Long-term outcomes of secondary atrial fibrillation in the community: the Framingham Heart Study.


BACKGROUND:Guidelines have proposed that atrial fibrillation (AF) can occur as an isolated event, particularly when precipitated by a secondary, or reversible, condition. However, knowledge of long-term AF outcomes after diagnosis during a secondary precipitant is limited. METHODS AND RESULTS:In 1409 Framingham Heart Study participants with new-onset AF, we examined associations between first-detected AF episodes occurring with and without a secondary precipitant and both long-term AF recurrence and morbidity. We selected secondary precipitants based on guidelines (surgery, infection, acute myocardial infarction, thyrotoxicosis, acute alcohol consumption, acute pericardial disease, pulmonary embolism, or other acute pulmonary disease). Among 439 patients (31%) with AF diagnosed during a secondary precipitant, cardiothoracic surgery (n=131 [30%]), infection (n=102 [23%]), noncardiothoracic surgery (n=87 [20%]), and acute myocardial infarction (n=78 [18%]) were most common. AF recurred in 544 of 846 eligible individuals without permanent AF (5-, 10-, and 15-year recurrences of 42%, 56%, and 62% with versus 59%, 69%, and 71% without secondary precipitants; multivariable-adjusted hazard ratio, 0.65 [95% confidence interval, 0.54-0.78]). Stroke risk (n=209/1262 at risk; hazard ratio, 1.13 [95% confidence interval, 0.82-1.57]) and mortality (n=1098/1409 at risk; hazard ratio, 1.00 [95% confidence interval, 0.87-1.15]) were similar between those with and without secondary precipitants, although heart failure risk was reduced (n=294/1107 at risk; hazard ratio, 0.74 [95% confidence interval, 0.56-0.97]). CONCLUSIONS:AF recurs in most individuals, including those diagnosed with secondary precipitants. Long-term AF-related stroke and mortality risks were similar between individuals with and without secondary AF precipitants. Future studies may determine whether increased arrhythmia surveillance or adherence to general AF management principles in patients with reversible AF precipitants will reduce morbidity.






Lubitz SA,Yin X,Rienstra M,Schnabel RB,Walkey AJ,Magnani JW,Rahman F,McManus DD,Tadros TM,Levy D,Vasan RS,Larson MG,Ellinor PT,Benjamin EJ




Has Abstract


2015-05-12 00:00:00














  • Sympathetic nervous system-dependent vasoconstriction in humans. Evidence for mechanistic role of endogenous purine compounds.

    abstract::Purine compounds modulate sympathetic neurotransmission; this modulation decreases nervous discharge by stimulating presynaptic inhibitory adenosine receptors, an effect antagonized by theophylline, and causes vasoconstriction through the stimulation of postsynaptic ATP receptors. In humans we evaluated the effect of ...


    pub_type: 杂志文章


    authors: Taddei S,Pedrinelli R,Salvetti A

    更新日期:1990-12-01 00:00:00

  • Molecular basis of autosomal dominant hypercholesterolemia: assessment in a large cohort of hypercholesterolemic children.

    abstract:BACKGROUND:Autosomal dominant hypercholesterolemia (ADH) is characterized by elevated low-density lipoprotein cholesterol levels and premature cardiovascular disease. Mutations in the genes encoding for low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin 9 (PCSK9...


    pub_type: 杂志文章


    authors: van der Graaf A,Avis HJ,Kusters DM,Vissers MN,Hutten BA,Defesche JC,Huijgen R,Fouchier SW,Wijburg FA,Kastelein JJ,Wiegman A

    更新日期:2011-03-22 00:00:00

  • Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall.

    abstract:BACKGROUND:-Recent studies have suggested that testosterone has a protective effect in the arterial vascular system. However, little is known about the molecular aspects of the mechanism(s) involved in these processes. The aim of the present study was to investigate the effect of testosterone on neointimal plaque devel...


    pub_type: 杂志文章


    authors: Hanke H,Lenz C,Hess B,Spindler KD,Weidemann W

    更新日期:2001-03-13 00:00:00

  • Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.

    abstract:BACKGROUND:Endothelin (ET)-1 and norepinephrine (NE) are involved in myocardial ischemia/reperfusion injury. We investigated the role of ET-1 in ischemia/reperfusion-induced NE overflow and cardiac dysfunction using a selective ET(A) receptor antagonist (ABT-627), a selective ET(B) receptor antagonist (A-192621), and t...


    pub_type: 杂志文章


    authors: Yamamoto S,Matsumoto N,Kanazawa M,Fujita M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

    更新日期:2005-01-25 00:00:00

  • Direct vasoconstriction and endothelium-dependent vasodilation. Mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries.

    abstract::An endothelium-dependent vasodilator response to acetylcholine has been described recently in patients with coronary artery disease. Those studies determined responses only of large epicardial arteries. Our study was designed to determine the integrated effects of acetylcholine on epicardial diameter, coronary flow, a...


    pub_type: 杂志文章


    authors: Hodgson JM,Marshall JJ

    更新日期:1989-05-01 00:00:00

  • Effects of intensive versus moderate lipid-lowering therapy on myocardial ischemia in older patients with coronary heart disease: results of the Study Assessing Goals in the Elderly (SAGE).

    abstract:BACKGROUND:Clinical trials have demonstrated that, compared with placebo, intensive statin therapy reduces ischemia in patients with acute coronary syndromes and in patients with stable coronary artery disease. However, no studies to date have assessed intensive versus moderate statin therapy in older patients with sta...


    pub_type: 杂志文章,随机对照试验


    authors: Deedwania P,Stone PH,Bairey Merz CN,Cosin-Aguilar J,Koylan N,Luo D,Ouyang P,Piotrowicz R,Schenck-Gustafsson K,Sellier P,Stein JH,Thompson PL,Tzivoni D

    更新日期:2007-02-13 00:00:00

  • Angiographic determination of arterial patency after percutaneous catheterization in infants and small children.

    abstract::Patency of the femoral artery of infants and children who previously had percutaneous arterial catheterization at a weight of less than 25 kg was studied angiographically. During the study period, 118 patients had repeat arterial catheterization. 48 from the opposite leg. Femoral artery occlusion was found in four pat...


    pub_type: 杂志文章


    authors: Hurwitz RA,Franken EA Jr,Girod DA,Smith JA,Smith WL

    更新日期:1977-07-01 00:00:00

  • Effective regurgitant orifice area by the color Doppler flow convergence method for evaluating the severity of chronic aortic regurgitation. An animal study.

    abstract:BACKGROUND:The aim of the present study was to evaluate dynamic changes in aortic regurgitant (AR) orifice area with the use of calibrated electromagnetic (EM) flowmeters and to validate a color Doppler flow convergence (FC) method for evaluating effective AR orifice area and regurgitant volume. METHODS AND RESULTS:In...


    pub_type: 杂志文章


    authors: Shiota T,Jones M,Yamada I,Heinrich RS,Ishii M,Sinclair B,Holcomb S,Yoganathan AP,Sahn DJ

    更新日期:1996-02-01 00:00:00

  • Lipoprotein oxidation and progression of carotid atherosclerosis.

    abstract:BACKGROUND:Epidemiological studies and animal experiments have provided evidence supporting the role of lipid peroxidation in atherogenesis and cardiovascular diseases. Direct evidence linking lipid oxidation to atherosclerotic progression in humans, however, has been lacking. We investigated the association of lipid o...


    pub_type: 杂志文章


    authors: Salonen JT,Nyyssönen K,Salonen R,Porkkala-Sarataho E,Tuomainen TP,Diczfalusy U,Björkhem I

    更新日期:1997-02-18 00:00:00

  • Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts.

    abstract:BACKGROUND:Xenografts ultimately fail as a result of acute vascular rejection (AVR), a process characterized by intravascular thrombosis, fibrin deposition, and endothelial cell activation. METHODS AND RESULTS:We studied whether targeted deletion of Fgl-2, an inducible endothelial cell procoagulant, (Fgl-2-/-) in the ...


    pub_type: 杂志文章


    authors: Mendicino M,Liu M,Ghanekar A,He W,Koscik C,Shalev I,Javadi M,Turnbull J,Chen W,Fung L,Sakamoto S,Marsden P,Waddell TK,Phillips MJ,Gorczynski R,Levy GA,Grant D

    更新日期:2005-07-12 00:00:00

  • Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis.

    abstract:BACKGROUND:Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors. METHODS AND RESULTS:Our results in rat cardiac allografts established alloimmune response as an alternativ...


    pub_type: 杂志文章


    authors: Lemström KB,Krebs R,Nykänen AI,Tikkanen JM,Sihvola RK,Aaltola EM,Häyry PJ,Wood J,Alitalo K,Ylä-Herttuala S,Koskinen PK

    更新日期:2002-05-28 00:00:00

  • Pressor response to saralasin (1-sar-8-ala-angiotensin II) bolus injection in hypertensive patients.

    abstract::A 10 mg bolus of the angiotensin blocker saralasin was injected 113 times in 68 subjects with essential or renovascular hypertension. Ninety percent of injections caused a transient increase in blood pressure, which correlated with plasma renin activity (PRA) (r = -0.54); Mean increase at 2 minutes was 21/13.4 mm Hg (...


    pub_type: 杂志文章


    authors: Waks UA,Maxwell MH,Marks L,Zawada ET,Kaufman JJ

    更新日期:1978-06-01 00:00:00

  • Long-term results of the radial artery used for myocardial revascularization.

    abstract:BACKGROUND:No information is available on the long-term results of radial artery (RA) grafts used as coronary artery bypass conduits. METHODS AND RESULTS:In this report, we describe the long-term (105+/-9 months) angiographic results of a series of 90 consecutive patients in whom the RA was used as a coronary artery b...


    pub_type: 临床试验,杂志文章


    authors: Possati G,Gaudino M,Prati F,Alessandrini F,Trani C,Glieca F,Mazzari MA,Luciani N,Schiavoni G

    更新日期:2003-09-16 00:00:00

  • Cost-effectiveness of aspirin treatment in the primary prevention of cardiovascular disease events in subgroups based on age, gender, and varying cardiovascular risk.

    abstract:BACKGROUND:Aspirin is effective for the primary prevention of cardiovascular events, but it remains unclear for which subgroups of individuals aspirin is beneficial. We assessed the cost-effectiveness of aspirin separately for men and women of different ages with various levels of cardiovascular disease risk. METHODS ...


    pub_type: 杂志文章


    authors: Greving JP,Buskens E,Koffijberg H,Algra A

    更新日期:2008-06-03 00:00:00

  • Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs.

    abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic in vitro and in vivo. It has been hypothesized that VEGF plays a role in myocardial collateral formation; however, the effects of VEGF on collateral flow to ischemic myocardium are unknown. METHODS AND RESUL...


    pub_type: 杂志文章


    authors: Banai S,Jaklitsch MT,Shou M,Lazarous DF,Scheinowitz M,Biro S,Epstein SE,Unger EF

    更新日期:1994-05-01 00:00:00

  • Effects of calcium entry blockade on hypertension-induced left ventricular hypertrophy.

    abstract::Left ventricular hypertrophy (LVH) is a structural adaptation of the heart and is a response to increased hemodynamic and metabolic demands, which are most commonly caused by systemic hypertension. LVH induced by hypertension is associated with reduced myocardial compliance, structural alterations, and changes in coro...


    pub_type: 临床试验,杂志文章,评审


    authors: Frishman WH,Skolnick AE,Strom JA

    更新日期:1989-12-01 00:00:00

  • Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis.

    abstract:BACKGROUND:Increased plasma levels of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) have been identified as predictors of cardiac dysfunction and prognosis in congestive heart failure and ischemic heart disease. In severe sepsis patients, however, no information is available yet about the prognos...


    pub_type: 杂志文章


    authors: Brueckmann M,Huhle G,Lang S,Haase KK,Bertsch T,Weiss C,Kaden JJ,Putensen C,Borggrefe M,Hoffmann U

    更新日期:2005-07-26 00:00:00

  • Anticardiolipin antibodies and recurrent coronary events: a prospective study of 1150 patients. Thrombogenic Factors, and Recurrent Coronary Events Investigators.

    abstract:BACKGROUND:The association of anticardiolipin (aCL) antibodies with coronary artery disease has been shown in several studies but remains controversial. We evaluated the association of aCL and anti-beta(2)-glycoprotein I (abeta(2)GPI) antibodies with the risk of recurrent cardiac events in postinfarction patients. MET...


    pub_type: 杂志文章,多中心研究


    authors: Bili A,Moss AJ,Francis CW,Zareba W,Watelet LF,Sanz I

    更新日期:2000-09-12 00:00:00

  • Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis.

    abstract:BACKGROUND:The formation of prostacyclin (PGI(2)), thromboxane (TX) A(2), and isoprostanes is markedly enhanced in atherosclerosis. We examined the relative contribution of cyclooxygenase (COX)-1 and -2 to the generation of these eicosanoids in patients with atherosclerosis. METHODS AND RESULTS:The study population co...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Belton O,Byrne D,Kearney D,Leahy A,Fitzgerald DJ

    更新日期:2000-08-22 00:00:00

  • Arterial imaging with a new forward-viewing intravascular ultrasound catheter, II. Three-dimensional reconstruction and display of data.

    abstract:BACKGROUND:Current intravascular ultrasound (IVUS) catheters provide transverse imaging at the level of the ultrasound transducer. This limits imaging to large-diameter segments without critical atherosclerotic narrowings. We have developed a prototype 20-MHz forward-viewing IVUS catheter that provides two-dimensional ...


    pub_type: 杂志文章


    authors: Ng KH,Evans JL,Vonesh MJ,Meyers SN,Mills TA,Kane BJ,Aldrich WN,Jang YT,Yock PG,Rold MD

    更新日期:1994-02-01 00:00:00

  • Value of programmed ventricular stimulation after tetralogy of fallot repair: a multicenter study.

    abstract:BACKGROUND:Studies have consistently shown that ventricular tachycardia (VT) and sudden cardiac death (SCD) complicate the long-term outcome after tetralogy of Fallot repair, yet the diagnostic and predictive value of electrophysiological testing in this population is uncertain. METHODS AND RESULTS:A multicenter cohor...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Khairy P,Landzberg MJ,Gatzoulis MA,Lucron H,Lambert J,Marçon F,Alexander ME,Walsh EP

    更新日期:2004-04-27 00:00:00

  • The power of play: Innovations in Getting Active Summit 2011: a science panel proceedings report from the American Heart Association.

    abstract:BACKGROUND:To examine the influence active-play video gaming (also referred to as exergaming, exertainment, and active gaming) might have on improving health-related skills, enhancing self-esteem and self-efficacy, promoting social support, and ultimately motivating positive changes in health behaviors, the American He...




    authors: Lieberman DA,Chamberlin B,Medina E Jr,Franklin BA,Sanner BM,Vafiadis DK,Power of Play: Innovations in Getting Active Summit Planning Committee.

    更新日期:2011-05-31 00:00:00

  • Exercise pulmonary hypertension in asymptomatic degenerative mitral regurgitation.

    abstract:BACKGROUND:Current guidelines recommend mitral valve surgery for asymptomatic patients with severe degenerative mitral regurgitation and preserved left ventricular systolic function when exercise pulmonary hypertension (PHT) is present. However, the determinants of exercise PHT have not been evaluated. The aim of this ...


    pub_type: 杂志文章


    authors: Magne J,Lancellotti P,Piérard LA

    更新日期:2010-07-06 00:00:00

  • Near drowning.

    abstract::Several conditions that contribute to drowning and near drowning must be considered in the treatment of near-drowned victims. Regardless of the cause, mechanical ventilation should begin as soon as possible and closed-chest cardiac massage should be administered when there is any question about the adequacy of cardiac...


    pub_type: 杂志文章


    authors: Modell JH

    更新日期:1986-12-01 00:00:00

  • Optimizing the exercise test for pharmacological investigations.

    abstract::Exercise trials in cardiology are often hindered by inconsistent approaches to exercise testing. These inconsistencies include the choice of exercise protocol, exercise end points, points of analysis, and absence or misuse of gas exchange data. Gas exchange techniques greatly enhance the accuracy with which cardiopulm...


    pub_type: 杂志文章,评审


    authors: Myers J,Froelicher VF

    更新日期:1990-11-01 00:00:00

  • Lower Risk of Heart Failure and Death in Patients Initiated on Sodium-Glucose Cotransporter-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotranspo

    abstract:BACKGROUND:Reduction in cardiovascular death and hospitalization for heart failure (HHF) was recently reported with the sodium-glucose cotransporter-2 inhibitor (SGLT-2i) empagliflozin in patients with type 2 diabetes mellitus who have atherosclerotic cardiovascular disease. We compared HHF and death in patients newly ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kosiborod M,Cavender MA,Fu AZ,Wilding JP,Khunti K,Holl RW,Norhammar A,Birkeland KI,Jørgensen ME,Thuresson M,Arya N,Bodegård J,Hammar N,Fenici P,CVD-REAL Investigators and Study Group*.

    更新日期:2017-07-18 00:00:00

  • Limitations and late complications of third-generation automatic cardioverter-defibrillators.

    abstract:BACKGROUND:This study examines the limitations and complex management problems associated with the use of tiered-therapy, implantable cardioverter-defibrillators (ICDs). METHODS AND RESULTS:The study group comprises the first 154 patients undergoing implantation of tiered-therapy ICDs at our institution. Pulse generat...


    pub_type: 杂志文章


    authors: Nunain SO,Roelke M,Trouton T,Osswald S,Kim YH,Sosa-Suarez G,Brooks DR,McGovern B,Guy M,Torchiana DF

    更新日期:1995-04-15 00:00:00

  • Systolic and diastolic mechanics in stress cardiomyopathy.

    abstract:BACKGROUND:Stress cardiomyopathy (SCM) is a peculiar form of reversible left ventricular dysfunction seen predominantly in women and occurs in response to emotional or physical stress. Because dysfunction in SCM is reversible and that of acute myocardial infarction (MI) is not, we hypothesized that these fundamental me...


    pub_type: 杂志文章


    authors: Medeiros K,O'Connor MJ,Baicu CF,Fitzgibbons TP,Shaw P,Tighe DA,Zile MR,Aurigemma GP

    更新日期:2014-04-22 00:00:00

  • Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association.

    abstract::Transthyretin amyloid cardiomyopathy (ATTR-CM) results in a restrictive cardiomyopathy caused by extracellular deposition of transthyretin, normally involved in the transportation of the hormone thyroxine and retinol-binding protein, in the myocardium. Enthusiasm about ATTR-CM has grown as a result of 3 simultaneous a...


    pub_type: 杂志文章


    authors: Kittleson MM,Maurer MS,Ambardekar AV,Bullock-Palmer RP,Chang PP,Eisen HJ,Nair AP,Nativi-Nicolau J,Ruberg FL,American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology.

    更新日期:2020-07-07 00:00:00

  • Slowing Progression of Cardiovascular Calcification With SNF472 in Patients on Hemodialysis: Results of a Randomized Phase 2b Study.

    abstract:BACKGROUND:The high cardiovascular morbidity and mortality in patients with end-stage kidney disease could be partially caused by extensive cardiovascular calcification. SNF472, intravenous myo-inositol hexaphosphate, selectively inhibits the formation and growth of hydroxyapatite. METHODS:This double-blind, placebo-c...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Raggi P,Bellasi A,Bushinsky D,Bover J,Rodriguez M,Ketteler M,Sinha S,Salcedo C,Gillotti K,Padgett C,Garg R,Gold A,Perelló J,Chertow GM

    更新日期:2020-03-03 00:00:00