Is there still a role for a diet very low in protein, with or without supplements, in the management of patients with end-stage renal failure?

abstract：PURPOSE OF REVIEW:Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in patients with calci...

journal_title：Current opinion in nephrology and hypertension

authors： Nigwekar SU

更新日期：2017-07-01 00:00:00

abstract：:Several lines of evidence indicate a significant association between insulin and cardiovascular disease. This association might be explained by direct (cardio) vascular effects of insulin. Two hemodynamic actions of insulin are discussed in this review; it induces direct vasodilation in skeletal muscle and stimulation...

journal_title：Current opinion in nephrology and hypertension

authors： Tack CJ,Lenders JW,Goldstein DS,Lutterman JA,Smits P,Thien T

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review surveys the literature on the search for the genetic basis of hypertension during the 10 months since November 2003. The goals set forth by this search are defined and the highlights of the work accomplished are provided. RECENT FINDINGS:The search for the genetic basis of hypertension is...

journal_title：Current opinion in nephrology and hypertension

authors： Yagil Y,Yagil C

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the role of restricting dietary sodium intake in chronic kidney disease (CKD) and its complications. RECENT FINDINGS:A consistent line of evidence shows that high dietary sodium intake is a determinant of therapy resistance to blockade of the renin-angiotensin-aldosterone system (RAAS). A...

journal_title：Current opinion in nephrology and hypertension

authors： Krikken JA,Laverman GD,Navis G

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The pathogenesis and optimal therapy of renal bone disease remains poorly understood in chronic kidney disease (CKD) and dialysis patients. Bone biopsy is thus far the only window into cellular and molecular events in bone. This review will focus on recent insights into the pathophysiology of renal bo...

journal_title：Current opinion in nephrology and hypertension

authors： Christov M,Pereira R,Wesseling-Perry K

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Acid-base (H and HCO3) transport in the kidney is crucial for maintaining blood pH, cellular pH and excreting metabolic acid. HCO3 transport in the kidney is mediated by HCO3 transporter proteins which occur in two gene families in humans, vertebrates and invertebrates (SLC4 and SLC26). Since SLC26 tr...

journal_title：Current opinion in nephrology and hypertension

authors： Romero MF

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization. RECENT FINDINGS:Mice that are null for the sodium-phosphate cotransporter (NPT)2a gene (NPT2a(-/...

journal_title：Current opinion in nephrology and hypertension

authors： Prié D,Beck L,Friedlander G,Silve C

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now a...

journal_title：Current opinion in nephrology and hypertension

authors： Nguyen Dinh Cat A,Jaisser F

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:The purpose of this review is to explain the rationale and limitations for use of mineralocorticoid receptor blockers (MRBs) for the treatment of chronic kidney disease (CKD) and its complications. RECENT FINDINGS:Recent studies in animal models of CKD demonstrate that blockade of the mineraloco...

journal_title：Current opinion in nephrology and hypertension

authors： Toto RD

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Mammalian target of rapamycin (mTOR) is an evolutionarily conserved protein kinase. mTOR forms two distinct functional multiprotein kinase complexes that mutually phosphorylate different substrates and regulate a wide array of essential cellular processes including translation, transcription and autop...

journal_title：Current opinion in nephrology and hypertension

authors： Inoki K,Huber TB

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The prevalence of nephrolithiasis has been on the rise over recent decades. There have also been extensive efforts to identify risk factors for chronic kidney disease (CKD). The purpose of this review is to highlight recent evidence on the association of nephrolithiasis with the development of CKD and...

journal_title：Current opinion in nephrology and hypertension

authors： Keddis MT,Rule AD

更新日期：2013-07-01 00:00:00

abstract：:Growth hormone and a number of polypeptide growth factors exert actions on renal development, growth, and metabolism and on repair processes following renal injury. There is increasing evidence that under selected circumstances, these agents play roles in the pathogenesis of kidney disease and that under others, they ...

journal_title：Current opinion in nephrology and hypertension

authors： O'Shea M,Miller SB,Finkel K,Hammerman MR

更新日期：1993-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of 'cumulative metabolic stress'. This article discusses mechanisms of AGE formation and reviews published literature on SAF as a biomarker and risk factor across the spec...

journal_title：Current opinion in nephrology and hypertension

authors： Viramontes Hörner D,Taal MW

更新日期：2019-11-01 00:00:00

abstract：:Recent advances in the genetics of hypertension include studies on localizations of many loci involved in blood pressure regulation in the rat, elucidation of the molecular mechanisms underlying monogenetic forms of hypertension, and studies of candidate genes in primary hypertension. Evidence that the angiotensinogen...

journal_title：Current opinion in nephrology and hypertension

authors： Lathrop GM,Soubrier F

更新日期：1994-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the maturational changes that occur in renal tubules during postnatal development. RECENT FINDINGS:The ability to study transport in neonatal tubules and the use of molecular techniques have allowed studies that not only examine the mechanism of solute and water transport in neon...

journal_title：Current opinion in nephrology and hypertension

authors： Baum M,Quigley R,Satlin L

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Ischemia reperfusion injury (IRI) is an inevitable complication in solid organ transplantation. Limiting this injury can increase patient and graft survival and can decrease complications associated with transplantation. We provide an extensive literature review analyzing the available evidence for is...

journal_title：Current opinion in nephrology and hypertension

authors： Nadarajah L,Yaqoob MM,McCafferty K

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Calcium is an essential ion for the maintenance of normal bone health and physiologic functions. The extracellular and intracellular levels of calcium are maintained through hormonal regulation called homeostasis. Balance, the net intake minus excretion of calcium, is maintained by hormonal regulation...

journal_title：Current opinion in nephrology and hypertension

authors： Moe SM

更新日期：2018-07-01 00:00:00

abstract：:There is ample evidence to support the recommendation of renin-angiotensin system blockade therapy as the standard of care for strategies aimed at preserving renal function in chronic renal disease. Nevertheless, despite the well established antihypertensive effects of these drugs, the use of renin-angiotensin system ...

journal_title：Current opinion in nephrology and hypertension

authors： Remuzzi G,Perico N

更新日期：2002-01-01 00:00:00

abstract：:The complex multifactorial inheritance pattern of systemic lupus erythematosus in various murine models has been dissected via both classic genetic analysis and the use of modern technologies in genomic manipulation. Current information suggests that lupus may be mediated by a multitude of genetic abnormalities that i...

journal_title：Current opinion in nephrology and hypertension

authors： Yim YS,Wakeland EK

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Adverse events due to drug-drug interactions remain a challenge in the postsurgical care of transplant recipients. A combination of potent and selective immunosuppressive drugs, which have a narrow therapeutic index, with medications for the treatment of comorbidities such as dyslipidemia, infection, ...

journal_title：Current opinion in nephrology and hypertension

authors： Manitpisitkul W,McCann E,Lee S,Weir MR

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Renal acid-base homeostasis, to a very large extent, depends on renal ammonia production and transport. A putative ammonia transporter family of proteins has recently been identified, and at least two members of this family are expressed in the renal connecting segment and collecting duct. The purpose...

journal_title：Current opinion in nephrology and hypertension

authors： Weiner ID

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an up-to-date understanding of how peroxisome proliferator activated receptor γ (PPARγ) exerts its cardioprotective effect in the vasculature through its activation of novel PPARγ target genes in endothelium and vascular smooth muscle. RECENT FINDINGS:In vascular endothelial cell...

journal_title：Current opinion in nephrology and hypertension

authors： Fang S,Sigmund CD

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent efforts in identifying with-no-lysine kinase 4 (WNK4) as a physiological intracellular chloride sensor and exploring regulators of intracellular chloride concentration ([Cl-]i) in the distal convoluted tubule (DCT). RECENT FINDINGS:The discovery of WNK1's chloride-bindin...

journal_title：Current opinion in nephrology and hypertension

authors： Chen JC,Lin MX,Cheng CJ

更新日期：2021-03-01 00:00:00

abstract：:There is mounting evidence that elevated serum phosphorus is an important cardiovascular risk factor in patients with end stage renal disease. Recent work has shown that vascular smooth muscle cells have the ability to undergo osteoblastic differentiation and produce an environment conducive to mineralization. Serum p...

journal_title：Current opinion in nephrology and hypertension

authors： Block GA

更新日期：2001-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To characterize the mechanism and clinical impact of the angiotensin-receptor blocker losartan on both renal uric acid handling and thereby serum uric acid. RECENT FINDINGS:Losartan effect on serum uric acid has been demonstrated at various stages of renal failure including most recently observations...

journal_title：Current opinion in nephrology and hypertension

authors： Sica DA,Schoolwerth AC

更新日期：2002-09-01 00:00:00

abstract：:An increasing number of population-based studies and clinical trials have examined the role of blood pressure in renal disease. Recent reports indicate that elevations of blood pressure, even within the normotensive range, may result in renal damage. The available evidence suggests that blood pressure reduction dimini...

journal_title：Current opinion in nephrology and hypertension

authors： Perneger TV,Whelton PK

更新日期：1993-05-01 00:00:00

abstract：PURPOSE OF REVIEW:There is much interest in cystatin C to replace or supplement serum creatinine to estimate the glomerular filtration rate (GFR). Here we review the performance of cystatin C and combined creatinine-cystatin C estimating equations compared to creatinine-based estimating equations in chronic and acute k...

journal_title：Current opinion in nephrology and hypertension

authors： Inker LA,Okparavero A

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been significant progress in our understanding of the structural and functional properties and regulation of the electrogenic sodium bicarbonate cotansporter NBCe1, a membrane transporter that plays a key role in renal acid-base physiology. The NBCe1 variant NBCe1-A mediates basolateral elec...

journal_title：Current opinion in nephrology and hypertension

authors： Kurtz I,Zhu Q

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Due to the organ shortage, which prevents over 90 000 individuals in the United States from receiving life-saving transplants, the transplant community has begun to critically reevaluate whether organ sources that were previously considered too risky provide a survival benefit to waitlist candidates. ...

journal_title：Current opinion in nephrology and hypertension

authors： Ruck JM,Segev DL

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To clarify misconceptions about the feasibility and risks of peritoneal dialysis that unnecessarily limit peritoneal dialysis uptake or continuation in patients for whom peritoneal dialysis is the preferred dialysis modality. The inappropriate choice of haemodialysis as a result of these misconception...

journal_title：Current opinion in nephrology and hypertension

authors： Lee MB,Bargman JM

更新日期：2016-11-01 00:00:00