Insight into renal Mg2+ transporters.

abstract：PURPOSE OF REVIEW:Carboxyl-terminal parathyroid hormone (C-PTH) fragments constitute 80% of circulating PTH. Since the first 34 amino acids of the PTH structure are sufficient to explain PTH classical biological effects on the type I PTH/PTHrP receptor and since C-PTH fragments do not bind to this receptor, they have l...

journal_title：Current opinion in nephrology and hypertension

authors： D'Amour P,Brossard JH

更新日期：2005-07-01 00:00:00

abstract：:Several recently completed or ongoing large-scale clinical trials, including the Modification of Diet in Renal Disease Study, the Diabetes Control and Complications Trial, and the African-American Study of Kidney Disease and Hypertension, have all chosen the renal clearance of sodium 125I-iothalmate to monitor renal d...

journal_title：Current opinion in nephrology and hypertension

authors： Hall PM,Rolin H

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequately controlled blood pressure is considered an important risk factor for both chronic kidney disease (CKD) progression and cardiovascular disease progression in CKD patients. Patients with CKD and hypertension are typically followed in primary care practice settings and blood pressure is not ...

journal_title：Current opinion in nephrology and hypertension

authors： St Peter WL,Farley TM,Carter BL

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Klotho is a transmembrane protein that acts as a co-receptor for fibroblast growth factor 23 (FGF23). Recent investigations have discovered the presence of Klotho in bone-forming osteoblasts and osteocytes. This review summarizes emerging literature on the roles of bone Klotho in mineral and bone meta...

journal_title：Current opinion in nephrology and hypertension

authors： Komaba H,Lanske B

更新日期：2018-07-01 00:00:00

abstract：:The signalling mechanisms and biological significance of the angiotensin II type 2 receptor have long been unknown. In recent years, studies, first in cell culture models but now increasingly also in vivo, have shed some light on the molecular events occurring after a stimulation of the receptor with its ligand as wel...

journal_title：Current opinion in nephrology and hypertension

authors： Blume A,Kaschina E,Unger T

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings on the relationship between congestive heart failure and renal failure are summarized in this review. RECENT FINDINGS:Congestive heart failure is found in about one-quarter of cases of chronic kidney disease. The most common cause of congestive heart failure is ischemic heart disease....

journal_title：Current opinion in nephrology and hypertension

authors： Silverberg D,Wexler D,Blum M,Schwartz D,Iaina A

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS:Sin...

journal_title：Current opinion in nephrology and hypertension

authors： Rubinstein M,Dvash E

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Fibrosis is an important biomarker of chronic kidney injury, and a powerful predictor of renal outcome. Currently, the only method for measuring fibrotic burden is histologic analysis, which requires a kidney biopsy in humans, or kidney removal in animal models. These requirements have not only hinder...

journal_title：Current opinion in nephrology and hypertension

authors： Hysi E,Yuen DA

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute kidney injury (AKI) is a serious problem. Understanding an individual patient's risk profile may offer opportunities for prevention or early intervention. The aim of this review is to describe novel nontraditional risk factors. RECENT FINDINGS:The risk of AKI is determined by patient factors an...

journal_title：Current opinion in nephrology and hypertension

authors： Varrier M,Ostermann M

更新日期：2014-11-01 00:00:00

abstract：:Because long-term results of kidney transplantation are still unsatisfactory, efforts are needed to improve them, particularly through the allocation of well-matched kidneys to recipients. In the past 7 years, the United Network of Organ Sharing 6-antigen match program has established that superior results can be obta...

journal_title：Current opinion in nephrology and hypertension

authors： Terasaki PI,Gjertson DW,Cecka JM,Takemoto S

更新日期：1994-11-01 00:00:00

abstract：:The present review considers the role that bisphosphonates might have in patients with renal failure. Although bisphosphonates are widely used to reduce fracture risk in patients with osteoporosis, few studies have documented their effect in patients with renal osteodystrophy. The pathogenesis of bone loss after renal...

journal_title：Current opinion in nephrology and hypertension

authors： Fan SL,Cunningham J

更新日期：2001-09-01 00:00:00

abstract：:Overexpression of the cytokine transforming growth factor-beta has been identified as the key mediator of chronic progressive kidney fibrosis in experimental and human kidney diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have recently been linked to downregulation of transformin...

journal_title：Current opinion in nephrology and hypertension

authors： Peters H,Noble NA,Border WA

更新日期：1997-07-01 00:00:00

abstract：:The target hematocrit to be achieved when treating anemia in hemodialysis patients with erythropoietin is controversial. Current evidence-based recommendations suggest a target hematocrit range of 33% to 36%. Small studies suggest that normalization of hematocrit with erythropoietin may benefit hemodialysis patients i...

journal_title：Current opinion in nephrology and hypertension

authors： Murphy ST,Parfrey PS

更新日期：1999-09-01 00:00:00

abstract：:The L-arginine: nitric oxide pathway is widely recognized as an important regulator of cell function and communication in a variety of physiological and pathophysiological situations. Recent advances in the biochemistry and molecular biology of nitric oxide synthases have contributed significantly to our understanding...

journal_title：Current opinion in nephrology and hypertension

authors： Palmer RM

更新日期：1993-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Structural biology is one of the most informative disciplines available to biochemical research. It unites technologies that can reveal high-resolution (often atomic) details of the inner workings of biochemical systems. These insights are crucial for an understanding of basic life processes, such as ...

journal_title：Current opinion in nephrology and hypertension

authors： Machius M

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity, which has reached epidemic prevalence, is now recognized as an independent risk factor for increasing blood pressure. The complex mechanisms of obesity-related hypertension are unclear, but several studies have provided evidence of a hypertensive shift in pressure natriuresis. Excess sympathe...

journal_title：Current opinion in nephrology and hypertension

authors： Coatmellec-Taglioni G,Ribière C

更新日期：2003-05-01 00:00:00

abstract：:The cells of the renal medulla osmotically adapt to chronic alterations in extracellular tonicity by appropriate changes in the intracellular contents of organic osmoeffectors. The major organic osmolytes are glycerophosphorylcholine, betaine, myo-inositol, sorbitol, and, possibly, taurine. When the concentrations of ...

journal_title：Current opinion in nephrology and hypertension

authors： Beck FX,Schmolke M,Guder WG

更新日期：1992-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex ...

journal_title：Current opinion in nephrology and hypertension

authors： Simons M,Hartleben B,Huber TB

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Epithelial sodium channels mediate Na+ transport across high resistance, Na+-transporting epithelia. This review describes recent findings that indicate that epithelial sodium channels are activated by the proteolytic release of inhibitory peptides from the alpha and gamma subunits. RECENT FINDINGS:N...

journal_title：Current opinion in nephrology and hypertension

authors： Hughey RP,Carattino MD,Kleyman TR

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:MRI can noninvasively assess the structure and function of the kidney in a single MRI scan session. This review summarizes recent advancements in functional renal MRI techniques, with a particular focus on clinical applications. RECENT FINDINGS:A number of MRI techniques now provide measures of relev...

journal_title：Current opinion in nephrology and hypertension

authors： Mahmoud H,Buchanan C,Francis ST,Selby NM

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Several factors are now known to contribute to the development and progression of nephropathy, particularly in diabetes. In recent times, there has been surge of interest in the role of small noncoding RNA, with several reports focusing on the effects of microRNAs on their target genes that are of rel...

journal_title：Current opinion in nephrology and hypertension

authors： McClelland A,Hagiwara S,Kantharidis P

更新日期：2014-01-01 00:00:00

abstract：:Data suggest that ischemic renal disease secondary to atherosclerotic renal artery stenosis is a prevalent health problem. Atherosclerotic renal artery stenosis is a rapidly progressive process that can result in end-stage renal disease. Renal arteriography is the current diagnostic method of choice for the demonstrat...

journal_title：Current opinion in nephrology and hypertension

authors： Breyer JA,Jacobson HR

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In advanced chronic kidney disease (CKD) patients with progressive uremia, dialysis has traditionally been the dominant treatment paradigm. However, there is increasing interest in conservative and preservative management of kidney function as alternative patient-centered treatment approaches in this ...

journal_title：Current opinion in nephrology and hypertension

authors： Zarantonello D,Rhee CM,Kalantar-Zadeh K,Brunori G

更新日期：2021-01-01 00:00:00

abstract：:The pathogenesis of acute renal failure has been attributed to persistent vasoconstriction and leukocyte-endothelial interactions, resulting in inflammation and compromise of local blood flow to the outer medulla, the loss of tubular epithelial cell polarity with multiple functional sequelae, necrosis or apoptosis of ...

journal_title：Current opinion in nephrology and hypertension

authors： Sheridan AM,Bonventre JV

更新日期：2000-07-01 00:00:00

abstract：:It has been 6 years since the first reports of the use of recombinant human erythropoietin for the treatment of renal anemia appeared in the medical literature. During this period, erythropoietin has become established as a safe and highly effective therapy, and it is currently being evaluated for other nonrenal types...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic kidney disease (CKD) is associated with oxidative stress and inflammation which contribute to progression of kidney disease and its numerous complications. Until recently, little attention had been paid to the role of the intestine and its microbial flora in the pathogenesis of CKD-associated ...

journal_title：Current opinion in nephrology and hypertension

authors： Vaziri ND

更新日期：2012-11-01 00:00:00

abstract：:The cellular and molecular mechanisms whereby hypertension causes vascular and cardiac disease are beginning to be understood. Angiotensin II, perhaps because so many probes to explore its action are available, is emerging as a central pathogenetic factor in the development of both vascular and cardiac hypertrophy. It...

journal_title：Current opinion in nephrology and hypertension

authors： Oliver JA

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:The purpose of this review is to explain the rationale and limitations for use of mineralocorticoid receptor blockers (MRBs) for the treatment of chronic kidney disease (CKD) and its complications. RECENT FINDINGS:Recent studies in animal models of CKD demonstrate that blockade of the mineraloco...

journal_title：Current opinion in nephrology and hypertension

authors： Toto RD

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade post-hoc analyses of clinical trials and observational studies have tended to show that participants treated with thiazide diuretics are at greater risk for newly diagnosed diabetes mellitus than those treated with other medication classes. We review the results of several recent ...

journal_title：Current opinion in nephrology and hypertension

authors： Barzilay JI,Cutler JA,Davis BR

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension is an important risk factor for adverse cardiovascular and renal outcomes particularly in patients with chronic kidney disease. This review compares blood pressure measurements obtained in the clinic with those obtained outside the clinic to predict cardiovascular and renal injury and out...

journal_title：Current opinion in nephrology and hypertension

authors： Agarwal R

更新日期：2006-05-01 00:00:00