Arteriosclerosis, vascular calcifications and cardiovascular disease in uremia.

abstract：PURPOSE OF REVIEW:Inadequately controlled blood pressure is considered an important risk factor for both chronic kidney disease (CKD) progression and cardiovascular disease progression in CKD patients. Patients with CKD and hypertension are typically followed in primary care practice settings and blood pressure is not ...

journal_title：Current opinion in nephrology and hypertension

authors： St Peter WL,Farley TM,Carter BL

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this mini-review is to highlight some unresolved questions and controversies in the evolving story of apolipoprotein L1 (APOL1) nephropathy. RECENT FINDINGS:We highlight studies that introduce complexity in unraveling the mechanisms whereby APOL1 risk variant alleles cause disease. The...

journal_title：Current opinion in nephrology and hypertension

authors： Kruzel-Davila E,Skorecki K

更新日期：2019-01-01 00:00:00

abstract：:Acute ischemic or toxic injury to the kidney induces alterations in the expression of many genes. Some of these molecular responses have been termed 'maladaptive' because they exacerbate the tubular damage induced by the initiating insult. Some maladaptive responses include alterations in the activity of nitric oxide ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieberthal W

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The majority of uric acid nephrolithiasis in humans occurs in the absence of frank hyperuricosuria and is primarily a disease of excessively low urinary pH. Uric acid is substantially less soluble than urate salts so in low urine pH urate is protonated, thus favoring precipitation even under what is c...

journal_title：Current opinion in nephrology and hypertension

authors： Moe OW

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the recent findings concerning novel Mg transporters as putative interesting players in renal transepithelial Mg transport. RECENT FINDINGS:So far, the best characterized Mg transport proteins are found in prokaryotes and yeast cells. In recent years, phylogenetic analysi...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrè S,Hoenderop JG,Bindels RJ

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in understanding of how clinical outcomes for hemodialysis patients may be improved by achieving longer or more frequent treatment times, lower ultrafiltration rates (UFRs), improving nutritional status, and individualizing dialysate composition. This review also d...

journal_title：Current opinion in nephrology and hypertension

authors： Fissell R,Hakim RM

更新日期：2013-11-01 00:00:00

abstract：:The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor belongs to a newly discovered family of G protein-coupled receptors. Members of this family, which have been isolated from mammals, include the receptors for PTH/PTHrP, calcitonin, secretin, growth hormone-releasing hormone, vasoactive ...

journal_title：Current opinion in nephrology and hypertension

authors： Jüppner H

更新日期：1994-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In advanced chronic kidney disease (CKD) patients with progressive uremia, dialysis has traditionally been the dominant treatment paradigm. However, there is increasing interest in conservative and preservative management of kidney function as alternative patient-centered treatment approaches in this ...

journal_title：Current opinion in nephrology and hypertension

authors： Zarantonello D,Rhee CM,Kalantar-Zadeh K,Brunori G

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In the present review, we aim to describe the state of knowledge concerning antibody-mediated rejection (ABMR) spectrum and diagnosis criteria before analyzing the present and future promising leads regarding ABMR prognosis markers and treatment. RECENT FINDINGS:Recent studies regarding complement-bi...

journal_title：Current opinion in nephrology and hypertension

authors： Gosset C,Lefaucheur C,Glotz D

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension (HTN) and chronic kidney disease (CKD) are significant problems. With recent advances in technologies, biosensors have shown a great potential to provide better home monitoring in hypertension (HTN), medication compliance, diagnostic device for kidney disease, CKD/end-stage renal disease ...

journal_title：Current opinion in nephrology and hypertension

authors： Park SH,Zhang Y,Rogers JA,Gallon L

更新日期：2019-07-01 00:00:00

abstract：:Dopamine is one of the major natriuretic hormone. It acts as an autocrine or paracrine factor to inhibit Na+ transport in several tubular segments. Na+,K(+)-ATPase is an important target protein for dopamine. Studies of the tubular effects of dopamine have provided new information about the coupling of dopamine to int...

journal_title：Current opinion in nephrology and hypertension

authors： Aperia A

更新日期：1994-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Sodium-glucose cotransporter 2 (SGLT2) inhibitors are antihyperglycemic drugs that act by inhibiting renal sodium-glucose cotransport. Here we present new insights into 'off target', or indirect, effects of SGLT2 inhibitors. RECENT FINDINGS:SGLT2 inhibition causes an acute increase in urinary glucose...

journal_title：Current opinion in nephrology and hypertension

authors： Dominguez Rieg JA,Xue J,Rieg T

更新日期：2020-09-01 00:00:00

abstract：:Elevated serum uric acid is a frequent finding in patients with kidney disease and cardiovascular disease. Intrarenal ischaemia, induced by hypertension, increased sympathetic nervous system activity, and hyperinsulinaemia have all been implicated in reduced renal clearance of urate. This frequently results in elevate...

journal_title：Current opinion in nephrology and hypertension

authors： Culleton BF

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The analysis of renal tissue from kidney biopsies by histology, electron microscopy and immunohistology represents the current standards used to establish a specific diagnosis in nephrology. Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal b...

journal_title：Current opinion in nephrology and hypertension

authors： Henger A,Schmid H,Kretzler M

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to emphasize that single gene disorders are an important and sometimes unrecognized cause of progressive chronic kidney disease. We provide an overview of the benefits of making a genetic diagnosis, the currently available genetic testing methods and examples of diseases ...

journal_title：Current opinion in nephrology and hypertension

authors： Armstrong ME,Thomas CP

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:With the increasing incidence and prevalence of ESRD in the elderly, we are now transplanting more elderly patients. Although we know from previous reports that transplantation provides increased survival advantage and/or quality of life when compared to being on dialysis, we also know that transplant...

journal_title：Current opinion in nephrology and hypertension

authors： Kodali L,Turner A

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The discovery of the extracellular calcium-sensing receptor, CasR has broadened our understanding of calcium homeostasis and led to the development of new pharmacological agents, calcimimetics, for treating hyperparathyroidism. In the present review, I discuss the function of CasR as well as provide e...

journal_title：Current opinion in nephrology and hypertension

authors： Quarles LD

更新日期：2003-07-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a recently discovered neurotransmitter that is extensively localized in fibers innervating vascular and endocrine systems. CGRP possesses potent vasorelaxant effects, and a role for this peptide in the regional regulation of blood flow has been suggested. Although pharmacologi...

journal_title：Current opinion in nephrology and hypertension

authors： Villarreal D,Reams G,Freeman R

更新日期：1994-07-01 00:00:00

abstract：:Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieske JC,Toback FG

更新日期：2000-07-01 00:00:00

abstract：:Renal tubular cells die by apoptosis as well as necrosis in experimental models of ischemic and toxic acute renal failure as well as in humans with acute tubular necrosis. It is not yet possible, however, to determine the relative contribution of these two forms of cell death to loss of renal tubular cells in acute tu...

journal_title：Current opinion in nephrology and hypertension

authors： Bonegio R,Lieberthal W

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The discovery of the importance of proteins localized to cilia and basal bodies has provided novel insights into the pathogenesis of various human disorders including cystic kidney disease. The physiological role of cilium-generated signaling in most tissues including the kidney has remained elusive, ...

journal_title：Current opinion in nephrology and hypertension

authors： Benzing T,Walz G

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Although glomerular cell apoptosis may be detrimental in acute and chronic inflammation, it is also a key component of the reparative glomerular remodelling that can follow injury. All glomerular cells are vulnerable to apoptosis although there are often differences in the nature of the initiating sti...

journal_title：Current opinion in nephrology and hypertension

authors： Hughes J,Savill JS

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Adverse events due to drug-drug interactions remain a challenge in the postsurgical care of transplant recipients. A combination of potent and selective immunosuppressive drugs, which have a narrow therapeutic index, with medications for the treatment of comorbidities such as dyslipidemia, infection, ...

journal_title：Current opinion in nephrology and hypertension

authors： Manitpisitkul W,McCann E,Lee S,Weir MR

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Secretion and reabsorption of organic cations in kidney is mediated by polyspecific transporters with broadly overlapping substrate specificity. Knowledge concerning function, transported compounds, clinical impact of mutations in the transporters and drug-drug interactions is rapidly increasing. Rece...

journal_title：Current opinion in nephrology and hypertension

authors： Koepsell H

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Klotho is a transmembrane protein that acts as a co-receptor for fibroblast growth factor 23 (FGF23). Recent investigations have discovered the presence of Klotho in bone-forming osteoblasts and osteocytes. This review summarizes emerging literature on the roles of bone Klotho in mineral and bone meta...

journal_title：Current opinion in nephrology and hypertension

authors： Komaba H,Lanske B

更新日期：2018-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Insulin resistance is a known complication of end-stage renal disease that also appears to be present in earlier stages of chronic kidney disease (CKD). It is a risk factor for cardiovascular disease and an important potential therapeutic target in this population. Measurement of insulin resistance is...

journal_title：Current opinion in nephrology and hypertension

authors： Pham H,Utzschneider KM,de Boer IH

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an up-to-date understanding of how peroxisome proliferator activated receptor γ (PPARγ) exerts its cardioprotective effect in the vasculature through its activation of novel PPARγ target genes in endothelium and vascular smooth muscle. RECENT FINDINGS:In vascular endothelial cell...

journal_title：Current opinion in nephrology and hypertension

authors： Fang S,Sigmund CD

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Cytochrome (CYP) P450 metabolites of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) contribute to the regulation of renal tubular and vascular function. This review highlights the results of the recent genetic studies in humans and rodent models, indic...

journal_title：Current opinion in nephrology and hypertension

authors： Fan F,Muroya Y,Roman RJ

更新日期：2015-01-01 00:00:00

abstract：:The possible association between low-level lead exposure and blood pressure and the causal nature of any such relationship continue to be debated. A recent meta-analysis of the human model data showed that on average a doubling of blood lead was associated with a rise in blood pressure averaging 1 mm Hg systolic and 0...

journal_title：Current opinion in nephrology and hypertension

authors： Staessen JA,Lauwerys RR,Bulpitt CJ,Fagard R,Lijnen P,Roels H,Thijs L,Amery A

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The prevalence of nephrolithiasis has been on the rise over recent decades. There have also been extensive efforts to identify risk factors for chronic kidney disease (CKD). The purpose of this review is to highlight recent evidence on the association of nephrolithiasis with the development of CKD and...

journal_title：Current opinion in nephrology and hypertension

authors： Keddis MT,Rule AD

更新日期：2013-07-01 00:00:00