Abstract:
BACKGROUND:Restenosis after initial, successful percutaneous transluminal coronary angioplasty (PTCA) is due to fibrocellular proliferation. METHODS AND RESULTS:The present study focused on the nature of fibrocellular tissue in humans by use of immunocytochemical techniques. Four hearts (five coronary arteries) were investigated; time lapse between PTCA and death varied between 20 days (two arteries) and 1 year 7 months. Proliferating cells stained positive with smooth muscle cell-specific monoclonal antibodies. Cells from early proliferative lesions (20 days) have a phenotypic expression different from cells in "old" lesions. Proliferating cells stained positive with vimentin but were negative with desmin, irrespective of the lesion's age. CONCLUSIONS:The findings indicate a change in actin isoform expression of smooth muscle cells while adapting to a pathological state.
journal_name
Circulationjournal_title
Circulationauthors
Ueda M,Becker AE,Tsukada T,Numano F,Fujimoto Tdoi
10.1161/01.cir.83.4.1327subject
Has Abstractpub_date
1991-04-01 00:00:00pages
1327-32issue
4eissn
0009-7322issn
1524-4539journal_volume
83pub_type
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