Characterization of the cardiomyopathy in infants of diabetic mothers.

abstract：BACKGROUND:Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS:We genera...

journal_title：Circulation

authors： Hoffmann CJ,Harms U,Rex A,Szulzewsky F,Wolf SA,Grittner U,Lättig-Tünnemann G,Sendtner M,Kettenmann H,Dirnagl U,Endres M,Harms C

更新日期：2015-05-19 00:00:00

abstract：BACKGROUND:Previous studies in animal models of angioplasty have suggested a role in neointimal hyperplasia for endothelins (ETs), potent vasoconstricting peptides that also exert growth-promoting effects. The present studies were undertaken to test the hypothesis that endothelin receptor blockade can reduce neointimal...

journal_title：Circulation

authors： Huckle WR,Drag MD,Acker WR,Powers M,McFall RC,Holder DJ,Walsh TF,Schwartz RS,Greenlee WJ,Johnson RG Jr

更新日期：2001-04-10 00:00:00

abstract：:The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Local biological responses to these retained lipoproteins, including a chronic and maladaptive macrophage- and T-cell-dominated inflammatory response, promote subsequent lesion development. The most...

journal_title：Circulation

authors： Tabas I,Williams KJ,Borén J

更新日期：2007-10-16 00:00:00

abstract：BACKGROUND:Current guidelines recommend mitral valve surgery for asymptomatic patients with severe degenerative mitral regurgitation and preserved left ventricular systolic function when exercise pulmonary hypertension (PHT) is present. However, the determinants of exercise PHT have not been evaluated. The aim of this ...

journal_title：Circulation

authors： Magne J,Lancellotti P,Piérard LA

更新日期：2010-07-06 00:00:00

abstract：BACKGROUND:In animal models of cardiac arrest, the benefit afforded by hypothermia is closely linked to the rapidity of the decrease in body temperature after resuscitation. Because total liquid ventilation (TLV) with temperature-controlled perfluorocarbons induces a very rapid and generalized cooling, we aimed to dete...

journal_title：Circulation

authors： Chenoune M,Lidouren F,Adam C,Pons S,Darbera L,Bruneval P,Ghaleh B,Zini R,Dubois-Randé JL,Carli P,Vivien B,Ricard JD,Berdeaux A,Tissier R

更新日期：2011-08-23 00:00:00

abstract：BACKGROUND:Pulmonary veno-occlusive disease is caused by excessive cell proliferation and fibrosis, which obliterate the lumen of pulmonary venules, leading to pulmonary hypertension, right ventricular failure, and death. This condition has no effective treatment and a 5-year survival of <5%. Understanding the mechanis...

journal_title：Circulation

authors： Lathen C,Zhang Y,Chow J,Singh M,Lin G,Nigam V,Ashraf YA,Yuan JX,Robbins IM,Thistlethwaite PA

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Sporadic aortic aneurysm and dissection (AAD), caused by progressive aortic smooth muscle cell (SMC) loss and extracellular matrix degradation, is a highly lethal condition. Identifying mechanisms that drive aortic degeneration is a crucial step in developing an effective pharmacologic treatment to prevent d...

journal_title：Circulation

authors： Luo W,Wang Y,Zhang L,Ren P,Zhang C,Li Y,Azares AR,Zhang M,Guo J,Ghaghada KB,Starosolski ZA,Rajapakshe K,Coarfa C,Li Y,Chen R,Fujiwara K,Abe JI,Coselli JS,Milewicz DM,LeMaire SA,Shen YH

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Mild and moderate functional ischemic mitral insufficiency present at the time of surgical revascularization present clinical uncertainty. It is unclear whether the relatively poor outcomes in this cohort are dependent on valvular function or related to left ventricular dysfunction. The purpose of this study...

journal_title：Circulation

authors： Grossi EA,Crooke GA,DiGiorgi PL,Schwartz CF,Jorde U,Applebaum RM,Ribakove GH,Galloway AC,Grau JB,Colvin SB

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Recent in vitro studies have shown that disturbed flow and oxidative conditions induce the expression of bone morphogenic proteins (BMPs 2 and 4) in cultured endothelial cells. BMPs can stimulate superoxide production and inflammatory responses in endothelial cells, raising the possibility that BMPs may play...

journal_title：Circulation

authors： Miriyala S,Gongora Nieto MC,Mingone C,Smith D,Dikalov S,Harrison DG,Jo H

更新日期：2006-06-20 00:00:00

abstract：BACKGROUND:The role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously. METHODS AND RESULTS:Clustering of cardiovascular risk factors was analyzed by factor analysis to investigate whether these clusters (facto...

journal_title：Circulation

authors： Lempiäinen P,Mykkänen L,Pyörälä K,Laakso M,Kuusisto J

更新日期：1999-07-13 00:00:00

abstract：BACKGROUND:Carotid artery stenting (CAS) has recently emerged as a potential alternative to carotid endarterectomy. Cerebral embolization is the most devastating complication of CAS, and the echogenicity of carotid plaque has been indicated as one of the risk factors involved. This is the first study to analyze the rol...

journal_title：Circulation

authors： Biasi GM,Froio A,Diethrich EB,Deleo G,Galimberti S,Mingazzini P,Nicolaides AN,Griffin M,Raithel D,Reid DB,Valsecchi MG

更新日期：2004-08-10 00:00:00

abstract：BACKGROUND:Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support. The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to characteristics of left ventricular unloading, and exercise performance remains largely unstudied. METHODS...

journal_title：Circulation

authors： Haft J,Armstrong W,Dyke DB,Aaronson KD,Koelling TM,Farrar DJ,Pagani FD

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide is an important modulator of resting vascular tone in animals and humans. However, the contribution of nitric oxide to exercise-induced vasodilation is unknown. METHODS AND RESULTS:The effect of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, on ex...

journal_title：Circulation

authors： Gilligan DM,Panza JA,Kilcoyne CM,Waclawiw MA,Casino PR,Quyyumi AA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) and myocardial infarction (MI) are caused in part by genetic factors. Recently, the MEF2A gene was linked to MI/CAD in a single pedigree with autosomal-dominant pattern of inheritance. In addition, genetic variants within the gene have been associated with MI in case-control set...

journal_title：Circulation

authors： Lieb W,Mayer B,König IR,Borwitzky I,Götz A,Kain S,Hengstenberg C,Linsel-Nitschke P,Fischer M,Döring A,Wichmann HE,Meitinger T,Kreutz R,Ziegler A,Schunkert H,Erdmann J

更新日期：2008-01-15 00:00:00

abstract：:Ultrasonic tissue characterization is a new area of investigation in the field of cardiac ultrasound. The amplitude and frequency of the ultrasound signal are normally altered as the signal penetrates through tissue. It is assumed that the amplitude distribution and frequency shift of diseased or edematous tissue are ...

journal_title：Circulation

authors： Schnittger I,Vieli A,Heiserman JE,Director BA,Billingham ME,Ellis SG,Kernoff RS,Takamoto T,Popp RL

更新日期：1985-07-01 00:00:00

abstract：:Long-term tocainide therapy has been evaluated in 17 patients with ventricular arrhythmias. Ventricular tachycardia and/or fibrillation was recurrent and sustained in nine patients, and symptomatic but unsustained in three others. Five patients had frequent but only mildly symptomatic ventricular irritability. In all ...

journal_title：Circulation

authors： Winkle RA,Meffin PJ,Harrison DC

更新日期：1978-05-01 00:00:00

abstract：:We examined the temporal kinetics of onset and offset of the cardiac electrophysiologic effects of orally administered amiodarone in chronically instrumented, unsedated adult dogs (n = 8). Right atrial (RA), atrioventricular nodal (AVN), and right ventricular (RV) effective refractory period (ERP), and AVN functional ...

journal_title：Circulation

authors： Tuna IC,Qi AC,Gornick C,Bolman RM 3rd,Benditt DG

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) plasma levels have been associated with short- and long-term occurrence of coronary events. We investigated whether circulating inflammatory cell responsiveness to low-grade stimuli could contribute to the reported association between CRP and coronary events. METHODS AND RESULTS:We ...

journal_title：Circulation

authors： Liuzzo G,Angiolillo DJ,Buffon A,Rizzello V,Colizzi C,Ginnetti F,Biasucci LM,Maseri A

更新日期：2001-05-08 00:00:00

abstract：BACKGROUND:Angiogenesis is a promising treatment strategy for patients who are not candidates for standard revascularization, because it promotes the growth of new blood vessels in ischemic myocardium. METHODS AND RESULTS:We conducted a randomized, double-blind, placebo-controlled study of basic fibroblast growth fact...

journal_title：Circulation

authors： Laham RJ,Sellke FW,Edelman ER,Pearlman JD,Ware JA,Brown DL,Gold JP,Simons M

更新日期：1999-11-02 00:00:00

abstract：BACKGROUND:The rate-corrected QT interval (QTc) is heritable, and the discovery of quantitative trait loci that influence the QTc would be an important step in identifying the genes responsible for life-threatening arrhythmias in the general population. We studied 66 pairs of unselected normal dizygotic (DZ) twin subje...

journal_title：Circulation

authors： Busjahn A,Knoblauch H,Faulhaber HD,Boeckel T,Rosenthal M,Uhlmann R,Hoehe M,Schuster H,Luft FC

更新日期：1999-06-22 00:00:00

abstract：BACKGROUND:Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. METHODS AND RESULTS:In wild-type mice, Sirt7 expression increa...

journal_title：Circulation

authors： Araki S,Izumiya Y,Rokutanda T,Ianni A,Hanatani S,Kimura Y,Onoue Y,Senokuchi T,Yoshizawa T,Yasuda O,Koitabashi N,Kurabayashi M,Braun T,Bober E,Yamagata K,Ogawa H

更新日期：2015-09-22 00:00:00

abstract：:D8/17, a B cell alloantigen, and its occurrence with DR/DQ antigens was examined in 54 patients with rheumatic heart disease and matched North Indian controls. Thirty-four patients (62.9%) carried D8/17 as compared with a frequency of 12.5% in controls (chi 2 by Yates', 18.75; p less than 0.0001). A marginally increas...

journal_title：Circulation

authors： Taneja V,Mehra NK,Reddy KS,Narula J,Tandon R,Vaidya MC,Bhatia ML

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability in the degree of new collateral formation in patients with coronary artery disease. The basis for this interindividual heterogeneity ...

journal_title：Circulation

authors： Schultz A,Lavie L,Hochberg I,Beyar R,Stone T,Skorecki K,Lavie P,Roguin A,Levy AP

更新日期：1999-08-03 00:00:00

abstract：BACKGROUND:It has been suggested that the survival benefit associated with primary percutaneous coronary intervention (PPCI) in ST-segment elevation myocardial infarction may be attenuated if door-to-balloon (DB) time is delayed by >1 hour beyond door-to-needle (DN) times for fibrinolytic therapy. Whereas DB times are ...

journal_title：Circulation

authors： Pinto DS,Kirtane AJ,Nallamothu BK,Murphy SA,Cohen DJ,Laham RJ,Cutlip DE,Bates ER,Frederick PD,Miller DP,Carrozza JP Jr,Antman EM,Cannon CP,Gibson CM

更新日期：2006-11-07 00:00:00

abstract：:Novel compounds that induce or inhibit platelet aggregation and constrict or dilate blood vessels were recently discovered. These compounds are all derivatives of arachidonic acid and include prostaglandin endoperoxides, thromboxane A2, prostaglandin E2, prostaglandin D2 and prostacyclin. Thromboxane A2 (TxA2) could b...

journal_title：Circulation

authors： Smith JB,Araki H,Lefer AM

更新日期：1980-12-01 00:00:00

abstract：:Postoperative fever and pericardial-pleural reaction, designated postpericardiotomy syndrome (PPS), is a common complication of cardiac surgery involving entry into the pericardium. To determine whether the etiology of PPS is viral or immunologic, we undertook a prospective, triple-blind study of consecutive long-term...

journal_title：Circulation

authors： Engle MA,Zabriskie JB,Senterfit LB,Gay WA Jr,O'Loughlin JE Jr,Ehlers KH

更新日期：1980-12-01 00:00:00

abstract：:In 72% of 143 patients undergoing a second coronary bypass grafting, mural or occlusive late thrombosis was observed histologically in 69% of 173 resected grafts. Late thrombosis was particularly prevalent in atherosclerotic grafts (80.2% vs. 40.4% in nonatherosclerotic grafts) and was always noted in 16 grafts with a...

journal_title：Circulation

authors： Solymoss BC,Nadeau P,Millette D,Campeau L

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that several subsets of regulatory T cells that actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally administered anti-CD3 monoclonal antibody has been shown as an inducer of novel regulatory T cells expressing latency-associated peptide ...

journal_title：Circulation

authors： Sasaki N,Yamashita T,Takeda M,Shinohara M,Nakajima K,Tawa H,Usui T,Hirata K

更新日期：2009-11-17 00:00:00

abstract：BACKGROUND:As cardiovascular clinical trials improve in sophistication and therapies target specific cardiac mechanisms of death, a more objective and precise system to identify specific cause of death is needed. Ideally, sudden cardiac death would describe patients dying of ventricular tachycardia and ventricular fibr...

journal_title：Circulation

authors： Pratt CM,Greenway PS,Schoenfeld MH,Hibben ML,Reiffel JA

更新日期：1996-02-01 00:00:00

abstract：:Twelve consecutive patients who developed torsade de pointes (polymorphous ventricular tachycardia with marked QT prolongation, TdP) over a 4 year period were treated with intravenous injections of magnesium sulfate. In nine of the patients a single bolus of 2 g completely abolished the TdP within 1 to 5 min, and in t...

journal_title：Circulation

authors： Tzivoni D,Banai S,Schuger C,Benhorin J,Keren A,Gottlieb S,Stern S

更新日期：1988-02-01 00:00:00