Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling.

Abstract:

BACKGROUND:Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated. METHODS AND RESULTS:Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices as part of a randomized trial. Echocardiograms were acquired at randomization and at 6-week intervals until completion of 12 weeks of continuous BVS. There were no changes in heart rate or QRS duration after 12 weeks of BVS. Serum norepinephrine values did not change with BVS. After 12 weeks of BVS, left atrial volume decreased. Left ventricular end-systolic and end-diastolic dimensions and left ventricular end-systolic volume also decreased after 12 weeks of BVS. Sphericity index did not change. Measures of systolic function, including left ventricular outflow tract and aortic velocity time integral and myocardial performance index, improved. CONCLUSIONS:Long-term resynchronization therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.

journal_name

Circulation

journal_title

Circulation

authors

Saxon LA,De Marco T,Schafer J,Chatterjee K,Kumar UN,Foster E,VIGOR Congestive Heart Failure Investigators.

doi

10.1161/hc1102.105730

subject

Has Abstract

pub_date

2002-03-19 00:00:00

pages

1304-10

issue

11

eissn

0009-7322

issn

1524-4539

journal_volume

105

pub_type

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