Differential effects of the cyclin-dependent kinase inhibitors p27(Kip1), p21(Cip1), and p16(Ink4) on vascular smooth muscle cell proliferation.

abstract：BACKGROUND:Degeneration of xenografts or homografts is a major cause for reoperation in young patients after pulmonary valve replacement. We present the early results of fresh decellularized pulmonary homografts (DPH) implantation compared with glutaraldehyde-fixed bovine jugular vein (BJV) and cryopreserved homografts...

journal_title：Circulation

authors： Cebotari S,Tudorache I,Ciubotaru A,Boethig D,Sarikouch S,Goerler A,Lichtenberg A,Cheptanaru E,Barnaciuc S,Cazacu A,Maliga O,Repin O,Maniuc L,Breymann T,Haverich A

更新日期：2011-09-13 00:00:00

abstract：BACKGROUND:The aim of this prospective, randomized study was to examine whether additional school exercise lessons would result in improved peak oxygen uptake (primary end point) and body mass index-standard deviation score, motor and coordinative abilities, circulating progenitor cells, and high-density lipoprotein ch...

journal_title：Circulation

authors： Walther C,Gaede L,Adams V,Gelbrich G,Leichtle A,Erbs S,Sonnabend M,Fikenzer K,Körner A,Kiess W,Bruegel M,Thiery J,Schuler G

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The evolution of cell phenotypes and matrix architecture in cardiac valves during fetal maturation and postnatal adaptation through senescence remains unexplored. METHODS AND RESULTS:We hypothesized that valvular interstitial (VIC) and endothelial cell (VEC) phenotypes, critical for maintaining valve functi...

journal_title：Circulation

authors： Aikawa E,Whittaker P,Farber M,Mendelson K,Padera RF,Aikawa M,Schoen FJ

更新日期：2006-03-14 00:00:00

abstract：:The ability to quantify the quality of cardiovascular care critically depends on the translation of recommendations for high-quality care into the measurement of that care. As payers and regulatory agencies increasingly seek to quantify healthcare quality, the implications of the measurement process on practicing phys...

journal_title：Circulation

authors： Spertus JA,Eagle KA,Krumholz HM,Mitchell KR,Normand SL,American College of Cardiology.,American Heart Association Task Force on Performance Measures.

更新日期：2005-04-05 00:00:00

abstract：BACKGROUND:Development of left ventricular hypertrophy in aortic stenosis (AS) is accompanied by coronary microcirculatory dysfunction, demonstrated by an impaired coronary vasodilator reserve (CVR). However, evidence for regional abnormalities in myocardial blood flow (MBF) and the potential mechanisms is limited. The...

journal_title：Circulation

authors： Rajappan K,Rimoldi OE,Dutka DP,Ariff B,Pennell DJ,Sheridan DJ,Camici PG

更新日期：2002-01-29 00:00:00

abstract：:We studied the inferior vena cava (IVC) as an index of right-heart function in 111 patients. A two-dimensional echocardiographic sector was used to visualize the IVC, and its M-mode cursor was used to generate a time-motion record of the IVC size and pulsation. Normal subjects had a small presystolic A wave (less than...

journal_title：Circulation

authors： Mintz GS,Kotler MN,Parry WR,Iskandrian AS,Kane SA

更新日期：1981-11-01 00:00:00

abstract：:To assess myocardial infarction quantitatively in 15 mm thick transverse sections of the canine heart in vivo we utilized a new technique, positron emission transaxial tomography (PETT) and cyclotron-produced 11C-palmitate (11C-P) injected intravenously. Results were compared to regional myocardial creatine phosphokin...

journal_title：Circulation

authors： Weiss ES,Ahmed SA,Welch MJ,Williamson JR,Ter-Pogossian MM,Sobel BE

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Ischemic mitral regurgitation (MR) was first ascribed to papillary muscle (PM) contractile dysfunction. Current theories include apical leaflet tethering caused by left ventricular (LV) distortion, but PM dysfunction is still postulated and commonly diagnosed. PM contraction, however, parallels apical tether...

journal_title：Circulation

authors： Messas E,Guerrero JL,Handschumacher MD,Chow CM,Sullivan S,Schwammenthal E,Levine RA

更新日期：2001-10-16 00:00:00

abstract：:We have previously shown that a brief episode of ischemia slows the rate of ATP depletion during subsequent ischemic episodes. Additionally, intermittent reperfusion may be beneficial to the myocardium by washing out catabolites that have accumulated during ischemia. Thus, we proposed that multiple brief ischemic epis...

journal_title：Circulation

authors： Murry CE,Jennings RB,Reimer KA

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Flavone-8-acetic acid (FAA; [Flavonoid]), an adjuvant antitumor drug, inhibits ristocetin-induced aggregation of human platelets. The effect of FAA on platelet-dependent thrombosis was studied in vivo in the porcine carotid artery after deep arterial injury by balloon angioplasty. METHODS AND RESULTS:(111)I...

journal_title：Circulation

authors： Mruk JS,Webster MW,Heras M,Reid JM,Grill DE,Chesebro JH

更新日期：2000-01-25 00:00:00

abstract：BACKGROUND:Single-site ventricular pacing in patients with heart failure, atrial fibrillation, and severe atrioventricular (AV) nodal block risks the generation of discoordinate contraction. Whether altering the site of stimulation can offset this detrimental effect and what role sequential right ventricular-left ventr...

journal_title：Circulation

authors： Hay I,Melenovsky V,Fetics BJ,Judge DP,Kramer A,Spinelli J,Reister C,Kass DA,Berger RD

更新日期：2004-11-30 00:00:00

abstract：:The patterns of aortic and tricuspid valve motion in 50 patients with mitral valve prolapse were analyzed by wide-angle, phased-array, two-dimensional echocardiography. Twelve patients (24%) had redundant aortic leaflets bulging into the left ventricular outflow tract during diastole. Eight of 12 patients had aortic r...

journal_title：Circulation

authors： Ogawa S,Hayashi J,Sasaki H,Tani M,Akaishi M,Mitamura H,Sano M,Hoshino T,Handa S,Nakamura Y

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Abnormal coronary endothelial reactivity has been demonstrated in diabetes and is associated with an increased rate of cardiovascular events. Our objectives were to investigate the presence of functional coronary circulatory abnormalities over the full spectrum of insulin resistance and to determine whether ...

journal_title：Circulation

authors： Prior JO,Quiñones MJ,Hernandez-Pampaloni M,Facta AD,Schindler TH,Sayre JW,Hsueh WA,Schelbert HR

更新日期：2005-05-10 00:00:00

abstract：BACKGROUND:Together with pulmonary veins, many extrapulmonary vein areas may be the source of initiation and maintenance of atrial fibrillation. The left atrial appendage (LAA) is an underestimated site of initiation of atrial fibrillation. Here, we report the prevalence of triggers from the LAA and the best strategy f...

journal_title：Circulation

authors： Di Biase L,Burkhardt JD,Mohanty P,Sanchez J,Mohanty S,Horton R,Gallinghouse GJ,Bailey SM,Zagrodzky JD,Santangeli P,Hao S,Hongo R,Beheiry S,Themistoclakis S,Bonso A,Rossillo A,Corrado A,Raviele A,Al-Ahmad A,Wang P,

更新日期：2010-07-13 00:00:00

abstract：:Of 1,801 patients in the 1985-1986 Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry, 122 (6.8%) had periprocedural occlusion (4.9% in the catheterization laboratory, 1.9% outside the laboratory). Baseline patient factors independently associated with increased occlusion rates included triple-vessel disea...

journal_title：Circulation

authors： Detre KM,Holmes DR Jr,Holubkov R,Cowley MJ,Bourassa MG,Faxon DP,Dorros GR,Bentivoglio LG,Kent KM,Myler RK

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. METHODS AND RESULTS:Administration of doxorubicin...

journal_title：Circulation

authors： De Angelis A,Piegari E,Cappetta D,Marino L,Filippelli A,Berrino L,Ferreira-Martins J,Zheng H,Hosoda T,Rota M,Urbanek K,Kajstura J,Leri A,Rossi F,Anversa P

更新日期：2010-01-19 00:00:00

abstract：:Two-dimensional suprasternal notch echocardiography was performed in 1033 patients, ages 1 day to 18 years. For the long-axis suprasternal notch view, the transducer was positioned in the suprasternal notch and angled to obtain a plane passing between the right nipple and left scapular tip. In this view, the entire ao...

journal_title：Circulation

authors： Snider AR,Silverman NH

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:We developed autologous prosthetic implants by simple and safe in-body tissue architecture technology. We present the first report on the development of autologous valved conduit with the sinus of Valsalva (BIOVALVE) by using this unique technology and its subsequent implantation in the pulmonary valves in a...

journal_title：Circulation

authors： Yamanami M,Yahata Y,Uechi M,Fujiwara M,Ishibashi-Ueda H,Kanda K,Watanabe T,Tajikawa T,Ohba K,Yaku H,Nakayama Y

更新日期：2010-09-14 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) mortality is rising in many developing countries. We examined how much of the increase in CHD mortality in Beijing, China, between 1984 and 1999 could be attributed to changes in major cardiovascular risk factors and assessed the impact of medical and surgical treatments. METHOD...

journal_title：Circulation

authors： Critchley J,Liu J,Zhao D,Wei W,Capewell S

更新日期：2004-09-07 00:00:00

abstract：BACKGROUND:Re-stenting of in-stent restenosis (ISR) improves acute angiographic results. Methods and Results- Volumetric intravascular ultrasound analysis was performed in 70 ISR lesions that received either placebo (n=36) or (192)Ir radiation (n=34). ISR lesions treated by re-stenting were divided into 3 groups: old s...

journal_title：Circulation

authors： Morino Y,Limpijankit T,Honda Y,Lansky AJ,Waksman R,Bonneau HN,Yock PG,Mintz GS,Fitzgerald PJ

更新日期：2002-05-28 00:00:00

abstract：BACKGROUND:Coronary blood flow occurs mainly during the diastolic phase of each cardiac cycle and is mainly dependent on diastolic driving pressure, especially in the left anterior descending coronary artery (LAD). We hypothesized that calculation of the ratio of the diastolic driving pressure of a stenotic LAD to its ...

journal_title：Circulation

authors： Abe M,Tomiyama H,Yoshida H,Doba N

更新日期：2000-11-07 00:00:00

abstract：:The elevated blood pressure and vascular resistance in patients with systemic hypertension are paralleled by a proportional rise in pressure and resistance in the lesser circulation. We evaluated the hypothesis that the increased systemic reaction to adrenergic stimulation is shared by the pulmonary vessels. For this ...

journal_title：Circulation

authors： Guazzi MD,De Cesare N,Fiorentini C,Galli C,Moruzzi P,Tamborini G

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Among patients with documented stable coronary artery disease and in whom no revascularization was performed, we compared the respective values of angiographic diameter stenosis (DS) and fractional flow reserve (FFR) in predicting natural history. METHODS:The present analysis included the 607 patients from ...

journal_title：Circulation

authors： Ciccarelli G,Barbato E,Toth GG,Gahl B,Xaplanteris P,Fournier S,Milkas A,Bartunek J,Vanderheyden M,Pijls N,Tonino P,Fearon WF,Jüni P,De Bruyne B

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Clinical manifestations of acute myocarditis, with distinct onset, vary from asymptomatic to fatal. The predictors of the course of the disease in patients with acute myocarditis at initial presentation have not yet been established. In this study, we examined the predictive values of various parameters in t...

journal_title：Circulation

authors： Fuse K,Kodama M,Okura Y,Ito M,Hirono S,Kato K,Hanawa H,Aizawa Y

更新日期：2000-12-05 00:00:00

abstract：BACKGROUND:To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility. METHODS AND RESULTS:The comparison was based on the first echocardiographic recording obtained on 735 children of HIV-infected mothers at 10 clinical sites focusing on...

journal_title：Circulation

authors： Lipshultz SE,Easley KA,Orav EJ,Kaplan S,Starc TJ,Bricker JT,Lai WW,Moodie DS,Sopko G,Schluchter MD,Colan SD

更新日期：2001-07-17 00:00:00

abstract：BACKGROUND:Because complement-mediated vascular injury participates in atherosclerosis and C-reactive protein (CRP) can activate the complement cascade, we sought to determine whether CRP affects the expression of the protective complement-inhibitory factors on the cell surface of endothelial cells (ECs). METHODS AND ...

journal_title：Circulation

authors： Li SH,Szmitko PE,Weisel RD,Wang CH,Fedak PW,Li RK,Mickle DA,Verma S

更新日期：2004-02-24 00:00:00

abstract：BACKGROUND:Insulin sensitivity and cardiovascular risk profile were examined in 20 healthy, nonobese, middle-aged men who were long-term users of nicotine-containing chewing gum and in 20 matched control subjects who did not use nicotine. METHODS AND RESULTS:Long-term use of nicotine-containing chewing gum was associa...

journal_title：Circulation

authors： Eliasson B,Taskinen MR,Smith U

更新日期：1996-09-01 00:00:00

abstract：:Patients with heart failure frequently exhibit abnormal skeletal muscle metabolic responses to exercise, as assessed with 31P NMR. To investigate whether these metabolic abnormalities are due to intrinsic skeletal muscle changes, we performed gastrocnemius muscle biopsies on 22 patients with heart failure (peak VO2, 1...

journal_title：Circulation

authors： Mancini DM,Coyle E,Coggan A,Beltz J,Ferraro N,Montain S,Wilson JR

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:We have previously demonstrated vasculoprotective effects after repeated intravenous administration of recombinant apolipoprotein A-IMilano (apoA-Im)/phospholipid complex. In this study, we sought to determine the effects of local recombinant apoA-Im/1-palmitoyl,2-oleoyl phosphatidylcholine complex (ETC-216)...

journal_title：Circulation

authors： Kaul S,Rukshin V,Santos R,Azarbal B,Bisgaier CL,Johansson J,Tsang VT,Chyu KY,Cercek B,Mirocha J,Shah PK

更新日期：2003-05-27 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) is considered when respiratory failure (RF) persists despite increasing conventional mechanical ventilation (CMV). High-frequency jet ventilation (HFJV) can improve ventilation with comparable mean airway pressure (PAW) to that found on CMV. This study was undertake...

journal_title：Circulation

authors： Kocis KC,Meliones JN,Dekeon MK,Callow LB,Lupinetti FM,Bove EL

更新日期：1992-11-01 00:00:00