Vacuolar H(+)-ATPase plays a crucial role in growth and phenotypic modulation of myofibroblasts in cultured human saphenous vein.

abstract：BACKGROUND:Coronary revascularization with bypass has been shown to improve survival in patients with coronary artery disease and left ventricular dysfunction. In these patients, use of nonsurgical revascularization with percutaneous transluminal coronary angioplasty (PTCA) is increasing, although their long-term outco...

journal_title：Circulation

authors： Holmes DR Jr,Detre KM,Williams DO,Kent KM,King SB 3rd,Yeh W,Steenkiste A

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Unstable atherosclerotic lesions typically have an abundant inflammatory cell infiltrate, including activated T cells, macrophages, and mast cells, which may decrease plaque stability. The pathophysiology of inflammatory cell recruitment and activation in the human atheroma is incompletely described. METHOD...

journal_title：Circulation

authors： Haley KJ,Lilly CM,Yang JH,Feng Y,Kennedy SP,Turi TG,Thompson JF,Sukhova GH,Libby P,Lee RT

更新日期：2000-10-31 00:00:00

abstract：BACKGROUND:Visceral adiposity is generally considered to play a key role in the metabolic syndrome, including hypertension. The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin....

journal_title：Circulation

authors： Hayashi T,Boyko EJ,Leonetti DL,McNeely MJ,Newell-Morris L,Kahn SE,Fujimoto WY

更新日期：2003-10-07 00:00:00

abstract：BACKGROUND:Wine consumption decreases the risk of myocardial infarction. Intimal hyperplasia contributes to restenosis after angioplasty. Local ethanol delivery inhibits intimal hyperplasia after balloon injury in rabbit iliac and pig coronary arteries. The effects of wine consumption on intimal response and monocyte c...

journal_title：Circulation

authors： Feng AN,Chen YL,Chen YT,Ding YZ,Lin SJ

更新日期：1999-11-30 00:00:00

abstract：BACKGROUND:Fe2+ released from tissue iron stores may accelerate lipid peroxidation by virtue of its pro-oxidant properties and thus promote early atherogenesis. METHODS AND RESULTS:The present prospective survey addresses the potential association between serum ferritin concentrations and the 5-year progression of car...

journal_title：Circulation

authors： Kiechl S,Willeit J,Egger G,Poewe W,Oberhollenzer F

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:In the congenital long-QT syndrome (LQTS), there can be a marked phenotypic heterogeneity. Founder effects, by which many individuals share a mutation identical by descent, represent a powerful tool to further understand the underlying mechanisms and to predict the natural history of mutation-associated effe...

journal_title：Circulation

authors： Brink PA,Crotti L,Corfield V,Goosen A,Durrheim G,Hedley P,Heradien M,Geldenhuys G,Vanoli E,Bacchini S,Spazzolini C,Lundquist AL,Roden DM,George AL Jr,Schwartz PJ

更新日期：2005-10-25 00:00:00

abstract：BACKGROUND:To assess the long-term results of the edge-to-edge mitral repair performed without annuloplasty in degenerative mitral regurgitation (MR). METHODS AND RESULTS:From 1993 to 2002, 61 patients with degenerative MR were treated with an isolated edge-to-edge suture without any annuloplasty. Annuloplasty was omi...

journal_title：Circulation

authors： De Bonis M,Lapenna E,Maisano F,Barili F,La Canna G,Buzzatti N,Pappalardo F,Calabrese M,Nisi T,Alfieri O

更新日期：2014-09-09 00:00:00

abstract：BACKGROUND:Adrenergic activation is thought to be an important determinant of outcome in subjects with chronic heart failure (CHF), but baseline or serial changes in adrenergic activity have not been previously investigated in a large patient sample treated with a powerful antiadrenergic agent. METHODS AND RESULTS:Sys...

journal_title：Circulation

authors： Bristow MR,Krause-Steinrauf H,Nuzzo R,Liang CS,Lindenfeld J,Lowes BD,Hattler B,Abraham WT,Olson L,Krueger S,Thaneemit-Chen S,Hare JM,Loeb HS,Domanski MJ,Eichhorn EJ,Zelis R,Lavori P

更新日期：2004-09-14 00:00:00

abstract：BACKGROUND:We hypothesized that during demand ischemia, abnormal perfusion will precede abnormal function, the spatial extent of perfusion abnormality will be greater than that of functional abnormality, and the spatiotemporal disparity between abnormal perfusion and abnormal function will be more marked in the presenc...

journal_title：Circulation

authors： Leong-Poi H,Rim SJ,Le DE,Fisher NG,Wei K,Kaul S

更新日期：2002-02-26 00:00:00

abstract：BACKGROUND:Creation of a complete bidirectional inferior vena cava-tricuspid annulus isthmus block (CBIB) by radiofrequency catheter ablation is now a well-accepted criterion for prevention of common atrial flutter (AFl) recurrences. However, some patients still complain of palpitations after ablation, and it is not kn...

journal_title：Circulation

authors： Anselme F,Saoudi N,Poty H,Douillet R,Cribier A

更新日期：1999-02-02 00:00:00

abstract：:Cardiac output and pressure-flow measurements were made in left internal mammary artery-to-left anterior descending coronary artery grafts and left subclavian artery-to-left circumflex coronary artery vein grafts after proximal coronary artery ligation. Similar measurements were also made in left internal mammary arte...

journal_title：Circulation

authors： McCormick JR,Kaneko M,Baue AE,Geha AS

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:In the Basel Antiarrhythmic Study of Infarct Survival trial, low-dose amiodarone improved 1-year survival in patients with asymptomatic complex ventricular arrhythmias persisting 2 weeks after myocardial infarction. To assess whether this beneficial effect persisted despite discontinuation of amiodarone afte...

journal_title：Circulation

authors： Pfisterer ME,Kiowski W,Brunner H,Burckhardt D,Burkart F

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:The time constant of ventricular relaxation (tau) is a quantitative measure of diastolic performance requiring intraventricular pressure recording. This study validates in humans an equation relating tau to left ventricular pressure at peak -dP/dt (P0), pressure at mitral valve opening (PMV), and isovolumic ...

journal_title：Circulation

authors： Scalia GM,Greenberg NL,McCarthy PM,Thomas JD,Vandervoort PM

更新日期：1997-01-07 00:00:00

abstract：BACKGROUND:Some large epidemiological studies have shown an increase in mortality at low levels of total and LDL cholesterol. It has been speculated that low cholesterol levels may play a causative role in this association. To investigate this question, we analyzed all deaths occurring among middle-aged men in the Müns...

journal_title：Circulation

authors： Cullen P,Schulte H,Assmann G

更新日期：1997-10-07 00:00:00

abstract：:Many vasodilators have been tried as antianginal agents, but the reflex increase in sympathetic tone produced by these drugs necessitate their use with caution in patients with angina. In the first part of this study, captopril was given to 14 patients with angina and systolic arterial pressures of greater than 120 mm...

journal_title：Circulation

authors： Daly P,Mettauer B,Rouleau JL,Cousineau D,Burgess JH

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Hyperhomocysteinemia is an independent risk factor for coronary heart disease (CHD). Dietary supplementation with B vitamins lowers plasma homocysteine by up to 30%. However, little is known about the potential beneficial effects of homocysteine lowering on vascular function in patients with CHD. METHODS AN...

journal_title：Circulation

authors： Chambers JC,Ueland PM,Obeid OA,Wrigley J,Refsum H,Kooner JS

更新日期：2000-11-14 00:00:00

abstract：BACKGROUND:The incidence of perinatal morbidity arising from birth hypoxia or asphyxia has not changed significantly in recent years despite marked improvements in labor management. Perinatal mortality in these circumstances may therefore reflect antenatal compromise and subsequent alteration of the fetal capacity to r...

journal_title：Circulation

authors： Gardner DS,Fowden AL,Giussani DA

更新日期：2002-10-22 00:00:00

abstract：BACKGROUND:The long-term administration of ACE inhibitors to selected patients with left ventricular dysfunction appears to reduce the incidence of recurrent myocardial infarction (MI) and unstable angina pectoris. The mechanisms responsible for the reduction in ischemic events are unknown, but likely candidates includ...

journal_title：Circulation

authors： Vaughan DE,Rouleau JL,Ridker PM,Arnold JM,Menapace FJ,Pfeffer MA

更新日期：1997-07-15 00:00:00

abstract：:Fifty-four Japanese patients with occlusive thromboaortopathy (OTAP), including four males, were classified according to evidence of complications attributed to OTAP at the time when the diagnosis was established: Group I, uncomplicated OTAP with or without the involvement of the pulmonary artery. Group II, mono-compl...

journal_title：Circulation

authors： Ishikawa K

更新日期：1978-01-01 00:00:00

abstract：:A quantitative analysis of adventitial inflammation of the coronary artery with intimal lesions is described in 12 patients who suffered coronary death and had had unstable angina (crescendo angina) at rest (group 1). After autopsy in these patients we examined epon-embedded cross sections by light and electron micros...

journal_title：Circulation

authors： Kohchi K,Takebayashi S,Hiroki T,Nobuyoshi M

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Comprehensive data based on single-beat analysis of the ventricular activation sequence during sinus rhythm in infarcted hearts are currently not available. It was the aim of our study (1) to measure and analyze these activation sequences on the epicardial surface of the right and left ventricles and on the ...

journal_title：Circulation

authors： Hatala R,Savard P,Tremblay G,Pagé P,Cardinal R,Molin F,Kus T,Nadeau R

更新日期：1995-03-01 00:00:00

abstract：:The purpose of this study was to develop a clinically applicable system for quantifying premortem myocardial area at risk. Coronary artery occlusion was performed in 18 closed-chest dogs (11 left anterior descending and seven circumflex). 99mTc (15 mCi)-labeled macroaggregated albumin was then injected through an angi...

journal_title：Circulation

authors： Feiring AJ,Bruch P,Husayni TS,Kirchner PT,Marcus ML

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Preconditioning protects the myocardium from ischemia and may be a potent means of endogenous cardioprotection during cardioplegic arrest and rewarming. However, fundamental mechanisms that potentially contribute to the beneficial effects of preconditioning during cardioplegic arrest and rewarming remain unc...

journal_title：Circulation

authors： O SJ,Zellner JL,Cox MH,Hebbar L,Brothers TE,Mukherjee R,Tempel GE,Dorman BH,Crawford FA Jr,Spinale FG

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Ischemic mitral regurgitation (MR) was first ascribed to papillary muscle (PM) contractile dysfunction. Current theories include apical leaflet tethering caused by left ventricular (LV) distortion, but PM dysfunction is still postulated and commonly diagnosed. PM contraction, however, parallels apical tether...

journal_title：Circulation

authors： Messas E,Guerrero JL,Handschumacher MD,Chow CM,Sullivan S,Schwammenthal E,Levine RA

更新日期：2001-10-16 00:00:00

abstract：BACKGROUND:Natural history of aortic dissection (AD) with intimal tear in the descending or abdominal aorta and retrograde extension into the ascending aorta (retrograde AD) remains unknown. The purpose of this study was to elucidate medium-term prognosis of patients with retrograde AD. METHODS AND RESULTS:Study popul...

journal_title：Circulation

authors： Kaji S,Akasaka T,Katayama M,Yamamuro A,Yamabe K,Tamita K,Akiyama M,Watanabe N,Tanemoto K,Morioka S,Yoshida K

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Although acute pericarditis is a common complication of beta-thalassemia major, the prevalence and consequences of myocarditis in this disease have not been investigated. METHODS AND RESULTS:A prospective 5-year follow-up study was carried out in all patients with beta-thalassemia major in whom the diagnosi...

journal_title：Circulation

authors： Kremastinos DT,Tiniakos G,Theodorakis GN,Katritsis DG,Toutouzas PK

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:The rate of coronary heart disease (CHD) mortality in eastern Finland has been the highest in the world. The official mortality statistics suggest, however, that is has declined by 60% during the past 20 years. The aim of the present study was to examine the contributions of incidence, recurrence, and case f...

journal_title：Circulation

authors： Salomaa V,Miettinen H,Kuulasmaa K,Niemelä M,Ketonen M,Vuorenmaa T,Lehto S,Palomäki P,Mähönen M,Immonen-Räihä P,Arstila M,Kaarsalo E,Mustaniemi H,Torppa J,Tuomilehto J,Puska P,Pyörälä K

更新日期：1996-12-15 00:00:00

abstract：BACKGROUND:Right ventricular (RV) function is the major determinant for both functional capacity and survival in patients with pulmonary arterial hypertension (PAH). Despite the recognized clinical importance of preserving RV function, the subcellular mechanisms that govern the transition from a compensated to a decomp...

journal_title：Circulation

authors： Omura J,Habbout K,Shimauchi T,Wu WH,Breuils-Bonnet S,Tremblay E,Martineau S,Nadeau V,Gagnon K,Mazoyer F,Perron J,Potus F,Lin JH,Zafar H,Kiely DG,Lawrie A,Archer SL,Paulin R,Provencher S,Boucherat O,Bonnet S

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF), the most common clinical arrhythmia, is a major cause of morbidity and mortality. Although AF is often associated with other cardiovascular conditions, many patients present without an obvious etiology. Inherited forms of AF exist, but the causative gene has been defined only in a s...

journal_title：Circulation

authors： Ellinor PT,Shin JT,Moore RK,Yoerger DM,MacRae CA

更新日期：2003-06-17 00:00:00

abstract：:The major problem associated with percutaneous transluminal coronary angioplasty is recurrence of the stenotic lesion. Balloon catheter-mounted intracoronary stent devices may reduce restenosis by improving luminal morphology and flow characteristics. This study assessed the effects of a stainless steel wire, interdig...

journal_title：Circulation

authors： Robinson KA,Roubin GS,Siegel RJ,Black AJ,Apkarian RP,King SB 3rd

更新日期：1988-09-01 00:00:00