Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus.

abstract：BACKGROUND:CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogen...

journal_title：Circulation

authors： Jansson AM,Aukrust P,Ueland T,Smith C,Omland T,Hartford M,Caidahl K

更新日期：2009-06-30 00:00:00

abstract：BACKGROUND:Vasodilator drugs have variable effects on veins and arteries. However, direct measurements of their effects on the splanchnic veins, perhaps the most important volume reservoir, have not been reported. We assessed the effect of acute heart failure and the subsequent administration of hydralazine, enalaprila...

journal_title：Circulation

authors： Wang SY,Manyari DE,Scott-Douglas N,Smiseth OA,Smith ER,Tyberg JV

更新日期：1995-02-15 00:00:00

abstract：:Neuroendocrine activation is known to occur in patients with congestive heart failure, but there is uncertainty as to whether this occurs before or after the presence of overt symptoms. In the Studies of Left Ventricular Dysfunction (SOLVD), a multicenter study of patients with ejection fractions of 35% or less, we co...

journal_title：Circulation

authors： Francis GS,Benedict C,Johnstone DE,Kirlin PC,Nicklas J,Liang CS,Kubo SH,Rudin-Toretsky E,Yusuf S

更新日期：1990-11-01 00:00:00

abstract：:A series of 252 isolated aortic homograft valves in 248 patients have been followed for 9 to 16.5 years (mean 10.8). The valves were sterilized in antibiotic solution and stored in a nutrient medium at 4 degrees C and were nonvital. There were 15 in-hospital deaths (6%) and a mortality of 2.7% in patients undergoing a...

journal_title：Circulation

authors： Barratt-Boyes BG,Roche AH,Subramanyan R,Pemberton JR,Whitlock RM

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Coronary sinus access by electrode catheters is easier in patients with atrioventricular junctional reentry tachycardia (AVJRT) than in patients with other supraventricular tachyarrhythmias. The reason for this has not been addressed. METHODS AND RESULTS:The size and shape of the proximal coronary sinus wer...

journal_title：Circulation

authors： Doig JC,Saito J,Harris L,Downar E

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Iron deficiency is common in patients with heart failure (HF) and is associated with reduced exercise capacity and poor outcomes. Whether correction of iron deficiency with (intravenous) ferric carboxymaltose (FCM) affects peak oxygen consumption [peak VO2], an objective measure of exercise intolerance in HF...

journal_title：Circulation

authors： van Veldhuisen DJ,Ponikowski P,van der Meer P,Metra M,Böhm M,Doletsky A,Voors AA,Macdougall IC,Anker SD,Roubert B,Zakin L,Cohen-Solal A,EFFECT-HF Investigators.

更新日期：2017-10-10 00:00:00

abstract：BACKGROUND:The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle a...

journal_title：Circulation

authors： Ranchoux B,Antigny F,Rucker-Martin C,Hautefort A,Péchoux C,Bogaard HJ,Dorfmüller P,Remy S,Lecerf F,Planté S,Chat S,Fadel E,Houssaini A,Anegon I,Adnot S,Simonneau G,Humbert M,Cohen-Kaminsky S,Perros F

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND AND PURPOSE:The guidelines presented in this consensus statement are intended to serve researchers, clinicians, reviewers, and regulators in the selection of the most appropriate primary outcome for a clinical trial of cardiac arrest therapies. The American Heart Association guidelines for the treatment of c...

journal_title：Circulation

authors： Becker LB,Aufderheide TP,Geocadin RG,Callaway CW,Lazar RM,Donnino MW,Nadkarni VM,Abella BS,Adrie C,Berg RA,Merchant RM,O'Connor RE,Meltzer DO,Holm MB,Longstreth WT,Halperin HR,American Heart Association Emergency Cardiova

更新日期：2011-11-08 00:00:00

abstract：BACKGROUND:Administration of protease inhibitors (PIs) to HIV-infected individuals has been associated with hyperlipidemia. In this study, we characterized the lipoprotein profile in subjects receiving ritonavir, indinavir, or nelfinavir, alone or in combination with saquinavir. METHODS AND RESULTS:Plasma lipoprotein ...

journal_title：Circulation

authors： Périard D,Telenti A,Sudre P,Cheseaux JJ,Halfon P,Reymond MJ,Marcovina SM,Glauser MP,Nicod P,Darioli R,Mooser V

更新日期：1999-08-17 00:00:00

abstract：BACKGROUND:PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thrombin receptors noted in black subjects compared with white subjects. Litt...

journal_title：Circulation

authors： Mao G,Songdej N,Voora D,Goldfinger LE,Del Carpio-Cano FE,Myers RA,Rao AK

更新日期：2017-09-05 00:00:00

abstract：BACKGROUND:During the development of heart failure (HF), the chief myocardial energy substrate switches from fatty acids to glucose. This metabolic switch, which recapitulates fetal cardiac energy substrate preferences, is thought to maintain aerobic energetic balance. The regulatory mechanisms involved in this metabol...

journal_title：Circulation

authors： Sack MN,Rader TA,Park S,Bastin J,McCune SA,Kelly DP

更新日期：1996-12-01 00:00:00

abstract：:We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...

journal_title：Circulation

authors： Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Although the dominant product of vascular Cyclooxygenase-2 (COX-2), prostacyclin (PGI(2)), restrains atherogenesis, inhibition and deletion of COX-2 have yielded conflicting results in mouse models of atherosclerosis. Floxed mice were used to parse distinct cellular contributions of COX-2 in macrophages and ...

journal_title：Circulation

authors： Hui Y,Ricciotti E,Crichton I,Yu Z,Wang D,Stubbe J,Wang M,Puré E,FitzGerald GA

更新日期：2010-06-22 00:00:00

abstract：BACKGROUND:Mutations in sarcomere protein, PRKAG2, LAMP2, alpha-galactosidase A (GLA), and several mitochondrial genes can cause rare familial cardiomyopathies, but their contribution to increased left ventricular wall thickness (LVWT) in the community is unknown. METHODS AND RESULTS:We studied 1862 unrelated particip...

journal_title：Circulation

authors： Morita H,Larson MG,Barr SC,Vasan RS,O'Donnell CJ,Hirschhorn JN,Levy D,Corey D,Seidman CE,Seidman JG,Benjamin EJ

更新日期：2006-06-13 00:00:00

abstract：BACKGROUND:Cardiopulmonary resuscitation (CPR) is initiated in hospitalized children with bradycardia and poor perfusion. However, their rate of progression to pulseless cardiac arrest despite CPR and the differences in survival compared with initially pulseless arrest are unknown. We examined the prevalence and predic...

journal_title：Circulation

authors： Khera R,Tang Y,Girotra S,Nadkarni VM,Link MS,Raymond TT,Guerguerian AM,Berg RA,Chan PS,American Heart Association’s Get With the Guidelines-Resuscitation Investigators.

更新日期：2019-07-30 00:00:00

abstract：BACKGROUND:We examined the relationship between hypertension subtype and cardiovascular disease incidence and mortality in Chinese adults. METHODS AND RESULTS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged >or=40 years. Data on systolic (SBP) and dia...

journal_title：Circulation

authors： Kelly TN,Gu D,Chen J,Huang JF,Chen JC,Duan X,Wu X,Yau CL,Whelton PK,He J

更新日期：2008-10-07 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) or idiopathic hypertrophic subaortic stenosis (IHSS) has been defined as an autosomal dominant myocardial disease characterized by specific physical findings, echocardiographic features, asymmetric septal hypertrophy and disordered myocardial architecture. Echocardiographic and scinti...

journal_title：Circulation

authors： Come PC,Bulkley BH,Goodman ZD,Hutchins GM,Pitt B,Fortuin NJ

更新日期：1977-06-01 00:00:00

abstract：:The antiarrhythmic efficacy and safety of oral flecainide acetate and quinidine sulfate were compared in a double-blind, 16-center parallel trial involving 280 patients with chronic premature ventricular complexes (PVCs). Eighty-five percent of the flecainide patients had at least 80% suppression of PVCs, vs 57% of th...

journal_title：Circulation

authors：

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Congestive heart failure (CHF) is characterized by enhanced immune activation, and immune-mediated mechanisms may play a pathogenic role in this disorder. Based on the immunomodulatory effects of intravenous immunoglobulin (IVIG), we hypothesized that IVIG could downregulate inflammatory responses in CHF pat...

journal_title：Circulation

authors： Gullestad L,Aass H,Fjeld JG,Wikeby L,Andreassen AK,Ihlen H,Simonsen S,Kjekshus J,Nitter-Hauge S,Ueland T,Lien E,Frøland SS,Aukrust P

更新日期：2001-01-16 00:00:00

abstract：BACKGROUND:Endothelial dysfunction is associated with atherosclerosis and may contribute to ischemic syndromes. We assessed the contribution of endothelium-derived nitric oxide (NO) and vasodilator prostanoids to resting blood flow, metabolic vasodilation, and flow reserve in the human coronary circulation. METHODS AN...

journal_title：Circulation

authors： Duffy SJ,Castle SF,Harper RW,Meredith IT

更新日期：1999-11-09 00:00:00

abstract：:We made continuous electrocardiographic recordings on magnetic tape during 15 episodes of ischemia in five patients with variant angina to determine the characteristics of the QRS changes. Orthogonal leads were used and the electrocardiograms were analyzed visually and by digital computer. Changes were quantified by s...

journal_title：Circulation

authors： Barnhill JE,Wikswo JP Jr,Dawson AK,Gundersen S,Robertson RM,Robertson D,Virmani R,Smith RF

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Apoptotic microparticles are responsible for almost all tissue factor activity of the plaque lipid core. We hypothesized that elevated levels of procoagulant microparticles could also circulate in the peripheral blood of patients with recent clinical signs of plaque disruption and thrombosis. METHODS AND RE...

journal_title：Circulation

authors： Mallat Z,Benamer H,Hugel B,Benessiano J,Steg PG,Freyssinet JM,Tedgui A

更新日期：2000-02-29 00:00:00

abstract：:Numerous criteria for the diagnosis of inferior wall myocardial infarction by electrocardiogram (ECG) and vectorcardiogram (VCG) have been published, but they have not been subjected to a systematic, independent evaluation. Accordingly, we studied 146 patients undergoing cardiac catheterization; 63 were normal and 83 ...

journal_title：Circulation

authors： Hurd HP 2nd,Starling MR,Crawford MH,Dlabal PW,O'Rourke RA

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:Re-stenting of in-stent restenosis (ISR) improves acute angiographic results. Methods and Results- Volumetric intravascular ultrasound analysis was performed in 70 ISR lesions that received either placebo (n=36) or (192)Ir radiation (n=34). ISR lesions treated by re-stenting were divided into 3 groups: old s...

journal_title：Circulation

authors： Morino Y,Limpijankit T,Honda Y,Lansky AJ,Waksman R,Bonneau HN,Yock PG,Mintz GS,Fitzgerald PJ

更新日期：2002-05-28 00:00:00

abstract：BACKGROUND:We previously reported beneficial effects of pentoxifylline, a xanthine-derived agent known to inhibit the production of tumor necrosis factor-alpha, in patients with idiopathic dilated cardiomyopathy treated with diuretics, digoxin, and ACE inhibitors. Since then, 3 large clinical trials showed important cl...

journal_title：Circulation

authors： Skudicky D,Bergemann A,Sliwa K,Candy G,Sareli P

更新日期：2001-02-27 00:00:00

abstract：:Six cases of classical dissecting aneurysm of the aorta complicating aortic valvular disease in which aortic stenosis was dominant are described. In three of the cases the aortic complication occurred after the natural aortic valve had been replaced by a prosthetic valve. The longest postoperative period was four mont...

journal_title：Circulation

authors： Fukuda T,Tadavarthy SM,Edwards JE

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Thrombolytic therapy is a promising alternative to valve replacement in the management of prosthetic valve thrombosis. We sought to determine the short- and long-term results of treating thrombosed St. Jude heart valves with thrombolytic therapy as the primary treatment modality. METHODS AND RESULTS:Between...

journal_title：Circulation

authors： Silber H,Khan SS,Matloff JM,Chaux A,DeRobertis M,Gray R

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Recent studies of beta-adrenergic receptor (beta-AR) subtype signaling in in vitro preparations have raised doubts as to whether the cAMP/protein kinase A (PKA) signaling is activated in the same manner in response to beta2-AR versus beta1-AR stimulation. METHODS AND RESULTS:The present study compared, in t...

journal_title：Circulation

authors： Kuschel M,Zhou YY,Spurgeon HA,Bartel S,Karczewski P,Zhang SJ,Krause EG,Lakatta EG,Xiao RP

更新日期：1999-05-11 00:00:00

abstract：BACKGROUND:The signal transduction mechanism linking mitochondrial ATP synthesis with cytosolic ATP utilization in heart changes during postnatal development in vivo. This maturational process occurs in parallel with accumulation of mitochondrial adenine nucleotide translocator (ANT), which provides a possible site for...

journal_title：Circulation

authors： Portman MA,Xiao Y,Qian K,Tucker RL,Parish SM,Ning XH

更新日期：2000-09-12 00:00:00

abstract：:The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-...

journal_title：Circulation

authors： Moore CA,Cannon J,Watson DD,Kaul S,Beller GA

更新日期：1990-05-01 00:00:00