Fibrocellular tissue response after percutaneous transluminal coronary angioplasty. An immunocytochemical analysis of the cellular composition.

Abstract:

BACKGROUND:Restenosis after initial, successful percutaneous transluminal coronary angioplasty (PTCA) is due to fibrocellular proliferation. METHODS AND RESULTS:The present study focused on the nature of fibrocellular tissue in humans by use of immunocytochemical techniques. Four hearts (five coronary arteries) were investigated; time lapse between PTCA and death varied between 20 days (two arteries) and 1 year 7 months. Proliferating cells stained positive with smooth muscle cell-specific monoclonal antibodies. Cells from early proliferative lesions (20 days) have a phenotypic expression different from cells in "old" lesions. Proliferating cells stained positive with vimentin but were negative with desmin, irrespective of the lesion's age. CONCLUSIONS:The findings indicate a change in actin isoform expression of smooth muscle cells while adapting to a pathological state.

journal_name

Circulation

journal_title

Circulation

authors

Ueda M,Becker AE,Tsukada T,Numano F,Fujimoto T

doi

10.1161/01.cir.83.4.1327

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

1327-32

issue

4

eissn

0009-7322

issn

1524-4539

journal_volume

83

pub_type

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