Modeling hypercalciuria in the genetic hypercalciuric stone-forming rat.

abstract：PURPOSE OF REVIEW:The sodium-hydrogen exchanger isoform-1 (NHE1) functions in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of extracellular sodium and intracellular hydrogen. Recent studies have revealed the structural functions of NHE1 as an anchor for actin filaments and a sca...

journal_title：Current opinion in nephrology and hypertension

authors： Meima ME,Mackley JR,Barber DL

更新日期：2007-07-01 00:00:00

abstract：:Data suggest that ischemic renal disease secondary to atherosclerotic renal artery stenosis is a prevalent health problem. Atherosclerotic renal artery stenosis is a rapidly progressive process that can result in end-stage renal disease. Renal arteriography is the current diagnostic method of choice for the demonstrat...

journal_title：Current opinion in nephrology and hypertension

authors： Breyer JA,Jacobson HR

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. PLA2R and THSD7A antigens were described in 2009 and 2014 using classical immunochemical techniques. In the last 2 years, thanks to the combination of laser microdissection of glomeruli and mass ...

journal_title：Current opinion in nephrology and hypertension

authors： Ronco P,Debiec H

更新日期：2021-01-21 00:00:00

abstract：:Acute hypertension provokes a rapid decrease in proximal tubule salt and water reabsorption that increases the levels of sodium chloride at the macula densa, the error signal to increase arteriolar resistance to autoregulate renal blood flow and glomerular filtration rate, and contributes to pressure natriuresis. The ...

journal_title：Current opinion in nephrology and hypertension

authors： Magyar CE,McDonough AA

更新日期：2000-03-01 00:00:00

abstract：:There has been an increasing focus on renovascular disease, particularly in renal failure, and on the role of renal angioplasty and stenting. Significant improvements have occurred in non-invasive imaging techniques. This review concentrates on the recent developments in imaging that specifically targets the renal art...

journal_title：Current opinion in nephrology and hypertension

authors： Reidy JF

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Incretin mimetics, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as dipeptidyl peptidase-IV (DPP-IV) inhibitors, are used in the treatment of type 2 diabetes mellitus (T2DM). In addition to stimulating insulin secretion from pancreatic β cells,...

journal_title：Current opinion in nephrology and hypertension

authors： Tanaka T,Nangaku M,Nishiyama A

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Hyperphosphatemia remains an important aspect in the management of end-stage renal disease patients. Consequently, there is a need for new, efficient and well-tolerated phosphate binders. In this review, a new phosphate-binding drug, lanthanum carbonate, with an attractive preclinical efficacy profile...

journal_title：Current opinion in nephrology and hypertension

authors： Behets GJ,Verberckmoes SC,D'Haese PC,De Broe ME

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate homeostasis is tightly controlled by the coordinated activity of bone, kidney, intestine, and parathyroid gland. The renal phosphate transporters have emerged as key regulators of both total body phosphate homeostasis and serum phosphate concentration. This review focuses on the latest updat...

journal_title：Current opinion in nephrology and hypertension

authors： Lederer E

更新日期：2014-09-01 00:00:00

abstract：:The precise adaptation of renal sodium excretion to systemic needs is to a large extent achieved by the regulation of sodium re-absorption in the aldosterone-sensitive distal nephron. Transcellular sodium re-absorption by the segment-specific cells of the aldosterone-sensitive distal nephron (often called principal ce...

journal_title：Current opinion in nephrology and hypertension

authors： Verrey F

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The majority of uric acid nephrolithiasis in humans occurs in the absence of frank hyperuricosuria and is primarily a disease of excessively low urinary pH. Uric acid is substantially less soluble than urate salts so in low urine pH urate is protonated, thus favoring precipitation even under what is c...

journal_title：Current opinion in nephrology and hypertension

authors： Moe OW

更新日期：2006-07-01 00:00:00

abstract：:Several lines of evidence indicate a significant association between insulin and cardiovascular disease. This association might be explained by direct (cardio) vascular effects of insulin. Two hemodynamic actions of insulin are discussed in this review; it induces direct vasodilation in skeletal muscle and stimulation...

journal_title：Current opinion in nephrology and hypertension

authors： Tack CJ,Lenders JW,Goldstein DS,Lutterman JA,Smits P,Thien T

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Both cognitive and physical function are commonly impaired in individuals with chronic kidney disease (CKD), resulting in important impacts on their quality of life and overall health. This review summarizes the burden of cognitive and physical impairment in CKD, focusing on recent research that highl...

journal_title：Current opinion in nephrology and hypertension

authors： Weiner DE,Seliger SL

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The nephrology community lacks a unified view of protein sieving through the glomerular capillary wall. The glomerular capillary wall consists of three distinct but closely interacting layers: the fenestrated endothelium, with its glycocalyx; the podocytes, with their interdigitated foot processes and...

journal_title：Current opinion in nephrology and hypertension

authors： Jarad G,Miner JH

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Insulin resistance is a known complication of end-stage renal disease that also appears to be present in earlier stages of chronic kidney disease (CKD). It is a risk factor for cardiovascular disease and an important potential therapeutic target in this population. Measurement of insulin resistance is...

journal_title：Current opinion in nephrology and hypertension

authors： Pham H,Utzschneider KM,de Boer IH

更新日期：2011-11-01 00:00:00

abstract：:Magnesium is an important, predominantly intracellular cation that is required for a wide variety of cellular processes. The mammalian kidney plays a key role in whole-body magnesium homeostasis, but the molecular and cellular mechanisms that underlie renal epithelial magnesium reabsorption are poorly understood. Trad...

journal_title：Current opinion in nephrology and hypertension

authors： Yu AS

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Adverse events due to drug-drug interactions remain a challenge in the postsurgical care of transplant recipients. A combination of potent and selective immunosuppressive drugs, which have a narrow therapeutic index, with medications for the treatment of comorbidities such as dyslipidemia, infection, ...

journal_title：Current opinion in nephrology and hypertension

authors： Manitpisitkul W,McCann E,Lee S,Weir MR

更新日期：2009-09-01 00:00:00

abstract：:Tests have become available that not only give an index of iron stores and availability but also provide an integrated assessment of the efficacy of its utilization. This has allowed the revision of previously accepted criteria of iron deficiency as well as the most appropriate strategies for iron administration. By o...

journal_title：Current opinion in nephrology and hypertension

authors： van Zyl-Smit R

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The calcium-sensing receptor gene (CaSR, chr. 3q13.3-21) is a candidate to explain nephrolithiasis. This review analyzes the potential role of CaSR in lithogenesis according to findings of functional and genetic studies. RECENT FINDINGS:CaSR is a cation receptor located in the tubular cell plasma mem...

journal_title：Current opinion in nephrology and hypertension

authors： Vezzoli G,Terranegra A,Soldati L

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The success of any given kidney transplant is closely tied to the ability to monitor patients and responsively change their medications. Transplant monitoring is still, however, dependent on relatively old technologies: serum creatinine levels, urine output, blood pressure, blood glucose and histopath...

journal_title：Current opinion in nephrology and hypertension

authors： Wishart DS

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This article will review briefly the emerging new concepts in the diagnosis and treatment of myocardial fibrosis in patients with hypertensive heart disease. RECENT FINDINGS:Although hypertensive heart disease is characterized clinically by development of left-ventricular hypertrophy in the absence o...

journal_title：Current opinion in nephrology and hypertension

authors： González A,López B,Díez J

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings on the relationship between congestive heart failure and renal failure are summarized in this review. RECENT FINDINGS:Congestive heart failure is found in about one-quarter of cases of chronic kidney disease. The most common cause of congestive heart failure is ischemic heart disease....

journal_title：Current opinion in nephrology and hypertension

authors： Silverberg D,Wexler D,Blum M,Schwartz D,Iaina A

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Autonomic dysfunction is well recognized in chronic kidney disease. The baroreflex arc is an important component of the autonomic nervous system and influences vasodilatation and heart rate in response to information derived from baroreceptors located in the aorta and common carotid arteries. Appropri...

journal_title：Current opinion in nephrology and hypertension

authors： Chesterton LJ,McIntyre CW

更新日期：2005-11-01 00:00:00

abstract：:The pathogenesis of acute renal failure has been attributed to persistent vasoconstriction and leukocyte-endothelial interactions, resulting in inflammation and compromise of local blood flow to the outer medulla, the loss of tubular epithelial cell polarity with multiple functional sequelae, necrosis or apoptosis of ...

journal_title：Current opinion in nephrology and hypertension

authors： Sheridan AM,Bonventre JV

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss if there will still be a role for the originator ESAs after the already available biosimilars and the approval of HIF stabilizers in the near future. RECENT FINDINGS:Current treatment with erythropoiesis-simulating agents (ESAs) is effective and generally well tolerated, but requires paren...

journal_title：Current opinion in nephrology and hypertension

authors： Locatelli F,Del Vecchio L

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Arterial calcification in chronic kidney disease (CKD) is associated with increased cardiovascular risk. The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins. RECENT FINDINGS:Arterial calcification is similar to ...

journal_title：Current opinion in nephrology and hypertension

authors： London GM,Marchais SJ,Guérin AP,Métivier F

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent trial data have resulted in a reevaluation of the management of anemia in chronic kidney disease, including the use of erythropoiesis-stimulating agents, intravenous iron, and novel pharmaceuticals. In this review, we evaluate the latest research on anemia management in chronic kidney disease. ...

journal_title：Current opinion in nephrology and hypertension

authors： Novak JE,Szczech LA

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate lowering toward the normal range is advocated and widely practiced in patients with end-stage renal disease receiving dialysis. This approach is guided by basic science data and large observational studies that have demonstrated a consistent association between hyperphosphatemia and adverse ...

journal_title：Current opinion in nephrology and hypertension

authors： Wald R,Thorpe KE,Walsh MW

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:With the increasing incidence and prevalence of ESRD in the elderly, we are now transplanting more elderly patients. Although we know from previous reports that transplantation provides increased survival advantage and/or quality of life when compared to being on dialysis, we also know that transplant...

journal_title：Current opinion in nephrology and hypertension

authors： Kodali L,Turner A

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin-aldosterone system is an important modulator of renal salt excretion and arterial pressure. An important body of evidence now supports that angiotensin II (AngII) modulates the function of the renal sodium-chloride cotransporter (NCC), independently of aldosterone. Here we summar...

journal_title：Current opinion in nephrology and hypertension

authors： Castañeda-Bueno M,Gamba G

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The term 'focal segmental glomerulosclerosis' covers a variety of diseases with different histopathological patterns. There is a need for clues to interpret histological findings in terms of etiology. Studies in transgenic animal models published in recent years have targeted the podocyte with respect...

journal_title：Current opinion in nephrology and hypertension

authors： LeHir M,Kriz W

更新日期：2007-05-01 00:00:00