Biology of ischemic and toxic renal tubular cell injury: role of nitric oxide and the inflammatory response.

abstract：:The possible association between low-level lead exposure and blood pressure and the causal nature of any such relationship continue to be debated. A recent meta-analysis of the human model data showed that on average a doubling of blood lead was associated with a rise in blood pressure averaging 1 mm Hg systolic and 0...

journal_title：Current opinion in nephrology and hypertension

authors： Staessen JA,Lauwerys RR,Bulpitt CJ,Fagard R,Lijnen P,Roels H,Thijs L,Amery A

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin D has diverse biological actions, and consequently the mechanisms behind how it regulates gene transcription are diverse. Unlike its well described positive effects on gene transcription, little is known about how vitamin D induces transcriptional repression. RECENT FINDINGS:Vitamin D-induced...

journal_title：Current opinion in nephrology and hypertension

authors： Kato S,Kim MS,Yamaoka K,Fujiki R

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron deficiency anaemia (IDA) is common and associated with fatigue, reduced quality of life and poorer clinical outcomes. Treatment with oral iron is often inadequate and international guidelines recommend intravenous (i.v.) iron as the preferred option for the treatment of IDA in certain clinical si...

journal_title：Current opinion in nephrology and hypertension

authors： Kalra PA,Bhandari S

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the study is to review recent studies on the management of acute and chronic hyponatremia. RECENT FINDINGS:In acute symptomatic hyponatremia, bolus infusion of hypertonic saline improves hyponatremia and neurological status more quickly than continuous infusion. In chronic hyponatremia, ne...

journal_title：Current opinion in nephrology and hypertension

authors： Hoorn EJ,Spasovski G

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Nitric oxide is a potent, endogenous vasodilator that regulates systemic blood pressure and renal function, among other functions. The bioactivity of nitric oxide is reduced by superoxide, a major reactive oxygen species. Overproduction of superoxide and other related reactive oxygen species resulting...

journal_title：Current opinion in nephrology and hypertension

authors： Araujo M,Welch WJ

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial nitric oxide synthase (eNOS) and nicotinamide adenine dinucleotide (phosphate) oxidase [NAD(P)H oxidase] are both expressed in tubular epithelial cells within the renal medulla, particularly the thick ascending limb of the loop of Henle (mTALH). Thick ascending limbs contribute to long-ter...

journal_title：Current opinion in nephrology and hypertension

authors： Evans RG,Fitzgerald SM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The review describes studies investigating the role of microRNAs in the signaling pathway of the mineralocorticoid hormone, aldosterone. RECENT FINDINGS:Emerging evidence indicates that aldosterone alters the expression of microRNAs in target tissues thereby modulating the expression of key regulator...

journal_title：Current opinion in nephrology and hypertension

authors： Butterworth MB

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of 'cumulative metabolic stress'. This article discusses mechanisms of AGE formation and reviews published literature on SAF as a biomarker and risk factor across the spec...

journal_title：Current opinion in nephrology and hypertension

authors： Viramontes Hörner D,Taal MW

更新日期：2019-11-01 00:00:00

abstract：:Proteinuria (protein excretion > 300 mg/d) is an independent risk factor for the development of cardiovascular disease and renal failure. The finding of persistent proteinuria in otherwise asymptomatic patients often precedes the development of arterial hypertension and renal failure. When proteinuria is accompanied b...

journal_title：Current opinion in nephrology and hypertension

authors： Ruilope LM,Rodicio JL

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity is becoming recognized as one of the most important risk factors for the development of hypertension. The purpose of the review is to examine the latest evidence linking hypertension to obesity, summarize the benefits of weight reduction and present results of recent clinical trials evaluating...

journal_title：Current opinion in nephrology and hypertension

authors： Chrostowska M,Szczech R,Narkiewicz K

更新日期：2006-09-01 00:00:00

abstract：:Understanding the nature of allorecognition is fundamental to the design of antigen-specific therapies for transplantation. As recently as 10 years ago it was generally believed that recognition of major histocompatibility complex (MHC) molecules by T lymphocytes was direct and represented the "simplest" kind of T-lym...

journal_title：Current opinion in nephrology and hypertension

authors： Krensky AM,Clayberger C

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss how the genetic hypercalciuric stone-forming (GHS) rats, which closely model idiopathic hypercalciuria and stone formation in humans, provide insights into the pathophysiology and consequences of clinical hypercalciuria. RECENT FINDINGS:Hypercalciuria in the GHS rats is due...

journal_title：Current opinion in nephrology and hypertension

authors： Frick KK,Krieger NS,Bushinsky DA

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in understanding of how clinical outcomes for hemodialysis patients may be improved by achieving longer or more frequent treatment times, lower ultrafiltration rates (UFRs), improving nutritional status, and individualizing dialysate composition. This review also d...

journal_title：Current opinion in nephrology and hypertension

authors： Fissell R,Hakim RM

更新日期：2013-11-01 00:00:00

abstract：:There has been an increasing focus on renovascular disease, particularly in renal failure, and on the role of renal angioplasty and stenting. Significant improvements have occurred in non-invasive imaging techniques. This review concentrates on the recent developments in imaging that specifically targets the renal art...

journal_title：Current opinion in nephrology and hypertension

authors： Reidy JF

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular endothelial growth factors (VEGFs) influence renal function through angiogenesis, with VEGF-A being the most potent inducer of vascular formation. In the normal glomerulus, tight homeostatic balance is maintained between the levels of VEGF-A isoforms produced by podocyte cells, and the VEGF r...

journal_title：Current opinion in nephrology and hypertension

authors： Logue OC,McGowan JW,George EM,Bidwell GL 3rd

更新日期：2016-09-01 00:00:00

abstract：:It has been 6 years since the first reports of the use of recombinant human erythropoietin for the treatment of renal anemia appeared in the medical literature. During this period, erythropoietin has become established as a safe and highly effective therapy, and it is currently being evaluated for other nonrenal types...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：1992-12-01 00:00:00

abstract：:Data suggest that ischemic renal disease secondary to atherosclerotic renal artery stenosis is a prevalent health problem. Atherosclerotic renal artery stenosis is a rapidly progressive process that can result in end-stage renal disease. Renal arteriography is the current diagnostic method of choice for the demonstrat...

journal_title：Current opinion in nephrology and hypertension

authors： Breyer JA,Jacobson HR

更新日期：1993-03-01 00:00:00

abstract：:Substantial evidence indicates that the adverse effects of hypertension on the kidney depend on the degree to which systemic blood pressure elevations are transmitted to the renal microvasculature. Such blood pressure transmission and consequent susceptibility to hypertensive renal damage is markedly exacerbated in st...

journal_title：Current opinion in nephrology and hypertension

authors： Bidani AK,Griffin KA

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin superfamily of carrier proteins. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. Here, we review the expression, siderophore-...

journal_title：Current opinion in nephrology and hypertension

authors： Schmidt-Ott KM,Mori K,Kalandadze A,Li JY,Paragas N,Nicholas T,Devarajan P,Barasch J

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Both type 1 and type 2 diabetes are associated with severe complications including diabetic nephropathy. With the rapidly rising number of patients with diabetes worldwide, diabetic nephropathy is becoming one of the most common causes of renal disease. Much research effort is being put into how to id...

journal_title：Current opinion in nephrology and hypertension

authors： Valk EJ,Bruijn JA,Bajema IM

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Potassium channels in the distal nephron are precisely controlled to regulate potassium secretion in accord with physiological demands. In recent years, it has become evident that membrane trafficking processes play a fundamental role. This short review highlights recent developments in elucidating th...

journal_title：Current opinion in nephrology and hypertension

authors： Welling PA

更新日期：2013-09-01 00:00:00

abstract：:Renal tubular cells die by apoptosis as well as necrosis in experimental models of ischemic and toxic acute renal failure as well as in humans with acute tubular necrosis. It is not yet possible, however, to determine the relative contribution of these two forms of cell death to loss of renal tubular cells in acute tu...

journal_title：Current opinion in nephrology and hypertension

authors： Bonegio R,Lieberthal W

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In advanced chronic kidney disease (CKD) patients with progressive uremia, dialysis has traditionally been the dominant treatment paradigm. However, there is increasing interest in conservative and preservative management of kidney function as alternative patient-centered treatment approaches in this ...

journal_title：Current opinion in nephrology and hypertension

authors： Zarantonello D,Rhee CM,Kalantar-Zadeh K,Brunori G

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with chronic kidney disease (CKD) endure compromised health-related quality of life (HRQOL). Although the link between HRQOL and increased mortality in patients with end-stage renal disease (ESRD) is well documented, less is known about the relationship between CKD and HRQOL. This article rev...

journal_title：Current opinion in nephrology and hypertension

authors： Soni RK,Weisbord SD,Unruh ML

更新日期：2010-03-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a recently discovered neurotransmitter that is extensively localized in fibers innervating vascular and endocrine systems. CGRP possesses potent vasorelaxant effects, and a role for this peptide in the regional regulation of blood flow has been suggested. Although pharmacologi...

journal_title：Current opinion in nephrology and hypertension

authors： Villarreal D,Reams G,Freeman R

更新日期：1994-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex ...

journal_title：Current opinion in nephrology and hypertension

authors： Simons M,Hartleben B,Huber TB

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate homeostasis is tightly controlled by the coordinated activity of bone, kidney, intestine, and parathyroid gland. The renal phosphate transporters have emerged as key regulators of both total body phosphate homeostasis and serum phosphate concentration. This review focuses on the latest updat...

journal_title：Current opinion in nephrology and hypertension

authors： Lederer E

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The discovery of the importance of proteins localized to cilia and basal bodies has provided novel insights into the pathogenesis of various human disorders including cystic kidney disease. The physiological role of cilium-generated signaling in most tissues including the kidney has remained elusive, ...

journal_title：Current opinion in nephrology and hypertension

authors： Benzing T,Walz G

更新日期：2006-05-01 00:00:00

abstract：:Growth hormone and a number of polypeptide growth factors exert actions on renal development, growth, and metabolism and on repair processes following renal injury. There is increasing evidence that under selected circumstances, these agents play roles in the pathogenesis of kidney disease and that under others, they ...

journal_title：Current opinion in nephrology and hypertension

authors： O'Shea M,Miller SB,Finkel K,Hammerman MR

更新日期：1993-01-01 00:00:00

abstract：:Heat shock proteins, or stress proteins, are molecular chaperones responsible for protein processing and protection against cellular injury through the prevention of inappropriate peptide interactions. The distribution of individual stress proteins varies between regions of the kidney and within subcellular compartmen...

journal_title：Current opinion in nephrology and hypertension

authors： Van Why SK,Siegel NJ

更新日期：1998-07-01 00:00:00