Temporal Trends in Percutaneous Coronary Intervention Appropriateness: Insights From the Clinical Outcomes Assessment Program.

abstract：BACKGROUND:Pulmonary veno-occlusive disease is caused by excessive cell proliferation and fibrosis, which obliterate the lumen of pulmonary venules, leading to pulmonary hypertension, right ventricular failure, and death. This condition has no effective treatment and a 5-year survival of <5%. Understanding the mechanis...

journal_title：Circulation

authors： Lathen C,Zhang Y,Chow J,Singh M,Lin G,Nigam V,Ashraf YA,Yuan JX,Robbins IM,Thistlethwaite PA

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Swimming-induced pulmonary edema (SIPE) occurs during swimming or scuba diving, often in young individuals with no predisposing conditions, and its pathophysiology is poorly understood. This study tested the hypothesis that pulmonary artery and pulmonary artery wedge pressures are higher in SIPE-susceptible ...

journal_title：Circulation

authors： Moon RE,Martina SD,Peacher DF,Potter JF,Wester TE,Cherry AD,Natoli MJ,Otteni CE,Kernagis DN,White WD,Freiberger JJ

更新日期：2016-03-08 00:00:00

abstract：OBJECTIVE:Previous studies comparing off-pump coronary artery bypass surgery (OPCABG) to conventional techniques utilizing cardiopulmonary bypass (CABG-CPB) have failed to provide patient selection guidelines. We sought to determine guidelines, attempting to rectify the limitations of previous studies. METHODS AND RES...

journal_title：Circulation

authors： Magee MJ,Coombs LP,Peterson ED,Mack MJ

更新日期：2003-09-09 00:00:00

abstract：:A definitive diagnosis of myocarditis requires right ventricular biopsy. Despite its specificity, however, right ventricular biopsy may lack sensitivity due to the focal nature of the disease. Because indium 111-monoclonal antimyosin antibody imaging can be used to detect myocardial necrosis, this procedure was perfor...

journal_title：Circulation

authors： Yasuda T,Palacios IF,Dec GW,Fallon JT,Gold HK,Leinbach RC,Strauss HW,Khaw BA,Haber E

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Cardiac troponin and B-type natriuretic peptide (BNP) concentrations are associated with adverse cardiovascular outcome in primary prevention populations. Whether statin therapy modifies this association is poorly understood. METHODS AND RESULTS:We measured high-sensitivity cardiac troponin I (hsTnI) in 12 ...

journal_title：Circulation

authors： Everett BM,Zeller T,Glynn RJ,Ridker PM,Blankenberg S

更新日期：2015-05-26 00:00:00

abstract：:The relationship between the degree of obesity and the incidence of cardiovascular disease (CVD) was reexamined in the 5209 men and women of the original Framingham cohort. Recent observations of disease occurrence over 26 years indicate that obesity, measured by Metropolitan Relative Weight, was a significant indepen...

journal_title：Circulation

authors： Hubert HB,Feinleib M,McNamara PM,Castelli WP

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:The substitution variants K35A,E38A,K74A, E75A,R77A (SakSTAR.M38) and K74A,E75A,R77A,E80A, D82A (SakSTAR.M89) of recombinant staphylokinase (SakSTAR) with reduced antibody reactivity were assayed for thrombolytic potency and antibody induction in animal models and in patients. METHODS AND RESULTS:In a 125I-...

journal_title：Circulation

authors： Collen D,Moreau H,Stockx L,Vanderschueren S

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Depressive symptoms have been associated with increased risk of coronary artery disease and poor prognosis among patients with existing coronary artery disease, but whether depressive symptoms specifically influence atherosclerotic progression among such patients is uncertain. METHODS AND RESULTS:The Post-C...

journal_title：Circulation

authors： Wellenius GA,Mukamal KJ,Kulshreshtha A,Asonganyi S,Mittleman MA

更新日期：2008-05-06 00:00:00

abstract：:The purpose of this study was to develop a clinically applicable system for quantifying premortem myocardial area at risk. Coronary artery occlusion was performed in 18 closed-chest dogs (11 left anterior descending and seven circumflex). 99mTc (15 mCi)-labeled macroaggregated albumin was then injected through an angi...

journal_title：Circulation

authors： Feiring AJ,Bruch P,Husayni TS,Kirchner PT,Marcus ML

更新日期：1986-03-01 00:00:00

abstract：:One hundred eighteen consecutive patients undergoing valve replacement for aortic stenosis were analyzed to determine the incidence of and predisposing factors to postoperative atrial tachyarrhythmias. Univariate and multivariate analyses were performed on 70 clinical, hemodynamic, radiographic, electrocardiographic, ...

journal_title：Circulation

authors： Douglas PS,Hirshfeld JW Jr,Edmunds LH Jr

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Cardiac Na/K-ATPase (NKA) regulates intracellular Na ([Na](i)), which in turn affects intracellular Ca and thus contractility via Na/Ca exchange. Recent evidence shows that phosphorylation of the NKA-associated small transmembrane protein phospholemman (PLM) mediates beta-adrenergic-induced NKA stimulation. ...

journal_title：Circulation

authors： Despa S,Tucker AL,Bers DM

更新日期：2008-04-08 00:00:00

abstract：BACKGROUND:Current methods of signal-averaged ECG analysis interrogate the terminal 40 msec of the QRS complex and/or the ST segment and have a low positive-predictive accuracy for detecting vulnerability to sustained ventricular tachycardia (VT). The extent to which abnormalities detected during these ECG intervals ar...

journal_title：Circulation

authors： Hood MA,Pogwizd SM,Peirick J,Cain ME

更新日期：1992-12-01 00:00:00

abstract：:To define the factors influencing the success of emergency ventricular defibrillation, we identified 52 patients defibrillated at the University of Iowa Hospital during 1974--1976. Thirty-eight patients were successfully defibrillated at least once; 14 could not be defibrillated, despite multiple attempts. Comparisons...

journal_title：Circulation

authors： Kerber RE,Sarnat W

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:An imbalance of sympathetic and parasympathetic drive to the heart is an important risk factor for cardiac death in patients with coronary heart disease, diabetes, and renal insufficiency. The amount of neurotransmitter released from peripheral autonomic nerves is modulated by presynaptic receptor systems. I...

journal_title：Circulation

authors： Oberhauser V,Schwertfeger E,Rutz T,Beyersdorf F,Rump LC

更新日期：2001-03-27 00:00:00

abstract：BACKGROUND:Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate plate...

journal_title：Circulation

authors： Audoly LP,Rocca B,Fabre JE,Koller BH,Thomas D,Loeb AL,Coffman TM,FitzGerald GA

更新日期：2000-06-20 00:00:00

abstract：:The clinical use of citrate-phosphate-dextrose during blood-product transfusion is known to affect ionized calcium levels and can result in depression of myocardial contractility. The immature heart appears to have an intrinsic reduction in contractile state compared with the adult heart and may be more dependent on t...

journal_title：Circulation

authors： Rebeyka IM,Yeh T Jr,Hanan SA,Borges MR,Lee KF,Tuchy GE,Abd-Elfattah AS,Wechsler AS

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Fat inflammation may play an important role in comorbidities associated with obesity such as atherosclerosis. METHODS AND RESULTS:To first establish feasibility of fat transplantation, epididymal fat pads were harvested from wild-type C57BL/6J mice and transplanted into leptin-deficient (Lep(ob/ob)) mice. F...

journal_title：Circulation

authors： Ohman MK,Shen Y,Obimba CI,Wright AP,Warnock M,Lawrence DA,Eitzman DT

更新日期：2008-02-12 00:00:00

abstract：BACKGROUND:Although both 201Tl scintigraphy and low-dose dobutamine echocardiography (LDDE) have been proposed as effective methods of assessing myocardial viability, their relative efficacies are unknown. The aim of the present study was to compare the two imaging techniques in the prediction of improvement of regiona...

journal_title：Circulation

authors： Arnese M,Cornel JH,Salustri A,Maat A,Elhendy A,Reijs AE,Ten Cate FJ,Keane D,Balk AH,Roelandt JR

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Specific transcription factors (TFs) modulate cardiac gene expression in murine models of heart failure, but their relevance in human subjects remains untested. We developed and applied a computational approach called transcriptional genomics to test the hypothesis that a discrete set of cardiac TFs is assoc...

journal_title：Circulation

authors： Hannenhalli S,Putt ME,Gilmore JM,Wang J,Parmacek MS,Epstein JA,Morrisey EE,Margulies KB,Cappola TP

更新日期：2006-09-19 00:00:00

abstract：BACKGROUND:ε protein kinase C (εPKC) is involved in vascular smooth muscle cell (VSMC) activation, but little is known about its function in vascular pathology. We aimed at assessing the role of εPKC in the development of restenosis. METHODS AND RESULTS:Rat models of aortic balloon injury with or without subsequent st...

journal_title：Circulation

authors： Deuse T,Koyanagi T,Erben RG,Hua X,Velden J,Ikeno F,Reichenspurner H,Robbins RC,Mochly-Rosen D,Schrepfer S

更新日期：2010-09-14 00:00:00

abstract：:The clinical and pathologic features of 18 consecutive patients with peripartum cardiomyopathy at The Johns Hopkins Hospital were examined in an attempt to define the incidence of myocarditis and to determine its response to immunosuppressive agents. In addition to routine studies, patients were evaluated with echocar...

journal_title：Circulation

authors： Midei MG,DeMent SH,Feldman AM,Hutchins GM,Baughman KL

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:The detection and differentiation of intracardiac masses is still challenging and may include neoplasms and thrombi. The aim of this study was the investigation of a targeted, fibrin-specific contrast agent (EP-2104R) for molecular targeted magnetic resonance imaging (MRI) of left atrial clots. METHODS AND ...

journal_title：Circulation

authors： Spuentrup E,Fausten B,Kinzel S,Wiethoff AJ,Botnar RM,Graham PB,Haller S,Katoh M,Parsons EC Jr,Manning WJ,Busch T,Günther RW,Buecker A

更新日期：2005-07-19 00:00:00

abstract：BACKGROUND:Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle and pregnancy. Accumulating clinical evidence suggests a role for progesterone; however, the effect of progesterone on cardia...

journal_title：Circulation

authors： Nakamura H,Kurokawa J,Bai CX,Asada K,Xu J,Oren RV,Zhu ZI,Clancy CE,Isobe M,Furukawa T

更新日期：2007-12-18 00:00:00

abstract：:This review discusses the role of growth factors on the proliferation of smooth muscle cells (SMCs) in injured arteries. We have used a variety of procedures to injure rat carotid arteries and noted that removal of endothelium followed by platelet adherence does not always initiate SMC replication. Furthermore, thromb...

journal_title：Circulation

authors： Reidy MA,Fingerle J,Lindner V

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Recombinant staphylokinase (STAR) was shown recently to offer promise for coronary arterial thrombolysis in patients with evolving myocardial infarction. The present multicenter randomized open trial was designed to assess the thrombolytic efficacy, safety, and fibrin specificity of STAR relative to accelera...

journal_title：Circulation

authors： Vanderschueren S,Barrios L,Kerdsinchai P,Van den Heuvel P,Hermans L,Vrolix M,De Man F,Benit E,Muyldermans L,Collen D

更新日期：1995-10-15 00:00:00

abstract：:Paclitaxel drug-coated balloons and drug-eluting stents became commercially available for the treatment of intermittent claudication in 2015 and 2012, respectively. Both devices demonstrated superiority in limb revascularization compared with non-paclitaxel-coated devices and were rapidly accepted into clinical practi...

journal_title：Circulation

authors： Beckman JA,White CJ

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:It remains unclear how mineralocorticoids induce cardiac hypertrophy and fibrosis. Recently, activation of the calcium-dependent phosphatase, calcineurin, has been shown to induce cardiac hypertrophy. In the present study, we examine the role of calcineurin in mineralocorticoid-induced cardiac hypertrophy an...

journal_title：Circulation

authors： Takeda Y,Yoneda T,Demura M,Usukura M,Mabuchi H

更新日期：2002-02-12 00:00:00

abstract：:In 72% of 143 patients undergoing a second coronary bypass grafting, mural or occlusive late thrombosis was observed histologically in 69% of 173 resected grafts. Late thrombosis was particularly prevalent in atherosclerotic grafts (80.2% vs. 40.4% in nonatherosclerotic grafts) and was always noted in 16 grafts with a...

journal_title：Circulation

authors： Solymoss BC,Nadeau P,Millette D,Campeau L

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Automatic implantable cardioverter-defibrillator therapy is considered the only effective treatment for high-risk patients with Brugada syndrome. Quinidine depresses I(to) current, which may play an important role in the arrhythmogenesis of this disease. METHODS AND RESULTS:The effects of quinidine bisulfat...

journal_title：Circulation

authors： Belhassen B,Glick A,Viskin S

更新日期：2004-09-28 00:00:00

abstract：BACKGROUND:Cardiovascular events are less prevalent in premenopausal women and women receiving estrogen replacement than in postmenopausal women or men. Endothelium-derived relaxing factor (EDRF) is an important local modulator of vascular tone, and abnormal endothelial function is related, in part, to the oxidative mo...

journal_title：Circulation

authors： Keaney JF Jr,Shwaery GT,Xu A,Nicolosi RJ,Loscalzo J,Foxall TL,Vita JA

更新日期：1994-05-01 00:00:00