Regulation of parathyroid cell proliferation.

abstract：PURPOSE OF REVIEW:The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now a...

journal_title：Current opinion in nephrology and hypertension

authors： Nguyen Dinh Cat A,Jaisser F

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the study is to review recent studies on the management of acute and chronic hyponatremia. RECENT FINDINGS:In acute symptomatic hyponatremia, bolus infusion of hypertonic saline improves hyponatremia and neurological status more quickly than continuous infusion. In chronic hyponatremia, ne...

journal_title：Current opinion in nephrology and hypertension

authors： Hoorn EJ,Spasovski G

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the recent findings concerning novel Mg transporters as putative interesting players in renal transepithelial Mg transport. RECENT FINDINGS:So far, the best characterized Mg transport proteins are found in prokaryotes and yeast cells. In recent years, phylogenetic analysi...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrè S,Hoenderop JG,Bindels RJ

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Nox-4 is a member of the NADPH oxidase (Nox) family of enzymes implicated in reactive oxygen species generation. Nox-4 is distributed in many tissues; however, its physiological functions remain poorly understood. In contrast to other Nox isoforms, it is unique in that it produces large amounts of hyd...

journal_title：Current opinion in nephrology and hypertension

authors： Thallas-Bonke V,Jandeleit-Dahm KA,Cooper ME

更新日期：2015-01-01 00:00:00

abstract：:It has been 6 years since the first reports of the use of recombinant human erythropoietin for the treatment of renal anemia appeared in the medical literature. During this period, erythropoietin has become established as a safe and highly effective therapy, and it is currently being evaluated for other nonrenal types...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss if there will still be a role for the originator ESAs after the already available biosimilars and the approval of HIF stabilizers in the near future. RECENT FINDINGS:Current treatment with erythropoiesis-simulating agents (ESAs) is effective and generally well tolerated, but requires paren...

journal_title：Current opinion in nephrology and hypertension

authors： Locatelli F,Del Vecchio L

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Arterial stiffness due to alterations in extracellular matrix is one of the mechanisms responsible for increased peripheral resistance in hypertension. Recent evidence points to arterial stiffness as an independent predictor of cardiovascular events. This review focuses on recent advances in the biolo...

journal_title：Current opinion in nephrology and hypertension

authors： Briones AM,Arribas SM,Salaices M

更新日期：2010-03-01 00:00:00

abstract：:Historically, studies in humans have not shown conclusively that low-protein diets ameloriate the progression of renal disease. However, recent trials have demonstrated that, in patients with advanced renal insufficiency, low-protein diets may slow the loss of renal function and defer the onset of end-stage renal dise...

journal_title：Current opinion in nephrology and hypertension

authors： Klahr S

更新日期：1996-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in patients with calci...

journal_title：Current opinion in nephrology and hypertension

authors： Nigwekar SU

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in understanding of how clinical outcomes for hemodialysis patients may be improved by achieving longer or more frequent treatment times, lower ultrafiltration rates (UFRs), improving nutritional status, and individualizing dialysate composition. This review also d...

journal_title：Current opinion in nephrology and hypertension

authors： Fissell R,Hakim RM

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Adverse events due to drug-drug interactions remain a challenge in the postsurgical care of transplant recipients. A combination of potent and selective immunosuppressive drugs, which have a narrow therapeutic index, with medications for the treatment of comorbidities such as dyslipidemia, infection, ...

journal_title：Current opinion in nephrology and hypertension

authors： Manitpisitkul W,McCann E,Lee S,Weir MR

更新日期：2009-09-01 00:00:00

abstract：:The ability to record sympathetic nerve activity in conscious human subjects using intraneural microelectrodes (microneurography) has proven to be a powerful clinical research tool, which has shed new light on the pathophysiology of important blood pressure problems as exemplified in studies of patients with chronic r...

journal_title：Current opinion in nephrology and hypertension

authors： Hansen J,Victor RG

更新日期：1994-11-01 00:00:00

abstract：:Magnesium is an important, predominantly intracellular cation that is required for a wide variety of cellular processes. The mammalian kidney plays a key role in whole-body magnesium homeostasis, but the molecular and cellular mechanisms that underlie renal epithelial magnesium reabsorption are poorly understood. Trad...

journal_title：Current opinion in nephrology and hypertension

authors： Yu AS

更新日期：2001-09-01 00:00:00

abstract：:Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieske JC,Toback FG

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The gut-kidney axis plays a critical role in oxalate homeostasis, and better understanding of oxalate transport regulatory mechanisms is essential for developing novel therapies. RECENT FINDINGS:Oxalate potentially contributes to chronic kidney disease (CKD) progression, CKD - and end stage renal dis...

journal_title：Current opinion in nephrology and hypertension

authors： Alshaikh AE,Hassan HA

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The review will examine clinically relevant advances in the area of polycystic kidney disease (PKD), mainly focusing on autosomal dominant polycystic kidney disease (ADPKD). Discussion will focus on predicting the course of ADPKD, clinical trials and new research endeavors. RECENT FINDINGS:During the...

journal_title：Current opinion in nephrology and hypertension

authors： Steinman TI

更新日期：2012-03-01 00:00:00

abstract：:Several recently completed or ongoing large-scale clinical trials, including the Modification of Diet in Renal Disease Study, the Diabetes Control and Complications Trial, and the African-American Study of Kidney Disease and Hypertension, have all chosen the renal clearance of sodium 125I-iothalmate to monitor renal d...

journal_title：Current opinion in nephrology and hypertension

authors： Hall PM,Rolin H

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The success of any given kidney transplant is closely tied to the ability to monitor patients and responsively change their medications. Transplant monitoring is still, however, dependent on relatively old technologies: serum creatinine levels, urine output, blood pressure, blood glucose and histopath...

journal_title：Current opinion in nephrology and hypertension

authors： Wishart DS

更新日期：2006-11-01 00:00:00

abstract：:Secondary hyperparathyroidism remains the predominant histologic lesion in pediatric patients undergoing regular dialysis, but recent evidence indicates that the regulation of parathyroid hormone secretion by calcium does not differ substantially between patients with osteitis fibrosa and subjects with normal renal fu...

journal_title：Current opinion in nephrology and hypertension

authors： Salusky IB,Ramirez JA,Goodman WG

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There is increasing evidence that endothelin receptor blockade and, in particular, ET(A) receptor blockade not only confers protection against proteinuric renal disease in diabetes but also confers vasculoprotection. RECENT FINDINGS:Recent clinical trials using ET(A) receptor blockade in treating pro...

journal_title：Current opinion in nephrology and hypertension

authors： Jandeleit-Dahm KA,Watson AM

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The direct oral anticoagulants (DOACs) have emerged as an effective and safe alternative to vitamin K antagonists (VKAs) for stroke and venous thromboembolism (VTE) prevention. However, patients with chronic kidney disease (CKD) experience an increase in the risk of both thromboembolism and bleeding, ...

journal_title：Current opinion in nephrology and hypertension

authors： Ha JT,Badve SV,Jun M

更新日期：2019-05-01 00:00:00

abstract：:There is substantial evidence to suggest that regular physical activity reduces the risk of heart disease. Less clear is the extent to which this is caused by blood pressure reduction. This review considers effects of exercise on blood pressure and overall cardiovascular risk in normotensive and hypertensive individua...

journal_title：Current opinion in nephrology and hypertension

authors： Puddey IB,Beilin LJ

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Glucose 6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. G6PD is the main source of the essential cellular reductant, NADPH. The purpose of this review is to describe the biochemistry of G6PD and NADPH, cellular factors that regulate G6PD, normal physiolog...

journal_title：Current opinion in nephrology and hypertension

authors： Spencer NY,Stanton RC

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial nitric oxide synthase (eNOS) and nicotinamide adenine dinucleotide (phosphate) oxidase [NAD(P)H oxidase] are both expressed in tubular epithelial cells within the renal medulla, particularly the thick ascending limb of the loop of Henle (mTALH). Thick ascending limbs contribute to long-ter...

journal_title：Current opinion in nephrology and hypertension

authors： Evans RG,Fitzgerald SM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In light of the recent changes to the kidney allocation system (KAS) and the observed increase in the rate of transplantation of the highly sensitized kidney transplant candidate, the evaluation and care of this population is a timely topic. RECENT FINDINGS:In its first year, the new KAS has already ...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar V

更新日期：2015-11-01 00:00:00

abstract：:The vasculature wall is an active, integrated organ composed of endothelial cells and vascular smooth muscle cells, as well as other cell types depending on the specific vascular segment (e.g. fibroblasts in many vascular regions). The vascular wall is not static; the vascular components (cells and extracellular matri...

journal_title：Current opinion in nephrology and hypertension

authors： Dubey RK,Jackson EK,Rupprecht HD,Sterzel RB

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin system plays an important role in cardiovascular disease via the production of angiotensin II. Over the past decades, however, more and more evidence has accumulated suggesting an important role for another angiotensin: Angiotensin-(1-7) [Ang-(1-7)]. In this review, we discuss th...

journal_title：Current opinion in nephrology and hypertension

authors： van Twist DJ,Kroon AA,de Leeuw PW

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Cytochrome (CYP) P450 metabolites of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) contribute to the regulation of renal tubular and vascular function. This review highlights the results of the recent genetic studies in humans and rodent models, indic...

journal_title：Current opinion in nephrology and hypertension

authors： Fan F,Muroya Y,Roman RJ

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Development of the mammalian kidney is a complex process involving numerous signals and signaling pathways. Other complex tissues have benefited enormously from studies in lower, simpler organisms. The present review provides an update on what we have learned from the fruitfly Drosophila melanogaster,...

journal_title：Current opinion in nephrology and hypertension

authors： Cagan R

更新日期：2003-01-01 00:00:00

abstract：:Ischemic nephropathy is a major cause of chronic renal failure in people over 50 years of age. In addition, renal artery stenosis is associated with increased mortality, particularly if renal or cardiac function is compromised. The diagnosis is made both by clinical characteristics and imaging studies. At present, dup...

journal_title：Current opinion in nephrology and hypertension

authors： Tuttle KR

更新日期：2001-03-01 00:00:00