Disruption in the temporal sequence of regional ventricular contraction. I. Characteristics and incidence in coronary artery disease.

abstract：:Acute aortic regurgitation was created experimentally in 21 mongrel dogs to examine the relationship of the regurgitant jet to observed echocardiographic findings. The direction of the regurgitant jet was studied by echo contrast injections in the aortic root. Diastolic fluttering of the anterior mitral leaflet (AML) ...

journal_title：Circulation

authors： Nakao S,Tanaka H,Tahara M,Yoshimura H,Sakurai S,Tei C,Kashima T

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Failure to differentiate supraventricular from ventricular arrhythmias is the most frequent cause of inappropriate implantable cardioverter-defibrillator therapies. Although a sudden-onset criterion is available to differentiate sustained monomorphic ventricular tachycardias (SMVTs) and sinus tachycardias (S...

journal_title：Circulation

authors： Arenal A,Almendral J,Villacastin J,Morris R,Castellanos E,Delcan JL

更新日期：1998-08-18 00:00:00

abstract：BACKGROUND:Doxycycline has been shown to effectively inhibit aneurysm formation in animal models of abdominal aortic aneurysm. Although this effect is ascribed to matrix metalloproteinase-9 inhibition, such an effect is unclear in human studies. We reevaluated the effect of doxycycline on aortic wall protease content i...

journal_title：Circulation

authors： Lindeman JH,Abdul-Hussien H,van Bockel JH,Wolterbeek R,Kleemann R

更新日期：2009-04-28 00:00:00

abstract：BACKGROUND:Previous studies suggest that rigid fixation of the mitral annulus with an annuloplasty ring may impair left ventricular (LV) systolic performance. We used load-insensitive indexes of global and regional LV contractile mechanics to test the hypothesis that rigid fixation of the mitral annulus alters LV systo...

journal_title：Circulation

authors： Rayhill SC,Castro LJ,Nizyporuk MA,Ingels NB Jr,Daughters GT,Derby GC,Tye TL,Bolger AF,Miller DC

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Recently, it was shown that intraindividual variation in low-density lipoprotein cholesterol (LDL-C) predicts both cerebrovascular and cardiovascular events. We aimed to examine whether this extends to cognitive function and examined possible pathways using a magnetic resonance imaging substudy. METHODS:We ...

journal_title：Circulation

authors： Smit RA,Trompet S,Sabayan B,le Cessie S,van der Grond J,van Buchem MA,de Craen AJ,Jukema JW

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Ibutilide is an action potential-prolonging antiarrhythmic currently in clinical trials. The drug shares structural similarities with E-4031 and dofetilide, specific blockers of the rapidly activating delayed rectifier K+ current (IKr). However, previous in vitro studies in guinea pig myocytes have indicated...

journal_title：Circulation

authors： Yang T,Snyders DJ,Roden DM

更新日期：1995-03-15 00:00:00

abstract：:Patients with idiopathic hypertrophic subaortic stenosis (IHSS) have supernormal left ventricular systolic function at rest. Septal myotomy/myectomy reduces outflow obstruction and symptoms. However, it has been proposed that operation causes myocardial damage, with consequent reduction in left ventricular function an...

journal_title：Circulation

authors： Borer JS,Bacharach SL,Green MV,Kent KM,Rosing DR,Seides SF,Morrow AG,Epstein SE

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:From animal studies it emerged that nitric oxide is important for the modulation of CO2-mediated cerebral blood flow (CBF chemoregulation) but not for the pressor-dependent mechanism (mechanoregulation). This hypothesis was tested in 18 healthy subjects. METHODS AND RESULTS:Peak velocity (PV), diastolic vel...

journal_title：Circulation

authors： Lavi S,Egbarya R,Lavi R,Jacob G

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:Intravascular ultrasound imaging was performed in 27 patients after coronary balloon angioplasty to quantify the lumen and atheroma cross-sectional areas. METHODS AND RESULTS:A 20-MHz ultrasound catheter was inserted through a 1.6-mm plastic introducer sheath across the dilated area to obtain real-time imag...

journal_title：Circulation

authors： Tobis JM,Mallery J,Mahon D,Lehmann K,Zalesky P,Griffith J,Gessert J,Moriuchi M,McRae M,Dwyer ML

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Cardiac-targeted expression of truncated K(v)4.2 subunit (K(v)4.2N) reduces transient outward current (I(to)) density, prolongs action potentials (APs), and enhances contractility in 3- to 4-week-old transgenic mice. By 13 to 15 weeks of age, these mice develop severely impaired cardiac function and signs of...

journal_title：Circulation

authors： Sah R,Oudit GY,Nguyen TT,Lim HW,Wickenden AD,Wilson GJ,Molkentin JD,Backx PH

更新日期：2002-04-16 00:00:00

abstract：BACKGROUND:Oxidized LDLs (oxLDLs) and matrix metalloproteinases (MMPs) are present in atherosclerotic lesions. OxLDLs activate various signaling pathways potentially involved in atherogenesis. OxLDLs induce smooth muscle cell (SMC) proliferation mediated by the activation of the sphingomyelin/ceramide pathway and tyros...

journal_title：Circulation

authors： Augé N,Maupas-Schwalm F,Elbaz M,Thiers JC,Waysbort A,Itohara S,Krell HW,Salvayre R,Nègre-Salvayre A

更新日期：2004-08-03 00:00:00

abstract：BACKGROUND:Operator-independent isotropic 3D MRI may greatly simplify the assessment of complex morphology in congenital heart disease. We sought to evaluate the reliability of this new approach. METHODS AND RESULTS:In 31 adolescent and adult patients (age, 6 to 42 years; median, 16 years) with congenital heart diseas...

journal_title：Circulation

authors： Sørensen TS,Körperich H,Greil GF,Eichhorn J,Barth P,Meyer H,Pedersen EM,Beerbaum P

更新日期：2004-07-13 00:00:00

abstract：BACKGROUND:The heart contains a variety of morphologically distinct nerve terminals known to influence cardiac function. Little is known about the distribution, morphology, and neurochemistry of these terminals in the human heart. METHODS AND RESULTS:We examined the entire endocardial and epicardial surfaces of infant...

journal_title：Circulation

authors： Marron K,Wharton J,Sheppard MN,Fagan D,Royston D,Kuhn DM,de Leval MR,Whitehead BF,Anderson RH,Polak JM

更新日期：1995-10-15 00:00:00

abstract：:We have monitored ambulant intra-arterial blood pressure with the Oxford system in six subjects with autonomic failure who exhibited postural hypotension. Plotting pooled hourly mean values we have demonstrated a consistent circadian trend in blood pressure that was the inverse of the normal pattern, with the highest ...

journal_title：Circulation

authors： Mann S,Altman DG,Raftery EB,Bannister R

更新日期：1983-09-01 00:00:00

abstract：:The indications for biventricular versus left ventricular mechanical circulatory support as a bridge to cardiac transplantation are not well established. In this study, 27 potential heart transplant candidates who were in imminent risk of dying before donor heart procurement were implanted with Thoratec prosthetic ven...

journal_title：Circulation

authors： Farrar DJ,Hill JD,Gray LA Jr,Galbraith TA,Chow E,Hershon JJ

更新日期：1989-11-01 00:00:00

abstract：:To study the variability of the fraction of CPK released from the infarcted heart which enters the serum (serum entry ratio, or SER) with size and model of infarction, nine dogs underwent homogeneous infarctions (LAD ligation) of varying sizes, and 10 dogs underwent scattered infarctions (left coronary embolization). ...

journal_title：Circulation

authors： Cairns JA,Missirlis E,Fallen EL

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:We investigated whether electrical stimulation (STIM) of efferent vagus nerves may suppress nuclear factor (NF)-kappaB activation and the inflammatory cascade in hemorrhagic (Hem) shock. METHODS AND RESULTS:Rats were subjected to bilateral cervical vagotomy (VGX) or sham surgical procedures. Hem shock was i...

journal_title：Circulation

authors： Guarini S,Altavilla D,Cainazzo MM,Giuliani D,Bigiani A,Marini H,Squadrito G,Minutoli L,Bertolini A,Marini R,Adamo EB,Venuti FS,Squadrito F

更新日期：2003-03-04 00:00:00

abstract：:Eighty-six of 452 patients (19%) with chronic bifascicular block were found to have no clinically apparent associated organic heart disease (OHD) and were defined as having primary conduction disease (PCD). Comparison of patients with PCD and OHD revealed a significantly lower incidence of the following clinical varia...

journal_title：Circulation

authors： Dhingra RC,Wyndham C,Bauernfeind R,Denes P,Wu D,Swiryn S,Rosen KM

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:The relationship between autonomic activation and the mechanisms of paroxysmal atrial fibrillation remains unclear. METHODS AND RESULTS:We implanted a pacemaker and a radio transmitter in 7 dogs (group 1). After baseline recording, we paced the left atrium at 20 Hz for 1 week and then monitored left stellat...

journal_title：Circulation

authors： Tan AY,Zhou S,Ogawa M,Song J,Chu M,Li H,Fishbein MC,Lin SF,Chen LS,Chen PS

更新日期：2008-08-26 00:00:00

abstract：BACKGROUND:Muscle sympathetic nerve activity (MSNA) is increased in patients with obstructive sleep apnea (OSA). We tested the hypothesis that tonic activation of excitatory chemoreceptor afferents contributes to the elevated sympathetic activity in OSA. METHODS AND RESULTS:Using a double-blind, randomized, vehicle-co...

journal_title：Circulation

authors： Narkiewicz K,van de Borne PJ,Montano N,Dyken ME,Phillips BG,Somers VK

更新日期：1998-03-17 00:00:00

abstract：BACKGROUND:Blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) has been used to measure T2* changes in skeletal muscle tissue of healthy volunteers. The BOLD effect is assumed to primarily reflect changes in blood oxygenation at the tissue level. We compared the calf muscle BOLD response of patien...

journal_title：Circulation

authors： Ledermann HP,Schulte AC,Heidecker HG,Aschwanden M,Jäger KA,Scheffler K,Steinbrich W,Bilecen D

更新日期：2006-06-27 00:00:00

abstract：BACKGROUND:Endothelin 1 has been implicated in various human diseases, including atherosclerosis. In this study, we examined the expression and localization of endothelin-converting enzyme-1 (ECE-1), the final key enzyme of endothelin 1 processing, in rat carotid arteries after balloon injury and in human coronary athe...

journal_title：Circulation

authors： Minamino T,Kurihara H,Takahashi M,Shimada K,Maemura K,Oda H,Ishikawa T,Uchiyama T,Tanzawa K,Yazaki Y

更新日期：1997-01-07 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) plasma levels have been associated with short- and long-term occurrence of coronary events. We investigated whether circulating inflammatory cell responsiveness to low-grade stimuli could contribute to the reported association between CRP and coronary events. METHODS AND RESULTS:We ...

journal_title：Circulation

authors： Liuzzo G,Angiolillo DJ,Buffon A,Rizzello V,Colizzi C,Ginnetti F,Biasucci LM,Maseri A

更新日期：2001-05-08 00:00:00

abstract：:A consecutive series of 17 patients surgically treated for asymptomatic coronary artery disease was surveyed for survival, clinical status, and graft patency after a mean follow-up of 75 months. Documented myocardial infarction (MI), 14 transmural and 3 subendocardial, was the major indication for catheterization. All...

journal_title：Circulation

authors： Thurer RL,Lytle BW,Cosgrove DM,Loop FD

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Many patients with implanted cardioverter defibrillators (ICDs) receive adjunctive antiarrhythmic drug therapy, most commonly amiodarone or sotalol. The effects of these drugs on defibrillation energy requirements have not been previously assessed in a randomized controlled trial. METHODS AND RESULTS:The Op...

journal_title：Circulation

authors： Hohnloser SH,Dorian P,Roberts R,Gent M,Israel CW,Fain E,Champagne J,Connolly SJ

更新日期：2006-07-11 00:00:00

abstract：BACKGROUND:Cardiac dyssynchrony in the failing heart worsens global function and efficiency and generates regional loading disparities that may exacerbate stress-response molecular signaling and worsen cell survival. We hypothesized that cardiac resynchronization (CRT) from biventricular stimulation reverses such molec...

journal_title：Circulation

authors： Chakir K,Daya SK,Tunin RS,Helm RH,Byrne MJ,Dimaano VL,Lardo AC,Abraham TP,Tomaselli GF,Kass DA

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:Cardiac tamponade is associated with fatal outcomes for patients with acute type A aortic dissection, and the presence of cardiac tamponade should prompt urgent aortic repair. However, treatment of the patient with critical cardiac tamponade who cannot survive until surgery remains unclear. We analyzed our e...

journal_title：Circulation

authors： Hayashi T,Tsukube T,Yamashita T,Haraguchi T,Matsukawa R,Kozawa S,Ogawa K,Okita Y

更新日期：2012-09-11 00:00:00

abstract：:Three patients developed late pulmonary vein obstruction (PVO) following Mustard's operation for transposition of the great arteries. In all three the absence of PVO had been documented by an earlier postoperative cardiac catheterization. At reoperation shrinkage and kinking of the dacron baffle was evident. After Mus...

journal_title：Circulation

authors： Driscoll DJ,Nihill MR,Vargo TA,Mullins CE,McNamara DG

更新日期：1977-03-01 00:00:00

abstract：:Over a 3 year period we evaluated 23 patients (16 men, seven women) with apical hypertrophic cardiomyopathy by noninvasive and invasive methods. Sixteen patients had chest pain. In 17, results of cardiovascular examination were normal. The electrocardiogram showed precordial inverted T waves in all patients and these ...

journal_title：Circulation

authors： Keren G,Belhassen B,Sherez J,Miller HI,Megidish R,Berenfeld D,Laniado S

更新日期：1985-01-01 00:00:00

abstract：:High frequency notching of the QRS complex is associated with transmural infarction, cardiomyopathies, and ventricular hypertrophy from any cause. The mechanism producing notching is unknown; but the presence of a discrete anatomic lesion is not an essential feature. The hypothesis that notching was produced by activa...

journal_title：Circulation

authors： Vanderark CR,Reynolds EW

更新日期：1975-02-01 00:00:00