Gene expression analysis of human renal biopsies: recent developments towards molecular diagnosis of kidney disease.

abstract：:Experimental animal models and cell culture techniques, highlighting the central role of glucose metabolism, have provided important insight into the pathogenesis of diabetic nephropathy. Microalbuminuria and other candidate phenotypic or genotypic markers for the early onset of disease are discussed. Management recom...

journal_title：Current opinion in nephrology and hypertension

authors： Mogyorósi A,Ziyadeh FN

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension is an important risk factor for adverse cardiovascular and renal outcomes particularly in patients with chronic kidney disease. This review compares blood pressure measurements obtained in the clinic with those obtained outside the clinic to predict cardiovascular and renal injury and out...

journal_title：Current opinion in nephrology and hypertension

authors： Agarwal R

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate lowering toward the normal range is advocated and widely practiced in patients with end-stage renal disease receiving dialysis. This approach is guided by basic science data and large observational studies that have demonstrated a consistent association between hyperphosphatemia and adverse ...

journal_title：Current opinion in nephrology and hypertension

authors： Wald R,Thorpe KE,Walsh MW

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron deficiency anaemia (IDA) is common and associated with fatigue, reduced quality of life and poorer clinical outcomes. Treatment with oral iron is often inadequate and international guidelines recommend intravenous (i.v.) iron as the preferred option for the treatment of IDA in certain clinical si...

journal_title：Current opinion in nephrology and hypertension

authors： Kalra PA,Bhandari S

更新日期：2016-11-01 00:00:00

abstract：:The aquaporin water channels are expressed in various fluid-transporting epithelia. Physiological and genetic investigations have revealed that aquaporin channel-like intrinsic protein is expressed in numerous tissues, but its significance in water transport physiology is unclear. It has been shown that aquaporin-coll...

journal_title：Current opinion in nephrology and hypertension

authors： Fushimi K,Marumo F

更新日期：1995-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Dialysis has been the prevailing treatment paradigm in advanced chronic kidney disease (CKD) for patients ineligible for or unlikely to receive kidney transplantation. As dialysis may neither offer survival benefit nor improved quality of life in certain groups, there has been increasing interest in c...

journal_title：Current opinion in nephrology and hypertension

authors： Rhee CM,Nguyen DV,Nyamathi A,Kalantar-Zadeh K

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the maturational changes that occur in renal tubules during postnatal development. RECENT FINDINGS:The ability to study transport in neonatal tubules and the use of molecular techniques have allowed studies that not only examine the mechanism of solute and water transport in neon...

journal_title：Current opinion in nephrology and hypertension

authors： Baum M,Quigley R,Satlin L

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of vitamin D beyond its importance for bone health is under much debate. In this article, we review recent evidence for genetic influences on 25-hydroxyvitamin D [25(OH)D] and discuss the uses of this information and its importance for public health. RECENT FINDINGS:Findings from large-scale...

journal_title：Current opinion in nephrology and hypertension

authors： Berry D,Hyppönen E

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The current article reviews the available literature on the incidence, complications, outcomes, and management of pregnancies in kidney transplant recipients. RECENT FINDINGS:Pregnancy can be a reasonable option for women with a kidney transplant. More than 4700 successful pregnancies have been repor...

journal_title：Current opinion in nephrology and hypertension

authors： Vijayan M,Pavlakis M

更新日期：2017-11-01 00:00:00

abstract：:The L-arginine: nitric oxide pathway is widely recognized as an important regulator of cell function and communication in a variety of physiological and pathophysiological situations. Recent advances in the biochemistry and molecular biology of nitric oxide synthases have contributed significantly to our understanding...

journal_title：Current opinion in nephrology and hypertension

authors： Palmer RM

更新日期：1993-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequately controlled blood pressure is considered an important risk factor for both chronic kidney disease (CKD) progression and cardiovascular disease progression in CKD patients. Patients with CKD and hypertension are typically followed in primary care practice settings and blood pressure is not ...

journal_title：Current opinion in nephrology and hypertension

authors： St Peter WL,Farley TM,Carter BL

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an up-to-date understanding of how peroxisome proliferator activated receptor γ (PPARγ) exerts its cardioprotective effect in the vasculature through its activation of novel PPARγ target genes in endothelium and vascular smooth muscle. RECENT FINDINGS:In vascular endothelial cell...

journal_title：Current opinion in nephrology and hypertension

authors： Fang S,Sigmund CD

更新日期：2020-03-01 00:00:00

abstract：:The cardinal feature of systemic lupus erythematosus is the formation of anti-nuclear antibodies. In recent years, it has become clear that the nucleosome is a major autoantigen that drives this T cell-dependent autoimmune response, as exemplified by the presence of nucleosome-specific T helper cells and the high prev...

journal_title：Current opinion in nephrology and hypertension

authors： Berden JH,Licht R,van Bruggen MC,Tax WJ

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in hemodialysis technology, a stable and well functioning vascular access remains the bane of every hemodialysis patient. It is recognized that vascular access contributes to cardiovascular disease mortality through a number of mechanisms. This review describes the relationship betwee...

journal_title：Current opinion in nephrology and hypertension

authors： MacRae JM

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity, which has reached epidemic prevalence, is now recognized as an independent risk factor for increasing blood pressure. The complex mechanisms of obesity-related hypertension are unclear, but several studies have provided evidence of a hypertensive shift in pressure natriuresis. Excess sympathe...

journal_title：Current opinion in nephrology and hypertension

authors： Coatmellec-Taglioni G,Ribière C

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Multiple studies have established the beneficial role of mesenchymal stem cell (MSC) therapy for kidney injury. In this review we will discuss the recent identification of Gli1 as a marker for perivascular MSC and the role of this cell population in kidney fibrosis. RECENT FINDINGS:Recent studies dem...

journal_title：Current opinion in nephrology and hypertension

authors： Kuppe C,Kramann R

更新日期：2016-07-01 00:00:00

abstract：:Heat shock proteins, or stress proteins, are molecular chaperones responsible for protein processing and protection against cellular injury through the prevention of inappropriate peptide interactions. The distribution of individual stress proteins varies between regions of the kidney and within subcellular compartmen...

journal_title：Current opinion in nephrology and hypertension

authors： Van Why SK,Siegel NJ

更新日期：1998-07-01 00:00:00

abstract：:Our basic understanding of sodium mechanisms provides unique insights into epithelial transport processes, and unusual clinical syndromes can arise from mutations of these ion transporters. These genetic disorders affect sodium balance, with both sodium-retaining and sodium-wasting conditions being the consequence. A ...

journal_title：Current opinion in nephrology and hypertension

authors： Warnock DG

更新日期：2001-07-01 00:00:00

abstract：:The immunosuppressants cyclosporine and FK506 (tacrolimus) are extremely potent inhibitors of T-lymphocyte activation. Recent studies have shown that these agents are actually prodrugs that become active only when bound to specific members of the cyclophilin or FK506 binding protein receptor gene families. The cyclosp...

journal_title：Current opinion in nephrology and hypertension

authors： Tocci MJ,Sigal NH

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin system is not what it was, or for that matter not necessarily where we thought it should be. For example, there is a novel angiotensin I-metabolizing enzyme that generates angiotensin 1-7 rather than angiotensin II. Moreover, we are slowly realizing the importance of local rather...

journal_title：Current opinion in nephrology and hypertension

authors： Fleming I,Kohlstedt K,Busse R

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Incretin mimetics, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as dipeptidyl peptidase-IV (DPP-IV) inhibitors, are used in the treatment of type 2 diabetes mellitus (T2DM). In addition to stimulating insulin secretion from pancreatic β cells,...

journal_title：Current opinion in nephrology and hypertension

authors： Tanaka T,Nangaku M,Nishiyama A

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron deficiency is a major contributory cause to the development of anaemia in chronic kidney disease (CKD), and thus, iron replacement therapy plays a critical role in the management of this condition. The two main routes for administering iron are oral and intravenous, and there have been a number o...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：2018-09-01 00:00:00

abstract：:The ability to record sympathetic nerve activity in conscious human subjects using intraneural microelectrodes (microneurography) has proven to be a powerful clinical research tool, which has shed new light on the pathophysiology of important blood pressure problems as exemplified in studies of patients with chronic r...

journal_title：Current opinion in nephrology and hypertension

authors： Hansen J,Victor RG

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with chronic kidney disease (CKD) endure compromised health-related quality of life (HRQOL). Although the link between HRQOL and increased mortality in patients with end-stage renal disease (ESRD) is well documented, less is known about the relationship between CKD and HRQOL. This article rev...

journal_title：Current opinion in nephrology and hypertension

authors： Soni RK,Weisbord SD,Unruh ML

更新日期：2010-03-01 00:00:00

abstract：:The prevalence of hypertension is extremely high in end-stage renal disease, and is a probable contributor to the epidemic of cardiovascular disease in end-stage renal disease. However, the paucity of prospective, randomized clinical trials makes it difficult to precisely define treatment strategies. Therefore, at pre...

journal_title：Current opinion in nephrology and hypertension

authors： Zager P,Nikolic J,Raj DS,Tzamaloukas A,Campbell M

更新日期：2000-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Mammalian target of rapamycin (mTOR) is an evolutionarily conserved protein kinase. mTOR forms two distinct functional multiprotein kinase complexes that mutually phosphorylate different substrates and regulate a wide array of essential cellular processes including translation, transcription and autop...

journal_title：Current opinion in nephrology and hypertension

authors： Inoki K,Huber TB

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The majority of uric acid nephrolithiasis in humans occurs in the absence of frank hyperuricosuria and is primarily a disease of excessively low urinary pH. Uric acid is substantially less soluble than urate salts so in low urine pH urate is protonated, thus favoring precipitation even under what is c...

journal_title：Current opinion in nephrology and hypertension

authors： Moe OW

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity is becoming recognized as one of the most important risk factors for the development of hypertension. The purpose of the review is to examine the latest evidence linking hypertension to obesity, summarize the benefits of weight reduction and present results of recent clinical trials evaluating...

journal_title：Current opinion in nephrology and hypertension

authors： Chrostowska M,Szczech R,Narkiewicz K

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:With the increasing incidence and prevalence of ESRD in the elderly, we are now transplanting more elderly patients. Although we know from previous reports that transplantation provides increased survival advantage and/or quality of life when compared to being on dialysis, we also know that transplant...

journal_title：Current opinion in nephrology and hypertension

authors： Kodali L,Turner A

更新日期：2019-11-01 00:00:00

abstract：:After renal transplantation, acute allograft dysfunction secondary to acute rejection occurs in around 30-40% of patients. Although in the majority of patients these episodes are reversible, acute rejection remains a major risk factor for the development of chronic rejection. Remarkably, prior episodes of acute allogr...

journal_title：Current opinion in nephrology and hypertension

authors： Chandraker A

更新日期：1999-11-01 00:00:00