Leveraging pragmatic clinical trial design to advance phosphate management in end-stage renal disease.

abstract：PURPOSE OF REVIEW:Despite advances in hemodialysis technology, a stable and well functioning vascular access remains the bane of every hemodialysis patient. It is recognized that vascular access contributes to cardiovascular disease mortality through a number of mechanisms. This review describes the relationship betwee...

journal_title：Current opinion in nephrology and hypertension

authors： MacRae JM

更新日期：2006-11-01 00:00:00

abstract：:There is ample evidence to support the recommendation of renin-angiotensin system blockade therapy as the standard of care for strategies aimed at preserving renal function in chronic renal disease. Nevertheless, despite the well established antihypertensive effects of these drugs, the use of renin-angiotensin system ...

journal_title：Current opinion in nephrology and hypertension

authors： Remuzzi G,Perico N

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin system is not what it was, or for that matter not necessarily where we thought it should be. For example, there is a novel angiotensin I-metabolizing enzyme that generates angiotensin 1-7 rather than angiotensin II. Moreover, we are slowly realizing the importance of local rather...

journal_title：Current opinion in nephrology and hypertension

authors： Fleming I,Kohlstedt K,Busse R

更新日期：2006-01-01 00:00:00

abstract：:Acute ischemic or toxic injury to the kidney induces alterations in the expression of many genes. Some of these molecular responses have been termed 'maladaptive' because they exacerbate the tubular damage induced by the initiating insult. Some maladaptive responses include alterations in the activity of nitric oxide ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieberthal W

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate homeostasis is tightly controlled by the coordinated activity of bone, kidney, intestine, and parathyroid gland. The renal phosphate transporters have emerged as key regulators of both total body phosphate homeostasis and serum phosphate concentration. This review focuses on the latest updat...

journal_title：Current opinion in nephrology and hypertension

authors： Lederer E

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic kidney disease (CKD) is associated with oxidative stress and inflammation which contribute to progression of kidney disease and its numerous complications. Until recently, little attention had been paid to the role of the intestine and its microbial flora in the pathogenesis of CKD-associated ...

journal_title：Current opinion in nephrology and hypertension

authors： Vaziri ND

更新日期：2012-11-01 00:00:00

abstract：:Our basic understanding of sodium mechanisms provides unique insights into epithelial transport processes, and unusual clinical syndromes can arise from mutations of these ion transporters. These genetic disorders affect sodium balance, with both sodium-retaining and sodium-wasting conditions being the consequence. A ...

journal_title：Current opinion in nephrology and hypertension

authors： Warnock DG

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS:Sin...

journal_title：Current opinion in nephrology and hypertension

authors： Rubinstein M,Dvash E

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we will discuss (i) how the recent advancements in digital technology and computational engineering are currently applied to nephropathology in the setting of clinical research, trials, and practice; (ii) the benefits of the new digital environment; (iii) how recognizing its challenges...

journal_title：Current opinion in nephrology and hypertension

authors： Barisoni L,Hodgin JB

更新日期：2017-11-01 00:00:00

abstract：:Several lines of evidence indicate a significant association between insulin and cardiovascular disease. This association might be explained by direct (cardio) vascular effects of insulin. Two hemodynamic actions of insulin are discussed in this review; it induces direct vasodilation in skeletal muscle and stimulation...

journal_title：Current opinion in nephrology and hypertension

authors： Tack CJ,Lenders JW,Goldstein DS,Lutterman JA,Smits P,Thien T

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now a...

journal_title：Current opinion in nephrology and hypertension

authors： Nguyen Dinh Cat A,Jaisser F

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In light of the recent changes to the kidney allocation system (KAS) and the observed increase in the rate of transplantation of the highly sensitized kidney transplant candidate, the evaluation and care of this population is a timely topic. RECENT FINDINGS:In its first year, the new KAS has already ...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar V

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The direct oral anticoagulants (DOACs) have emerged as an effective and safe alternative to vitamin K antagonists (VKAs) for stroke and venous thromboembolism (VTE) prevention. However, patients with chronic kidney disease (CKD) experience an increase in the risk of both thromboembolism and bleeding, ...

journal_title：Current opinion in nephrology and hypertension

authors： Ha JT,Badve SV,Jun M

更新日期：2019-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial nitric oxide synthase (eNOS) and nicotinamide adenine dinucleotide (phosphate) oxidase [NAD(P)H oxidase] are both expressed in tubular epithelial cells within the renal medulla, particularly the thick ascending limb of the loop of Henle (mTALH). Thick ascending limbs contribute to long-ter...

journal_title：Current opinion in nephrology and hypertension

authors： Evans RG,Fitzgerald SM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:To discuss new insights regarding chronic antibody-mediated rejection (CAMR) and its progression to transplant glomerulopathy. We will describe the progression to transplant glomerulopathy from a histologic perspective and provide updates on what is known about its pathophysiology, prognosis, and...

journal_title：Current opinion in nephrology and hypertension

authors： Schinstock CA,Stegall M,Cosio F

更新日期：2014-11-01 00:00:00

abstract：:The target hematocrit to be achieved when treating anemia in hemodialysis patients with erythropoietin is controversial. Current evidence-based recommendations suggest a target hematocrit range of 33% to 36%. Small studies suggest that normalization of hematocrit with erythropoietin may benefit hemodialysis patients i...

journal_title：Current opinion in nephrology and hypertension

authors： Murphy ST,Parfrey PS

更新日期：1999-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Several genetic and acquired abnormalities leading to abnormal activation of the alternative pathway of complement have been identified in patients with atypical hemolytic uremic syndrome (aHUS). The purpose of this review is to shed light on how advances in the understanding of aHUS pathogenesis have...

journal_title：Current opinion in nephrology and hypertension

authors： Noris M,Remuzzi G

更新日期：2013-11-01 00:00:00

abstract：:Tests have become available that not only give an index of iron stores and availability but also provide an integrated assessment of the efficacy of its utilization. This has allowed the revision of previously accepted criteria of iron deficiency as well as the most appropriate strategies for iron administration. By o...

journal_title：Current opinion in nephrology and hypertension

authors： van Zyl-Smit R

更新日期：2000-11-01 00:00:00

abstract：:The cellular and molecular mechanisms whereby hypertension causes vascular and cardiac disease are beginning to be understood. Angiotensin II, perhaps because so many probes to explore its action are available, is emerging as a central pathogenetic factor in the development of both vascular and cardiac hypertrophy. It...

journal_title：Current opinion in nephrology and hypertension

authors： Oliver JA

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been significant progress in our understanding of the structural and functional properties and regulation of the electrogenic sodium bicarbonate cotansporter NBCe1, a membrane transporter that plays a key role in renal acid-base physiology. The NBCe1 variant NBCe1-A mediates basolateral elec...

journal_title：Current opinion in nephrology and hypertension

authors： Kurtz I,Zhu Q

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:With the increasing incidence and prevalence of ESRD in the elderly, we are now transplanting more elderly patients. Although we know from previous reports that transplantation provides increased survival advantage and/or quality of life when compared to being on dialysis, we also know that transplant...

journal_title：Current opinion in nephrology and hypertension

authors： Kodali L,Turner A

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The term 'focal segmental glomerulosclerosis' covers a variety of diseases with different histopathological patterns. There is a need for clues to interpret histological findings in terms of etiology. Studies in transgenic animal models published in recent years have targeted the podocyte with respect...

journal_title：Current opinion in nephrology and hypertension

authors： LeHir M,Kriz W

更新日期：2007-05-01 00:00:00

abstract：:Mesangial cells possess Ca(2+)-activated Cl- channels, Ca(2+)-activated K+ channels, voltage-gated Ca2+ channels, ATP-sensitive K+ channels, and two types of nonselective cation channels. Angiotensin II and arginine vasopressin depolarize the membrane. This membrane depolarization is caused by the activation of Ca(2+)...

journal_title：Current opinion in nephrology and hypertension

authors： Matsunaga H,Yamashita N,Okuda T,Kurokawa K

更新日期：1994-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The prevalence of nephrolithiasis has been on the rise over recent decades. There have also been extensive efforts to identify risk factors for chronic kidney disease (CKD). The purpose of this review is to highlight recent evidence on the association of nephrolithiasis with the development of CKD and...

journal_title：Current opinion in nephrology and hypertension

authors： Keddis MT,Rule AD

更新日期：2013-07-01 00:00:00

abstract：:The signalling mechanisms and biological significance of the angiotensin II type 2 receptor have long been unknown. In recent years, studies, first in cell culture models but now increasingly also in vivo, have shed some light on the molecular events occurring after a stimulation of the receptor with its ligand as wel...

journal_title：Current opinion in nephrology and hypertension

authors： Blume A,Kaschina E,Unger T

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the article is to review studies on bone health and oxalate metabolism/therapeutics in the obese rodent model of Roux-en-Y gastric bypass (RYGB) and examine pathways to decrease procedural morbidity. RECENT FINDINGS:Compared with controls, RYGB rodents have up to 40-fold more fat in their ...

journal_title：Current opinion in nephrology and hypertension

authors： Kwenda EP,Rabley AK,Canales BK

更新日期：2020-07-01 00:00:00

abstract：:Vascular endothelial growth factor is a diffusible endothelial cell-specific mitogen and angiogenic factor that can also increase vascular permeability. The vascular endothelial growth factor receptors are specifically expressed on the cell surface of vascular endothelial cells. Recent studies point to vascular endoth...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrara N,Bunting S

更新日期：1996-01-01 00:00:00

abstract：:Elevated serum uric acid is a frequent finding in patients with kidney disease and cardiovascular disease. Intrarenal ischaemia, induced by hypertension, increased sympathetic nervous system activity, and hyperinsulinaemia have all been implicated in reduced renal clearance of urate. This frequently results in elevate...

journal_title：Current opinion in nephrology and hypertension

authors： Culleton BF

更新日期：2001-05-01 00:00:00

abstract：:Substantial evidence indicates that the adverse effects of hypertension on the kidney depend on the degree to which systemic blood pressure elevations are transmitted to the renal microvasculature. Such blood pressure transmission and consequent susceptibility to hypertensive renal damage is markedly exacerbated in st...

journal_title：Current opinion in nephrology and hypertension

authors： Bidani AK,Griffin KA

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Assessment of fluid status to reach normovolemia in patients with chronic kidney disease (CKD) continues to be a tough task. Besides clinical observation, technological methods have been introduced, yet, the best approach is still uncertain. The present review looks at fluid overload in CKD from three...

journal_title：Current opinion in nephrology and hypertension

authors： de Ruiter A,Bello A,Braam B

更新日期：2020-11-01 00:00:00