Transplantation of nanoparticle transfected skeletal myoblasts overexpressing vascular endothelial growth factor-165 for cardiac repair.

abstract：:It has been suggested that the beneficial effects of reperfusing ischemic myocardium might be in part reversed by the occurrence of "reperfusion injury." One possible mechanism could be the generation of oxygen free radicals. Superoxide dismutase enzymatically scavenges superoxide radicals by dismutation to hydrogen p...

journal_title：Circulation

authors： Ambrosio G,Weisfeldt ML,Jacobus WE,Flaherty JT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Both thallium imaging and low-dose dobutamine echocardiography have been proposed to predict the reversibility of left ventricular (LV) dysfunction in patients with coronary disease. The present study was designed to evaluate whether the use of these techniques during the preoperative assessment of coronary ...

journal_title：Circulation

authors： Vanoverschelde JL,Gerber BL,D'Hondt AM,De Kock M,Dion R,Wijns W,Melin JA

更新日期：1995-11-01 00:00:00

abstract：:Recent reports of selected observational studies and a meta-analysis have stirred controversy and have become the impetus for calls to abandon recommendations for reduced sodium intake by the US general population. A detailed review of these studies documents substantial methodological concerns that limit the usefulne...

journal_title：Circulation

authors： Whelton PK,Appel LJ,Sacco RL,Anderson CA,Antman EM,Campbell N,Dunbar SB,Frohlich ED,Hall JE,Jessup M,Labarthe DR,MacGregor GA,Sacks FM,Stamler J,Vafiadis DK,Van Horn LV

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is an ischemic wound that recruits millions of leukocytes. MI-associated blood leukocytosis correlates inversely with patient survival, yet the signals driving heightened leukocyte production after MI remain incompletely understood. METHODS AND RESULTS:With the use of parabiosis s...

journal_title：Circulation

authors： Sager HB,Heidt T,Hulsmans M,Dutta P,Courties G,Sebas M,Wojtkiewicz GR,Tricot B,Iwamoto Y,Sun Y,Weissleder R,Libby P,Swirski FK,Nahrendorf M

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Guidelines have proposed that atrial fibrillation (AF) can occur as an isolated event, particularly when precipitated by a secondary, or reversible, condition. However, knowledge of long-term AF outcomes after diagnosis during a secondary precipitant is limited. METHODS AND RESULTS:In 1409 Framingham Heart ...

journal_title：Circulation

authors： Lubitz SA,Yin X,Rienstra M,Schnabel RB,Walkey AJ,Magnani JW,Rahman F,McManus DD,Tadros TM,Levy D,Vasan RS,Larson MG,Ellinor PT,Benjamin EJ

更新日期：2015-05-12 00:00:00

abstract：BACKGROUND:Thioredoxin 2 (Trx2) is a key mitochondrial protein that regulates cellular redox and survival by suppressing mitochondrial reactive oxygen species generation and by inhibiting apoptosis stress kinase-1 (ASK1)-dependent apoptotic signaling. To date, the role of the mitochondrial Trx2 system in heart failure ...

journal_title：Circulation

authors： Huang Q,Zhou HJ,Zhang H,Huang Y,Hinojosa-Kirschenbaum F,Fan P,Yao L,Belardinelli L,Tellides G,Giordano FJ,Budas GR,Min W

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:Several methods have been developed to improve the efficacy of mechanical resuscitation, because organ perfusion achieved with conventional manual resuscitation is often insufficient. In animal studies, phased chest and abdominal compression-decompression resuscitation by use of the Lifestick device has resu...

journal_title：Circulation

authors： Arntz HR,Agrawal R,Richter H,Schmidt S,Rescheleit T,Menges M,Burbach H,Schröder J,Schultheiss HP

更新日期：2001-08-14 00:00:00

abstract：:A patient is described in whom a large congenital aneurysm or diverticulum of the right atrium caused repeated attacks of supraventricular arrhythmia and a strikingly reduced cardiac output. The aneurysm, which contained a large thrombus, was demonstrated by preoperative angiographic examinations. At the time of opera...

journal_title：Circulation

authors： Morrow AG,Behrendt DM

更新日期：1968-07-01 00:00:00

abstract：BACKGROUND:Joint National Committee goal blood pressure for all adults was <140/<90 mm Hg or lower from 1984 to 2013. Adults aged ≥60 years (older) have mainly isolated systolic hypertension, with major trials attaining systolic blood pressure <150 but not <140 mm Hg. The main objective was to assess changes in hyperte...

journal_title：Circulation

authors： Egan BM,Li J,Shatat IF,Fuller JM,Sinopoli A

更新日期：2014-05-20 00:00:00

abstract：BACKGROUND:Diabetes is an independent risk factor for the development of neointimal hyperplasia and subsequent vein graft failure after coronary or peripheral artery bypass grafting. We evaluate a new mouse model of surgical vein grafting to investigate the mechanisms of neointimal formation in the setting of type 2 di...

journal_title：Circulation

authors： Salzberg SP,Filsoufi F,Anyanwu A,von Harbou K,Karlof E,Carpentier A,Dansky HM,Adams DH

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:We determined the intraclass correlation coefficients (ICC) of repeated measures of the mean levels and variability of RR and muscle sympathetic nerve activity (MSNA) in 7 normal subjects. We examined whether spontaneous fluctuations in RR and MSNA over repeated measurements were mirrored by changes in spect...

journal_title：Circulation

authors： van de Borne P,Montano N,Zimmerman B,Pagani M,Somers VK

更新日期：1997-12-16 00:00:00

abstract：BACKGROUND:We have reported that there is a limitation of exercise capacity in mice with defects in the expression of endothelial nitric oxide (NO) synthase, which is associated with a greater increase in whole-body oxygen consumption (VO2). We hypothesized that in states in which superoxide anion (O2-) is increased, e...

journal_title：Circulation

authors： Kinugawa S,Wang Z,Kaminski PM,Wolin MS,Edwards JG,Kaley G,Hintze TH

更新日期：2005-03-29 00:00:00

abstract：:Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for patients who have had a cardiac arrest. As a result, the number of people surviving sudden cardiac arrest is increasing. However, physical, cognitive, and emotiona...

journal_title：Circulation

authors： Sawyer KN,Camp-Rogers TR,Kotini-Shah P,Del Rios M,Gossip MR,Moitra VK,Haywood KL,Dougherty CM,Lubitz SA,Rabinstein AA,Rittenberger JC,Callaway CW,Abella BS,Geocadin RG,Kurz MC,American Heart Association Emergency Cardiovasc

更新日期：2020-03-24 00:00:00

abstract：:BACKGROUND-Catecholamine-induced apoptosis is mediated by activation of the beta-adrenergic signaling pathway. We tested the hypothesis that beta(1)- and beta(2)-adrenergic receptor (AR) subtypes differentially affect apoptosis in adult rat ventricular myocytes in vitro. METHODS AND RESULTS-Myocytes were first exposed...

journal_title：Circulation

authors： Zaugg M,Xu W,Lucchinetti E,Shafiq SA,Jamali NZ,Siddiqui MA

更新日期：2000-07-18 00:00:00

abstract：BACKGROUND:Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipose-specific plasma protein, accumulated to the injured artery and attenuated vascular inflammatory response. Clinically, high plasma adiponect...

journal_title：Circulation

authors： Kumada M,Kihara S,Ouchi N,Kobayashi H,Okamoto Y,Ohashi K,Maeda K,Nagaretani H,Kishida K,Maeda N,Nagasawa A,Funahashi T,Matsuzawa Y

更新日期：2004-05-04 00:00:00

abstract：BACKGROUND:Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated. METHODS AND RESULTS:We studied the role of MIF on neointima lesion formation after ...

journal_title：Circulation

authors： Schober A,Bernhagen J,Thiele M,Zeiffer U,Knarren S,Roller M,Bucala R,Weber C

更新日期：2004-01-27 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) after cardiac surgery is associated with increased risk of complications, length of stay, and cost of care. Observational evidence suggests that patients who have undergone previous statin therapy have a lower incidence of postoperative AF. We tested this observation in a randomized,...

journal_title：Circulation

authors： Patti G,Chello M,Candura D,Pasceri V,D'Ambrosio A,Covino E,Di Sciascio G

更新日期：2006-10-03 00:00:00

abstract：BACKGROUND:An inverse association between moderate alcohol consumption and coronary heart disease (CHD) has been observed in several epidemiological studies. To assess whether a similar association exists among diabetics, we examined the relation between light to moderate alcohol consumption and CHD in men with and wit...

journal_title：Circulation

authors： Ajani UA,Gaziano JM,Lotufo PA,Liu S,Hennekens CH,Buring JE,Manson JE

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of midpregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later-life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in ...

journal_title：Circulation

authors： Benschop L,Schalekamp-Timmermans S,Broere-Brown ZA,Roeters van Lennep JE,Jaddoe VWV,Roos-Hesselink JW,Ikram MK,Steegers EAP,Roberts JM,Gandley RE

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Abnormalities in HDL and an increased risk of coronary artery disease (CAD) coexist in non-insulin-dependent diabetes mellitus (NIDDM). HDLs can be separated by their apolipoprotein (apo) content into particles containing apoA-I but not apoA-II (LpA-I) and those containing both apoA-I and apoA-II (LpA-I:A-II...

journal_title：Circulation

authors： Syvänne M,Kahri J,Virtanen KS,Taskinen MR

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Up to 50% of patients fail to meet ST-segment-elevation myocardial infarction (STEMI) guideline goals recommending a first medical contact-to-device time of <90 minutes for patients directly presenting to percutaneous coronary intervention-capable hospitals and <120 minutes for transferred patients. We sough...

journal_title：Circulation

authors： Jollis JG,Al-Khalidi HR,Roettig ML,Berger PB,Corbett CC,Dauerman HL,Fordyce CB,Fox K,Garvey JL,Gregory T,Henry TD,Rokos IC,Sherwood MW,Suter RE,Wilson BH,Granger CB,Mission: Lifeline STEMI Systems Accelerator Project.

更新日期：2016-08-02 00:00:00

abstract：BACKGROUND:Collaterals limit infarct size, preserve viability, and reduce mortality in patients with acute myocardial infarction. In patients with stable coronary disease, collaterals are associated with less angina and ischemia during angioplasty and fewer ischemic events during follow-up. The role of collaterals has ...

journal_title：Circulation

authors： Nathoe HM,Buskens E,Jansen EW,Suyker WJ,Stella PR,Lahpor JR,van Boven WJ,van Dijk D,Diephuis JC,Borst C,Moons KG,Grobbee DE,de Jaegere PP

更新日期：2004-09-28 00:00:00

abstract：:Total body surface maps from 15 subjects with left bundle branch block and normal axis (LBBB-NA) and 10 subjects with left bundle branch block and left axis (LBBB-LA) were analyzed and compared with maps from normal subjects. In 19 of the 25 subjects with LBBB, the timing of early upper sternal positivity was similar ...

journal_title：Circulation

authors： Sohi GS,Flowers NC,Horan LG,Sridharan MR,Johnson JC

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:The long-term administration of ACE inhibitors to selected patients with left ventricular dysfunction appears to reduce the incidence of recurrent myocardial infarction (MI) and unstable angina pectoris. The mechanisms responsible for the reduction in ischemic events are unknown, but likely candidates includ...

journal_title：Circulation

authors： Vaughan DE,Rouleau JL,Ridker PM,Arnold JM,Menapace FJ,Pfeffer MA

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Thrombi are known to induce activation of the coagulation system, which may be a mechanism for progression of thrombosis and its recurrence after thrombolysis. This study was designed to characterize the relative role of thrombin and activated factor X (factor Xa) as mediators of procoagulant activity of who...

journal_title：Circulation

authors： Prager NA,Abendschein DR,McKenzie CR,Eisenberg PR

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Mitral leaflet extension (MLE) combined with septal myectomy is a new surgical approach to treat hypertrophic obstructive cardiomyopathy (HOCM) and an enlarged mitral leaflet area. The study presents the long-term clinical results and outcome of this technique. METHODS AND RESULTS:MLE entails grafting a glu...

journal_title：Circulation

authors： van der Lee C,Kofflard MJ,van Herwerden LA,Vletter WB,ten Cate FJ

更新日期：2003-10-28 00:00:00

abstract：BACKGROUND:Whether myocardial reperfusion obtained with thrombolysis or primary angioplasty is associated with a similar recovery of function and with the same risk of hemorrhagic infarction is unknown. We evaluated the effects of mechanical and pharmacological reperfusion (with or without a plasma lytic state) on infa...

journal_title：Circulation

authors： Pislaru SV,Barrios L,Stassen T,Jun L,Pislaru C,Van de Werf F

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Recombinant DNA technologies have facilitated the development of a set of polymorphic DNA markers covering the human genome. General linkage analysis in families predisposed to inherited disease is now feasible. Linkage analysis can help identify a disease gene even when relatively little is known about the ...

journal_title：Circulation

authors： Keating M

更新日期：1992-06-01 00:00:00

abstract：:In seven patients who underwent Fontan procedures but in whom no valves were inserted, dynamics of right heart flow were evaluated with the use of a catheter-tipped velocity transducer, pulsed Doppler echocardiography, and angiocardiography. Right atrial (RA) contraction caused a forward flow to the pulmonary artery (...

journal_title：Circulation

authors： Nakazawa M,Nakanishi T,Okuda H,Satomi G,Nakae S,Imai Y,Takao A

更新日期：1984-02-01 00:00:00

abstract：:The pulmonary perfusion of 25 children who had total surgical correction of tetralogy of Fallot was evaluated by radionuclide perfusion scans. In addition, 18 had 133Xe ventilation studies. Eighteen of the children previously had palliative systemic-pulmonary shunts; 14 had aortic-pulmonary shunts (Waterston or Potts-...

journal_title：Circulation

authors： Alderson PO,Boonvisut S,McKnight RC,Hartman AF Jr

更新日期：1976-02-01 00:00:00