Clinical trials evaluating platelet-modifying drugs in patients with atherosclerotic cardiovascular disease and thrombosis.

abstract：BACKGROUND:Familial polymorphic ventricular tachycardia is an autosomal-dominant, inherited disease with a relatively early onset and a mortality rate of approximately 30% by the age of 30 years. Phenotypically, it is characterized by salvoes of bidirectional and polymorphic ventricular tachycardias in response to vigo...

journal_title：Circulation

authors： Laitinen PJ,Brown KM,Piippo K,Swan H,Devaney JM,Brahmbhatt B,Donarum EA,Marino M,Tiso N,Viitasalo M,Toivonen L,Stephan DA,Kontula K

更新日期：2001-01-30 00:00:00

abstract：BACKGROUND:Radiofrequency catheter ablation is the treatment of choice for patients with paroxysmal supraventricular tachycardias refractory to medical therapy. However, in symptomatic patients with inappropriate sinus tachycardia resistant to drug therapy, catheter ablation of the His' bundle with permanent pacemaker ...

journal_title：Circulation

authors： Lee RJ,Kalman JM,Fitzpatrick AP,Epstein LM,Fisher WG,Olgin JE,Lesh MD,Scheinman MM

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:Guidelines for the management of patients with suspected coronary artery disease (CAD) rely on the age, sex, and angina typicality-based pretest probabilities of angiographically significant CAD derived from invasive coronary angiography (guideline probabilities). Reliability of guideline probabilities has n...

journal_title：Circulation

authors： Cheng VY,Berman DS,Rozanski A,Dunning AM,Achenbach S,Al-Mallah M,Budoff MJ,Cademartiri F,Callister TQ,Chang HJ,Chinnaiyan K,Chow BJ,Delago A,Gomez M,Hadamitzky M,Hausleiter J,Karlsberg RP,Kaufmann P,Lin FY,Maffei E

更新日期：2011-11-29 00:00:00

abstract：:The elevated blood pressure and vascular resistance in patients with systemic hypertension are paralleled by a proportional rise in pressure and resistance in the lesser circulation. We evaluated the hypothesis that the increased systemic reaction to adrenergic stimulation is shared by the pulmonary vessels. For this ...

journal_title：Circulation

authors： Guazzi MD,De Cesare N,Fiorentini C,Galli C,Moruzzi P,Tamborini G

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Erythropoietin (Epo) receptors (EpoRs) are expressed in the heart. We have recently demonstrated that the endogenous Epo-EpoR system plays an important protective role in myocardial ischemia in mice and humans. In the present study, we tested our hypothesis that the endogenous Epo-EpoR system in nonhematopoi...

journal_title：Circulation

authors： Asaumi Y,Kagaya Y,Takeda M,Yamaguchi N,Tada H,Ito K,Ohta J,Shiroto T,Shirato K,Minegishi N,Shimokawa H

更新日期：2007-04-17 00:00:00

abstract：BACKGROUND:Circulatory arrest (CA), which provides a bloodless field and good visualization without the need of aortic cross-clamp, is commonly used to facilitate repair of aortic lesions. However, extended periods of CA may impair cerebral metabolism and cause ischemic injury. Studies were performed to evaluate the ef...

journal_title：Circulation

authors： Lin PJ,Chang CH,Tan PP,Chang CN,Lee ST,Wang CC,Chang JP,Liu DW,Chu JJ,Tsai KT,Kao CL,Hsieh MJ,Hua MS

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Despite the fact that nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated among patients with established cardiovascular disease, many receive NSAID treatment for a short period of time. However, little is known about the association between NSAID treatment duration and risk of cardiovascular d...

journal_title：Circulation

authors： Schjerning Olsen AM,Fosbøl EL,Lindhardsen J,Folke F,Charlot M,Selmer C,Lamberts M,Bjerring Olesen J,Køber L,Hansen PR,Torp-Pedersen C,Gislason GH

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Recent studies have identified critical roles for microRNAs (miRNAs) in a variety of cellular processes, including regulation of cardiomyocyte death. However, the signature of miRNA expression and possible roles of miRNA in the ischemic heart have been less well studied. METHODS AND RESULTS:We performed miR...

journal_title：Circulation

authors： Ren XP,Wu J,Wang X,Sartor MA,Jones K,Qian J,Nicolaou P,Pritchard TJ,Fan GC

更新日期：2009-05-05 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) activators, such as troglitazone (Tro), not only improve insulin resistance but also suppress the neointimal formation after balloon injury. However, the precise mechanisms have not been determined. Angiotensin II (Ang II) plays crucial roles in th...

journal_title：Circulation

authors： Takeda K,Ichiki T,Tokunou T,Funakoshi Y,Iino N,Hirano K,Kanaide H,Takeshita A

更新日期：2000-10-10 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide (BNP) and N-terminal (NT)-proBNP have recently emerged as promising parameters for risk assessment in acute pulmonary embolism (PE). However, their positive predictive value is low, and the prognostic implications of NT-proBNP or troponin elevation alone are questionable. METHODS A...

journal_title：Circulation

authors： Binder L,Pieske B,Olschewski M,Geibel A,Klostermann B,Reiner C,Konstantinides S

更新日期：2005-09-13 00:00:00

abstract：BACKGROUND:Coxsackievirus-induced myocarditis can be a serious cause of heart failure. In the absence of a specific antiviral therapy, modulating the host immune response may be protective. Interferons (IFNs)-alpha and -beta perform a fundamental role in innate and adaptive antiviral responses, thereby presenting as ca...

journal_title：Circulation

authors： Deonarain R,Cerullo D,Fuse K,Liu PP,Fish EN

更新日期：2004-12-07 00:00:00

abstract：BACKGROUND:Increased diastolic chamber stiffness (increased DCS) during angina (demand ischemia) has been postulated to be generated by increased diastolic myocyte calcium concentration. METHODS AND RESULTS:We reproduced demand ischemia in isolated isovolumically contracting red-cell-perfused rabbit hearts by imposing...

journal_title：Circulation

authors： Varma N,Eberli FR,Apstein CS

更新日期：2000-05-09 00:00:00

abstract：:An endothelium-dependent vasodilator response to acetylcholine has been described recently in patients with coronary artery disease. Those studies determined responses only of large epicardial arteries. Our study was designed to determine the integrated effects of acetylcholine on epicardial diameter, coronary flow, a...

journal_title：Circulation

authors： Hodgson JM,Marshall JJ

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Patients with chronic granulomatous disease (CGD) experience immunodeficiency because of defects in the phagocyte NADPH oxidase and the concomitant reduction in reactive oxygen intermediates. This may result in a reduction in atherosclerotic injury. METHODS AND RESULTS:We prospectively assessed the prevalen...

journal_title：Circulation

authors： Sibley CT,Estwick T,Zavodni A,Huang CY,Kwan AC,Soule BP,Long Priel DA,Remaley AT,Rudman Spergel AK,Turkbey EB,Kuhns DB,Holland SM,Malech HL,Zarember KA,Bluemke DA,Gallin JI

更新日期：2014-12-02 00:00:00

abstract：:Guiding surgical therapy of ventricular tachycardia by preoperative endocardial catheter mapping necessitates improvement of the accuracy of localization of the arrhythmogenic site. We therefore used a new mathematical cineradiographic method during catheter mapping to compute the position of left ventricular arrhythm...

journal_title：Circulation

authors： Hauer RN,de Zwart MT,de Bakker JM,Hitchcock JF,Penn OC,Nijsen-Karelse M,Robles de Medina EO

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Paraplegia continues to complicate thoracoabdominal aortic interventions. The elusive mechanism of spinal cord ischemia-reperfusion injury has delayed the development of pharmacological adjuncts. Microglia, the resident macrophages of the central nervous system, can have pathological responses after a variet...

journal_title：Circulation

authors： Bell MT,Puskas F,Agoston VA,Cleveland JC Jr,Freeman KA,Gamboni F,Herson PS,Meng X,Smith PD,Weyant MJ,Fullerton DA,Reece TB

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:The concept of natriuretic peptide guidance has been extensively studied in patients with chronic heart failure (HF), with only limited success. The effect of NT-proBNP (N-terminal probrain natriuretic peptide)-guided therapy in patients with acute decompensated HF using a relative NT-proBNP target has not b...

journal_title：Circulation

authors： Stienen S,Salah K,Moons AH,Bakx AL,van Pol P,Kortz RAM,Ferreira JP,Marques I,Schroeder-Tanka JM,Keijer JT,Bayés-Genis A,Tijssen JGP,Pinto YM,Kok WE

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Paroxysmal atrial fibrillation (AF) naturally progresses toward chronic AF at an estimated rate of 15% to 30% over a 1- to 3-year period. Pulmonary vein (PV) isolation is increasingly performed for the treatment of drug-refractory paroxysmal AF. The long-term data on clinical outcome after circumferential PV...

journal_title：Circulation

authors： Ouyang F,Tilz R,Chun J,Schmidt B,Wissner E,Zerm T,Neven K,Köktürk B,Konstantinidou M,Metzner A,Fuernkranz A,Kuck KH

更新日期：2010-12-07 00:00:00

abstract：BACKGROUND:Friedreich's ataxia (FA), the most common inherited ataxia, is associated frequently with cardiac hypertrophy, and death is often cardiac related. Recently, the disease has been associated with a mutation that consists of an unstable expansion of GAA repeats in the first intron of the gene encoding frataxin ...

journal_title：Circulation

authors： Isnard R,Kalotka H,Dürr A,Cossée M,Schmitt M,Pousset F,Thomas D,Brice A,Koenig M,Komajda M

更新日期：1997-05-06 00:00:00

abstract：BACKGROUND:Mendelian randomization studies have highlighted that lipoprotein(a) [Lp(a)] was associated with calcific aortic valve disease (CAVD). Lp(a) transports oxidized phospholipids with a high content in lysophosphatidylcholine. Autotaxin (ATX) transforms lysophosphatidylcholine into lysophosphatidic acid. We hypo...

journal_title：Circulation

authors： Bouchareb R,Mahmut A,Nsaibia MJ,Boulanger MC,Dahou A,Lépine JL,Laflamme MH,Hadji F,Couture C,Trahan S,Pagé S,Bossé Y,Pibarot P,Scipione CA,Romagnuolo R,Koschinsky ML,Arsenault BJ,Marette A,Mathieu P

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:The safety and efficacy of percutaneous coronary intervention of de novo lesions in unprotected left main coronary arteries remains an unresolved issue. METHODS AND RESULTS:We analyzed 67 consecutive patients treated with the following devices: 39 with stents, 12 with rotational atherectomy plus stents, 13 ...

journal_title：Circulation

authors： Takagi T,Stankovic G,Finci L,Toutouzas K,Chieffo A,Spanos V,Liistro F,Briguori C,Corvaja N,Albero R,Sivieri G,Paloschi R,Di Mario C,Colombo A

更新日期：2002-08-06 00:00:00

abstract：BACKGROUND:The Ross procedure and aortic homografts have both been shown to have superior hemodynamic performance after valve replacement, but there have been few comparisons. METHODS:Sequential Doppler echocardiograms were performed up to 5 years after aortic valve replacement in 132 patients with the Ross procedure ...

journal_title：Circulation

authors： Laforest I,Dumesnil JG,Briand M,Cartier PC,Pibarot P

更新日期：2002-09-24 00:00:00

abstract：BACKGROUND:Intracoronary radiotherapy (brachytherapy) has been proposed as treatment option for in-stent restenosis. Long-term results of brachytherapy with regard to vascular integrity and vasomotor responsiveness are unknown. The purpose of the present study was to determine the vasomotor response after brachytherapy...

journal_title：Circulation

authors： Togni M,Windecker S,Wenaweser P,Tueller D,Kaisaier A,Maier W,Meier B,Hess OM

更新日期：2004-07-13 00:00:00

abstract：BACKGROUND:This study was performed to determine whether chronic cocaine abuse is associated with left ventricular hypertrophy in humans. METHODS AND RESULTS:A consecutive series of 40 chronic cocaine abusers 23-44 years old who were enrolled in an inpatient drug rehabilitation program were considered for the study. S...

journal_title：Circulation

authors： Brickner ME,Willard JE,Eichhorn EJ,Black J,Grayburn PA

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:The age association of cardiovascular disease may be in part because its metabolic risk factors tend to rise with age. Few studies have analyzed age associations of multiple metabolic risks in the same population, especially in nationally representative samples. We examined worldwide variations in the age as...

journal_title：Circulation

authors： Singh GM,Danaei G,Pelizzari PM,Lin JK,Cowan MJ,Stevens GA,Farzadfar F,Khang YH,Lu Y,Riley LM,Lim SS,Ezzati M

更新日期：2012-05-08 00:00:00

abstract：BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) increases in patients with severe congestive heart failure (CHF) and cachexia. Two naturally occurring modulators of TNF-alpha activity have been identified in human serum. These two soluble proteins are the extracellular domains of the TNF receptors (sTNF-RI and sTNF-...

journal_title：Circulation

authors： Ferrari R,Bachetti T,Confortini R,Opasich C,Febo O,Corti A,Cassani G,Visioli O

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:High-density lipoproteins have antidiabetic properties in vitro. Furthermore, elevated high-density lipoprotein levels accompanying a genetic deficiency of cholesteryl ester transfer protein are associated with decreased levels of plasma glucose. We now investigate effects on glucose homeostasis of inhibitin...

journal_title：Circulation

authors： Barter PJ,Rye KA,Tardif JC,Waters DD,Boekholdt SM,Breazna A,Kastelein JJ

更新日期：2011-08-02 00:00:00

abstract：BACKGROUND:The T2G1s monoclonal antifibrin antibody binds specifically to fibrin but not to fibrinogen. METHODS AND RESULTS:In a canine model of acute arterial thrombosis, we determined the feasibility of imaging thrombi using a 99mTc-labeled Fab' fragment. In 14 dogs, 10 carotid and 13 femoral artery thrombi were pro...

journal_title：Circulation

authors： Cerqueira MD,Stratton JR,Vracko R,Schaible TF,Ritchie JL

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:In heart failure (HF), aldosterone has been implicated in the formation of reactive interstitial fibrosis, a maladaptation that contributes to left ventricular (LV) remodeling. Eplerenone is a novel selective aldosterone blocker. The present study examined the effects of long-term monotherapy with eplerenone...

journal_title：Circulation

authors： Suzuki G,Morita H,Mishima T,Sharov VG,Todor A,Tanhehco EJ,Rudolph AE,McMahon EG,Goldstein S,Sabbah HN

更新日期：2002-12-03 00:00:00

abstract：:Adults are living longer, and cardiovascular disease is endemic in the growing population of older adults who are surviving into old age. Functional capacity is a key metric in this population, both for the perspective it provides on aggregate health and as a vital goal of care. Whereas cardiorespiratory function has ...

journal_title：Circulation

authors： Forman DE,Arena R,Boxer R,Dolansky MA,Eng JJ,Fleg JL,Haykowsky M,Jahangir A,Kaminsky LA,Kitzman DW,Lewis EF,Myers J,Reeves GR,Shen WK,American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and St

更新日期：2017-04-18 00:00:00