Transcriptional genomics associates FOX transcription factors with human heart failure.

abstract：BACKGROUND:Current intravascular ultrasound (IVUS) catheters provide transverse imaging at the level of the ultrasound transducer. This limits imaging to large-diameter segments without critical atherosclerotic narrowings. We have developed a prototype 20-MHz forward-viewing IVUS catheter that provides two-dimensional ...

journal_title：Circulation

authors： Ng KH,Evans JL,Vonesh MJ,Meyers SN,Mills TA,Kane BJ,Aldrich WN,Jang YT,Yock PG,Rold MD

更新日期：1994-02-01 00:00:00

abstract：:Over the last 20 years, operative mortality has decreased and late survival has improved for patients with chronic stable angina who have coronary artery bypass surgery. However, this favorable trend may not continue because the operation is now extended to elderly and high-risk patients. The most powerful predictors ...

journal_title：Circulation

authors： Gersh BJ,Califf RM,Loop FD,Akins CW,Pryor DB,Takaro TC

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial r...

journal_title：Circulation

authors： van Der Velden J,Klein LJ,Zaremba R,Boontje NM,Huybregts MA,Stooker W,Eijsman L,de Jong JW,Visser CA,Visser FC,Stienen GJ

更新日期：2001-09-04 00:00:00

abstract：:A longitudinal study was made of 62 patients with dextro-transposition of the great arteries. The patients were managed with balloon atrial septostomy (BAS), palliative surgery if any operation was needed in the first year of life, and Mustard intra-atrial baffle repair after one year of age. Of the 47 patients with i...

journal_title：Circulation

authors： Gutgesell HP,McNamara DG

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:It remains unclear how mineralocorticoids induce cardiac hypertrophy and fibrosis. Recently, activation of the calcium-dependent phosphatase, calcineurin, has been shown to induce cardiac hypertrophy. In the present study, we examine the role of calcineurin in mineralocorticoid-induced cardiac hypertrophy an...

journal_title：Circulation

authors： Takeda Y,Yoneda T,Demura M,Usukura M,Mabuchi H

更新日期：2002-02-12 00:00:00

abstract：BACKGROUND:Persons with end-stage renal disease and those with lesser degrees of chronic kidney disease (CKD) have an increased risk of death after myocardial infarction (MI) that is not fully explained by associated comorbidities. Future cardiovascular event rates and the relative response to therapy in persons with m...

journal_title：Circulation

authors： Tokmakova MP,Skali H,Kenchaiah S,Braunwald E,Rouleau JL,Packer M,Chertow GM,Moyé LA,Pfeffer MA,Solomon SD

更新日期：2004-12-14 00:00:00

abstract：BACKGROUND:Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated. METHODS AND RESULTS:Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices a...

journal_title：Circulation

authors： Saxon LA,De Marco T,Schafer J,Chatterjee K,Kumar UN,Foster E,VIGOR Congestive Heart Failure Investigators.

更新日期：2002-03-19 00:00:00

abstract：BACKGROUND:In the congenital long-QT syndrome (LQTS), there can be a marked phenotypic heterogeneity. Founder effects, by which many individuals share a mutation identical by descent, represent a powerful tool to further understand the underlying mechanisms and to predict the natural history of mutation-associated effe...

journal_title：Circulation

authors： Brink PA,Crotti L,Corfield V,Goosen A,Durrheim G,Hedley P,Heradien M,Geldenhuys G,Vanoli E,Bacchini S,Spazzolini C,Lundquist AL,Roden DM,George AL Jr,Schwartz PJ

更新日期：2005-10-25 00:00:00

abstract：BACKGROUND:Autopsy studies in children have shown that atherosclerotic lesions begin to develop first in the intima of the aorta. Recent developments in ultrasound techniques have made it possible to visualize the intima-medial thickness of the abdominal aorta directly (aIMT). Therefore, we examined the feasibility of ...

journal_title：Circulation

authors： Järvisalo MJ,Jartti L,Näntö-Salonen K,Irjala K,Rönnemaa T,Hartiala JJ,Celermajer DS,Raitakari OT

更新日期：2001-12-11 00:00:00

abstract：:Our experimental studies since 1972 show that the heart is preserved best during cardiopulmonary bypass when it is in the beating, nonworking state. Results after mitral valve replacement (MVR) from 1968 to 1974 using various techniques of cardiac preservation were compared. In group I were 47 patients (1968 to 1972) ...

journal_title：Circulation

authors： Maloney JV Jr,Cooper N,Mulder DG,Buckberg GD

更新日期：1975-08-01 00:00:00

abstract：:Electrophysiologic studies were performed in 28 patients with documented atrioventricular (AV) nodal reentrant supraventricular tachycardia (SVT) to investigate the presence of AV nodal tissue situated between the tachycardia circuit and both the atrium (upper common pathway, UCP) and the His bundle (lower common path...

journal_title：Circulation

authors： Miller JM,Rosenthal ME,Vassallo JA,Josephson ME

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:An inverse association between moderate alcohol consumption and coronary heart disease (CHD) has been observed in several epidemiological studies. To assess whether a similar association exists among diabetics, we examined the relation between light to moderate alcohol consumption and CHD in men with and wit...

journal_title：Circulation

authors： Ajani UA,Gaziano JM,Lotufo PA,Liu S,Hennekens CH,Buring JE,Manson JE

更新日期：2000-08-01 00:00:00

abstract：:There is strong evidence that revascularization does not prevent myocardial infarction in patients with stable coronary artery disease (CAD). The anatomic basis for this counterintuitive conclusion seems to be that most myocardial infarctions occur at sites that did not previously exhibit an angiographically significa...

journal_title：Circulation

authors： Forrester JS,Shah PK

更新日期：1997-08-19 00:00:00

abstract：:This study examined quantitative regional myocardial perfusion (RMP) measured by the washout of 133Xe at rest and after an isoproterenol challenge in 50 patients (group I) studied 8 to 14 days after they underwent saphenous vein bypass grafting to the left coronary artery, and compared this with RMP measured in the na...

journal_title：Circulation

authors： Schmidt DH,Blau FM,Hendrix LJ,Kamath ML,Ray G

更新日期：1985-04-01 00:00:00

abstract：:Verapamil, a calcium antagonist, has been used extensively for treatment of cardiac arrhythmias. Concern persists, however, that it may seriously depress myocardial function in cardiac patients. To investigate this possibility, 20 patients with coronary artery disease (CAD) but no heart failure were given intravenous ...

journal_title：Circulation

authors： Ferlinz J,Easthope JL,Aronow WS

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs)-locations of ambiguous activation state-underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS for...

journal_title：Circulation

authors： Valderrábano M,Chen PS,Lin SF

更新日期：2003-07-22 00:00:00

abstract：:The indication for prophylactic temporary and permanent pacing during acute myocardial infarction (MI) complicated by bundle branch block is high risk of progression via a Type II pattern to second or third degree (high degree) AV block during hospitalization or follow-up. In this study, determinants of high degree AV...

journal_title：Circulation

authors： Hindman MC,Wagner GS,JaRo M,Atkins JM,Scheinman MM,DeSanctis RW,Hutter AH Jr,Yeatman L,Rubenfire M,Pujura C,Rubin M,Morris JJ

更新日期：1978-10-01 00:00:00

abstract：:Atherosclerotic coronary artery disease is the major cause of late cardiac transplant failure secondary to silent ischemia and infarction. To increase the longevity of cardiac homografts, we performed percutaneous transluminal coronary angioplasty (PTCA) in five male patients (aged 45 +/- 7 years, mean +/- SEM); 17 le...

journal_title：Circulation

authors： Vetrovec GW,Cowley MJ,Newton CM,Lewis SA,DiSciascio G,Thompson JA,Hastillo A,Lower R,Hess M

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:The effects of cardiac transplantation on cognitive brain function are uncertain. METHODS AND RESULTS:We measured cognitive brain function and quality of life in out-of-hospital cardiac transplant candidates (n = 55; ejection fraction, 19.9%; age, 54.8 years [means]). After transplantation, the patients wer...

journal_title：Circulation

authors： Grimm M,Yeganehfar W,Laufer G,Madl C,Kramer L,Eisenhuber E,Simon P,Kupilik N,Schreiner W,Pacher R,Bunzel B,Wolner E,Grimm G

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:Whether myocardial reperfusion obtained with thrombolysis or primary angioplasty is associated with a similar recovery of function and with the same risk of hemorrhagic infarction is unknown. We evaluated the effects of mechanical and pharmacological reperfusion (with or without a plasma lytic state) on infa...

journal_title：Circulation

authors： Pislaru SV,Barrios L,Stassen T,Jun L,Pislaru C,Van de Werf F

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Cardiac troponin I (cTnI), a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Small studies report that cTnI is elevated in severe heart failure (HF) and may predict adverse outcomes. METHODS AND RESULTS:The present study e...

journal_title：Circulation

authors： Horwich TB,Patel J,MacLellan WR,Fonarow GC

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:Peak early-diastolic mitral annulus velocity (e') by tissue Doppler imaging has been introduced as a clinical marker of diastolic function. This study investigates whether lengthening load (early-diastolic load) and restoring forces are determinants of e' in addition to rate of left ventricular (LV) relaxati...

journal_title：Circulation

authors： Opdahl A,Remme EW,Helle-Valle T,Lyseggen E,Vartdal T,Pettersen E,Edvardsen T,Smiseth OA

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:LDL and C-reactive protein (CRP) are important cardiovascular risk factors. Both LDL and CRP deposit in the arterial wall during atherogenesis. Stranded LDL is taken up by macrophages, causing foam cell formation. Because native LDL does not induce foam cell formation, we hypothesized that CRP may opsonize n...

journal_title：Circulation

authors： Zwaka TP,Hombach V,Torzewski J

更新日期：2001-03-06 00:00:00

abstract：:To examine whether nicardipine, a dihydropyridine derivative, limits size of myocardial infarction, and to compare the protective effects of nicardipine administered before and early and late after coronary artery occlusion, 99mTc-labeled albumin microspheres were injected into the left atrium during 5 min temporary c...

journal_title：Circulation

authors： Endo T,Nejima J,Fujita S,Kiuchi K,Iida N,Kikuchi K,Hayakawa H,Okumura H

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Connexin (Cx)40 and Cx45 are the major protein subunits of gap junction channels in the conduction system of mammals. To determine the role of Cx40, we correlated cardiac activation with Connexin distribution in normal and Cx40-deficient mice hearts. METHODS AND RESULTS:Epicardial and septal activation was ...

journal_title：Circulation

authors： van Rijen HV,van Veen TA,van Kempen MJ,Wilms-Schopman FJ,Potse M,Krueger O,Willecke K,Opthof T,Jongsma HJ,de Bakker JM

更新日期：2001-03-20 00:00:00

abstract：BACKGROUND:Little is known about the behavior with regard to restenosis of multiple lesions within the same patient treated with intracoronary stenting. Our objective was to test the hypothesis that there is an intrapatient dependence of restenosis between lesions. METHODS AND RESULTS:Quantitative analysis was carried...

journal_title：Circulation

authors： Kastrati A,Schömig A,Elezi S,Schühlen H,Wilhelm M,Dirschinger J

更新日期：1998-06-23 00:00:00

abstract：:We performed transventricular pulmonary valvotomy as initial surgery in 22 consecutive patients with pulmonary atresia and intact ventricular septum who had a patent infundibulum. Nineteen patients also had placement of a central aortopulmonary shunt. All patients survived surgery, and 16 patients have had preoperativ...

journal_title：Circulation

authors： Shaddy RE,Sturtevant JE,Judd VE,McGough EC

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. METHODS AND RESULTS:A myocardial inf...

journal_title：Circulation

authors： Pouzet B,Ghostine S,Vilquin JT,Garcin I,Scorsin M,Hagège AA,Duboc D,Schwartz K,Menasché P

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:Clinical trials have demonstrated that platelet glycoprotein (GP) IIb/IIIa antagonists effectively prevent acute thrombotic events. Orally active GP IIb/IIIa antagonists are essential to evaluate the clinical benefit of long-term treatment. We therefore investigated platelet inhibition by the GP IIb/IIIa ant...

journal_title：Circulation

authors： Müller TH,Weisenberger H,Brickl R,Narjes H,Himmelsbach F,Krause J

更新日期：1997-08-19 00:00:00

abstract：BACKGROUND:The clinical significance and pathophysiological mechanisms of reverse redistribution on stress-redistribution thallium-201 myocardial scintigraphy in patients with chronic coronary artery disease are unclear. Recent studies have shown that thallium-201 reinjection is a useful technique for the detection of ...

journal_title：Circulation

authors： Marin-Neto JA,Dilsizian V,Arrighi JA,Freedman NM,Perrone-Filardi P,Bacharach SL,Bonow RO

更新日期：1993-10-01 00:00:00