Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: a link between angiotensin II and intimal thickening.

Abstract:

BACKGROUND:Growth factors such as platelet-derived growth factor (PDGF) have been postulated to be important mediators of neointimal formation in balloon-injured artery. Binding of growth factors to their receptors activates intrinsic receptor tyrosine kinase, resulting in tyrosine phosphorylation of receptors themselves and cellular substrate proteins. We investigated in vivo activities of growth factors by determining the extent of tyrosine phosphorylation of growth factor receptors and substrate proteins in injured artery. METHODS AND RESULTS:Rat balloon-injured carotid artery was analyzed for phosphotyrosine content of PDGF alpha- and beta-receptors, epidermal growth factor (EGF) receptors, and insulin receptor substrate-1 (IRS-1) by immunoprecipitation and anti-phosphotyrosine Western blot. The development of intimal thickening after deendothelializing balloon catheterization of rat carotid artery was accompanied by transient twofold to threefold increases in the extent of tyrosyl phosphorylation of PDGF alpha- and beta-receptors but not EGF receptor or IRS-1. The AT1 angiotensin II (Ang II) receptor antagonist TCV-116 markedly inhibited both tyrosyl phosphorylation of PDGF alpha- and beta-receptors and intimal thickening. The AT1 antagonist reduced mRNA levels of both PDGF-A and -B chains in injured arteries. CONCLUSIONS:The present study provides direct evidence for increased PDGF activities in injured artery in situ and the involvement of Ang II in stimulated activation of PDGF receptors. These results are consistent with the pathogenetic role for PDGF in intimal thickening.

journal_name

Circulation

journal_title

Circulation

authors

Abe J,Deguchi J,Matsumoto T,Takuwa N,Noda M,Ohno M,Makuuchi M,Kurokawa K,Takuwa Y

doi

10.1161/01.cir.96.6.1906

subject

Has Abstract

pub_date

1997-09-16 00:00:00

pages

1906-13

issue

6

eissn

0009-7322

issn

1524-4539

journal_volume

96

pub_type

杂志文章
  • Early changes in ventricular geometry and ventricular septal defect size following Rastelli operation or intraventricular baffle repair for conotruncal anomaly. A cause for development of subaortic stenosis.

    abstract:BACKGROUND:Obstruction to left ventricular outflow can be seen after surgical repair of congenital heart disease in which a ventricular septal defect (VSD) is closed by means of a baffle to the systemic great artery arising from the right ventricle (Rastelli operation, intraventricular repair, for conotruncal anomaly)....

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Rychik J,Jacobs ML,Norwood WI

    更新日期:1994-11-01 00:00:00

  • Linear ablation of the isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. A study in the canine atrial flutter model.

    abstract:BACKGROUND:The isthmus between the inferior vena cava and the tricuspid annulus has been shown to be involved in the reentry circuit of common atrial flutter. The effects of radio-frequency catheter ablation of this isthmus were examined in the canine model of atrial flutter due to reentry around the tricuspid annulus....

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.5.1312

    authors: Tabuchi T,Okumura K,Matsunaga T,Tsunoda R,Jougasaki M,Yasue H

    更新日期:1995-09-01 00:00:00

  • Randomized trial of subcutaneous low-molecular-weight heparin CY 216 (Fraxiparine) compared with intravenous unfractionated heparin in the curative treatment of submassive pulmonary embolism. A dose-ranging study.

    abstract:BACKGROUND:We compared the efficacy and safety of different dosages of a low-molecular-weight heparin, CY 216 D (Fraxiparine), in the treatment of submassive pulmonary embolism with unfractionated heparin in a prospective, randomized, dose-finding study. METHODS AND RESULTS:The primary outcome was the evolution of pul...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.85.4.1380

    authors: Théry C,Simonneau G,Meyer G,Hélénon O,Bridey F,Armagnac C,d'Azemar P,Coquart JP

    更新日期:1992-04-01 00:00:00

  • Lipid lowering versus revascularization: an idea whose time (for testing) has come.

    abstract::There is strong evidence that revascularization does not prevent myocardial infarction in patients with stable coronary artery disease (CAD). The anatomic basis for this counterintuitive conclusion seems to be that most myocardial infarctions occur at sites that did not previously exhibit an angiographically significa...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.96.4.1360

    authors: Forrester JS,Shah PK

    更新日期:1997-08-19 00:00:00

  • Intimal thickening of the coronary arteries in infants in relation to family history of coronary artery disease.

    abstract:BACKGROUND:Intimal thickenings of the coronary arteries of newborn children are composed mainly of smooth muscle cell proliferations. To investigate whether thickening of the intima in infants is associated with a family history of coronary artery disease (CAD), we studied the relation of coronary death of grandparents...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.87.6.1960

    authors: Kaprio J,Norio R,Pesonen E,Sarna S

    更新日期:1993-06-01 00:00:00

  • Atherosclerotic renovascular disease in older US patients starting dialysis, 1996 to 2001.

    abstract:BACKGROUND:Temporal trends regarding the epidemiology of atherosclerotic renovascular disease (ARVD) in dialysis populations are poorly defined. METHODS AND RESULTS:United States Renal Data System data were used to identify patients aged 67 years or older at dialysis inception between 1996 and 2001 (n=146,973). Medica...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.637751

    authors: Guo H,Kalra PA,Gilbertson DT,Liu J,Chen SC,Collins AJ,Foley RN

    更新日期:2007-01-02 00:00:00

  • Altered contractile response in neonatal myocardium to citrate-phosphate-dextrose infusion.

    abstract::The clinical use of citrate-phosphate-dextrose during blood-product transfusion is known to affect ionized calcium levels and can result in depression of myocardial contractility. The immature heart appears to have an intrinsic reduction in contractile state compared with the adult heart and may be more dependent on t...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Rebeyka IM,Yeh T Jr,Hanan SA,Borges MR,Lee KF,Tuchy GE,Abd-Elfattah AS,Wechsler AS

    更新日期:1990-11-01 00:00:00

  • Early Risks of Death, Stroke/Systemic Embolism, and Major Bleeding in Patients With Newly Diagnosed Atrial Fibrillation.

    abstract:BACKGROUND:Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. METHODS:We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their rel...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.035012

    authors: Bassand JP,Virdone S,Goldhaber SZ,Camm AJ,Fitzmaurice DA,Fox KAA,Goto S,Haas S,Hacke W,Kayani G,Mantovani LG,Misselwitz F,Pieper KS,Turpie AGG,van Eickels M,Verheugt FWA,Kakkar AK

    更新日期:2019-02-05 00:00:00

  • Outcomes and long-term survival for patients undergoing mitral valve repair versus replacement: effect of age and concomitant coronary artery bypass grafting.

    abstract:BACKGROUND:A paucity of literature is available on the effects of age and coronary artery bypass grafting (CABG) on the outcomes of patients undergoing mitral valve (MV) repair versus replacement. METHODS AND RESULTS:A matched study was performed using prospectively collected data from the Emory cardiovascular databas...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000079169.15862.13

    authors: Thourani VH,Weintraub WS,Guyton RA,Jones EL,Williams WH,Elkabbani S,Craver JM

    更新日期:2003-07-22 00:00:00

  • Generic, simple risk stratification model for heart valve surgery.

    abstract:BACKGROUND:Heart valve surgery has an associated in-hospital mortality rate of 4% to 8%. This study aims to develop a simple risk model to predict the risk of in-hospital mortality for patients undergoing heart valve surgery to provide information to patients and clinicians and to facilitate institutional comparisons. ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.515049

    authors: Ambler G,Omar RZ,Royston P,Kinsman R,Keogh BE,Taylor KM

    更新日期:2005-07-12 00:00:00

  • Relations between enzymatically estimated myocardial infarct size and early ventricular dysrhythmia.

    abstract::The relation between ventricular dysrhythmia during the first 20 hours after hospitalization for acute myocardial infarction and enzymatically estimated infarct size was studied prospectively. The duration of dyshythmia was measured by the total time during which the average premature ventricular depolarization (PVC) ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Cox JR Jr,Roberts R,Ambos HD,Oliver GC,Sobel BE

    更新日期:1976-03-01 00:00:00

  • Long-term evolution and prognostic stratification of biopsy-proven active myocarditis.

    abstract:BACKGROUND:Active myocarditis is characterized by large heterogeneity of clinical presentation and evolution. This study describes the characteristics and the long-term evolution of a large sample of patients with biopsy-proven active myocarditis, looking for accessible and valid early predictors of long-term prognosis...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.003092

    authors: Anzini M,Merlo M,Sabbadini G,Barbati G,Finocchiaro G,Pinamonti B,Salvi A,Perkan A,Di Lenarda A,Bussani R,Bartunek J,Sinagra G

    更新日期:2013-11-26 00:00:00

  • Significance of mild transient release of creatine kinase-MB fraction after percutaneous coronary interventions.

    abstract:BACKGROUND:The clinical significance of minor elevations in creatine kinase-myocardial band isoenzyme (CK-MB) after coronary interventions has not been systematically evaluated. METHODS AND RESULTS:We examined 4484 patients who underwent successful percutaneous transluminal coronary angioplasty or directional coronary...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.7.1528

    authors: Abdelmeguid AE,Topol EJ,Whitlow PL,Sapp SK,Ellis SG

    更新日期:1996-10-01 00:00:00

  • Randomized comparison of sirolimus-eluting stent versus standard stent for percutaneous coronary revascularization in diabetic patients: the diabetes and sirolimus-eluting stent (DIABETES) trial.

    abstract:BACKGROUND:Outcomes after percutaneous coronary interventions in diabetic patients are shadowed by the increased rate of recurrence compared with nondiabetic patients. METHODS AND RESULTS:We conducted a multicenter, randomized trial to demonstrate the efficacy of sirolimus-eluting stents compared with standard stents ...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.105.562421

    authors: Sabaté M,Jiménez-Quevedo P,Angiolillo DJ,Gómez-Hospital JA,Alfonso F,Hernández-Antolín R,Goicolea J,Bañuelos C,Escaned J,Moreno R,Fernández C,Fernández-Avilés F,Macaya C,DIABETES Investigators.

    更新日期:2005-10-04 00:00:00

  • Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study.

    abstract:BACKGROUND:Biomarkers that predict response to cardiac resynchronization therapy (CRT) in heart failure patients with dyssynchrony (HFDYS) would be clinically important. Circulating extracellular microRNAs (miRNAs) have emerged as novel biomarkers that may also play important functional roles, but their relevance as ma...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.013220

    authors: Melman YF,Shah R,Danielson K,Xiao J,Simonson B,Barth A,Chakir K,Lewis GD,Lavender Z,Truong QA,Kleber A,Das R,Rosenzweig A,Wang Y,Kass D,Singh JP,Das S

    更新日期:2015-06-23 00:00:00

  • Physical training alters the pathogenesis of pacing-induced heart failure through endothelium-mediated mechanisms in awake dogs.

    abstract:BACKGROUND:Beneficial effects of exercise training on cardiovascular function in chronic heart failure (CHF) have been suggested previously, but the underlying mechanisms are unknown. We tested whether daily exercise training improves systemic hemodynamics and preserves endothelium-mediated vasodilator function during ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.96.8.2683

    authors: Wang J,Yi GH,Knecht M,Cai BL,Poposkis S,Packer M,Burkhoff D

    更新日期:1997-10-21 00:00:00

  • Prioritizing Functional Capacity as a Principal End Point for Therapies Oriented to Older Adults With Cardiovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association.

    abstract::Adults are living longer, and cardiovascular disease is endemic in the growing population of older adults who are surviving into old age. Functional capacity is a key metric in this population, both for the perspective it provides on aggregate health and as a vital goal of care. Whereas cardiorespiratory function has ...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIR.0000000000000483

    authors: Forman DE,Arena R,Boxer R,Dolansky MA,Eng JJ,Fleg JL,Haykowsky M,Jahangir A,Kaminsky LA,Kitzman DW,Lewis EF,Myers J,Reeves GR,Shen WK,American Heart Association Council on Clinical Cardiology; Council on Cardiovascular and St

    更新日期:2017-04-18 00:00:00

  • Physical training improves endothelial function in patients with chronic heart failure.

    abstract:BACKGROUND:Chronic heart failure is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). Since endothelial function is thought to play an important role in coordinating tissue perfusion and modulating arterial compliance, interventions to improve endothelial dy...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.93.2.210

    authors: Hornig B,Maier V,Drexler H

    更新日期:1996-01-15 00:00:00

  • Household Fuel Use and Cardiovascular Disease Mortality: Golestan Cohort Study.

    abstract:BACKGROUND:Household air pollution is the third largest risk factor for global disease burden, but direct links with cardiovascular disease mortality are limited. This study aimed to evaluate the relationship between household fuel use and cardiovascular disease mortality. METHODS AND RESULTS:The Golestan Cohort Study...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.115.020288

    authors: Mitter SS,Vedanthan R,Islami F,Pourshams A,Khademi H,Kamangar F,Abnet CC,Dawsey SM,Pharoah PD,Brennan P,Fuster V,Boffetta P,Malekzadeh R

    更新日期:2016-06-14 00:00:00

  • Twenty-four-hour ambulatory blood pressure in shift workers.

    abstract::Blood pressure and heart rate of 15 male shift workers were measured every 15 minutes for 24 hours during three work shifts: morning, 4:00 AM to noon; afternoon, noon to 8:00 PM; and night, 8:00 PM to 4:00 AM. For each shift, 24-hour systolic and diastolic blood pressure showed a large "trough" (the low pressure span)...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.80.2.341

    authors: Chau NP,Mallion JM,de Gaudemaris R,Ruche E,Siche JP,Pelen O,Mathern G

    更新日期:1989-08-01 00:00:00

  • The effect of timolol vs placebo on angina pectoris.

    abstract::The effect of timolol vs placebo on the frequency of anginal episodes, nitroglycerin consumption and exercise performance was investigated in a double-blind, randomized, crossover study in 23 patients with angina pectoris. The optimal dose of timolol (10-30 mg twice daily) for each patient was titrated by exercise stu...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.61.1.66

    authors: Aronow WS,Turbow M,Van Camp S,Lurie M,Whittaker K

    更新日期:1980-01-01 00:00:00

  • Chlamydia pneumoniae-specific circulating immune complexes in patients with chronic coronary heart disease.

    abstract:BACKGROUND:An association of chronic Chlamydia pneumoniae infection to coronary heart disease has been suggested recently. In a recent study, we demonstrated circulating immune complexes containing chlamydial genus-specific lipopolysaccharide in patients with coronary heart disease. The objective of the present study w...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.87.4.1130

    authors: Linnanmäki E,Leinonen M,Mattila K,Nieminen MS,Valtonen V,Saikku P

    更新日期:1993-04-01 00:00:00

  • Lipid-rich atherosclerotic plaques detected by gadofluorine-enhanced in vivo magnetic resonance imaging.

    abstract:BACKGROUND:MRI of specific components in atherosclerotic plaque may provide information on plaque stability and its potential to rupture. We evaluated gadofluorine in atherosclerotic rabbits using a new MR sequence that allows plaque detection within 1 hour after injection and assessed enhancement in lipid-rich and non...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000129310.17277.E7

    authors: Sirol M,Itskovich VV,Mani V,Aguinaldo JG,Fallon JT,Misselwitz B,Weinmann HJ,Fuster V,Toussaint JF,Fayad ZA

    更新日期:2004-06-15 00:00:00

  • Multiple Arterial Grafting Is Associated With Better Outcomes for Coronary Artery Bypass Grafting Patients.

    abstract:BACKGROUND:Observational studies have shown better survival in patients undergoing coronary artery bypass grafting (CABG) with 2 arterial grafts compared with 1. However, whether a third arterial graft is associated with incremental benefit remains uncertain. We sought to analyze the outcomes of 3 versus 2 arterial gra...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.118.034464

    authors: Rocha RV,Tam DY,Karkhanis R,Nedadur R,Fang J,Tu JV,Gaudino M,Royse A,Fremes SE

    更新日期:2018-11-06 00:00:00

  • Exercise-induced ST-segment depression in patients without restenosis after coronary angioplasty. Relation to preprocedural impaired left ventricular function.

    abstract:BACKGROUND:ST-segment depression during exercise testing is frequently observed in the absence of restenosis after coronary angioplasty. METHODS AND RESULTS:We studied the determinants of this phenomenon in 70 consecutive patients with unstable angina related to a single left anterior descending coronary artery lesion...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.90.1.148

    authors: Beregi JP,Bauters C,McFadden EP,Quandalle P,Bertrand ME,Lablanche JM

    更新日期:1994-07-01 00:00:00

  • Impaired maximal rate of left ventricular relaxation in patients with coronary artery disease and left ventricular dysfunction.

    abstract::It has been suggested that the rate of left ventricular (LV) relaxation is related to the inotropic state, end-systolic fiber length and peak LV pressure, but little information is available regarding the rate of LV relaxation in patients with coronary artery disease (CAD) and LV dysfunction. To assess the rate of LV ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.59.5.984

    authors: Papapietro SE,Coghlan HC,Zissermann D,Russell RO Jr,Rackley CE,Rogers WJ

    更新日期:1979-05-01 00:00:00

  • Increased plasminogen activator inhibitor type 1 in coronary artery atherectomy specimens from type 2 diabetic compared with nondiabetic patients: a potential factor predisposing to thrombosis and its persistence.

    abstract:BACKGROUND:Inhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 (PAI-1) in blood is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. Because we have shown that insulin can stimulate PAI-1 synthesis in vivo and because accelerated...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.97.22.2213

    authors: Sobel BE,Woodcock-Mitchell J,Schneider DJ,Holt RE,Marutsuka K,Gold H

    更新日期:1998-06-09 00:00:00

  • Paclitaxel balloon coating, a novel method for prevention and therapy of restenosis.

    abstract:BACKGROUND:Drug-eluting stents have shown promising antirestenotic effects in clinical trials. Non-stent-based local delivery of antiproliferative drugs may offer additional flexibility and also reach vessel areas beyond the immediate stent coverage. The aim of the present study was to evaluate a novel method of local ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000138929.71660.E0

    authors: Scheller B,Speck U,Abramjuk C,Bernhardt U,Böhm M,Nickenig G

    更新日期:2004-08-17 00:00:00

  • Relation of postural vasovagal syncope to splanchnic hypervolemia in adolescents.

    abstract:BACKGROUND:The mechanisms of simple faint remain elusive. We propose that postural fainting is related to excessive thoracic hypovolemia and splanchnic hypervolemia during orthostasis compared with healthy subjects. METHODS AND RESULTS:We studied 34 patients 12 to 22 years old referred for multiple episodes of postura...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000145543.88293.21

    authors: Stewart JM,McLeod KJ,Sanyal S,Herzberg G,Montgomery LD

    更新日期:2004-10-26 00:00:00

  • The cellular electrophysiologic changes induced by ablation: comparison between argon laser photoablation and high-energy electrical ablation.

    abstract::The cellular electrophysiologic effects of myocardial ablation performed in vitro with argon laser energy were compared with those of high-energy electrical shocks. A border zone of injured but nonnecrotic tissue surrounding the site of energy delivery was present after tissue ablation by both energy modalities. A dec...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.76.1.217

    authors: Levine JH,Merillat JC,Stern M,Weisman HF,Kadish AH,Moore EN,Spear JF,Fonger J,Guarnieri T

    更新日期:1987-07-01 00:00:00