Autologous culture-modified mononuclear cells confer vascular protection after arterial injury.

abstract：:Although a family history of ischemic heart disease is a well-accepted risk factor for cardiovascular disease, only three prospective studies--all in men--have examined the predictive strength of a positive family history after adjusting for other heart disease risk factors. The present analysis is based on a 9 year f...

journal_title：Circulation

authors： Barrett-Connor E,Khaw K

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Chronic, complete AV block (CAVB) in the dog leads to ventricular hypertrophy, which has been described as an independent risk factor for arrhythmias. In this model, we examined (1) whether the short- and long-term electrical adaptations predispose to acquired torsade de pointes arrhythmias (TdP) and (2) the...

journal_title：Circulation

authors： Vos MA,de Groot SH,Verduyn SC,van der Zande J,Leunissen HD,Cleutjens JP,van Bilsen M,Daemen MJ,Schreuder JJ,Allessie MA,Wellens HJ

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Although acute pericarditis is a common complication of beta-thalassemia major, the prevalence and consequences of myocarditis in this disease have not been investigated. METHODS AND RESULTS:A prospective 5-year follow-up study was carried out in all patients with beta-thalassemia major in whom the diagnosi...

journal_title：Circulation

authors： Kremastinos DT,Tiniakos G,Theodorakis GN,Katritsis DG,Toutouzas PK

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Previous studies suggest that the antifibrillatory action of class I and III drugs is due to prolongation of the atrial wavelength. The aim of the present study was to directly evaluate the electrophysiological action of antifibrillatory drugs in a goat model of chronic atrial fibrillation (AF). METHODS AND...

journal_title：Circulation

authors： Wijffels MC,Dorland R,Mast F,Allessie MA

更新日期：2000-07-11 00:00:00

abstract：:For estimating left ventricular mass (LVM), ECG criteria for left ventricular hypertrophy (LVH) were selected from conventional 12-lead ECGs, orthogonal three-lead ECGs, and multiple-dipole ECGs (MDECG). The three cardiograms were recorded in 139 patients for whom the degree of LVH was independently determined from bi...

journal_title：Circulation

authors： Dunn RA,Pipberger HV,Holt JH Jr,Barnard AC,Pipberger HA

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Although patients with heart failure express elevated circulating levels of tumor necrosis factor-alpha (TNF-alpha) in their peripheral circulation, the structural and functional effects of circulating levels of pathophysiologically relevant concentrations of TNF-alpha on the heart are not known. METHODS AN...

journal_title：Circulation

authors： Bozkurt B,Kribbs SB,Clubb FJ Jr,Michael LH,Didenko VV,Hornsby PJ,Seta Y,Oral H,Spinale FG,Mann DL

更新日期：1998-04-14 00:00:00

abstract：BACKGROUND:There is uncertainty as to the relative efficacy of coronary artery bypass graft surgery (CABG) in men and women. Differences between sexes may be of greater importance than heretofore because of increased frequency of risk factors for adverse outcome. It is the purpose of this study to examine the changing ...

journal_title：Circulation

authors： Weintraub WS,Wenger NK,Jones EL,Craver JM,Guyton RA

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...

journal_title：Circulation

authors： Tabereaux PB,Walcott GP,Rogers JM,Kim J,Dosdall DJ,Robertson PG,Killingsworth CR,Smith WM,Ideker RE

更新日期：2007-09-04 00:00:00

abstract：:To examine whether nicardipine, a dihydropyridine derivative, limits size of myocardial infarction, and to compare the protective effects of nicardipine administered before and early and late after coronary artery occlusion, 99mTc-labeled albumin microspheres were injected into the left atrium during 5 min temporary c...

journal_title：Circulation

authors： Endo T,Nejima J,Fujita S,Kiuchi K,Iida N,Kikuchi K,Hayakawa H,Okumura H

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:The signal transduction mechanism linking mitochondrial ATP synthesis with cytosolic ATP utilization in heart changes during postnatal development in vivo. This maturational process occurs in parallel with accumulation of mitochondrial adenine nucleotide translocator (ANT), which provides a possible site for...

journal_title：Circulation

authors： Portman MA,Xiao Y,Qian K,Tucker RL,Parish SM,Ning XH

更新日期：2000-09-12 00:00:00

abstract：BACKGROUND:Older coronary patients are at high risk of cardiac disability. Exercise conditioning programs have been demonstrated to improve functional capacity, particularly in younger coronary patients. In this study, the effects of aerobic conditioning on submaximal and maximal indicators of exercise performance were...

journal_title：Circulation

authors： Ades PA,Waldmann ML,Poehlman ET,Gray P,Horton ED,Horton ES,LeWinter MM

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Microvascular dysfunction posttreatment of stroke with recombinant human tissue-type plasminogen activator (rht-PA) constrains the therapeutic window to 3 hours. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) promote vascular thrombolysis and reduce the inflammation response. We therefo...

journal_title：Circulation

authors： Zhang L,Zhang ZG,Ding GL,Jiang Q,Liu X,Meng H,Hozeska A,Zhang C,Li L,Morris D,Zhang RL,Lu M,Chopp M

更新日期：2005-11-29 00:00:00

abstract：BACKGROUND:Contrary to expectation, most studies have demonstrated that initiation of an angiotensin-converting enzyme (ACE) inhibitor in conventional doses in patients with heart failure reduces the diuretic efficacy of furosemide. Recently, it has been suggested that single low doses (1 mg) but not high doses (25 mg)...

journal_title：Circulation

authors： Good JM,Brady AJ,Noormohamed FH,Oakley CM,Cleland JG

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Cellular transplantation is emerging as a promising strategy for the treatment of postinfarction ventricular dysfunction. Whether its beneficial effects can be extended to other cardiomyopathies remains an unexplored question. We evaluated the histological and functional effects of simultaneous autologous tr...

journal_title：Circulation

authors： Guarita-Souza LC,Carvalho KA,Woitowicz V,Rebelatto C,Senegaglia A,Hansen P,Miyague N,Francisco JC,Olandoski M,Faria-Neto JR,Brofman P

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Coronary artery bypass surgery (CABG) has been associated with a range of neurological and neuropsychological complications from stroke to cognitive problems such as memory and problem solving disturbance. However, little is known about the impact of percutaneous coronary intervention (PCI) on neuropsycholog...

journal_title：Circulation

authors： Währborg P,Booth JE,Clayton T,Nugara F,Pepper J,Weintraub WS,Sigwart U,Stables RH,SoS Neuropsychology Substudy Investigators.

更新日期：2004-11-30 00:00:00

abstract：:Regional myocardial function and blood flow were determined for 48 hours after permanent occlusion of the left circumflex coronary artery in conscious swine. Systolic wall thickening and end-diastolic wall thickness (EDWTh) were correlated with regional myocardial flow (RMBF) at 15 minutes, 24 and 48 hours after occlu...

journal_title：Circulation

authors： Savage RM,Guth B,White FC,Hagan AD,Bloor CM

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Prior small to modest-sized studies suggest a benefit of intravascular ultrasound (IVUS) guidance in noncomplex lesions. Whether IVUS guidance is associated with improved clinical outcomes after drug-eluting stent (DES) implantation in an unrestricted patient population is unknown. METHODS AND RESULTS:Asses...

journal_title：Circulation

authors： Witzenbichler B,Maehara A,Weisz G,Neumann FJ,Rinaldi MJ,Metzger DC,Henry TD,Cox DA,Duffy PL,Brodie BR,Stuckey TD,Mazzaferri EL Jr,Xu K,Parise H,Mehran R,Mintz GS,Stone GW

更新日期：2014-01-28 00:00:00

abstract：BACKGROUND:Pharmacological ventricular rate control is an acceptable atrial fibrillation (AF) therapy limited by systemic toxicity. We postulate that focal catheter-based drug delivery into the atrioventricular nodal (AVN) region may effectively control ventricular rate during AF without systemic toxicity. This study e...

journal_title：Circulation

authors： Sigg DC,Hiniduma-Lokuge P,Coles JA Jr,Falkner P,Rose R,Urban JF,Ujhelyi MR

更新日期：2006-05-23 00:00:00

abstract：BACKGROUND:Cardiopulmonary resuscitation (CPR) is initiated in hospitalized children with bradycardia and poor perfusion. However, their rate of progression to pulseless cardiac arrest despite CPR and the differences in survival compared with initially pulseless arrest are unknown. We examined the prevalence and predic...

journal_title：Circulation

authors： Khera R,Tang Y,Girotra S,Nadkarni VM,Link MS,Raymond TT,Guerguerian AM,Berg RA,Chan PS,American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

更新日期：2019-07-30 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate dynamic changes in aortic regurgitant (AR) orifice area with the use of calibrated electromagnetic (EM) flowmeters and to validate a color Doppler flow convergence (FC) method for evaluating effective AR orifice area and regurgitant volume. METHODS AND RESULTS:In...

journal_title：Circulation

authors： Shiota T,Jones M,Yamada I,Heinrich RS,Ishii M,Sinclair B,Holcomb S,Yoganathan AP,Sahn DJ

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:The CAPRICORN trial has shown that carvedilol improved outcome in patients with left ventricular dysfunction after acute myocardial infarction treated with ACE inhibitors. The aim of this substudy was to determine the effects of carvedilol on left ventricular remodeling in this patient group. METHODS AND RE...

journal_title：Circulation

authors： Doughty RN,Whalley GA,Walsh HA,Gamble GD,López-Sendón J,Sharpe N,CAPRICORN Echo Substudy Investigators.

更新日期：2004-01-20 00:00:00

abstract：:Although evidence suggests that primary percutaneous coronary intervention (PCI) is the preferred reperfusion strategy in the majority of patients with ST-segment-elevation myocardial infarction (STEMI), only a minority of patients with STEMI are treated with primary PCI, and of those, only a minority receive the trea...

journal_title：Circulation

authors： Jacobs AK,Antman EM,Ellrodt G,Faxon DP,Gregory T,Mensah GA,Moyer P,Ornato J,Peterson ED,Sadwin L,Smith SC,American Heart Association's Acute Myocardial Infarction Advisory Working Group.

更新日期：2006-05-02 00:00:00

abstract：BACKGROUND:We previously demonstrated that reduced vagal activity and/or increased sympathetic activity identify post-myocardial infarction patients at high risk for cardiac mortality. Simple and inexpensive autonomic markers are necessary to perform autonomic screening in large populations. We tested our hypothesis th...

journal_title：Circulation

authors： Falcone C,Buzzi MP,Klersy C,Schwartz PJ

更新日期：2005-09-27 00:00:00

abstract：BACKGROUND:Prospective data relating previous exposure to cytomegalovirus (CMV) to the risk of cardiac mortality are controversial. We investigated the effect of previous exposure to CMV infection on the risk of future cardiac disease-related death in relation to an underlying inflammatory response. METHODS AND RESULT...

journal_title：Circulation

authors： Blankenberg S,Rupprecht HJ,Bickel C,Espinola-Klein C,Rippin G,Hafner G,Ossendorf M,Steinhagen K,Meyer J

更新日期：2001-06-19 00:00:00

abstract：BACKGROUND:Although c-Kit+ adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such events are exceedingly rare. However, to determine if these rare events represent true de novo cardiomyocyte formation, we deleted the necessary cardiogenic tr...

journal_title：Circulation

authors： Maliken BD,Kanisicak O,Karch J,Khalil H,Fu X,Boyer JG,Prasad V,Zheng Y,Molkentin JD

更新日期：2018-09-04 00:00:00

abstract：BACKGROUND:NO has been advocated as an adjunct to cardioplegia solutions. However, NO undergoes a rapid biradical reaction with superoxide anions to produce peroxynitrite (ONOO(-)). ONOO(-) in crystalloid cardioplegia solution induces injury to coronary endothelium and to systolic function after cardioplegia and reperf...

journal_title：Circulation

authors： Nakamura M,Thourani VH,Ronson RS,Velez DA,Ma XL,Katzmark S,Robinson J,Schmarkey LS,Zhao ZQ,Wang NP,Guyton RA,Vinten-Johansen J

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Cerebral protection during surgery for acute aortic dissection type A relies on hypothermic circulatory arrest, either alone or in conjunction with cerebral perfusion. METHODS AND RESULTS:The perioperative and intraoperative conditions of 1558 patients submitted from 44 cardiac surgery centers in German-spe...

journal_title：Circulation

authors： Krüger T,Weigang E,Hoffmann I,Blettner M,Aebert H,GERAADA Investigators.

更新日期：2011-07-26 00:00:00

abstract：BACKGROUND:It is unknown whether the appropriate use of percutaneous coronary intervention (PCI) has improved over time and whether trends in PCI appropriateness have been accompanied by changes in the use of PCI. METHODS AND RESULTS:We applied appropriate use criteria to determine the appropriateness of all 51 872 PC...

journal_title：Circulation

authors： Bradley SM,Bohn CM,Malenka DJ,Graham MM,Bryson CL,McCabe JM,Curtis JP,Lambert-Kerzner A,Maynard C

更新日期：2015-07-07 00:00:00

abstract：BACKGROUND:Recent studies suggest that mutations in cardiac mitochondrial DNA (mtDNA) may contribute to the development of dilated cardiomyopathy. The mechanisms that regulate those mutations, however, remain undefined. Thus, we studied cardiac mtDNA repair mechanisms, mtDNA damage, and mitochondrial structure and func...

journal_title：Circulation

authors： Li YY,Chen D,Watkins SC,Feldman AM

更新日期：2001-11-13 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF), the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), is capable of producing symptoms that impact quality of life and is associated with risk for embolic stroke. However, the influence of AF on clinical course and outcome in HCM remains incompletely resolved. ...

journal_title：Circulation

authors： Rowin EJ,Hausvater A,Link MS,Abt P,Gionfriddo W,Wang W,Rastegar H,Estes NAM,Maron MS,Maron BJ

更新日期：2017-12-19 00:00:00