Abstract:
BACKGROUND:Although previous studies have shown functional improvements in patients who undergo coronary artery bypass graft (CABG) surgery, data are conflicting on whether the gains achieved by women are similar to or less than those achieved by men. METHODS AND RESULTS:We compared physical and psychological functional gains and readmission rates between 777 men and 295 women who underwent first CABG consecutively between February 1999 and February 2001. Physical function and mental health were measured by means of the Short Form 36-Item Health Survey (SF-36). At 6 months, both men and women showed, on average, a significant improvement in physical function and mental health, but men improved significantly more than women. After adjustment for baseline characteristics, the mean score improvement in women was half that of men for physical function (7.3 versus 14.0, P=0.0002) and 25% less than that of men for mental health (-3.0 versus 8.9, P=0.026). The absolute rates of adverse outcomes, such as hospital readmission, worsening functional status, and worsening mental health, were significantly higher in women (32.6%, 25.7%, and 17.5%, respectively) than in men (21.2%, 11.1%, and 12.6%, respectively) and remained significantly different in multivariable analysis. CONCLUSIONS:CABG surgery is associated with lower functional gains and higher readmission rates in women compared with men 6 months after operation.
journal_name
Circulationjournal_title
Circulationauthors
Vaccarino V,Lin ZQ,Kasl SV,Mattera JA,Roumanis SA,Abramson JL,Krumholz HMdoi
10.1161/01.CIR.0000097117.28614.D8subject
Has Abstractpub_date
2003-11-25 00:00:00pages
2642-7issue
21eissn
0009-7322issn
1524-4539pii
01.CIR.0000097117.28614.D8journal_volume
108pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:The main goal of the initial treatment of ST-segment elevation myocardial infarction is prompt reperfusion of the infarct-related artery. The value of pretreatment with clopidogrel before primary percutaneous coronary intervention is currently unclear. METHODS AND RESULTS:Studies were retrieved through MEDL...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.107.749531
更新日期:2008-10-28 00:00:00
abstract:BACKGROUND:Precise knowledge of the expected "normal" lumen diameter at a given coronary anatomic location is a first step toward developing a quantitative estimate of coronary disease severity that could be more useful than the traditional "percent stenosis." METHODS AND RESULTS:Eighty-three arteriograms were careful...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.1.232
更新日期:1992-07-01 00:00:00
abstract::Although thrombolytic therapy has been a major advance in the treatment of acute myocardial infarction, in at least 25% of patients the artery remains occluded after administration. In these patients, the strategy of "rescue" or "salvage" angioplasty is frequently used although follow-up data are limited. Sixty-three ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-03-01 00:00:00
abstract::Sustained-release diltiazem (D-SR) and sustained-release verapamil (V-SR) when given twice a day have been successfully used to treat both essential hypertension and angina pectoris. Review of available studies indicates that 120 to 180 mg D-SR twice a day and 240 mg V-SR once or twice a day can lower diastolic pressu...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:Prospective data relating previous exposure to cytomegalovirus (CMV) to the risk of cardiac mortality are controversial. We investigated the effect of previous exposure to CMV infection on the risk of future cardiac disease-related death in relation to an underlying inflammatory response. METHODS AND RESULT...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.103.24.2915
更新日期:2001-06-19 00:00:00
abstract:BACKGROUND:Congestive heart failure (CHF) is characterized by enhanced immune activation, and immune-mediated mechanisms may play a pathogenic role in this disorder. Based on the immunomodulatory effects of intravenous immunoglobulin (IVIG), we hypothesized that IVIG could downregulate inflammatory responses in CHF pat...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.103.2.220
更新日期:2001-01-16 00:00:00
abstract::In seven patients who underwent Fontan procedures but in whom no valves were inserted, dynamics of right heart flow were evaluated with the use of a catheter-tipped velocity transducer, pulsed Doppler echocardiography, and angiocardiography. Right atrial (RA) contraction caused a forward flow to the pulmonary artery (...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.69.2.306
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. METHODS AND RESULTS:The study used the explanted hearts of five human cardiac transplant recipients. Three right and t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.9.3013
更新日期:1997-11-04 00:00:00
abstract::A technique is described to control recurrent or sustained supraventricular tachycardia associated with rapid ventricular rates following open heart surgery. The technique utilizes a pair of temporarily implanted atrial epicardial wire electrodes to pace the heart. In one group of patients with recurrent atrial flutte...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.54.2.245
更新日期:1976-08-01 00:00:00
abstract::We studied regional myocardial perfusion by scintigraphic computer-assisted analysis of initial distribution, washout rates, and residual activity of 133Xe injected into the left coronary artery of four patients with normal arteriograms and 14 patients with coronary stenosis. At rest, residual activity in poststenotic...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.3.423
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:Inflammation and thrombosis coexist in several disorders. Although it is recognized that leukocytes may induce a procoagulant state at sites of inflammation, the critical molecular determinants of this process remain largely unknown. METHODS AND RESULTS:To examine mechanisms of inflammation-induced thrombos...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.873695
更新日期:2009-09-29 00:00:00
abstract::A mathematical model to measure infarct size from serial estimates of CPK has been developed by Shell et al. Norris et al. have recently introduced a modification of this method by calculating an individualized disappearance rate parameter (Kd) from the uniformly monoexponential portion of the CPK vs time curve. This ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.4.545
更新日期:1977-10-01 00:00:00
abstract::In 69 patients undergoing coronary artery bypass grafting for complete coronary revascularization, blood flow was measured in 140 grafts with 243 distal anastomoses (3.52 bypasses/patient). Total blood flow in single grafts and double and triple sequential grafts did not differ significantly, although mean distal flow...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.60.2.33
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:It has been proposed that bone marrow-derived cells infiltrate the neointima, where they differentiate into smooth muscle (SM) cells; however, technical limitations have hindered clear identification of the lineages of bone marrow-derived "SM cell-like" cells. METHODS AND RESULTS:Using a specific antibody a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.965202
更新日期:2010-11-16 00:00:00
abstract:BACKGROUND:In a correlative functional/histopathologic study, we investigated the regional deformation characteristics of both chronic nontransmural and transmural infarctions before and after a dobutamine challenge. METHODS AND RESULTS:After stenosing copper-coated stent implantation to produce circumflex artery endo...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000050146.66577.4b
更新日期:2003-02-18 00:00:00
abstract:BACKGROUND:Induction of matrix metalloproteinases (MMPs) contributes to adverse remodeling after myocardial infarction (MI). Whether a region- and type-specific distribution of MMPs occurs within the post-MI myocardium remained unknown. METHODS AND RESULTS:Ten sheep were instrumented with a sonomicrometry array to mea...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000068375.40887.FA
更新日期:2003-06-10 00:00:00
abstract::Recent reports of selected observational studies and a meta-analysis have stirred controversy and have become the impetus for calls to abandon recommendations for reduced sodium intake by the US general population. A detailed review of these studies documents substantial methodological concerns that limit the usefulne...
journal_title:Circulation
pub_type: 共识发展会议,杂志文章
doi:10.1161/CIR.0b013e318279acbf
更新日期:2012-12-11 00:00:00
abstract::The endogenous opioid system includes three major families of peptides: dynorphins (derived from pre-proenkephalin B), endorphins (derived from pre-proopiomelanocortin), and enkephalins (derived from pre-proenkephalin A). Multiple species of opioid peptides are derived from these major precursors and many of them poss...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:One of the features of high-risk atherosclerotic plaques is a preponderance of macrophages. Experimental studies with hyperlipidemic rabbits have shown that ultrasmall superparamagnetic particles of iron oxide (USPIOs) accumulate in plaques with a high macrophage content and that this induces magnetic resona...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000068315.98705.CC
更新日期:2003-05-20 00:00:00
abstract:BACKGROUND:Resistin, a plasma protein, induces insulin resistance in rodents. Recent reports suggest that circulating levels of resistin are elevated in obese and insulin-resistant rodents and humans. Whereas rodent resistin is made in adipocytes, macrophages are a major source of human resistin. Given the convergence ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000155620.10387.43
更新日期:2005-02-22 00:00:00
abstract:BACKGROUND:Chronic orthostatic intolerance (COI) is a debilitating autonomic condition in young adults. Its neurohumoral and hemodynamic profiles suggest possible alterations of postural sympathetic function and of baroreflex control of heart rate (HR). METHODS AND RESULTS:In 16 COI patients and 16 healthy volunteers,...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.20.2154
更新日期:1998-11-17 00:00:00
abstract::To assess myocardial infarction quantitatively in 15 mm thick transverse sections of the canine heart in vivo we utilized a new technique, positron emission transaxial tomography (PETT) and cyclotron-produced 11C-palmitate (11C-P) injected intravenously. Results were compared to regional myocardial creatine phosphokin...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.1.66
更新日期:1977-01-01 00:00:00
abstract::To evaluate the potential advantages of thallium-201 (201T1) single-photon emission computerized tomography (SPECT) to assess myocardial infarct size in the experimental animal, six normal dogs and 14 dogs with 6 to 8 hr closed-chest coronary occlusion (eight left anterior descending and six left circumflex) were stud...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.74.4.852
更新日期:1986-10-01 00:00:00
abstract:BACKGROUND:Molecular targeted chemotherapies have been shown to significantly improve the outcomes of patients who have cancer, but they often cause cardiovascular side effects that limit their use and impair patients' quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a dist...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.118.037357
更新日期:2019-05-21 00:00:00
abstract:BACKGROUND:Ultrasonic angioplasty was recently shown to ablate thrombi and atherosclerotic plaques in vitro and to recanalize occluded arteries in experimental animal models. The goal of the present study was to examine the clinical feasibility of ultrasonic angioplasty. METHODS AND RESULTS:Intraoperative ultrasonic a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.6.1976
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Insulin modulates sympathetic vasoconstriction, but the mechanisms underlying this effect are not completely elucidated. We have recently investigated the insulin effect on the alpha 1- and alpha 2-adrenergic vasoconstriction pathway, where it is still conflicting with the possible insulin influence on the b...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.7.1403
更新日期:1996-04-01 00:00:00
abstract:BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.035956
更新日期:2011-10-18 00:00:00
abstract::We performed transventricular pulmonary valvotomy as initial surgery in 22 consecutive patients with pulmonary atresia and intact ventricular septum who had a patent infundibulum. Nineteen patients also had placement of a central aortopulmonary shunt. All patients survived surgery, and 16 patients have had preoperativ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Myocardial perfusion during adenosine-induced hyperemia is used both in clinical diagnosis of coronary heart disease and for scientific investigations of the myocardial microcirculation. The objective of this study was to clarify whether adenosine-induced hyperemia is dependent on endothelial NO production o...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/hc4401.098293
更新日期:2001-11-06 00:00:00
abstract:BACKGROUND:We compared the efficacy and safety of different dosages of a low-molecular-weight heparin, CY 216 D (Fraxiparine), in the treatment of submassive pulmonary embolism with unfractionated heparin in a prospective, randomized, dose-finding study. METHODS AND RESULTS:The primary outcome was the evolution of pul...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.85.4.1380
更新日期:1992-04-01 00:00:00