Abstract:
BACKGROUND:Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated. METHODS AND RESULTS:Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices as part of a randomized trial. Echocardiograms were acquired at randomization and at 6-week intervals until completion of 12 weeks of continuous BVS. There were no changes in heart rate or QRS duration after 12 weeks of BVS. Serum norepinephrine values did not change with BVS. After 12 weeks of BVS, left atrial volume decreased. Left ventricular end-systolic and end-diastolic dimensions and left ventricular end-systolic volume also decreased after 12 weeks of BVS. Sphericity index did not change. Measures of systolic function, including left ventricular outflow tract and aortic velocity time integral and myocardial performance index, improved. CONCLUSIONS:Long-term resynchronization therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.
journal_name
Circulationjournal_title
Circulationauthors
Saxon LA,De Marco T,Schafer J,Chatterjee K,Kumar UN,Foster E,VIGOR Congestive Heart Failure Investigators.doi
10.1161/hc1102.105730subject
Has Abstractpub_date
2002-03-19 00:00:00pages
1304-10issue
11eissn
0009-7322issn
1524-4539journal_volume
105pub_type
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