Abstract:
BACKGROUND:It has been suggested that the survival benefit associated with primary percutaneous coronary intervention (PPCI) in ST-segment elevation myocardial infarction may be attenuated if door-to-balloon (DB) time is delayed by >1 hour beyond door-to-needle (DN) times for fibrinolytic therapy. Whereas DB times are rapid in randomized trials, they are often prolonged in routine practice. We hypothesized that in clinical practice, longer DB-DN times would be associated with higher mortality rates and reduced PPCI survival advantage. We also hypothesized that in addition to PPCI delays, patient risk factors would significantly modulate the relative survival advantage of PPCI over fibrinolysis. METHODS AND RESULTS:DB-DN times were calculated by subtracting median DN time from median DB time at a hospital using data from 192,509 patients at 645 National Registry of Myocardial Infarction hospitals. Hierarchical models that adjusted simultaneously for both patient-level risk factors and hospital-level covariates were used to evaluate the relationship between PCI-related delay, patient risk factors, and in-hospital mortality. Longer DB-DN times were associated with increased mortality (P<0.0001). The DB-DN time at which mortality rates with PPCI were no better than that of fibrinolysis varied considerably depending on patient age, symptom duration, and infarct location. CONCLUSIONS:As DB-DN times increase, the mortality advantage of PPCI over fibrinolysis declines, and this advantage varies considerably depending on patient characteristics. As indicated in the American College of Cardiology/American Heart Association guidelines, both the hospital-based PPCI-related delay (DB-DN time) and patient characteristics should be considered when a reperfusion strategy is selected.
journal_name
Circulationjournal_title
Circulationauthors
Pinto DS,Kirtane AJ,Nallamothu BK,Murphy SA,Cohen DJ,Laham RJ,Cutlip DE,Bates ER,Frederick PD,Miller DP,Carrozza JP Jr,Antman EM,Cannon CP,Gibson CMdoi
10.1161/CIRCULATIONAHA.106.638353subject
Has Abstractpub_date
2006-11-07 00:00:00pages
2019-25issue
19eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.106.638353journal_volume
114pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.699264
更新日期:2007-09-04 00:00:00
abstract:BACKGROUND:In the monocrotaline (MCT)-treated rat, there is marked stimulation of DNA synthesis and megalocytosis of pulmonary arterial endothelial cells (PAECs) within 3 to 4 days, followed by pulmonary hypertension (PH) 10 to 14 days later. Growing evidence implicates caveolin-1 (cav-1) in plasma membrane rafts as a ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000141576.39579.23
更新日期:2004-09-14 00:00:00
abstract:BACKGROUND:Adenosine has several potentially cardioprotective effects. We hypothesized that the effects of endogenous adenosine vary with degree of ischemia and that elevating endogenous levels is protective. METHODS AND RESULTS:Isolated blood-perfused piglet hearts underwent 120 minutes of low-flow ischemia (10% flow...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.9.3094
更新日期:1997-11-04 00:00:00
abstract:BACKGROUND:Premedication with clopidogrel has reduced thrombotic complications after percutaneous coronary revascularization procedures. However, because of the enhanced and irreversible platelet inhibition by clopidogrel, patients requiring surgical revascularization have a higher risk of bleeding complications and tr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.571828
更新日期:2006-04-04 00:00:00
abstract:BACKGROUND:Enzymatic, nonoxidative modification transforms LDL to an atherogenic molecule (E-LDL) that activates complement and macrophages and is present in early atherosclerotic lesions. METHODS AND RESULTS:We report on the atherogenic effects of E-LDL on human vascular smooth muscle cells (SMC). E-LDL accumulated i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.15.1799
更新日期:2000-04-18 00:00:00
abstract:BACKGROUND:Treatment of aortocaval fistulae (ACFs) by open surgery is known to be a high-risk procedure. In this experimental study, we developed a percutaneous model of ACF to test a new nonsurgical method of treatment of ACF using endovascular stent grafts. METHODS AND RESULTS:An ACF was created percutaneously in ei...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.1.108
更新日期:1996-07-01 00:00:00
abstract::We assessed the effects of ethanol and autonomic blockade on left ventricular function in nine normal subjects, age 20--35 years, using M-mode echocardiography and systolic time intervals. On day 1, measurements were made of heart rate, mean velocity of circumferential fiber shortening, and left ventricular pre-ejecti...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.59.1.120
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation is common in advanced heart failure, but its prognostic significance is controversial. METHODS AND RESULTS:We evaluated the relation of atrial rhythm to overall survival and sudden death in 390 consecutive advanced heart failure patients. Etiology of heart failure was coronary artery dis...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.1.40
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Enteroviridae such as coxsackievirus B3 (CVB3) are important infectious agents involved in viral heart disease, hepatitis, and pancreatitis, but no specific antiviral therapy is available. METHODS AND RESULTS:The aim of the present study was to evaluate the impact of RNA interference on viral replication, c...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000160360.02040.AB
更新日期:2005-04-05 00:00:00
abstract:BACKGROUND:Fe2+ released from tissue iron stores may accelerate lipid peroxidation by virtue of its pro-oxidant properties and thus promote early atherogenesis. METHODS AND RESULTS:The present prospective survey addresses the potential association between serum ferritin concentrations and the 5-year progression of car...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.10.3300
更新日期:1997-11-18 00:00:00
abstract::Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there ar...
journal_title:Circulation
pub_type: 杂志文章,meta分析
doi:10.1161/CIR.0000000000000604
更新日期:2019-04-02 00:00:00
abstract::Regional myocardial function and blood flow were determined for 48 hours after permanent occlusion of the left circumflex coronary artery in conscious swine. Systolic wall thickening and end-diastolic wall thickness (EDWTh) were correlated with regional myocardial flow (RMBF) at 15 minutes, 24 and 48 hours after occlu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.64.4.699
更新日期:1981-10-01 00:00:00
abstract::A longitudinal study was made of 62 patients with dextro-transposition of the great arteries. The patients were managed with balloon atrial septostomy (BAS), palliative surgery if any operation was needed in the first year of life, and Mustard intra-atrial baffle repair after one year of age. Of the 47 patients with i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.51.1.32
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:The ability of apolipoprotein (apo)A-I to induce regression of preexisting atherosclerotic lesions has not been determined, and a mouse model of atherosclerosis regression has not yet been reported. METHODS AND RESULTS:LDL receptor-deficient mice were fed a western-type diet for 5 weeks to induce atheroscle...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.17.1816
更新日期:1999-10-26 00:00:00
abstract:BACKGROUND:Hypoxia-induced pulmonary hypertension is a major cause of morbidity and mortality. Hypoxia induces pulmonary vasoconstriction, in part, by decreasing endothelial nitric oxide synthase (eNOS) expression. The mechanism by which hypoxia decreases eNOS expression is not known but may involve Rho-kinase-induced ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000020682.73694.ab
更新日期:2002-07-02 00:00:00
abstract::The capability of a pulsed Doppler flowmeter combined with a phased-array imaging system to measure volume flow was tested in vitro and in patients undergoing cardiac catheterization. The Doppler-phased-array system (DPA) was used to determine vessel diameter and a superimposed cursor was used to locate the range and ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.63.2.388
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:High blood pressure (BP) is a known risk factor for mobility and cognitive impairment in older adults. This study tested the association of cumulative BP exposure from young adulthood to midlife with gait and cognitive function in midlife. Furthermore, we tested whether these associations were modified by ce...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.119.042502
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:Three trials demonstrated recently that a long detection window reduces implantable cardioverter-defibrillator (ICD) therapy in primary prevention patients. Avoid Delivering Therapies for Nonsustained Arrhythmias in ICD Patients III (ADVANCE III) was the only trial that enrolled both primary and secondary pr...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.114.009468
更新日期:2014-07-22 00:00:00
abstract:BACKGROUND:The aim of the study was to establish the influence of proximal coronary artery atheroma and smoking habit on the stimulated release of tissue plasminogen activator (tPA) from the heart. METHODS AND RESULTS:After diagnostic coronary angiography in 25 patients, the left anterior descending coronary artery (L...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.103.15.1936
更新日期:2001-04-17 00:00:00
abstract:BACKGROUND:Clinical manifestations of acute myocarditis, with distinct onset, vary from asymptomatic to fatal. The predictors of the course of the disease in patients with acute myocarditis at initial presentation have not yet been established. In this study, we examined the predictive values of various parameters in t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.23.2829
更新日期:2000-12-05 00:00:00
abstract::Cardiovascular disease continues to be the leading cause of death among women in the United States. One of the barriers to improving cardiovascular disease outcomes in women is the lack of reliable, effective screening modalities. Breast arterial calcification has emerged as a potential risk stratification tool. Local...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.118.038092
更新日期:2019-02-19 00:00:00
abstract:BACKGROUND:Arterial hypertension is a prime cause of morbidity and mortality in the general population. Pharmacological treatment has limitations resulting from drug side effects, costs, and patient compliance. Thus, we investigated whether traditional Chinese medicine acupuncture is able to lower blood pressure. METH...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.106.661140
更新日期:2007-06-19 00:00:00
abstract::A Y-shaped lesion in the right atrium allows induction of atrial flutter in dogs. We recorded the activation sequence during this tachycardia from 96 endocardial bipolar electrodes using intracavitary electrode arrays during 12 separate episodes in three isolated perfused hearts. In each case a reentrant impulse circu...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.76.5.1155
更新日期:1987-11-01 00:00:00
abstract::To estimate the extent of myocardial infarction after coronary artery reperfusion, serum levels of cardiac myosin light chain (LC) I and creatine kinase (CK) were determined serially in 49 patients with acute myocardial infarction. Intracoronary thrombolysis was successful in 25 patients (reperfusion group), and 24 pa...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.76.6.1251
更新日期:1987-12-01 00:00:00
abstract::In 72% of 143 patients undergoing a second coronary bypass grafting, mural or occlusive late thrombosis was observed histologically in 69% of 173 resected grafts. Late thrombosis was particularly prevalent in atherosclerotic grafts (80.2% vs. 40.4% in nonatherosclerotic grafts) and was always noted in 16 grafts with a...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:The biological response to antiplatelet drugs has repeatedly been shown to predict the recurrence of major adverse cardiovascular events (MACEs). However, most studies involved coronary artery disease patients with recent vessel injury shortly after the initiation of antiplatelet therapy. Data on stable card...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.085464
更新日期:2012-06-26 00:00:00
abstract:BACKGROUND:Myocardial perfusion reserve can be noninvasively assessed with cardiovascular MR. In this study, the diagnostic accuracy of this technique for the detection of significant coronary artery stenosis was evaluated. METHODS AND RESULTS:In 15 patients with single-vessel coronary artery disease and 5 patients wi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.12.1379
更新日期:2000-03-28 00:00:00
abstract::This review defines the substantial pediatric morbidity from tobacco use, including health effects on the cardiovascular system, the respiratory system, the fetus and newborn, and risk-taking behaviors of adolescents. More recent research suggests effects may extend to other areas, including reports that cigarette smo...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.90.5.2581
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:The composition of plaque is a major determinant of coronary-related clinical syndromes. Intravascular ultrasound (IVUS) elastography has proven to be a technique capable of reflecting the mechanical properties of phantom material and the femoral arterial wall. The aim of this study was to investigate the ca...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.6.617
更新日期:2000-08-08 00:00:00
abstract:BACKGROUND:Matricellular proteins are extracellular matrix proteins that do not contribute directly to tissue integrity but are capable of modulating cell function. We hypothesized that the matricellular protein thrombospondin (TSP)-1, a potent inhibitor of angiogenesis and activator of transforming growth factor (TGF-...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.510354
更新日期:2005-06-07 00:00:00