Transforming growth factor-beta in human glomerular injury.

abstract：:Recent advances in the genetics of hypertension include studies on localizations of many loci involved in blood pressure regulation in the rat, elucidation of the molecular mechanisms underlying monogenetic forms of hypertension, and studies of candidate genes in primary hypertension. Evidence that the angiotensinogen...

journal_title：Current opinion in nephrology and hypertension

authors： Lathrop GM,Soubrier F

更新日期：1994-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Autoregulation of renal blood flow has traditionally been considered to stabilize glomerular filtration, and thus tubular load, in the face of blood pressure fluctuations. This view arose because of the contribution of tubuloglomerular feedback, which senses distal tubular fluid composition, to regula...

journal_title：Current opinion in nephrology and hypertension

authors： Cupples WA

更新日期：2007-01-01 00:00:00

abstract：:It has been suspected that abnormalities of the L-arginine-nitric oxide pathway could underlie certain forms of hypertension. In this review, we will consider the role of nitric oxide in primary and secondary models of experimental hypertension and discuss potential abnormalities of the L-arginine-nitric oxide pathway...

journal_title：Current opinion in nephrology and hypertension

authors： Arnal JF,Michel JB,Harrison DG

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of 'cumulative metabolic stress'. This article discusses mechanisms of AGE formation and reviews published literature on SAF as a biomarker and risk factor across the spec...

journal_title：Current opinion in nephrology and hypertension

authors： Viramontes Hörner D,Taal MW

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Adverse events due to drug-drug interactions remain a challenge in the postsurgical care of transplant recipients. A combination of potent and selective immunosuppressive drugs, which have a narrow therapeutic index, with medications for the treatment of comorbidities such as dyslipidemia, infection, ...

journal_title：Current opinion in nephrology and hypertension

authors： Manitpisitkul W,McCann E,Lee S,Weir MR

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization. RECENT FINDINGS:Mice that are null for the sodium-phosphate cotransporter (NPT)2a gene (NPT2a(-/...

journal_title：Current opinion in nephrology and hypertension

authors： Prié D,Beck L,Friedlander G,Silve C

更新日期：2004-11-01 00:00:00

abstract：:Vascular endothelial growth factor is a diffusible endothelial cell-specific mitogen and angiogenic factor that can also increase vascular permeability. The vascular endothelial growth factor receptors are specifically expressed on the cell surface of vascular endothelial cells. Recent studies point to vascular endoth...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrara N,Bunting S

更新日期：1996-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In light of the recent changes to the kidney allocation system (KAS) and the observed increase in the rate of transplantation of the highly sensitized kidney transplant candidate, the evaluation and care of this population is a timely topic. RECENT FINDINGS:In its first year, the new KAS has already ...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar V

更新日期：2015-11-01 00:00:00

abstract：:Several recently completed or ongoing large-scale clinical trials, including the Modification of Diet in Renal Disease Study, the Diabetes Control and Complications Trial, and the African-American Study of Kidney Disease and Hypertension, have all chosen the renal clearance of sodium 125I-iothalmate to monitor renal d...

journal_title：Current opinion in nephrology and hypertension

authors： Hall PM,Rolin H

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin D has diverse biological actions, and consequently the mechanisms behind how it regulates gene transcription are diverse. Unlike its well described positive effects on gene transcription, little is known about how vitamin D induces transcriptional repression. RECENT FINDINGS:Vitamin D-induced...

journal_title：Current opinion in nephrology and hypertension

authors： Kato S,Kim MS,Yamaoka K,Fujiki R

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Sirtuins are a family of nicotinamide adenine dinucleotide+-dependent enzymes catalyzing target protein deacetylation to modulate cellular metabolism, response to oxidative stress and inflammation, senescence, autophagy and apoptosis. In this review, we provide an overview of recent studies regarding ...

journal_title：Current opinion in nephrology and hypertension

authors： Wang W,Li J,Cai L

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:There is currently a major debate on the mechanisms of albuminuria, and this review appraises recent studies in this area. RECENT FINDINGS:The traditional view of albuminuria is that it is the result of damage to an essentially impermeable glomerular barrier. However, over the years, critical evidenc...

journal_title：Current opinion in nephrology and hypertension

authors： Comper WD,Russo LM

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Several genetic and acquired abnormalities leading to abnormal activation of the alternative pathway of complement have been identified in patients with atypical hemolytic uremic syndrome (aHUS). The purpose of this review is to shed light on how advances in the understanding of aHUS pathogenesis have...

journal_title：Current opinion in nephrology and hypertension

authors： Noris M,Remuzzi G

更新日期：2013-11-01 00:00:00

abstract：:Recent investigations cast some doubts on the status of insulin resistance as a trigger in hyperinsulinemia-associated hypertension or obesity-related hypertension, or both. Major epidemiological studies have shown that central adiposity is a powerful risk factor for stroke or coronary artery disease when accompanied ...

journal_title：Current opinion in nephrology and hypertension

authors： Reisin E,Messerli FH

更新日期：1995-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the recent findings concerning novel Mg transporters as putative interesting players in renal transepithelial Mg transport. RECENT FINDINGS:So far, the best characterized Mg transport proteins are found in prokaryotes and yeast cells. In recent years, phylogenetic analysi...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrè S,Hoenderop JG,Bindels RJ

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Aldosterone and the mineralocorticoid receptor contribute to resistant hypertension and cardiovascular mortality, and mineralocorticoid receptor antagonists effectively reduce these complications. Their use is limited in certain populations with a higher risk of hyperkalemia or renal dysfunction. This...

journal_title：Current opinion in nephrology and hypertension

authors： Luther JM

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Calcium is an essential ion for the maintenance of normal bone health and physiologic functions. The extracellular and intracellular levels of calcium are maintained through hormonal regulation called homeostasis. Balance, the net intake minus excretion of calcium, is maintained by hormonal regulation...

journal_title：Current opinion in nephrology and hypertension

authors： Moe SM

更新日期：2018-07-01 00:00:00

abstract：:Hypertension in kidney transplant patients is a common complication that affects long-term patient and allograft survival. Although multifactorial in nature, at least two causes can be corrected by surgical or radiologic intervention--stenosis and native kidney-associated hypertension. Unfortunately, the current immun...

journal_title：Current opinion in nephrology and hypertension

authors： Curtis JJ

更新日期：1992-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The pathogenesis and optimal therapy of renal bone disease remains poorly understood in chronic kidney disease (CKD) and dialysis patients. Bone biopsy is thus far the only window into cellular and molecular events in bone. This review will focus on recent insights into the pathophysiology of renal bo...

journal_title：Current opinion in nephrology and hypertension

authors： Christov M,Pereira R,Wesseling-Perry K

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron deficiency is a major contributory cause to the development of anaemia in chronic kidney disease (CKD), and thus, iron replacement therapy plays a critical role in the management of this condition. The two main routes for administering iron are oral and intravenous, and there have been a number o...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：2018-09-01 00:00:00

abstract：:Aldosterone plays a major role in the regulation of renal sodium reabsorption, of extracellular fluid volume and blood pressure. Such specific mineralocorticoid physiological adaptations occur despite the large prevalence of glucocorticoid hormones over aldosterone in the plasma. Indeed both classes of hormones bind w...

journal_title：Current opinion in nephrology and hypertension

authors： Farman N

更新日期：1999-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Cytochrome (CYP) P450 metabolites of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) contribute to the regulation of renal tubular and vascular function. This review highlights the results of the recent genetic studies in humans and rodent models, indic...

journal_title：Current opinion in nephrology and hypertension

authors： Fan F,Muroya Y,Roman RJ

更新日期：2015-01-01 00:00:00

abstract：:Cells in renal medullas are exposed to a high concentration of salt during antidiuresis. They adapt in part by accumulating myo-inositol, glycine betaine, taurine, and other amino acids by transporting them from the interstitial fluid. This transport is osmotically regulated by changes in transcription of the transpor...

journal_title：Current opinion in nephrology and hypertension

authors： Burg MB

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Both cognitive and physical function are commonly impaired in individuals with chronic kidney disease (CKD), resulting in important impacts on their quality of life and overall health. This review summarizes the burden of cognitive and physical impairment in CKD, focusing on recent research that highl...

journal_title：Current opinion in nephrology and hypertension

authors： Weiner DE,Seliger SL

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The sodium-hydrogen exchanger isoform-1 (NHE1) functions in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of extracellular sodium and intracellular hydrogen. Recent studies have revealed the structural functions of NHE1 as an anchor for actin filaments and a sca...

journal_title：Current opinion in nephrology and hypertension

authors： Meima ME,Mackley JR,Barber DL

更新日期：2007-07-01 00:00:00

abstract：:The ability to record sympathetic nerve activity in conscious human subjects using intraneural microelectrodes (microneurography) has proven to be a powerful clinical research tool, which has shed new light on the pathophysiology of important blood pressure problems as exemplified in studies of patients with chronic r...

journal_title：Current opinion in nephrology and hypertension

authors： Hansen J,Victor RG

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an update on the current knowledge regarding the role of the intrarenal rennin-angiotensin system (RAS) in the regulation of glomerular function including glomerular dynamics and filtration rate, glomerular permeability and structural alterations during chronic...

journal_title：Current opinion in nephrology and hypertension

authors： Navar LG

更新日期：2014-01-01 00:00:00

abstract：:Dopamine is one of the major natriuretic hormone. It acts as an autocrine or paracrine factor to inhibit Na+ transport in several tubular segments. Na+,K(+)-ATPase is an important target protein for dopamine. Studies of the tubular effects of dopamine have provided new information about the coupling of dopamine to int...

journal_title：Current opinion in nephrology and hypertension

authors： Aperia A

更新日期：1994-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with chronic kidney disease (CKD) endure compromised health-related quality of life (HRQOL). Although the link between HRQOL and increased mortality in patients with end-stage renal disease (ESRD) is well documented, less is known about the relationship between CKD and HRQOL. This article rev...

journal_title：Current opinion in nephrology and hypertension

authors： Soni RK,Weisbord SD,Unruh ML

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The review describes studies investigating the role of microRNAs in the signaling pathway of the mineralocorticoid hormone, aldosterone. RECENT FINDINGS:Emerging evidence indicates that aldosterone alters the expression of microRNAs in target tissues thereby modulating the expression of key regulator...

journal_title：Current opinion in nephrology and hypertension

authors： Butterworth MB

更新日期：2018-09-01 00:00:00