Managing and preventing atypical hemolytic uremic syndrome recurrence after kidney transplantation.

abstract：PURPOSE OF REVIEW:Glucose 6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. G6PD is the main source of the essential cellular reductant, NADPH. The purpose of this review is to describe the biochemistry of G6PD and NADPH, cellular factors that regulate G6PD, normal physiolog...

journal_title：Current opinion in nephrology and hypertension

authors： Spencer NY,Stanton RC

更新日期：2017-01-01 00:00:00

abstract：:During the past 12 months additional evidence has emerged from several studies, indicating that hepatitis C virus infection is the most important liver disease after renal transplantation. A new, severe and rare entity called fibrosing cholestatic hepatitis can lead to early liver failure, although the most important ...

journal_title：Current opinion in nephrology and hypertension

authors： Morales JM,Campistol JM,Andrés A,Rodicio JL

更新日期：1998-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin superfamily of carrier proteins. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. Here, we review the expression, siderophore-...

journal_title：Current opinion in nephrology and hypertension

authors： Schmidt-Ott KM,Mori K,Kalandadze A,Li JY,Paragas N,Nicholas T,Devarajan P,Barasch J

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Strong epidemiological and pathologic evidence associates NSAIDs with kidney disease, both acute and chronic. Hence, the usage of NSAIDs has decreased in patients with, or at risk for, chronic kidney disease (CKD). Coupled with this has been a rise in use of opioids and other non-NSAID alternatives, w...

journal_title：Current opinion in nephrology and hypertension

authors： Sriperumbuduri S,Hiremath S

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors activated by nutrient molecules and their derivatives. Their role has been increasingly recognized to be important in hypertension, metabolic disorders and cardiovascular disease, including atherosclerosis. Control o...

journal_title：Current opinion in nephrology and hypertension

authors： Duan SZ,Usher MG,Mortensen RM

更新日期：2009-03-01 00:00:00

abstract：:Patient non-compliance with the dialysis treatment prescription has often been overlooked as an important variable that contributes to outcomes in end-stage renal disease. This review discusses evidence from a limited number of researchers that such behavior may be as important as the traditional medical indicators th...

journal_title：Current opinion in nephrology and hypertension

authors： Bander SJ,Walters BA

更新日期：1998-11-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization. RECENT FINDINGS:Mice that are null for the sodium-phosphate cotransporter (NPT)2a gene (NPT2a(-/...

journal_title：Current opinion in nephrology and hypertension

authors： Prié D,Beck L,Friedlander G,Silve C

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The association between dysbiosis and CKD is well established. This review focuses on the current understanding of microbiome, in normal individuals and CKD patients, in order to hypothesize how to correct uremic toxins levels and preserve the renal function and reduce associated comorbidities. Here w...

journal_title：Current opinion in nephrology and hypertension

authors： Caggiano G,Cosola C,Di Leo V,Gesualdo M,Gesualdo L

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity is becoming recognized as one of the most important risk factors for the development of hypertension. The purpose of the review is to examine the latest evidence linking hypertension to obesity, summarize the benefits of weight reduction and present results of recent clinical trials evaluating...

journal_title：Current opinion in nephrology and hypertension

authors： Chrostowska M,Szczech R,Narkiewicz K

更新日期：2006-09-01 00:00:00

abstract：:Because long-term results of kidney transplantation are still unsatisfactory, efforts are needed to improve them, particularly through the allocation of well-matched kidneys to recipients. In the past 7 years, the United Network of Organ Sharing 6-antigen match program has established that superior results can be obta...

journal_title：Current opinion in nephrology and hypertension

authors： Terasaki PI,Gjertson DW,Cecka JM,Takemoto S

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The analysis of renal tissue from kidney biopsies by histology, electron microscopy and immunohistology represents the current standards used to establish a specific diagnosis in nephrology. Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal b...

journal_title：Current opinion in nephrology and hypertension

authors： Henger A,Schmid H,Kretzler M

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:With the aging population of kidney transplant candidates, a history of malignancy is an increasingly prevalent finding. Tumors can constitute a contraindication for transplantation or can lead to a delay of acceptance to the waiting-list. Current waiting time guidelines mainly refer to early data col...

journal_title：Current opinion in nephrology and hypertension

authors： Bojic M,Watschinger C,Reiter T,Watschinger B

更新日期：2020-11-01 00:00:00

abstract：:It has been 6 years since the first reports of the use of recombinant human erythropoietin for the treatment of renal anemia appeared in the medical literature. During this period, erythropoietin has become established as a safe and highly effective therapy, and it is currently being evaluated for other nonrenal types...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：1992-12-01 00:00:00

abstract：:The parathyroid normally has very few cells in mitosis but it retains the potential to proliferate. In-vivo studies in rats have demonstrated that hypocalcaemia and high serum phosphate both lead to an increase in the number of proliferating cells, which is relevant to the increased parathyroid cell proliferation in c...

journal_title：Current opinion in nephrology and hypertension

authors： Silver J,Sela SB,Naveh-Many T

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The term 'focal segmental glomerulosclerosis' covers a variety of diseases with different histopathological patterns. There is a need for clues to interpret histological findings in terms of etiology. Studies in transgenic animal models published in recent years have targeted the podocyte with respect...

journal_title：Current opinion in nephrology and hypertension

authors： LeHir M,Kriz W

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review addresses the recent literature demonstrating important differences in the rate of progression of kidney function decline between transplant recipients and patients with native kidney disease. It also highlights the need for prospective studies to determine the importance of nonimmu...

journal_title：Current opinion in nephrology and hypertension

authors： Woo YM,Pereira BJ,Gill JS

更新日期：2004-11-01 00:00:00

abstract：:Secondary hyperparathyroidism remains the predominant histologic lesion in pediatric patients undergoing regular dialysis, but recent evidence indicates that the regulation of parathyroid hormone secretion by calcium does not differ substantially between patients with osteitis fibrosa and subjects with normal renal fu...

journal_title：Current opinion in nephrology and hypertension

authors： Salusky IB,Ramirez JA,Goodman WG

更新日期：1993-07-01 00:00:00

abstract：:The target hematocrit to be achieved when treating anemia in hemodialysis patients with erythropoietin is controversial. Current evidence-based recommendations suggest a target hematocrit range of 33% to 36%. Small studies suggest that normalization of hematocrit with erythropoietin may benefit hemodialysis patients i...

journal_title：Current opinion in nephrology and hypertension

authors： Murphy ST,Parfrey PS

更新日期：1999-09-01 00:00:00

abstract：:It has been suspected that abnormalities of the L-arginine-nitric oxide pathway could underlie certain forms of hypertension. In this review, we will consider the role of nitric oxide in primary and secondary models of experimental hypertension and discuss potential abnormalities of the L-arginine-nitric oxide pathway...

journal_title：Current opinion in nephrology and hypertension

authors： Arnal JF,Michel JB,Harrison DG

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the latest information on body composition among patients with chronic kidney disease and its association with outcomes. RECENT FINDINGS:Obesity is increasing among patients with end-stage renal disease and is more prevalent when direct measures of adiposity are used rather than BMI. Hig...

journal_title：Current opinion in nephrology and hypertension

authors： Johansen KL,Lee C

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Incretin mimetics, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as dipeptidyl peptidase-IV (DPP-IV) inhibitors, are used in the treatment of type 2 diabetes mellitus (T2DM). In addition to stimulating insulin secretion from pancreatic β cells,...

journal_title：Current opinion in nephrology and hypertension

authors： Tanaka T,Nangaku M,Nishiyama A

更新日期：2011-09-01 00:00:00

abstract：:Magnesium is an important, predominantly intracellular cation that is required for a wide variety of cellular processes. The mammalian kidney plays a key role in whole-body magnesium homeostasis, but the molecular and cellular mechanisms that underlie renal epithelial magnesium reabsorption are poorly understood. Trad...

journal_title：Current opinion in nephrology and hypertension

authors： Yu AS

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Both cognitive and physical function are commonly impaired in individuals with chronic kidney disease (CKD), resulting in important impacts on their quality of life and overall health. This review summarizes the burden of cognitive and physical impairment in CKD, focusing on recent research that highl...

journal_title：Current opinion in nephrology and hypertension

authors： Weiner DE,Seliger SL

更新日期：2014-05-01 00:00:00

abstract：:Ischemic heart disease is the major cause of death in dialysis patients. Efforts at coronary artery disease detection in end-stage renal disease patients have primarily focused on the cardiac evaluation of 'high-risk' renal transplant candidates. Despite their high cardiac risk, no data exist on the results of reperfu...

journal_title：Current opinion in nephrology and hypertension

authors： Herzog CA

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Renal acid-base homeostasis, to a very large extent, depends on renal ammonia production and transport. A putative ammonia transporter family of proteins has recently been identified, and at least two members of this family are expressed in the renal connecting segment and collecting duct. The purpose...

journal_title：Current opinion in nephrology and hypertension

authors： Weiner ID

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article will review briefly the emerging new concepts in the diagnosis and treatment of myocardial fibrosis in patients with hypertensive heart disease. RECENT FINDINGS:Although hypertensive heart disease is characterized clinically by development of left-ventricular hypertrophy in the absence o...

journal_title：Current opinion in nephrology and hypertension

authors： González A,López B,Díez J

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate homeostasis is tightly controlled by the coordinated activity of bone, kidney, intestine, and parathyroid gland. The renal phosphate transporters have emerged as key regulators of both total body phosphate homeostasis and serum phosphate concentration. This review focuses on the latest updat...

journal_title：Current opinion in nephrology and hypertension

authors： Lederer E

更新日期：2014-09-01 00:00:00

abstract：:Increasing evidence implicates reactive oxygen species in the pathogenesis of hypertension and its cardiovascular complications. By altering the balance in the endothelium between vasoconstrictors such as thromboxane and isoprostanes and vasodilators such as nitric oxide, reactive oxygen species contribute to endothel...

journal_title：Current opinion in nephrology and hypertension

authors： Kitiyakara C,Wilcox CS

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Autonomic dysfunction is well recognized in chronic kidney disease. The baroreflex arc is an important component of the autonomic nervous system and influences vasodilatation and heart rate in response to information derived from baroreceptors located in the aorta and common carotid arteries. Appropri...

journal_title：Current opinion in nephrology and hypertension

authors： Chesterton LJ,McIntyre CW

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in hemodialysis technology, a stable and well functioning vascular access remains the bane of every hemodialysis patient. It is recognized that vascular access contributes to cardiovascular disease mortality through a number of mechanisms. This review describes the relationship betwee...

journal_title：Current opinion in nephrology and hypertension

authors： MacRae JM

更新日期：2006-11-01 00:00:00