Ventricular septal defects.

abstract：:The modulated receptor hypothesis states that sodium channels have a specific receptor for antiarrhythmic drugs. Therefore, two agents that block sodium channels by binding to this receptor are expected to compete for occupancy. Glycylxylidide (GX) is a deethylated metabolite of lidocaine that accumulates in patients ...

journal_title：Circulation

authors： Bennett PB,Woosley RL,Hondeghem LM

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Previous studies suggest that rigid fixation of the mitral annulus with an annuloplasty ring may impair left ventricular (LV) systolic performance. We used load-insensitive indexes of global and regional LV contractile mechanics to test the hypothesis that rigid fixation of the mitral annulus alters LV systo...

journal_title：Circulation

authors： Rayhill SC,Castro LJ,Nizyporuk MA,Ingels NB Jr,Daughters GT,Derby GC,Tye TL,Bolger AF,Miller DC

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) is a novel vasodilating peptide thought to have important effects on cardiovascular function. The aim of this study was to assess the activity of endogenous AM in the cardiovascular system using AM knockout mice. METHODS AND RESULTS:Mice heterozygous for an AM-null mutation (AM+/-) and t...

journal_title：Circulation

authors： Niu P,Shindo T,Iwata H,Iimuro S,Takeda N,Zhang Y,Ebihara A,Suematsu Y,Kangawa K,Hirata Y,Nagai R

更新日期：2004-04-13 00:00:00

abstract：BACKGROUND:Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS:To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic cir...

journal_title：Circulation

authors： Nemmar A,Hoet PH,Vanquickenborne B,Dinsdale D,Thomeer M,Hoylaerts MF,Vanbilloen H,Mortelmans L,Nemery B

更新日期：2002-01-29 00:00:00

abstract：BACKGROUND:The lysyl oxidases are extracellular copper enzymes that initiate the crosslinking of collagens and elastin, 5 human isoenzymes having been characterized so far. The crosslinks formed provide the tensile strength and elastic properties for various extracellular matrices, including vascular walls. We studied ...

journal_title：Circulation

authors： Mäki JM,Räsänen J,Tikkanen H,Sormunen R,Mäkikallio K,Kivirikko KI,Soininen R

更新日期：2002-11-05 00:00:00

abstract：BACKGROUND:Depressive symptoms have been associated with increased risk of coronary artery disease and poor prognosis among patients with existing coronary artery disease, but whether depressive symptoms specifically influence atherosclerotic progression among such patients is uncertain. METHODS AND RESULTS:The Post-C...

journal_title：Circulation

authors： Wellenius GA,Mukamal KJ,Kulshreshtha A,Asonganyi S,Mittleman MA

更新日期：2008-05-06 00:00:00

abstract：BACKGROUND:Receptors that couple via the stimulatory G protein, Gs, to adenylate cyclase and to a positive inotropic response have been extensively investigated in falling human heart. In contrast, much less is known about receptors, such as the A1-adenosine receptor, that couple to adenylate cyclase via the inhibitory...

journal_title：Circulation

authors： Hershberger RE,Feldman AM,Bristow MR

更新日期：1991-04-01 00:00:00

abstract：:An isolated perfused working rat heart model was used to investigate the extent to which various protective agents, used either singly or in combination, were able to increase the resistance of the heart to periods of transient ischemia. The aim of the studies was to develop a solution which, if infused into the coron...

journal_title：Circulation

authors： Hearse DJ,Stewart DA,Braimbridge MV

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:Subclinical inflammation is associated with an increased risk of heart failure and with adverse prognosis in patients with established heart failure. Yet, treatments specifically directed at reducing inflammation in patients with heart failure have not yet shown improved clinical outcomes. We tested the hypo...

journal_title：Circulation

authors： Everett BM,Cornel JH,Lainscak M,Anker SD,Abbate A,Thuren T,Libby P,Glynn RJ,Ridker PM

更新日期：2019-03-05 00:00:00

abstract：BACKGROUND:The quantity and intensity of physical activity required for the primary prevention of coronary heart disease (CHD) remain unclear. Therefore, we examined the association of the quantity and intensity of physical activity with CHD risk and the impact of other coronary risk factors. METHODS AND RESULTS:We fo...

journal_title：Circulation

authors： Sesso HD,Paffenbarger RS Jr,Lee IM

更新日期：2000-08-29 00:00:00

abstract：BACKGROUND:Apolipoprotein E (apoE) has long been known to play an important role in the clearance of plasma lipoproteins. More recently, a direct role for apoE in delaying atherogenesis has been proposed. Macrophage production of apoE in the artery wall has been demonstrated to provide protection against atheroscleroti...

journal_title：Circulation

authors： Hasty AH,Linton MF,Brandt SJ,Babaev VR,Gleaves LA,Fazio S

更新日期：1999-05-18 00:00:00

abstract：BACKGROUND:Chronic, complete AV block (CAVB) in the dog leads to ventricular hypertrophy, which has been described as an independent risk factor for arrhythmias. In this model, we examined (1) whether the short- and long-term electrical adaptations predispose to acquired torsade de pointes arrhythmias (TdP) and (2) the...

journal_title：Circulation

authors： Vos MA,de Groot SH,Verduyn SC,van der Zande J,Leunissen HD,Cleutjens JP,van Bilsen M,Daemen MJ,Schreuder JJ,Allessie MA,Wellens HJ

更新日期：1998-09-15 00:00:00

abstract：BACKGROUND:Patients with chronic stable angina are poorly characterized in terms of biomarkers that help in the assessment of prognosis. We investigated whether plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) may be used as a prognostic marker in patients with chronic stable angina treated with co...

journal_title：Circulation

authors： Ndrepepa G,Braun S,Niemöller K,Mehilli J,von Beckerath N,von Beckerath O,Vogt W,Schömig A,Kastrati A

更新日期：2005-10-04 00:00:00

abstract：BACKGROUND:Although early trials indicate the treatment of restenosis with radiation therapy is safe and effective, the long-term impact of this new technology has been questioned. The possibility of late untoward consequences, such as aneurysm formation, perforation, and accelerated vascular disease, is of significant...

journal_title：Circulation

authors： Teirstein PS,Massullo V,Jani S,Russo RJ,Cloutier DA,Schatz RA,Guarneri EM,Steuterman S,Sirkin K,Norman S,Tripuraneni P

更新日期：1999-01-19 00:00:00

abstract：:Coronary arteriography was performed before and after the intracoronary injection of nitroglycerin to determine the presence or absence of spasm in patients within the first 12 hours of acute myocardial infarction. Coronary arterial spasm was demonstrated in six of fifteen (40%) acute myocardial infarctions associated...

journal_title：Circulation

authors： Oliva PB,Breckinridge JC

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:Interleukin-8 (IL-8) secreted from endothelial cells is a powerful neutrophil chemoattractant and activator. We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia. Furthermore, we hypothesized that corona...

journal_title：Circulation

authors： Oz MC,Liao H,Naka Y,Seldomridge A,Becker DN,Michler RE,Smith CR,Rose EA,Stern DM,Pinsky DJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:A complete understanding of fluid mechanics in Fontan physiology includes knowledge of the caval contributions to right (RPA) and left (LPA) pulmonary arterial blood flow, total systemic venous return, and relative blood flow to each lung. METHODS AND RESULTS:Ten Fontan patients underwent cine MRI. Three ci...

journal_title：Circulation

authors： Fogel MA,Weinberg PM,Rychik J,Hubbard A,Jacobs M,Spray TL,Haselgrove J

更新日期：1999-03-09 00:00:00

abstract：BACKGROUND:Mutations in the ryanodine 2 receptor (RyR2) gene have been identified in patients with catecholaminergic polymorphic ventricular tachycardia. We examined the cellular basis for the ECG features and arrhythmia mechanisms using low-dose caffeine to mimic the defective calcium homeostasis encountered under the...

journal_title：Circulation

authors： Nam GB,Burashnikov A,Antzelevitch C

更新日期：2005-05-31 00:00:00

abstract：BACKGROUND:The purpose of this study was to compare differential effects of a segment of slow conduction during ventricular tachycardia (VT) due to depression of the action potential and electrical uncoupling. METHODS AND RESULTS:In 33 Langendorff-perfused rabbit hearts, a ring of anisotropic left ventricular subepica...

journal_title：Circulation

authors： Haberl K,Allessie M

更新日期：1999-02-23 00:00:00

abstract：:The importance of pulmonary artery size and the value of a standardized pulmonary artery index (PAI) in predicting outcome after Fontan's repair have previously been reported and questioned. We retrospectively reviewed 29 patients undergoing modified Fontan repair at The Children's Hospital of Philadelphia to examine ...

journal_title：Circulation

authors： Bridges ND,Farrell PE Jr,Pigott JD 3rd,Norwood WI,Chin AJ

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Resetting has been used to characterize reentrant circuits causing clinical tachycardias. METHODS AND RESULTS:To determine the mechanisms of resetting, sustained ventricular tachycardia was induced in dogs with 4-day-old myocardial infarctions by programmed stimulation. Premature stimulation was accomplishe...

journal_title：Circulation

authors： Hanna MS,Coromilas J,Josephson ME,Wit AL,Peters NS

更新日期：2001-02-27 00:00:00

abstract：BACKGROUND:The endothelium acts as the sensor of shear stress and as the mediator of flow-induced changes in vessel tone and structure. The purpose of this study was to delineate the signal transduction pathway of flow-induced release of endothelium-derived relaxing factor (EDRF). METHODS AND RESULTS:We used a shear s...

journal_title：Circulation

authors： Ohno M,Gibbons GH,Dzau VJ,Cooke JP

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle and pregnancy. Accumulating clinical evidence suggests a role for progesterone; however, the effect of progesterone on cardia...

journal_title：Circulation

authors： Nakamura H,Kurokawa J,Bai CX,Asada K,Xu J,Oren RV,Zhu ZI,Clancy CE,Isobe M,Furukawa T

更新日期：2007-12-18 00:00:00

abstract：BACKGROUND:The residual Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Score is an objective measure of the degree and complexity of residual stenosis after percutaneous coronary intervention (PCI). METHODS AND RESULTS:In the randomized PCI cohort of the SYNTAX Trial (n=903)...

journal_title：Circulation

authors： Farooq V,Serruys PW,Bourantas CV,Zhang Y,Muramatsu T,Feldman T,Holmes DR,Mack M,Morice MC,Ståhle E,Colombo A,de Vries T,Morel MA,Dawkins KD,Kappetein AP,Mohr FW

更新日期：2013-07-09 00:00:00

abstract：BACKGROUND:The TAXUS NIRx stent (Boston Scientific Corp) provides local delivery of paclitaxel via a slow-release polymer coating. The TAXUS I trial was the first in-human experience evaluating safety and feasibility of the TAXUS NIRx stent system compared with bare NIR stents (control) (Boston Scientific Corp) for tre...

journal_title：Circulation

authors： Grube E,Silber S,Hauptmann KE,Mueller R,Buellesfeld L,Gerckens U,Russell ME

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:Paraplegia continues to complicate thoracoabdominal aortic interventions. The elusive mechanism of spinal cord ischemia-reperfusion injury has delayed the development of pharmacological adjuncts. Microglia, the resident macrophages of the central nervous system, can have pathological responses after a variet...

journal_title：Circulation

authors： Bell MT,Puskas F,Agoston VA,Cleveland JC Jr,Freeman KA,Gamboni F,Herson PS,Meng X,Smith PD,Weyant MJ,Fullerton DA,Reece TB

更新日期：2013-09-10 00:00:00

abstract：BACKGROUND:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk ...

journal_title：Circulation

authors： Williams MC,Kwiecinski J,Doris M,McElhinney P,D'Souza MS,Cadet S,Adamson PD,Moss AJ,Alam S,Hunter A,Shah ASV,Mills NL,Pawade T,Wang C,Weir McCall J,Bonnici-Mallia M,Murrills C,Roditi G,van Beek EJR,Shaw LJ,Nicol E

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:It is uncertain whether Helicobacter pylori is associated with ischemic syndromes and whether this association is mediated by the induction of atherosclerosis. In this study, we tested the hypothesis that atherosclerotic stroke shows a selective association with virulent H pylori strains. METHODS AND RESULT...

journal_title：Circulation

authors： Pietroiusti A,Diomedi M,Silvestrini M,Cupini LM,Luzzi I,Gomez-Miguel MJ,Bergamaschi A,Magrini A,Carrabs T,Vellini M,Galante A

更新日期：2002-07-30 00:00:00

abstract：BACKGROUND:In the Basel Antiarrhythmic Study of Infarct Survival trial, low-dose amiodarone improved 1-year survival in patients with asymptomatic complex ventricular arrhythmias persisting 2 weeks after myocardial infarction. To assess whether this beneficial effect persisted despite discontinuation of amiodarone afte...

journal_title：Circulation

authors： Pfisterer ME,Kiowski W,Brunner H,Burckhardt D,Burkart F

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Orthostatic intolerance is characterized by postural tachycardia syndrome (POTS) with exaggerated tachycardia, orthostatic symptoms, and "pooling" (which comprises acrocyanosis and dependent edema when upright). My colleagues and I tested the hypothesis that pooling results from increased venous compliance i...

journal_title：Circulation

authors： Stewart JM

更新日期：2002-05-14 00:00:00