de Werf F,Pinto YM,Janssens S

更新日期：2005-08-23 00:00:00

abstract：:The linearity and sensitivity of the end-systolic pressure-volume (P-Ves) relation to the inotropic state of the left ventricle were investigated in 11 patients with coronary heart disease and one patient with congestive cardiomyopathy. To minimize autonomic reflex responses, propranolol, 0.15 mg/kg, and atropine, 1 m...

journal_title：Circulation

authors： Mehmel HC,Stockins B,Ruffmann K,von Olshausen K,Schuler G,Kübler W

更新日期：1981-06-01 00:00:00

abstract：:Early afterdepolarizations (EADs) are depolarizing potentials that occur before complete repolarization. They may be important in the acquired and possibly the idiopathic long QT syndrome and associated ventricular tachycardia (VT). The purpose of these experiments was to study in 20 open-chest dogs the effects of sym...

journal_title：Circulation

authors： Ben-David J,Zipes DP

更新日期：1988-11-01 00:00:00

abstract：:The effect of bretylium tosylate (BT) was determined in 27 consecutive cases of resistant ventricular fibrillation (VF) encountered by a hospital cardiac arrest team. The VF was sustained and completely resistant to multiple injections of lidocaine, sequential DC shocks at 400 watt-sec and one or a combination of intr...

journal_title：Circulation

authors： Holder DA,Sniderman AD,Fraser G,Fallen EL

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in the United States and is responsible for 17% of national health expenditures. As the population ages, these costs are expected to increase substantially. METHODS AND RESULTS:To prepare for future cardiovascular care needs, the American Heart Asso...

journal_title：Circulation

authors： Heidenreich PA,Trogdon JG,Khavjou OA,Butler J,Dracup K,Ezekowitz MD,Finkelstein EA,Hong Y,Johnston SC,Khera A,Lloyd-Jones DM,Nelson SA,Nichol G,Orenstein D,Wilson PW,Woo YJ,American Heart Association Advocacy Coordinating

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Mechanisms by which neutrophils are attracted to the myocardium in ischemia/reperfusion are not fully defined. Lipopolysaccharide-induced CXC chemokine (LIX), cytokine-induced neutrophil chemoattractant (KC), and macrophage inflammatory protein-2 (MIP-2) are rodent chemokines with potent neutrophil-chemotact...

journal_title：Circulation

authors： Chandrasekar B,Smith JB,Freeman GL

更新日期：2001-05-08 00:00:00

abstract：BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...

journal_title：Circulation

authors： Lam JY,Chesebro JH,Steele PM,Heras M,Webster MW,Badimon L,Fuster V

更新日期：1991-08-01 00:00:00

abstract：:Two-dimensional suprasternal notch echocardiography was performed in 1033 patients, ages 1 day to 18 years. For the long-axis suprasternal notch view, the transducer was positioned in the suprasternal notch and angled to obtain a plane passing between the right nipple and left scapular tip. In this view, the entire ao...

journal_title：Circulation

authors： Snider AR,Silverman NH

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Thrombolytic therapy of acute myocardial infarction (AMI) is evolving toward bolus administration. Derivatization of proteins with polyethylene glycol (PEG) may reduce their clearance. METHODS AND RESULTS:A staphylokinase (SakSTAR) variant with 12 amino acid substitutions to reduce its antigenicity, SakSTAR...

journal_title：Circulation

authors： Collen D,Sinnaeve P,Demarsin E,Moreau H,De Maeyer M,Jespers L,Laroche Y,Van de Werf F

更新日期：2000-10-10 00:00:00

abstract：BACKGROUND:The use of balloon coarctation angioplasty instead of surgery as treatment for unoperated coarctation of the aorta is controversial. The efficacy and complications of the two procedures have not been studied before in a prospective fashion. METHODS AND RESULTS:Thirty-six patients were prospectively randomiz...

journal_title：Circulation

authors： Shaddy RE,Boucek MM,Sturtevant JE,Ruttenberg HD,Jaffe RB,Tani LY,Judd VE,Veasy LG,McGough EC,Orsmond GS

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of viral myocarditis. METHODS AND RESULTS:Using a murine model of acute myocarditis caused by coxsackievirus B3, we analyzed the phenotypes and morphology of the infiltrating cells in the hearts by immunofluorescence and electron mi...

journal_title：Circulation

authors： Seko Y,Shinkai Y,Kawasaki A,Yagita H,Okumura K,Takaku F,Yazaki Y

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:A role for myeloperoxidase (MPO) as a mediator of coronary artery disease and acute coronary syndromes has recently received considerable attention. Although active MPO and hypochlorite-modified proteins and peptides have been detected in human atherosclerotic lesions, detection of novel chlorinated oxidized...

journal_title：Circulation

authors： Thukkani AK,McHowat J,Hsu FF,Brennan ML,Hazen SL,Ford DA

更新日期：2003-12-23 00:00:00

abstract：:Amiloride, a widely used diuretic, has multiple pharmacological actions, including inhibition of the sodium-hydronium ion and the sodium-calcium exchanger in heart. In terms of cardiac electrophysiology, amiloride prolongs action potential duration without alteration in upstroke velocity of phase 0 in Purkinje fibers....

journal_title：Circulation

authors： Duff HJ,Lester WM,Rahmberg M

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Sharing of patient-level clinical trial data has been widely endorsed. Little is known about how extensively these data have been used for cardiometabolic diseases. We sought to evaluate the availability and use of shared data from cardiometabolic clinical trials. METHODS:We extracted data from ClinicalStud...

journal_title：Circulation

authors： Vaduganathan M,Nagarur A,Qamar A,Patel RB,Navar AM,Peterson ED,Bhatt DL,Fonarow GC,Yancy CW,Butler J

更新日期：2018-02-27 00:00:00

abstract：BACKGROUND:The Na(+)/Ca(2+) exchange (NCX) extrudes Ca(2+) from cardiac myocytes, but it can also mediate Ca(2+) influx, load the sarcoplasmic reticulum with Ca(2+), and trigger Ca(2+) release from the sarcoplasmic reticulum. In ischemia/reperfusion or digitalis toxicity, increased levels of intracellular [Na(+)] ([Na(...

journal_title：Circulation

authors： Satoh H,Ginsburg KS,Qing K,Terada H,Hayashi H,Bers DM

更新日期：2000-03-28 00:00:00

abstract：BACKGROUND:Second trimester routine ultrasound evaluation of the fetal heart by means of the four-chamber view has been proposed for prenatal detection of cardiac anomalies. The aim of this study was to evaluate the efficacy of this procedure. METHODS AND RESULTS:A prospective follow-up study on 6922 scanned fetuses w...

journal_title：Circulation

authors： Buskens E,Grobbee DE,Frohn-Mulder IM,Stewart PA,Juttmann RE,Wladimiroff JW,Hess J

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Limited information exists on the intermediate-term graft patency and 5-year clinical outcomes of patients receiving saphenous vein grafts with multiple (m-SVG) versus single distal targets (s-SVG) during coronary artery bypass graft (CABG) surgery in the current era. METHODS AND RESULTS:We studied the asso...

journal_title：Circulation

authors： Mehta RH,Ferguson TB,Lopes RD,Hafley GE,Mack MJ,Kouchoukos NT,Gibson CM,Harrington RA,Califf RM,Peterson ED,Alexander JH,Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV Investigators.

更新日期：2011-07-19 00:00:00

abstract：BACKGROUND:Glycoprotein (GP) IIb/IIIa inhibitors are beneficial in patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS); their safe use in women, however, remains a concern. The contribution of dosing to the observed sex-related differences in bleeding is unknown. METHODS AND RESULTS:We explored ...

journal_title：Circulation

authors： Alexander KP,Chen AY,Newby LK,Schwartz JB,Redberg RF,Hochman JS,Roe MT,Gibler WB,Ohman EM,Peterson ED,CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC\/

更新日期：2006-09-26 00:00:00

abstract：:Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular ...

journal_title：Circulation

authors： Anderson KP,Walker R,Lux RL,Ershler PR,Menlove R,Williams MR,Krall R,Moddrelle D

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Despite a recent American Heart Association (AHA) consensus statement emphasizing the importance of resistant hypertension, the incidence and prognosis of this condition are largely unknown. METHODS AND RESULTS:This retrospective cohort study in 2 integrated health plans included patients with incident hype...

journal_title：Circulation

authors： Daugherty SL,Powers JD,Magid DJ,Tavel HM,Masoudi FA,Margolis KL,O'Connor PJ,Selby JV,Ho PM

更新日期：2012-04-03 00:00:00

abstract：BACKGROUND:The prevalence, prognostic import, and impact of renal insufficiency on the benefits of ACE inhibitors and beta-blockers in community-dwelling patients with heart failure are uncertain. METHODS AND RESULTS:We analyzed data from a prospective cohort of 754 patients with heart failure who had ejection fractio...

journal_title：Circulation

authors： McAlister FA,Ezekowitz J,Tonelli M,Armstrong PW

更新日期：2004-03-02 00:00:00

abstract：BACKGROUND:The differentiation of hypertrophic cardiomyopathy (HCM) from hypertensive left ventricular hypertrophy (H-LVH) on the basis of morphological information obtained by conventional echocardiography is occasionally problematic. We investigated whether strain rate (SR) imaging derived from tissue Doppler imaging...

journal_title：Circulation

authors： Kato TS,Noda A,Izawa H,Yamada A,Obata K,Nagata K,Iwase M,Murohara T,Yokota M

更新日期：2004-12-21 00:00:00