Paclitaxel balloon coating, a novel method for prevention and therapy of restenosis.

Abstract:

BACKGROUND:Drug-eluting stents have shown promising antirestenotic effects in clinical trials. Non-stent-based local delivery of antiproliferative drugs may offer additional flexibility and also reach vessel areas beyond the immediate stent coverage. The aim of the present study was to evaluate a novel method of local drug delivery based on angioplasty balloons. METHODS AND RESULTS:Stainless steel stents (n=40; diameter, 3.0 to 3.5 mm; length, 18 mm) were implanted in the left anterior descending and circumflex coronary arteries of domestic pigs. Both conventional uncoated and 3 different types of paclitaxel-coated, percutaneous transluminal coronary angioplasty balloons (contact with vessel wall for 1 minute) were used. No difference in short-term tolerance between coated and uncoated balloons and no signs of thrombotic events were observed. Quantitative angiography and histomorphometry of the stented arteries asserted the statistical equality of the baseline parameters between the control and the 3 treatment groups. Paclitaxel balloon coating led to a marked, dose-dependent reduction of parameters characterizing in-stent restenosis (reduction of neointimal area up to 63%). Despite the marked reduction in neointimal proliferation, endothelialization of stent struts was present in all samples. There was no evidence of a significant inflammatory response in the neighborhood of the stent struts. CONCLUSIONS:Paclitaxel balloon coating is safe, and it effectively inhibits restenosis after coronary angioplasty with stent implantation in the porcine model. The degree of reduction in neointimal formation was comparable to that achieved with drug-eluting stents.

journal_name

Circulation

journal_title

Circulation

authors

Scheller B,Speck U,Abramjuk C,Bernhardt U,Böhm M,Nickenig G

doi

10.1161/01.CIR.0000138929.71660.E0

subject

Has Abstract

pub_date

2004-08-17 00:00:00

pages

810-4

issue

7

eissn

0009-7322

issn

1524-4539

pii

01.CIR.0000138929.71660.E0

journal_volume

110

pub_type

杂志文章
  • Tight heart rate control reduces secondary adverse events in patients with type B acute aortic dissection.

    abstract:BACKGROUND:Although type B aortic dissection has been treated with beta blockers to lower the arterial blood pressure (BP), there has been little evidences about reduction in heart rate (HR). We assessed whether tight HR control improved the outcome of medical treatment in patients with aortic dissection. METHODS AND ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.755801

    authors: Kodama K,Nishigami K,Sakamoto T,Sawamura T,Hirayama T,Misumi H,Nakao K

    更新日期:2008-09-30 00:00:00

  • Randomized COMparison of platelet inhibition with abciximab, tiRofiban and eptifibatide during percutaneous coronary intervention in acute coronary syndromes: the COMPARE trial. Comparison Of Measurements of Platelet aggregation with Aggrastat, Reopro, an

    abstract:BACKGROUND:The relative anti-aggregatory effects of currently prescribed platelet glycoprotein IIb/IIIa receptor antagonists during and after percutaneous coronary intervention for acute coronary syndromes have not been established. METHODS AND RESULTS:We randomized 70 acute coronary syndrome patients undergoing percu...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.0000029744.01096.1f

    authors: Batchelor WB,Tolleson TR,Huang Y,Larsen RL,Mantell RM,Dillard P,Davidian M,Zhang D,Cantor WJ,Sketch MH Jr,Ohman EM,Zidar JP,Gretler D,DiBattiste PM,Tcheng JE,Califf RM,Harrington RA

    更新日期:2002-09-17 00:00:00

  • Efficacy of Long-Term β-Blocker Therapy for Secondary Prevention of Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery.

    abstract:BACKGROUND:Conflicting results from recent observational studies have raised questions concerning the benefit of β-blockers for patients undergoing coronary artery bypass grafting (CABG). Furthermore, the efficacy of long-term β-blocker therapy in CABG patients after hospital discharge is uncertain. METHODS AND RESULT...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.014209

    authors: Zhang H,Yuan X,Zhang H,Chen S,Zhao Y,Hua K,Rao C,Wang W,Sun H,Hu S,Zheng Z

    更新日期:2015-06-23 00:00:00

  • Sudden death after repair of double-outlet right ventricle.

    abstract::The outlook for patients with double-outlet right ventricle has improved since the development of corrective operations. Late arrhythmic deaths after successful procedures have been reported; however, the magnitude remains unknown. This study was undertaken to identify the magnitude of late sudden death and the signif...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.1.128

    authors: Shen WK,Holmes DR Jr,Porter CJ,McGoon DC,Ilstrup DM

    更新日期:1990-01-01 00:00:00

  • Linear ablation of the isthmus between the inferior vena cava and tricuspid annulus for the treatment of atrial flutter. A study in the canine atrial flutter model.

    abstract:BACKGROUND:The isthmus between the inferior vena cava and the tricuspid annulus has been shown to be involved in the reentry circuit of common atrial flutter. The effects of radio-frequency catheter ablation of this isthmus were examined in the canine model of atrial flutter due to reentry around the tricuspid annulus....

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.5.1312

    authors: Tabuchi T,Okumura K,Matsunaga T,Tsunoda R,Jougasaki M,Yasue H

    更新日期:1995-09-01 00:00:00

  • Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction.

    abstract:BACKGROUND:The extent of microvascular obstruction during acute coronary occlusion may determine the eventual magnitude of myocardial damage and thus, patient prognosis after infarction. By contrast-enhanced MRI, regions of profound microvascular obstruction at the infarct core are hypoenhanced and correspond to greate...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.97.8.765

    authors: Wu KC,Zerhouni EA,Judd RM,Lugo-Olivieri CH,Barouch LA,Schulman SP,Blumenthal RS,Lima JA

    更新日期:1998-03-03 00:00:00

  • Pregnancy in cyanotic congenital heart disease. Outcome of mother and fetus.

    abstract::In a series of 416 women with congenital heart disease seen in the Royal Brompton National Heart and Lung Hospital, London, and the Hospital Giovanni Bosco, Torino, Italy, there were 822 pregnancies. The outcomes of 96 pregnancies in 44 patients with cyanotic congenital heart disease were studied. Patients with the Ei...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.6.2673

    authors: Presbitero P,Somerville J,Stone S,Aruta E,Spiegelhalter D,Rabajoli F

    更新日期:1994-06-01 00:00:00

  • Atrial flutter with exit block.

    abstract::The mechanism of atrial flutter is controversial. A 76-year-old woman with rheumatic heart disease was referred to our clinic with an unusual rhythm disturbance which initially appeared to be classic atrial flutter at a rate of 300 beats/min. Later tracings, however, demonstrated a rate exactly one-half that of the ea...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.60.3.711

    authors: Homcy CJ,Lorell B,Yurchak PM

    更新日期:1979-09-01 00:00:00

  • Differential effects of kinins on cardiomyocyte hypertrophy and interstitial collagen matrix in the surviving myocardium after myocardial infarction in the rat.

    abstract:BACKGROUND:Left ventricular remodeling after myocardial infarction (MI) involves the hypertrophic growth of cardiomyocytes and the accumulation of fibrillar collagen in the interstitial space. We evaluated the role of kinins in postinfarction ventricular remodeling and their potential contribution to the antiremodeling...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.95.7.1910

    authors: Wollert KC,Studer R,Doerfer K,Schieffer E,Holubarsch C,Just H,Drexler H

    更新日期:1997-04-01 00:00:00

  • Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats.

    abstract:BACKGROUND:The renin-angiotensin system (RAS) is a key player in the progression of heart failure. Angiotensin-(1-7) is thought to modulate the activity of the RAS. Furthermore, this peptide may play a part in the beneficial effects of angiotensin-converting enzyme inhibitors in cardiovascular disease. We assessed the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000013847.07035.b9

    authors: Loot AE,Roks AJ,Henning RH,Tio RA,Suurmeijer AJ,Boomsma F,van Gilst WH

    更新日期:2002-04-02 00:00:00

  • Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study.

    abstract:BACKGROUND:Previous reports have suggested that an attenuated exercise heart rate response may be associated with coronary heart disease risk and with mortality. These observations may parallel the association between reduced heart rate variability during normal activities and adverse outcome. This investigation was de...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/01.cir.93.8.1520

    authors: Lauer MS,Okin PM,Larson MG,Evans JC,Levy D

    更新日期:1996-04-15 00:00:00

  • Endothelial function in healthy 11-year-old children after dietary intervention with onset in infancy: the Special Turku Coronary Risk Factor Intervention Project for children (STRIP).

    abstract:BACKGROUND:Early childhood introduction of nutritional habits aimed at atherosclerosis prevention reduces children's serum total cholesterol concentration, but its effect on vascular endothelial function is unknown. METHODS AND RESULTS:Between 1990 and 1992, we randomized healthy 7-month-old infants (n=1062) to interv...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.105.583195

    authors: Raitakari OT,Rönnemaa T,Järvisalo MJ,Kaitosaari T,Volanen I,Kallio K,Lagström H,Jokinen E,Niinikoski H,Viikari JS,Simell O

    更新日期:2005-12-13 00:00:00

  • Intracardiac, intravascular, two-dimensional, high-frequency ultrasound imaging of pulmonary artery and its branches in humans and animals.

    abstract::Intravascular ultrasound imaging is a promising new method for assessing vascular morphology. We evaluated the capability of intravascular ultrasound to quantify pulmonary artery (PA) morphology in vitro and explored the feasibility of in vivo PA imaging in animals and humans. In the in vitro study of 15 PA segments, ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.6.2007

    authors: Pandian NG,Weintraub A,Kreis A,Schwartz SL,Konstam MA,Salem DN

    更新日期:1990-06-01 00:00:00

  • Fibroblast growth factor receptor-1 signaling induces osteopontin expression and vascular smooth muscle cell-dependent adventitial fibroblast migration in vitro.

    abstract:BACKGROUND:Increased expression of osteopontin (OPN), fibroblast growth factors (FGFs), and their type-1 receptor (FGFR-1) is associated with neointima formation and atherosclerosis. This study tested the hypothesis that ligand activation of FGFR-1 stimulates OPN expression in rat aortic smooth muscle cells (RASMCs), e...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000024113.26985.cc

    authors: Li G,Oparil S,Kelpke SS,Chen YF,Thompson JA

    更新日期:2002-08-13 00:00:00

  • Association of heart rate variability with occupational and environmental exposure to particulate air pollution.

    abstract:BACKGROUND:Airborne particulate matter has been linked to excess morbidity and mortality. Recent attention has focused on the effects of particulate exposure on cardiac autonomic control. Inhaled particulates may affect the autonomic nervous system either directly, by eliciting a sympathetic stress response, or indirec...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/hc3401.095038

    authors: Magari SR,Hauser R,Schwartz J,Williams PL,Smith TJ,Christiani DC

    更新日期:2001-08-28 00:00:00

  • Psychosocial modulators of angina response to myocardial ischemia.

    abstract:BACKGROUND:Although angina is often caused by atherosclerotic obstruction of the coronary arteries, patients with similar amounts of myocardial ischemia may vary widely in their symptoms. We sought to compare clinical and psychosocial characteristics associated with more frequent angina after adjusting for the amount o...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.108.806034

    authors: Arnold SV,Spertus JA,Ciechanowski PS,Soine LA,Jordan-Keith K,Caldwell JH,Sullivan MD

    更新日期:2009-07-14 00:00:00

  • Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts.

    abstract:BACKGROUND:Xenografts ultimately fail as a result of acute vascular rejection (AVR), a process characterized by intravascular thrombosis, fibrin deposition, and endothelial cell activation. METHODS AND RESULTS:We studied whether targeted deletion of Fgl-2, an inducible endothelial cell procoagulant, (Fgl-2-/-) in the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.534271

    authors: Mendicino M,Liu M,Ghanekar A,He W,Koscik C,Shalev I,Javadi M,Turnbull J,Chen W,Fung L,Sakamoto S,Marsden P,Waddell TK,Phillips MJ,Gorczynski R,Levy GA,Grant D

    更新日期:2005-07-12 00:00:00

  • Multifactorial actions of beta-adrenergic blocking drugs in ischemic heart disease: current concepts.

    abstract::It is generally agreed that the conditions leading to myocardial ischemia occur when the oxygen demands of the myocardium exceed the oxygen supply. The major limitations of oxygen supply to the myocardium are atherogenic disease and vasospasm of the coronary arteries. The major hemodynamic determinants of myocardial o...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Frishman WH

    更新日期:1983-06-01 00:00:00

  • Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis.

    abstract:BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000146787.16297.E8

    authors: Fleiner M,Kummer M,Mirlacher M,Sauter G,Cathomas G,Krapf R,Biedermann BC

    更新日期:2004-11-02 00:00:00

  • Vasodilatory effects of C-type natriuretic peptide on forearm resistance vessels are distinct from those of atrial natriuretic peptide in chronic heart failure.

    abstract:BACKGROUND:C-type natriuretic peptide (CNP) is a newly identified peptide that is structurally related to atrial natriuretic peptide (ANP). Although it has been suggested that CNP is released from the endothelium for the regulation of local vascular tone, no data are available concerning the vasodilatory response to CN...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.90.3.1210

    authors: Nakamura M,Arakawa N,Yoshida H,Makita S,Hiramori K

    更新日期:1994-09-01 00:00:00

  • The tricuspid valve: current perspective and evolving management of tricuspid regurgitation.

    abstract::Cardiovascular specialists have entered an era of renewed interest and enthusiasm surrounding the diagnosis and treatment of valvular heart disease, driven in part by emerging percutaneous therapies for the treatment of aortic, pulmonic, and mitral valve disease. Despite this wave of investigation, little or no attent...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.108.842773

    authors: Rogers JH,Bolling SF

    更新日期:2009-05-26 00:00:00

  • Thallium-201 myocardial scintigraphy in patients with triple-vessel disease and ischemic exercise stress tests.

    abstract::Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.59.4.714

    authors: Leppo J,Yipintsoi T,Blankstein R,Bontemps R,Freeman LM,Zohman L,Scheuer J

    更新日期:1979-04-01 00:00:00

  • Implantable left ventricular assist device. Approaching an alternative for end-stage heart failure. Implantable LVAD Study Group.

    abstract:BACKGROUND:The implantable left ventricular assist device (LVAD) was designed to provide circulatory support as an alternative to heart transplantation or to continued medical therapy of end-stage heart failure. Initial experience with the implantable LVAD used as a bridge to heart transplantation provides a clinical o...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: McCarthy PM,James KB,Savage RM,Vargo R,Kendall K,Harasaki H,Hobbs RE,Pashkow FJ

    更新日期:1994-11-01 00:00:00

  • Nonselective versus selective beta-adrenergic receptor blockade in congestive heart failure: differential effects on sympathetic activity.

    abstract:BACKGROUND:Activation of the sympathetic nervous system has important prognostic implications in chronic heart failure. Nonselective versus selective beta-adrenergic receptor antagonists may have differential effects on norepinephrine release from nerve terminals mediated by prejunctional beta(2)-adrenergic receptors. ...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/hc4301.098282

    authors: Azevedo ER,Kubo T,Mak S,Al-Hesayen A,Schofield A,Allan R,Kelly S,Newton GE,Floras JS,Parker JD

    更新日期:2001-10-30 00:00:00

  • Distinct downregulation of C-type natriuretic peptide system in human aortic valve stenosis.

    abstract:BACKGROUND:Aortic valve calcification is an actively regulated process that displays hallmarks of atherosclerosis. Natriuretic peptides (A-, B-, and C-type natriuretic peptides [ANP, BNP, and CNP]) have been reported to have a role in the pathogenesis of vascular atherosclerosis, but their expression in aortic valves i...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.685743

    authors: Peltonen TO,Taskinen P,Soini Y,Rysä J,Ronkainen J,Ohtonen P,Satta J,Juvonen T,Ruskoaho H,Leskinen H

    更新日期:2007-09-11 00:00:00

  • Correlation of the width of the QRS complex with the pathologic anatomy of the cardiac conduction system in patients with chronic complete atrioventricular block.

    abstract::A study correlating the electrocardiographic findings and the histology of the atrioventricular (AV) conduction system was carried out in 14 cases with chronic complete AV block and in 13 cases without chronic complete AV block. Patients with chronic complete AV block were divided into two groups, based on the width o...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.63.4.938

    authors: Ohkawa S,Hackel DB,Ideker RE

    更新日期:1981-04-01 00:00:00

  • Reappraisal of Reported Genes for Sudden Arrhythmic Death: Evidence-Based Evaluation of Gene Validity for Brugada Syndrome.

    abstract:BACKGROUND:Implicit in the genetic evaluation of patients with suspected genetic diseases is the assumption that the genes evaluated are causative for the disease based on robust scientific and statistical evidence. However, in the past 20 years, considerable variability has existed in the study design and quality of e...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.035070

    authors: Hosseini SM,Kim R,Udupa S,Costain G,Jobling R,Liston E,Jamal SM,Szybowska M,Morel CF,Bowdin S,Garcia J,Care M,Sturm AC,Novelli V,Ackerman MJ,Ware JS,Hershberger RE,Wilde AAM,Gollob MH,National Institutes of Health C

    更新日期:2018-09-18 00:00:00

  • Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention,

    abstract::Although for most children the process of atherosclerosis is subclinical, dramatically accelerated atherosclerosis occurs in some pediatric disease states, with clinical coronary events occurring in childhood and very early adult life. As with most scientific statements about children and the future risk for cardiovas...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.106.179568

    authors: Kavey RE,Allada V,Daniels SR,Hayman LL,McCrindle BW,Newburger JW,Parekh RS,Steinberger J,American Heart Association Expert Panel on Population and Prevention Science.,American Heart Association Council on Cardiovascular Disease in the

    更新日期:2006-12-12 00:00:00

  • High-frequency jet ventilation for respiratory failure after congenital heart surgery.

    abstract:BACKGROUND:Extracorporeal membrane oxygenation (ECMO) is considered when respiratory failure (RF) persists despite increasing conventional mechanical ventilation (CMV). High-frequency jet ventilation (HFJV) can improve ventilation with comparable mean airway pressure (PAW) to that found on CMV. This study was undertake...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Kocis KC,Meliones JN,Dekeon MK,Callow LB,Lupinetti FM,Bove EL

    更新日期:1992-11-01 00:00:00

  • The lesser circulation in patients with systemic hypertension.

    abstract::The elevated blood pressure and vascular resistance in patients with systemic hypertension are paralleled by a proportional rise in pressure and resistance in the lesser circulation. We evaluated the hypothesis that the increased systemic reaction to adrenergic stimulation is shared by the pulmonary vessels. For this ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Guazzi MD,De Cesare N,Fiorentini C,Galli C,Moruzzi P,Tamborini G

    更新日期:1987-01-01 00:00:00