Cystatin C as a marker of glomerular filtration rate: prospects and limitations.

abstract：:The prevalence of hypertension is extremely high in end-stage renal disease, and is a probable contributor to the epidemic of cardiovascular disease in end-stage renal disease. However, the paucity of prospective, randomized clinical trials makes it difficult to precisely define treatment strategies. Therefore, at pre...

journal_title：Current opinion in nephrology and hypertension

authors： Zager P,Nikolic J,Raj DS,Tzamaloukas A,Campbell M

更新日期：2000-05-01 00:00:00

abstract：:The present review considers the role that bisphosphonates might have in patients with renal failure. Although bisphosphonates are widely used to reduce fracture risk in patients with osteoporosis, few studies have documented their effect in patients with renal osteodystrophy. The pathogenesis of bone loss after renal...

journal_title：Current opinion in nephrology and hypertension

authors： Fan SL,Cunningham J

更新日期：2001-09-01 00:00:00

abstract：:Increasing evidence implicates reactive oxygen species in the pathogenesis of hypertension and its cardiovascular complications. By altering the balance in the endothelium between vasoconstrictors such as thromboxane and isoprostanes and vasodilators such as nitric oxide, reactive oxygen species contribute to endothel...

journal_title：Current opinion in nephrology and hypertension

authors： Kitiyakara C,Wilcox CS

更新日期：1998-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the direct and indirect effects of estrogen on bone with special emphasis on the analysis of the recent findings related to the putative role of FGF23 in the estrogen-dependent parathyroid hormone (PTH) suppression. RECENT FINDINGS:Estrogens act directly on bone cells, downregulating oste...

journal_title：Current opinion in nephrology and hypertension

authors： Cannata-Andía JB,Carrillo-López N,Naves-Díaz M

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex ...

journal_title：Current opinion in nephrology and hypertension

authors： Simons M,Hartleben B,Huber TB

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Tubulointerstitial injury is characteristic of aging-associated renal injury and progressive renal disease. Salt-sensitive hypertension is also associated with tubulointerstitial inflammation, especially when accompanied by microvascular disease. Here we summarize recent studies on the pathogenesis an...

journal_title：Current opinion in nephrology and hypertension

authors： Nakagawa T,Kang DH,Ohashi R,Suga S,Herrera-Acosta J,Rodriguez-Iturbe B,Johnson RJ

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin system, traditionally viewed as a circulatory system, has significantly expanded in the last two decades to include independently regulated local systems in several tissues, newly identified active products of angiotensin II, and new receptors and functions of renin-angiotensin s...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar R,Singh VP,Baker KM

更新日期：2008-03-01 00:00:00

abstract：:Secondary hyperparathyroidism remains the predominant histologic lesion in pediatric patients undergoing regular dialysis, but recent evidence indicates that the regulation of parathyroid hormone secretion by calcium does not differ substantially between patients with osteitis fibrosa and subjects with normal renal fu...

journal_title：Current opinion in nephrology and hypertension

authors： Salusky IB,Ramirez JA,Goodman WG

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of vitamin D beyond its importance for bone health is under much debate. In this article, we review recent evidence for genetic influences on 25-hydroxyvitamin D [25(OH)D] and discuss the uses of this information and its importance for public health. RECENT FINDINGS:Findings from large-scale...

journal_title：Current opinion in nephrology and hypertension

authors： Berry D,Hyppönen E

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Arterial calcification in chronic kidney disease (CKD) is associated with increased cardiovascular risk. The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins. RECENT FINDINGS:Arterial calcification is similar to ...

journal_title：Current opinion in nephrology and hypertension

authors： London GM,Marchais SJ,Guérin AP,Métivier F

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Several factors are now known to contribute to the development and progression of nephropathy, particularly in diabetes. In recent times, there has been surge of interest in the role of small noncoding RNA, with several reports focusing on the effects of microRNAs on their target genes that are of rel...

journal_title：Current opinion in nephrology and hypertension

authors： McClelland A,Hagiwara S,Kantharidis P

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Glucose 6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway. G6PD is the main source of the essential cellular reductant, NADPH. The purpose of this review is to describe the biochemistry of G6PD and NADPH, cellular factors that regulate G6PD, normal physiolog...

journal_title：Current opinion in nephrology and hypertension

authors： Spencer NY,Stanton RC

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The analysis of renal tissue from kidney biopsies by histology, electron microscopy and immunohistology represents the current standards used to establish a specific diagnosis in nephrology. Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal b...

journal_title：Current opinion in nephrology and hypertension

authors： Henger A,Schmid H,Kretzler M

更新日期：2004-05-01 00:00:00

abstract：:The parathyroid normally has very few cells in mitosis but it retains the potential to proliferate. In-vivo studies in rats have demonstrated that hypocalcaemia and high serum phosphate both lead to an increase in the number of proliferating cells, which is relevant to the increased parathyroid cell proliferation in c...

journal_title：Current opinion in nephrology and hypertension

authors： Silver J,Sela SB,Naveh-Many T

更新日期：1997-07-01 00:00:00

abstract：:Understanding the nature of allorecognition is fundamental to the design of antigen-specific therapies for transplantation. As recently as 10 years ago it was generally believed that recognition of major histocompatibility complex (MHC) molecules by T lymphocytes was direct and represented the "simplest" kind of T-lym...

journal_title：Current opinion in nephrology and hypertension

authors： Krensky AM,Clayberger C

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade post-hoc analyses of clinical trials and observational studies have tended to show that participants treated with thiazide diuretics are at greater risk for newly diagnosed diabetes mellitus than those treated with other medication classes. We review the results of several recent ...

journal_title：Current opinion in nephrology and hypertension

authors： Barzilay JI,Cutler JA,Davis BR

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In light of the recent changes to the kidney allocation system (KAS) and the observed increase in the rate of transplantation of the highly sensitized kidney transplant candidate, the evaluation and care of this population is a timely topic. RECENT FINDINGS:In its first year, the new KAS has already ...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar V

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Incidence of end-stage renal disease has increased dramatically during the last 30 years and screening for early stages of chronic kidney disease is often suggested as a preventive measure. The relationship between chronic kidney disease and end-stage renal disease is complex, however, and recent stud...

journal_title：Current opinion in nephrology and hypertension

authors： Hallan SI,Vikse BE

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin-aldosterone system is an important modulator of renal salt excretion and arterial pressure. An important body of evidence now supports that angiotensin II (AngII) modulates the function of the renal sodium-chloride cotransporter (NCC), independently of aldosterone. Here we summar...

journal_title：Current opinion in nephrology and hypertension

authors： Castañeda-Bueno M,Gamba G

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic allograft nephropathy has fallen into disfavor as a morphologic term to describe parenchymal scarring in the renal allograft, with a recommendation that this be replaced by the more descriptive term 'interstitial fibrosis and tubular atrophy'. However, neither term addresses the underlying cau...

journal_title：Current opinion in nephrology and hypertension

authors： Haas M

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent trial data have resulted in a reevaluation of the management of anemia in chronic kidney disease, including the use of erythropoiesis-stimulating agents, intravenous iron, and novel pharmaceuticals. In this review, we evaluate the latest research on anemia management in chronic kidney disease. ...

journal_title：Current opinion in nephrology and hypertension

authors： Novak JE,Szczech LA

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Acid-base (H and HCO3) transport in the kidney is crucial for maintaining blood pH, cellular pH and excreting metabolic acid. HCO3 transport in the kidney is mediated by HCO3 transporter proteins which occur in two gene families in humans, vertebrates and invertebrates (SLC4 and SLC26). Since SLC26 tr...

journal_title：Current opinion in nephrology and hypertension

authors： Romero MF

更新日期：2005-09-01 00:00:00

abstract：PURPOSE OF REVIEW:African-Americans are more likely than Caucasians to develop hypertension-related end-stage renal disease. Elevations in blood pressure levels clearly potentiate pre-existing renal disease and also contribute to kidney injury independently of other primary renal diseases in this cohort. Until recently...

journal_title：Current opinion in nephrology and hypertension

authors： Kaperonis N,Bakris G

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammatory cytokines contribute to the pathogenesis of hypertension through effects on renal blood flow and sodium handling. This review will update recent advances that explore the renal actions of immune cells and cytokines in the pathogenesis of hypertension. RECENT FINDINGS:Populations of cells...

journal_title：Current opinion in nephrology and hypertension

authors： Wen Y,Crowley SD

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings on the relationship between congestive heart failure and renal failure are summarized in this review. RECENT FINDINGS:Congestive heart failure is found in about one-quarter of cases of chronic kidney disease. The most common cause of congestive heart failure is ischemic heart disease....

journal_title：Current opinion in nephrology and hypertension

authors： Silverberg D,Wexler D,Blum M,Schwartz D,Iaina A

更新日期：2004-03-01 00:00:00

abstract：:The cellular and molecular mechanisms whereby hypertension causes vascular and cardiac disease are beginning to be understood. Angiotensin II, perhaps because so many probes to explore its action are available, is emerging as a central pathogenetic factor in the development of both vascular and cardiac hypertrophy. It...

journal_title：Current opinion in nephrology and hypertension

authors： Oliver JA

更新日期：1993-03-01 00:00:00

abstract：:The complex multifactorial inheritance pattern of systemic lupus erythematosus in various murine models has been dissected via both classic genetic analysis and the use of modern technologies in genomic manipulation. Current information suggests that lupus may be mediated by a multitude of genetic abnormalities that i...

journal_title：Current opinion in nephrology and hypertension

authors： Yim YS,Wakeland EK

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Fibrosis is an important biomarker of chronic kidney injury, and a powerful predictor of renal outcome. Currently, the only method for measuring fibrotic burden is histologic analysis, which requires a kidney biopsy in humans, or kidney removal in animal models. These requirements have not only hinder...

journal_title：Current opinion in nephrology and hypertension

authors： Hysi E,Yuen DA

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The success of any given kidney transplant is closely tied to the ability to monitor patients and responsively change their medications. Transplant monitoring is still, however, dependent on relatively old technologies: serum creatinine levels, urine output, blood pressure, blood glucose and histopath...

journal_title：Current opinion in nephrology and hypertension

authors： Wishart DS

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This article will review briefly the emerging new concepts in the diagnosis and treatment of myocardial fibrosis in patients with hypertensive heart disease. RECENT FINDINGS:Although hypertensive heart disease is characterized clinically by development of left-ventricular hypertrophy in the absence o...

journal_title：Current opinion in nephrology and hypertension

authors： González A,López B,Díez J

更新日期：2005-09-01 00:00:00