Genetic forms of human hypertension.

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear transcription factor that regulates many important physiological processes including glucose and lipid metabolism, energy homeostasis, cell proliferation, inflammation, immunity and reproduction. The current review ...

journal_title：Current opinion in nephrology and hypertension

authors： Yang J,Zhou Y,Guan Y

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS:Sin...

journal_title：Current opinion in nephrology and hypertension

authors： Rubinstein M,Dvash E

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with chronic kidney disease (CKD) endure compromised health-related quality of life (HRQOL). Although the link between HRQOL and increased mortality in patients with end-stage renal disease (ESRD) is well documented, less is known about the relationship between CKD and HRQOL. This article rev...

journal_title：Current opinion in nephrology and hypertension

authors： Soni RK,Weisbord SD,Unruh ML

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:There has been significant progress in our understanding of the structural and functional properties and regulation of the electrogenic sodium bicarbonate cotansporter NBCe1, a membrane transporter that plays a key role in renal acid-base physiology. The NBCe1 variant NBCe1-A mediates basolateral elec...

journal_title：Current opinion in nephrology and hypertension

authors： Kurtz I,Zhu Q

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Both cognitive and physical function are commonly impaired in individuals with chronic kidney disease (CKD), resulting in important impacts on their quality of life and overall health. This review summarizes the burden of cognitive and physical impairment in CKD, focusing on recent research that highl...

journal_title：Current opinion in nephrology and hypertension

authors： Weiner DE,Seliger SL

更新日期：2014-05-01 00:00:00

abstract：:Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieske JC,Toback FG

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The gut-kidney axis plays a critical role in oxalate homeostasis, and better understanding of oxalate transport regulatory mechanisms is essential for developing novel therapies. RECENT FINDINGS:Oxalate potentially contributes to chronic kidney disease (CKD) progression, CKD - and end stage renal dis...

journal_title：Current opinion in nephrology and hypertension

authors： Alshaikh AE,Hassan HA

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The association between dysbiosis and CKD is well established. This review focuses on the current understanding of microbiome, in normal individuals and CKD patients, in order to hypothesize how to correct uremic toxins levels and preserve the renal function and reduce associated comorbidities. Here w...

journal_title：Current opinion in nephrology and hypertension

authors： Caggiano G,Cosola C,Di Leo V,Gesualdo M,Gesualdo L

更新日期：2020-01-01 00:00:00

abstract：:Vascular endothelial growth factor is a diffusible endothelial cell-specific mitogen and angiogenic factor that can also increase vascular permeability. The vascular endothelial growth factor receptors are specifically expressed on the cell surface of vascular endothelial cells. Recent studies point to vascular endoth...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrara N,Bunting S

更新日期：1996-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to emphasize that single gene disorders are an important and sometimes unrecognized cause of progressive chronic kidney disease. We provide an overview of the benefits of making a genetic diagnosis, the currently available genetic testing methods and examples of diseases ...

journal_title：Current opinion in nephrology and hypertension

authors： Armstrong ME,Thomas CP

更新日期：2019-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses on recent efforts in identifying with-no-lysine kinase 4 (WNK4) as a physiological intracellular chloride sensor and exploring regulators of intracellular chloride concentration ([Cl-]i) in the distal convoluted tubule (DCT). RECENT FINDINGS:The discovery of WNK1's chloride-bindin...

journal_title：Current opinion in nephrology and hypertension

authors： Chen JC,Lin MX,Cheng CJ

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. PLA2R and THSD7A antigens were described in 2009 and 2014 using classical immunochemical techniques. In the last 2 years, thanks to the combination of laser microdissection of glomeruli and mass ...

journal_title：Current opinion in nephrology and hypertension

authors： Ronco P,Debiec H

更新日期：2021-01-21 00:00:00

abstract：PURPOSE OF REVIEW:Adverse events due to drug-drug interactions remain a challenge in the postsurgical care of transplant recipients. A combination of potent and selective immunosuppressive drugs, which have a narrow therapeutic index, with medications for the treatment of comorbidities such as dyslipidemia, infection, ...

journal_title：Current opinion in nephrology and hypertension

authors： Manitpisitkul W,McCann E,Lee S,Weir MR

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the direct and indirect effects of estrogen on bone with special emphasis on the analysis of the recent findings related to the putative role of FGF23 in the estrogen-dependent parathyroid hormone (PTH) suppression. RECENT FINDINGS:Estrogens act directly on bone cells, downregulating oste...

journal_title：Current opinion in nephrology and hypertension

authors： Cannata-Andía JB,Carrillo-López N,Naves-Díaz M

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Sirtuins are a family of nicotinamide adenine dinucleotide+-dependent enzymes catalyzing target protein deacetylation to modulate cellular metabolism, response to oxidative stress and inflammation, senescence, autophagy and apoptosis. In this review, we provide an overview of recent studies regarding ...

journal_title：Current opinion in nephrology and hypertension

authors： Wang W,Li J,Cai L

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Potassium channels in the distal nephron are precisely controlled to regulate potassium secretion in accord with physiological demands. In recent years, it has become evident that membrane trafficking processes play a fundamental role. This short review highlights recent developments in elucidating th...

journal_title：Current opinion in nephrology and hypertension

authors： Welling PA

更新日期：2013-09-01 00:00:00

abstract：:Heat shock proteins, or stress proteins, are molecular chaperones responsible for protein processing and protection against cellular injury through the prevention of inappropriate peptide interactions. The distribution of individual stress proteins varies between regions of the kidney and within subcellular compartmen...

journal_title：Current opinion in nephrology and hypertension

authors： Van Why SK,Siegel NJ

更新日期：1998-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammatory cytokines contribute to the pathogenesis of hypertension through effects on renal blood flow and sodium handling. This review will update recent advances that explore the renal actions of immune cells and cytokines in the pathogenesis of hypertension. RECENT FINDINGS:Populations of cells...

journal_title：Current opinion in nephrology and hypertension

authors： Wen Y,Crowley SD

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The discovery of the extracellular calcium-sensing receptor, CasR has broadened our understanding of calcium homeostasis and led to the development of new pharmacological agents, calcimimetics, for treating hyperparathyroidism. In the present review, I discuss the function of CasR as well as provide e...

journal_title：Current opinion in nephrology and hypertension

authors： Quarles LD

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Dialysis has been the prevailing treatment paradigm in advanced chronic kidney disease (CKD) for patients ineligible for or unlikely to receive kidney transplantation. As dialysis may neither offer survival benefit nor improved quality of life in certain groups, there has been increasing interest in c...

journal_title：Current opinion in nephrology and hypertension

authors： Rhee CM,Nguyen DV,Nyamathi A,Kalantar-Zadeh K

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Renal acid-base homeostasis, to a very large extent, depends on renal ammonia production and transport. A putative ammonia transporter family of proteins has recently been identified, and at least two members of this family are expressed in the renal connecting segment and collecting duct. The purpose...

journal_title：Current opinion in nephrology and hypertension

authors： Weiner ID

更新日期：2004-09-01 00:00:00

abstract：PURPOSE OF REVIEW:There is increasing evidence that endothelin receptor blockade and, in particular, ET(A) receptor blockade not only confers protection against proteinuric renal disease in diabetes but also confers vasculoprotection. RECENT FINDINGS:Recent clinical trials using ET(A) receptor blockade in treating pro...

journal_title：Current opinion in nephrology and hypertension

authors： Jandeleit-Dahm KA,Watson AM

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights the role of phosphorylation in the trafficking and targeting of aquaporin 2. Current knowledge will be put into the context of modulating the cell surface expression of aquaporin 2 by vasopressin in renal epithelial cells, which is critical for regulation of urinary concentratio...

journal_title：Current opinion in nephrology and hypertension

authors： Brown D,Hasler U,Nunes P,Bouley R,Lu HA

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in hemodialysis technology, a stable and well functioning vascular access remains the bane of every hemodialysis patient. It is recognized that vascular access contributes to cardiovascular disease mortality through a number of mechanisms. This review describes the relationship betwee...

journal_title：Current opinion in nephrology and hypertension

authors： MacRae JM

更新日期：2006-11-01 00:00:00

abstract：:Acute hypertension provokes a rapid decrease in proximal tubule salt and water reabsorption that increases the levels of sodium chloride at the macula densa, the error signal to increase arteriolar resistance to autoregulate renal blood flow and glomerular filtration rate, and contributes to pressure natriuresis. The ...

journal_title：Current opinion in nephrology and hypertension

authors： Magyar CE,McDonough AA

更新日期：2000-03-01 00:00:00

abstract：:Data suggest that ischemic renal disease secondary to atherosclerotic renal artery stenosis is a prevalent health problem. Atherosclerotic renal artery stenosis is a rapidly progressive process that can result in end-stage renal disease. Renal arteriography is the current diagnostic method of choice for the demonstrat...

journal_title：Current opinion in nephrology and hypertension

authors： Breyer JA,Jacobson HR

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Arterial stiffness due to alterations in extracellular matrix is one of the mechanisms responsible for increased peripheral resistance in hypertension. Recent evidence points to arterial stiffness as an independent predictor of cardiovascular events. This review focuses on recent advances in the biolo...

journal_title：Current opinion in nephrology and hypertension

authors： Briones AM,Arribas SM,Salaices M

更新日期：2010-03-01 00:00:00

abstract：:The aquaporin water channels are expressed in various fluid-transporting epithelia. Physiological and genetic investigations have revealed that aquaporin channel-like intrinsic protein is expressed in numerous tissues, but its significance in water transport physiology is unclear. It has been shown that aquaporin-coll...

journal_title：Current opinion in nephrology and hypertension

authors： Fushimi K,Marumo F

更新日期：1995-09-01 00:00:00

abstract：:Cells in renal medullas are exposed to a high concentration of salt during antidiuresis. They adapt in part by accumulating myo-inositol, glycine betaine, taurine, and other amino acids by transporting them from the interstitial fluid. This transport is osmotically regulated by changes in transcription of the transpor...

journal_title：Current opinion in nephrology and hypertension

authors： Burg MB

更新日期：1997-09-01 00:00:00

abstract：:The cardinal feature of systemic lupus erythematosus is the formation of anti-nuclear antibodies. In recent years, it has become clear that the nucleosome is a major autoantigen that drives this T cell-dependent autoimmune response, as exemplified by the presence of nucleosome-specific T helper cells and the high prev...

journal_title：Current opinion in nephrology and hypertension

authors： Berden JH,Licht R,van Bruggen MC,Tax WJ

更新日期：1999-05-01 00:00:00