Abstract:
BACKGROUND:An imbalance of sympathetic and parasympathetic drive to the heart is an important risk factor for cardiac death in patients with coronary heart disease, diabetes, and renal insufficiency. The amount of neurotransmitter released from peripheral autonomic nerves is modulated by presynaptic receptor systems. In analogy to alpha-autoreceptors on sympathetic nerves, muscarinic autoreceptors activated by endogenous acetylcholine may exist on parasympathetic nerves in the human heart. METHODS AND RESULTS:We developed a technique to study acetylcholine release from human atria and investigated muscarinic autoreceptor function. A pharmacological and molecular approach was used to characterize the subtype involved. Of the 5 muscarinic receptor subtypes cloned, only mRNA encoding for M(2)- and M(3)-receptors were detected. Potencies of several muscarinic antagonists against the release-inhibiting effect of the nonselective muscarinic agonist carbachol at the cardiac autoreceptor were correlated with published data for human cloned M(1)- through M(5)-receptors. CONCLUSIONS:This analysis clearly indicates that acetylcholine release in human atria is controlled by muscarinic M(2)-receptors. Blockade of these receptors by atropine doubles the amount of acetylcholine released at a stimulation frequency of 5 Hz. In atria of patients >70 years of age and patients with late diabetic complications, acetylcholine release is reduced. Locally impaired cardiac acetylcholine release may therefore represent a pathophysiological link to sudden cardiac death in elderly and diabetic patients.
journal_name
Circulationjournal_title
Circulationauthors
Oberhauser V,Schwertfeger E,Rutz T,Beyersdorf F,Rump LCdoi
10.1161/01.cir.103.12.1638subject
Has Abstractpub_date
2001-03-27 00:00:00pages
1638-43issue
12eissn
0009-7322issn
1524-4539journal_volume
103pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:A growing body of evidence from animal studies supports the hypothesis that oxidative stress-mediated mechanisms play a central role in early atherogenesis. In contrast, clinical trials with antioxidant vitamins have not produced consistent results in humans with established atherosclerosis. METHODS AND RES...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000055186.40785.c4
更新日期:2003-02-04 00:00:00
abstract::Ultrasonic tissue characterization is a new area of investigation in the field of cardiac ultrasound. The amplitude and frequency of the ultrasound signal are normally altered as the signal penetrates through tissue. It is assumed that the amplitude distribution and frequency shift of diseased or edematous tissue are ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.72.1.193
更新日期:1985-07-01 00:00:00
abstract:BACKGROUND:Failure to differentiate supraventricular from ventricular arrhythmias is the most frequent cause of inappropriate implantable cardioverter-defibrillator therapies. Although a sudden-onset criterion is available to differentiate sustained monomorphic ventricular tachycardias (SMVTs) and sinus tachycardias (S...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.7.671
更新日期:1998-08-18 00:00:00
abstract:BACKGROUND:Previous experimental studies have shown that nitric oxide (NO) modulates cardiac function by an abbreviation of systolic contraction and an enhancement of diastolic relaxation. However, the response to NO donors of patients with severe pressure-overload hypertrophy and diastolic dysfunction is unknown. MET...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.99.18.2396
更新日期:1999-05-11 00:00:00
abstract::Since platelet accumulation may be an important determinant of restenosis after angioplasty, the time course of 51Cr-labeled platelet accumulation after experimental angioplasty was evaluated in a deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet accumulation (39.5 +/- 8.7 ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.75.3.636
更新日期:1987-03-01 00:00:00
abstract:BACKGROUND:We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. METHODS AND RESULTS:To identify genes regulated by the hypoxic response and not other effects of chronic anemia, we compared...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.005296
更新日期:2014-04-22 00:00:00
abstract:BACKGROUND:We have previously described two distinct mutations in the beta-myosin heavy chain gene with markedly different clinical presentations and outcome: The 908Leu-->Val mutation was associated with a low disease penetrance and a benign prognosis. In contrast, the 403Arg-->Gln mutation in a Caucasian kindred was ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.1.22
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Magnetic resonance (MR) phase-shift velocity mapping is an established method for measurement of nonturbulent intravascular flow. Shortening the echo time of the MR sequence to 3.6 msec allowed application of the technique to turbulent jet flow. The objective of this study was validation of MR jet velocity m...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.4.1239
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Progression of heart failure after initial myocardial injury is mediated in part by various redundant inflammatory mediators, including the widely expressed cyclooxygenase-2 (COX-2). Because COX-2 inhibitors are useful in treating many inflammation-mediated diseases, we asked whether COX-2 inhibition can att...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000121354.34067.48
更新日期:2004-03-23 00:00:00
abstract:BACKGROUND:Reperfusion of ischemic rat hearts in the presence of thrombin or norepinephrine but not endothelin-1 causes the generation of inositol 1,4,5-trisphosphate (Ins 1,4,5P3) and arrhythmias. The present study investigates the effect of endothelin-1 on these responses. METHODS AND RESULTS:Ins 1,4,5P3 generation ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.6.823
更新日期:1999-02-16 00:00:00
abstract:BACKGROUND:Left ventricular remodeling after myocardial infarction (MI) involves the hypertrophic growth of cardiomyocytes and the accumulation of fibrillar collagen in the interstitial space. We evaluated the role of kinins in postinfarction ventricular remodeling and their potential contribution to the antiremodeling...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.7.1910
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing myocardial oxygen demand. This study evaluated the antianginal and antiischemic effects of ivabradine, a new heart rate-lowering agent that acts specifically on the sinoatrial node. METHODS...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.0000048143.25023.87
更新日期:2003-02-18 00:00:00
abstract:BACKGROUND:Major gender-based differences in the incidence of ventricular tachyarrhythmia after myocardial infarction have been shown in humans. Although the underlying mechanisms are unclear, earlier studies suggest that estrogen receptor-mediated effects play a major role in this process. METHODS AND RESULTS:We exam...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000164262.08004.BB
更新日期:2005-05-10 00:00:00
abstract:BACKGROUND:Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support. The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to characteristics of left ventricular unloading, and exercise performance remains largely unstudied. METHODS...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.677898
更新日期:2007-09-11 00:00:00
abstract::The concept of plaque stabilization was developed to explain how lipid lowering could decrease adverse coronary events without a substantial reduction in the regression of atherosclerosis. Plaques were stabilized by reducing serum cholesterol leading to several favorable pathobiological changes in the vessel wall of l...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000012528.89469.8e
更新日期:2002-04-23 00:00:00
abstract::Using a mechanical sector-scanner, two-dimensional echocardiograms were obtained from 28 normal subjects, 15 patients with tetralogy of Fallot, 11 patients with complete transposition of the great arteries and six patients with double outlet right ventricle. The image obtained perpendicular to the long axis of the lef...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.2.267
更新日期:1977-08-01 00:00:00
abstract::This is a report of a 10-year-old child who underwent surgery for complex congenital heart disease consisting of corrected transposition of the great vessels, ventricular septal defect, patent ductus arterisus, severe left-sided atrioventricular (AV) valve insuffieicney (Ebstein's deformity) and Wolff-Parkinson-White ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.61.6.1256
更新日期:1980-06-01 00:00:00
abstract:BACKGROUND:It is uncertain whether Helicobacter pylori is associated with ischemic syndromes and whether this association is mediated by the induction of atherosclerosis. In this study, we tested the hypothesis that atherosclerotic stroke shows a selective association with virulent H pylori strains. METHODS AND RESULT...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000023894.10871.2f
更新日期:2002-07-30 00:00:00
abstract::To test the hypothesis that an area of slow conduction is present during reentrant ventricular tachycardia in man, and that the earliest activation site during ventricular tachycardia is within or orthodromically just distal to the area of slow conduction in the reentry loop, we studied 12 episodes of ventricular tach...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.75.2.369
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Erythropoietin (Epo) receptors (EpoRs) are expressed in the heart. We have recently demonstrated that the endogenous Epo-EpoR system plays an important protective role in myocardial ischemia in mice and humans. In the present study, we tested our hypothesis that the endogenous Epo-EpoR system in nonhematopoi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.659037
更新日期:2007-04-17 00:00:00
abstract::Analysis of the external brachial pulse recorded during standard blood pressure cuff deflation with use of a transducer with a wide frequency response has revealed a reproducible pattern with three distinct components that we have labeled K1, K2, and K3. K1 is a low-amplitude, low-frequency signal that is present with...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.77.6.1297
更新日期:1988-06-01 00:00:00
abstract::Eighteen of 388 patients with chronic bundle branch block, studied electrophysiologically and followed prospectively, had H-V intervals of 80 msec or greater. Five patients were functional class I, five class II, seven class III, and one class IV. Follow-up ranged from 103 to 1919 days (mean 711 +/- 118). Three patien...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.53.4.600
更新日期:1976-04-01 00:00:00
abstract:BACKGROUND:Gene-nutrient interactions affecting high-density lipoprotein cholesterol (HDL-C) concentrations may contribute to the interindividual variability of the cardiovascular disease risk associated with dietary fat intake. Hepatic lipase (HL) is a key determinant of HDL metabolism. Four polymorphisms in linkage d...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000036597.52291.c9
更新日期:2002-10-29 00:00:00
abstract::Little is known of the functional capacity of coronary collaterals in humans without occlusive coronary artery disease. We, therefore, measured peripheral coronary pressure (PCP) and retrograde flow (RF) from coronary arteries at aortic valve replacement in seven patients without occlusive coronary artery disease. Usi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.51.1.118
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:The identification of sites of dominant activation frequency during atrial fibrillation (AF) in humans and the effect of ablation at these sites have not been reported. METHODS AND RESULTS:Thirty-two patients undergoing AF ablation (19 paroxysmal, 13 permanent) during ongoing arrhythmia were studied. Electr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.517011
更新日期:2005-08-09 00:00:00
abstract::Various electrocardiographic and vectorcardiographic (ECG-VCG) patterns of ventricular conduction disturbances are inducible by premature right atrial stimulation (PRAS). These patterns are a consequence of different degrees of refractoriness in the specialized ventricular conduction system. We observed that the inter...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.59.5.1044
更新日期:1979-05-01 00:00:00
abstract::In this paper we examine the relationship between risk factors and angiographically determined coronary artery disease for blacks and whites enrolled in the Coronary Artery Surgery Study (CASS). Analysis of data from the CASS registry indicated that blacks had a higher incidence of hypertension and current cigarette s...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.1.64
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Endothelin-converting enzyme (ECE)-1 activates endothelin-1 (ET-1) and may thus contribute to the regulation of vascular tone and cell growth during atherosclerosis. METHODS AND RESULTS:To evaluate ECE-1 immunoreactivity concerning big ET-1/ET-1, we performed qualitative and quantitative immunohistochemistr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc3301.094742
更新日期:2001-08-21 00:00:00
abstract:BACKGROUND:Long-term rapid atrial pacing may result in atrial fibrillation (AF) in dogs. Whether there is histological evidence for neural remodeling is unclear. METHOD AND RESULTS:We performed rapid right atrial pacing in 6 dogs for 111+/-76 days to induce sustained AF. Tissues from 6 healthy dogs were used as contro...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.1.22
更新日期:2001-01-02 00:00:00
abstract:BACKGROUND:There is increasing evidence of a link between conduit vessel stiffness and cardiovascular events, although the association has never been tested in a large post-myocardial infarction patient population. METHODS AND RESULTS:We evaluated the relationship between baseline pulse pressure, measured by sphygmoma...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.96.12.4254
更新日期:1997-12-16 00:00:00