Functional right-heart replacement with skeletal muscle ventricles.

abstract：:The cause and associated pathophysiology of precordial ST-segment depression (ST decreases) during acute inferior myocardial infarction (IMI) are controversial. To investigate this problem, electrocardiographic findings in 48 consecutive patients with acute IMI were prospectively compared with results of coronary angi...

journal_title：Circulation

authors： Gibson RS,Crampton RS,Watson DD,Taylor GJ,Carabello BA,Holt ND,Beller GA

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. METHODS:Epigenetically controlled lncRNAs in human umbilical vein endothelia...

journal_title：Circulation

authors： Leisegang MS,Fork C,Josipovic I,Richter FM,Preussner J,Hu J,Miller MJ,Epah J,Hofmann P,Günther S,Moll F,Valasarajan C,Heidler J,Ponomareva Y,Freiman TM,Maegdefessel L,Plate KH,Mittelbronn M,Uchida S,Künne C,Stello

更新日期：2017-07-04 00:00:00

abstract：:To determine the contribution of disopyramide's suggested opposing direct depressant and indirect acceleratory actions on sinus node function, we studied the effects of disopyramide, 1 x 10(-7) to 1 x 10(-4) M, on isolated rabbit sinus node preparations using standard microelectrode techniques. Transmembrane potential...

journal_title：Circulation

authors： Katoh T,Karagueuzian HS,Jordan J,Mandel WJ

更新日期：1982-12-01 00:00:00

abstract：:Early afterdepolarizations (EADs) are depolarizing potentials that occur before complete repolarization. They may be important in the acquired and possibly the idiopathic long QT syndrome and associated ventricular tachycardia (VT). The purpose of these experiments was to study in 20 open-chest dogs the effects of sym...

journal_title：Circulation

authors： Ben-David J,Zipes DP

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Inhaled nitric oxide (iNO) has been used to assess the vasodilator capacity of the pulmonary vascular bed in children with congenital heart disease and elevated pulmonary vascular resistance. Inhaled iloprost is a pulmonary vasodilator for the long-term treatment of pulmonary hypertension (PHT). Because thes...

journal_title：Circulation

authors： Rimensberger PC,Spahr-Schopfer I,Berner M,Jaeggi E,Kalangos A,Friedli B,Beghetti M

更新日期：2001-01-30 00:00:00

abstract：BACKGROUND:In the last decades, interest has increased in the potential deleterious atherogenic effects of some cellular elastase activities. The results of experimental and clinical investigations were inconsistent. In this report, we assessed the associations of serum elastase activity and serum elastase inhibitors w...

journal_title：Circulation

authors： Zureik M,Robert L,Courbon D,Touboul PJ,Bizbiz L,Ducimetière P

更新日期：2002-06-04 00:00:00

abstract：BACKGROUND:We have developed a new measure of myocardial viability, the water-perfusable tissue index (PTI), which is calculated from transmission, C15O, and H2(15)O positron emission tomography (PET) data sets. It is defined as the proportion of the total anatomical tissue within a given region of interest (ROI) that ...

journal_title：Circulation

authors： Yamamoto Y,de Silva R,Rhodes CG,Araujo LI,Iida H,Rechavia E,Nihoyannopoulos P,Hackett D,Galassi AR,Taylor CJ

更新日期：1992-07-01 00:00:00

abstract：:Blood pressure and heart rate of 15 male shift workers were measured every 15 minutes for 24 hours during three work shifts: morning, 4:00 AM to noon; afternoon, noon to 8:00 PM; and night, 8:00 PM to 4:00 AM. For each shift, 24-hour systolic and diastolic blood pressure showed a large "trough" (the low pressure span)...

journal_title：Circulation

authors： Chau NP,Mallion JM,de Gaudemaris R,Ruche E,Siche JP,Pelen O,Mathern G

更新日期：1989-08-01 00:00:00

abstract：:Left main coronary artery disease (i.e., greater than or equal to 50% stenosis) was found in 1,477 of 20,137 patients in the Coronary Artery Surgery Study (CAS) registry. Of these patients, 53 (3.6%) were asymptomatic. Asymptomatic and symptomatic patients were similar in regard to 1) severity of left main coronary ar...

journal_title：Circulation

authors： Taylor HA,Deumite NJ,Chaitman BR,Davis KB,Killip T,Rogers WJ

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Endogenous nitric oxide (NO) has been reported to inhibit oxygen consumption in the normal heart, so that nonselective inhibition of NO synthase (NOS) caused an increase of myocardial oxygen consumption (MVO2). Although endothelial NOS responses are depressed in congestive heart failure (CHF), inducible NOS ...

journal_title：Circulation

authors： Chen Y,Traverse JH,Du R,Hou M,Bache RJ

更新日期：2002-07-09 00:00:00

abstract：BACKGROUND:Fingolimod, a sphingosine-1-phosphate receptor agonist, is used for the treatment of multiple sclerosis and exerts antiapoptotic properties. We hypothesized that sphingosine-1-phosphate receptor activation with fingolimod during acute myocardial infarction (MI) inhibits apoptosis, leading to increased myocar...

journal_title：Circulation

authors： Santos-Gallego CG,Vahl TP,Goliasch G,Picatoste B,Arias T,Ishikawa K,Njerve IU,Sanz J,Narula J,Sengupta PP,Hajjar RJ,Fuster V,Badimon JJ

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of adverse cardiac drug reactions are more common in patients with preexisting heart disease than the general population. Here we generated a library of hu...

journal_title：Circulation

authors： Liang P,Lan F,Lee AS,Gong T,Sanchez-Freire V,Wang Y,Diecke S,Sallam K,Knowles JW,Wang PJ,Nguyen PK,Bers DM,Robbins RC,Wu JC

更新日期：2013-04-23 00:00:00

abstract：:In this report we describe electrophysiologic and histologic findings in hearts and endocardially resected preparations from patients with sustained ventricular tachycardias in the chronic phase of myocardial infarction. We recorded simultaneously from 64 endocardial sites during tachycardia in 72 patients that were o...

journal_title：Circulation

authors： de Bakker JM,van Capelle FJ,Janse MJ,Wilde AA,Coronel R,Becker AE,Dingemans KP,van Hemel NM,Hauer RN

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND:Intentional weight loss is associated with lower risk of heart failure (HF) and atherosclerotic cardiovascular disease among patients with type 2 diabetes. However, the contribution of baseline measures and longitudinal changes in fat mass (FM), lean mass (LM), and waist circumference (WC) to the risk of HF ...

journal_title：Circulation

authors： Patel KV,Bahnson JL,Gaussoin SA,Johnson KC,Pi-Sunyer X,White U,Olson KL,Bertoni AG,Kitzman DW,Berry JD,Pandey A,Look AHEAD Research Group.

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:Cellular transplantation is emerging as a promising strategy for the treatment of postinfarction ventricular dysfunction. Whether its beneficial effects can be extended to other cardiomyopathies remains an unexplored question. We evaluated the histological and functional effects of simultaneous autologous tr...

journal_title：Circulation

authors： Guarita-Souza LC,Carvalho KA,Woitowicz V,Rebelatto C,Senegaglia A,Hansen P,Miyague N,Francisco JC,Olandoski M,Faria-Neto JR,Brofman P

更新日期：2006-07-04 00:00:00

abstract：:Between January 1, 1970, and December 31, 1974, 2981 patients underwent coronary arteriography. Twelve acute coronary dissections or embolizations occurred, an incidence of 0.4%. The incidences of acute occlusions for the Sones and Judkins techniques were 0.19% (4/2077 studies) and 0.88% (8/940), respectively. No inst...

journal_title：Circulation

authors： Guss SB,Zir LM,Garrison HB,Daggett WM,Block PC,Dinsmore RE

更新日期：1975-12-01 00:00:00

abstract：:Aspirin has been convincingly shown to reduce stroke and death in men with transient ischemic attacks (it may possibly be beneficial to women also), myocardial infarction and death in patients with unstable angina, thromboembolic complications associated with artificial heart valves in patients receiving oral anticoag...

journal_title：Circulation

authors： Harker LA

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Coconut oil is high in saturated fat and may, therefore, raise serum cholesterol concentrations, but beneficial effects on other cardiovascular risk factors have also been suggested. Therefore, we conducted a systematic review of the effect of coconut oil consumption on blood lipids and other cardiovascular ...

journal_title：Circulation

authors： Neelakantan N,Seah JYH,van Dam RM

更新日期：2020-03-10 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is an ischemic wound that recruits millions of leukocytes. MI-associated blood leukocytosis correlates inversely with patient survival, yet the signals driving heightened leukocyte production after MI remain incompletely understood. METHODS AND RESULTS:With the use of parabiosis s...

journal_title：Circulation

authors： Sager HB,Heidt T,Hulsmans M,Dutta P,Courties G,Sebas M,Wojtkiewicz GR,Tricot B,Iwamoto Y,Sun Y,Weissleder R,Libby P,Swirski FK,Nahrendorf M

更新日期：2015-11-17 00:00:00

abstract：:Accumulating experimental and clinical evidence indicates that a time for reappraisal of therapeutic modalities designed to inhibit the eicosanoid pathway as it may affect vascular disease may be approaching. Pharmacologic agents originally used were chosen because they were capable of suppressing platelet functions s...

journal_title：Circulation

authors： Marcus AJ,Safier LB,Ullman HL,Broekman MJ,Islam N,Oglesby TD,Gorman RR,Ward JW

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:The impact of abdominal arterial calcific deposits on the prediction of cardiovascular disease (CVD) over a long follow-up interval deserves greater scrutiny. METHODS AND RESULTS:Lateral lumbar radiographs were studied as a predictor of incident coronary heart disease (CHD), CVD, and CVD mortality in 1049 m...

journal_title：Circulation

authors： Wilson PW,Kauppila LI,O'Donnell CJ,Kiel DP,Hannan M,Polak JM,Cupples LA

更新日期：2001-03-20 00:00:00

abstract：BACKGROUND:The morphological characteristics of coronary plaques in patients with stable versus unstable coronary syndromes have been described in vivo with intravascular ultrasound, but the relationship between arterial remodeling and clinical presentation is not well known. METHODS AND RESULTS:We studied 85 patients...

journal_title：Circulation

authors： Schoenhagen P,Ziada KM,Kapadia SR,Crowe TD,Nissen SE,Tuzcu EM

更新日期：2000-02-15 00:00:00

abstract：BACKGROUND:Impaired endothelium-dependent NO-mediated vasodilation is a key feature of essential hypertension and may precede the increase in blood pressure. We investigated whether transport of the NO precursor L-arginine is related to decreased endothelial function. METHODS AND RESULTS:Radiotracer kinetics ([3H]L-ar...

journal_title：Circulation

authors： Schlaich MP,Parnell MM,Ahlers BA,Finch S,Marshall T,Zhang WZ,Kaye DM

更新日期：2004-12-14 00:00:00

abstract：BACKGROUND:Impaired endothelium-dependent vasodilation is an early sign of atherosclerosis in hypercholesterolemic patients. We hypothesized that lipid-lowering therapy can improve endothelial function and that this effect is mainly mediated by increased bioavailability of nitric oxide (NO). METHODS AND RESULTS:In a r...

journal_title：Circulation

authors： John S,Schlaich M,Langenfeld M,Weihprecht H,Schmitz G,Weidinger G,Schmieder RE

更新日期：1998-07-21 00:00:00

abstract：BACKGROUND:The alpha1-adrenergic receptors (alpha1-ARs) play a key role in cardiovascular homeostasis. However, the functional role of alpha1-AR subtypes in vivo is still unclear. The aim of this study was to evaluate the cardiovascular influences of alpha1b-AR. METHODS AND RESULTS:In transgenic mice lacking alpha1-AR...

journal_title：Circulation

authors： Vecchione C,Fratta L,Rizzoni D,Notte A,Poulet R,Porteri E,Frati G,Guelfi D,Trimarco V,Mulvany MJ,Agabiti-Rosei E,Trimarco B,Cotecchia S,Lembo G

更新日期：2002-04-09 00:00:00

abstract：BACKGROUND:Coronary flow reserve (CFR), an integrated measure of focal, diffuse, and small-vessel coronary artery disease (CAD), identifies patients at risk for cardiac death. We sought to determine the association between CFR, angiographic CAD, and cardiovascular outcomes. METHODS AND RESULTS:Consecutive patients (n=...

journal_title：Circulation

authors： Taqueti VR,Hachamovitch R,Murthy VL,Naya M,Foster CR,Hainer J,Dorbala S,Blankstein R,Di Carli MF

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:The rate of coronary heart disease (CHD) mortality in eastern Finland has been the highest in the world. The official mortality statistics suggest, however, that is has declined by 60% during the past 20 years. The aim of the present study was to examine the contributions of incidence, recurrence, and case f...

journal_title：Circulation

authors： Salomaa V,Miettinen H,Kuulasmaa K,Niemelä M,Ketonen M,Vuorenmaa T,Lehto S,Palomäki P,Mähönen M,Immonen-Räihä P,Arstila M,Kaarsalo E,Mustaniemi H,Torppa J,Tuomilehto J,Puska P,Pyörälä K

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...

journal_title：Circulation

authors： Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

更新日期：2007-09-04 00:00:00

abstract：BACKGROUND:Early-generation drug-eluting stents releasing sirolimus (SES) or paclitaxel (PES) are associated with increased risk of very late stent thrombosis occurring >1 year after stent implantation. It is unknown whether the risk of very late stent thrombosis persists with newer-generation everolimus-eluting stents...

journal_title：Circulation

authors： Räber L,Magro M,Stefanini GG,Kalesan B,van Domburg RT,Onuma Y,Wenaweser P,Daemen J,Meier B,Jüni P,Serruys PW,Windecker S

更新日期：2012-03-06 00:00:00

abstract：BACKGROUND:There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. METHODS AND RESULTS:A myocardial inf...

journal_title：Circulation

authors： Pouzet B,Ghostine S,Vilquin JT,Garcin I,Scorsin M,Hagège AA,Duboc D,Schwartz K,Menasché P

更新日期：2001-09-18 00:00:00