Importance of endogenous adenosine during ischemia and reperfusion in neonatal porcine hearts.

abstract：BACKGROUND:Coronary calcification detected by electron beam tomography may improve cardiovascular risk prediction. The technique is particularly promising in the elderly because the predictive power of cardiovascular risk factors weakens with age. We investigated the prognostic value of coronary calcification for cardi...

journal_title：Circulation

authors： Vliegenthart R,Oudkerk M,Hofman A,Oei HH,van Dijck W,van Rooij FJ,Witteman JC

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:The myocardial protective role of heat shock protein (HSP) has been demonstrated, and there has been increasing interest in stress response in the heart. We examined the DNA-binding activity of heat shock transcription factor (HSF), by which the transcription of heat shock genes is mainly regulated, during h...

journal_title：Circulation

authors： Nishizawa J,Nakai A,Higashi T,Tanabe M,Nomoto S,Matsuda K,Ban T,Nagata K

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:In heart failure, sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA2a) activity is decreased, resulting in abnormal calcium handling and contractile dysfunction. We have previously shown that increasing SERCA2a expression by gene transfer improves ventricular function in a rat model of heart failure created b...

journal_title：Circulation

authors： del Monte F,Williams E,Lebeche D,Schmidt U,Rosenzweig A,Gwathmey JK,Lewandowski ED,Hajjar RJ

更新日期：2001-09-18 00:00:00

abstract：:To define the prevalence, frequency and characteristics of premature ventricular complexes (PVCs) in adults free of recognizable heart disease, we performed 24-hour ambulatory electrocardiography on 101 subjects (51 men and 50 women, mean age 48.8 years) in whom physical examination, chest x-ray, ECG, echocardiogram, ...

journal_title：Circulation

authors： Kostis JB,McCrone K,Moreyra AE,Gotzoyannis S,Aglitz NM,Natarajan N,Kuo PT

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND:Data on outcomes after Stanford type A aortic dissection in patients with Marfan syndrome are limited. We investigated the primary surgery and long-term results in patients with Marfan syndrome who suffered aortic dissection. METHODS AND RESULTS:Among 1324 consecutive patients with aortic dissection type A,...

journal_title：Circulation

authors： Rylski B,Bavaria JE,Beyersdorf F,Branchetti E,Desai ND,Milewski RK,Szeto WY,Vallabhajosyula P,Siepe M,Kari FA

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Congestive heart failure (CHF) in humans is associated with a marked sympathoexcitation, including an augmented muscle sympathetic nerve activity (MSNA) in intraneural multiunit recordings. In the present study, single-unit recording was used to evaluate whether the firing properties of individual muscle vas...

journal_title：Circulation

authors： Macefield VG,Rundqvist B,Sverrisdottir YB,Wallin BG,Elam M

更新日期：1999-10-19 00:00:00

abstract：BACKGROUND:Epinephrine has been the mainstay for cardiac resuscitation for more than 30 years. Its vasopressor effect by which it increases coronary perfusion pressure is likely to favor initial resuscitation. Its beta-adrenergic action, however, may have detrimental effects on postresuscitation myocardial function whe...

journal_title：Circulation

authors： Tang W,Weil MH,Sun S,Noc M,Yang L,Gazmuri RJ

更新日期：1995-11-15 00:00:00

abstract：:To determine whether specific antiplatelet therapies improved vein graft patency after coronary artery bypass grafting (CABG) we compared (1) aspirin, 325 mg daily, (2) aspirin, 325 mg three times daily, (3) aspirin plus dipyridamole (325 mg and 75 mg, respectively, three times daily), (4) sulfinpyrazone (267 mg three...

journal_title：Circulation

authors： Goldman S,Copeland J,Moritz T,Henderson W,Zadina K,Ovitt T,Doherty J,Read R,Chesler E,Sako Y

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated. METHODS AND RESULTS:Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices a...

journal_title：Circulation

authors： Saxon LA,De Marco T,Schafer J,Chatterjee K,Kumar UN,Foster E,VIGOR Congestive Heart Failure Investigators.

更新日期：2002-03-19 00:00:00

abstract：BACKGROUND:For patients with acute dilated cardiomyopathy, definition of prognosis and of clinical features predictive of outcome is particularly important due to the availability of cardiac transplantation and other innovative treatment strategies. METHODS AND RESULTS:We reviewed our experience with 24 children under...

journal_title：Circulation

authors： Matitiau A,Perez-Atayde A,Sanders SP,Sluysmans T,Parness IA,Spevak PJ,Colan SD

更新日期：1994-09-01 00:00:00

abstract：:Three patients with total anomalous pulmonary venous drainage (TAPVD) into the innominate vein were studied by using M-mode and pulsed Doppler echocardiography. An abnormal continuous flow towards the transducer in a suprasternal notch position detected by pulsed Doppler echocardiography in the left hemithorax leftwar...

journal_title：Circulation

authors： Skovránek J,Tůma S,Urbancová D,Samánek M

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:The endocrine-disrupting chemical bisphenol A (BPA) is widely used in food and beverage packaging. Higher urinary BPA concentrations were cross-sectionally associated with heart disease in National Health and Nutrition Examination Survey (NHANES) 2003-2004 and NHANES 2005-2006, independent of traditional ris...

journal_title：Circulation

authors： Melzer D,Osborne NJ,Henley WE,Cipelli R,Young A,Money C,McCormack P,Luben R,Khaw KT,Wareham NJ,Galloway TS

更新日期：2012-03-27 00:00:00

abstract：BACKGROUND:Prior small to modest-sized studies suggest a benefit of intravascular ultrasound (IVUS) guidance in noncomplex lesions. Whether IVUS guidance is associated with improved clinical outcomes after drug-eluting stent (DES) implantation in an unrestricted patient population is unknown. METHODS AND RESULTS:Asses...

journal_title：Circulation

authors： Witzenbichler B,Maehara A,Weisz G,Neumann FJ,Rinaldi MJ,Metzger DC,Henry TD,Cox DA,Duffy PL,Brodie BR,Stuckey TD,Mazzaferri EL Jr,Xu K,Parise H,Mehran R,Mintz GS,Stone GW

更新日期：2014-01-28 00:00:00

abstract：BACKGROUND:The aim of this study was to compare the risk conferred by white-coat versus sustained mild hypertension for the development of cardiovascular disease. METHODS AND RESULTS:Patients (n=479) who underwent 24-hour intra-arterial ambulatory blood pressure monitoring on the basis of a persistently elevated clini...

journal_title：Circulation

authors： Khattar RS,Senior R,Lahiri A

更新日期：1998-11-03 00:00:00

abstract：BACKGROUND:The cyclin-dependent kinase inhibitors (CKIs) have different patterns of expression in vascular diseases. The Kip/Cip CKIs, p27(Kip1) and p21(Cip1), are upregulated during arterial repair and negatively regulate the growth of vascular smooth muscle cells (VSMCs). In contrast, the Ink CKI, p16(Ink4), is not e...

journal_title：Circulation

authors： Tanner FC,Boehm M,Akyürek LM,San H,Yang ZY,Tashiro J,Nabel GJ,Nabel EG

更新日期：2000-05-02 00:00:00

abstract：BACKGROUND:The results of angiographic studies have suggested that calcium channel-blocking agents may prevent new coronary lesion formation, the progression of minimal lesions, or both. METHODS AND RESULTS:The Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT) was a multicenter, rand...

journal_title：Circulation

authors： Pitt B,Byington RP,Furberg CD,Hunninghake DB,Mancini GB,Miller ME,Riley W

更新日期：2000-09-26 00:00:00

abstract：BACKGROUND:Radiofrequency catheter ablation of concealed posteroseptal accessory pathways (APS) has been a relatively difficult task for electrophysiologists. Without a detailed mapping procedure, the left versus the right posteroseptal AP could not be distinguished. We investigated the electrophysiological characteris...

journal_title：Circulation

authors： Chiang CE,Chen SA,Tai CT,Wu TJ,Lee SH,Cheng CC,Chiou CW,Ueng KC,Wen ZC,Chang MS

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by right ventricular dysfunction and ventricular arrhythmias. A recent study reported mutations in PKP2, encoding the desmosomal protein plakophilin-2, associated with ARVD/C. The purpose of our st...

journal_title：Circulation

authors： Dalal D,Molin LH,Piccini J,Tichnell C,James C,Bomma C,Prakasa K,Towbin JA,Marcus FI,Spevak PJ,Bluemke DA,Abraham T,Russell SD,Calkins H,Judge DP

更新日期：2006-04-04 00:00:00

abstract：BACKGROUND:Exercise echocardiography (digital cine-loop technique) and 201Tl single-photon emission computed tomography (SPECT) were performed simultaneously in 292 patients being evaluated for coronary artery disease. METHODS AND RESULTS:Pretreadmill and posttreadmill echocardiographic images of diagnostic quality we...

journal_title：Circulation

authors： Quiñones MA,Verani MS,Haichin RM,Mahmarian JJ,Suarez J,Zoghbi WA

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:The relationships between childhood lifestyle risk factors and adulthood pulse wave velocity (PWV) have not been reported. We studied whether childhood and adulthood lifestyle risk factors are associated with PWV assessed in adulthood. METHODS AND RESULTS:The study cohort comprised 1622 subjects of the Card...

journal_title：Circulation

authors： Aatola H,Koivistoinen T,Hutri-Kähönen N,Juonala M,Mikkilä V,Lehtimäki T,Viikari JS,Raitakari OT,Kähönen M

更新日期：2010-12-14 00:00:00

abstract：:The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...

journal_title：Circulation

authors： Keren G,Sonnenblick EH,LeJemtel TH

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Direct thrombin inhibitors are a new class of drugs that may offer a more effective and potentially simpler alternative to heparin. Hirulog is a synthetic peptide based on the leech-derived compound hirudin and, like hirudin, is a highly specific, direct inhibitor of free and clot-bound thrombin. METHODS AN...

journal_title：Circulation

authors： Fuchs J,Cannon CP

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Electrophysiological mechanisms by which adenosine may activate cardiac afferent neurons are unknown. Slow afterhyperpolarizations (AHPs) follow action potentials in a subset of vagal C afferents, rendering them inexcitable. The purpose of this study was to test the hypothesis that adenosine increases vagal ...

journal_title：Circulation

authors： Middlekauff HR,Doering A,Weiss JN

更新日期：2001-03-06 00:00:00

abstract：:Although ST-segment abnormalities during acute myocardial infarction are clinically important, the total thoracic distribution of these repolarization potentials has not been reported. To provide this information, 24 patients with acute myocardial infarction were studied. Isopotential body surface maps were constructe...

journal_title：Circulation

authors： Mirvis DM

更新日期：1980-10-01 00:00:00

abstract：:Real-time cross-sectional echocardiographic studies of the main coronary arteries were performed in 20 normal subjects, 12 patients with patent ductus arteriosus and 14 patients with coronary artery fistula in whom the diagnosis was established by angiography. In 12 patients, the coronary artery that formed the fistul...

journal_title：Circulation

authors： Yoshikawa J,Katao H,Yanagihara K,Takagi Y,Okumachi F,Yoshida K,Tomita Y,Fukaya T,Baba K

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:The incidence of pulmonary arterial hypertension secondary to the use of indirect serotinergic agonists such as aminorex and dexfenfluramine led to the "serotonin hypothesis" of pulmonary arterial hypertension; however, the role of serotonin in dexfenfluramine-induced pulmonary arterial hypertension remains ...

journal_title：Circulation

authors： Dempsie Y,Morecroft I,Welsh DJ,MacRitchie NA,Herold N,Loughlin L,Nilsen M,Peacock AJ,Harmar A,Bader M,MacLean MR

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:Recent advances in surgical techniques for the repair of left ventricular aneurysms (LVAs) include the use of an endoventricular patch to exclude the aneurysm cavity. This technique has replaced conventional linear plication of the aneurysm. The endoventricular patch technique remodels the left ventricular c...

journal_title：Circulation

authors： Grossi EA,Chinitz LA,Galloway AC,Delianides J,Schwartz DS,McLoughlin DE,Keller N,Kronzon I,Spencer FC,Colvin SB

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Although acute rheumatic fever (ARF) and its sequel, rheumatic heart disease (RHD), continue to cause a large burden of morbidity and mortality in disadvantaged populations, most studies investigating the effectiveness of control programs date from the 1950s. A control program, including a disease register, ...

journal_title：Circulation

authors： Lawrence JG,Carapetis JR,Griffiths K,Edwards K,Condon JR

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Myocardial ischemia is considered to be a possible stimulus for development of the coronary collateral circulation. We therefore hypothesized that chronic reduction of myocardial oxygen demand to lessen ischemia would attenuate coronary collateral development over an 8-week period using left circumflex coron...

journal_title：Circulation

authors： Symons JD,Pitsillides KF,Longhurst JC

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content i...

journal_title：Circulation

authors： Lindeman JH,Abdul-Hussien H,van Bockel JH,Wolterbeek R,Kleemann R

更新日期：2009-04-28 00:00:00