Recent advances in the mechanism of action of cyclosporine and FK506.

abstract：PURPOSE OF REVIEW:The term 'focal segmental glomerulosclerosis' covers a variety of diseases with different histopathological patterns. There is a need for clues to interpret histological findings in terms of etiology. Studies in transgenic animal models published in recent years have targeted the podocyte with respect...

journal_title：Current opinion in nephrology and hypertension

authors： LeHir M,Kriz W

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current understanding of hemodialysis-mediated clearance of commonly used cardiovascular medications. RECENT FINDINGS:Although cardiovascular drug dialyzability is poorly understood, many drug classes appear to include agents with substantially different degrees of dialyzability. Recent...

journal_title：Current opinion in nephrology and hypertension

authors： Tieu A,Leither M,Urquhart BL,Weir MA

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To characterize the mechanism and clinical impact of the angiotensin-receptor blocker losartan on both renal uric acid handling and thereby serum uric acid. RECENT FINDINGS:Losartan effect on serum uric acid has been demonstrated at various stages of renal failure including most recently observations...

journal_title：Current opinion in nephrology and hypertension

authors： Sica DA,Schoolwerth AC

更新日期：2002-09-01 00:00:00

abstract：:Data suggest that ischemic renal disease secondary to atherosclerotic renal artery stenosis is a prevalent health problem. Atherosclerotic renal artery stenosis is a rapidly progressive process that can result in end-stage renal disease. Renal arteriography is the current diagnostic method of choice for the demonstrat...

journal_title：Current opinion in nephrology and hypertension

authors： Breyer JA,Jacobson HR

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron deficiency anaemia (IDA) is common and associated with fatigue, reduced quality of life and poorer clinical outcomes. Treatment with oral iron is often inadequate and international guidelines recommend intravenous (i.v.) iron as the preferred option for the treatment of IDA in certain clinical si...

journal_title：Current opinion in nephrology and hypertension

authors： Kalra PA,Bhandari S

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Assessment of fluid status to reach normovolemia in patients with chronic kidney disease (CKD) continues to be a tough task. Besides clinical observation, technological methods have been introduced, yet, the best approach is still uncertain. The present review looks at fluid overload in CKD from three...

journal_title：Current opinion in nephrology and hypertension

authors： de Ruiter A,Bello A,Braam B

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. PLA2R and THSD7A antigens were described in 2009 and 2014 using classical immunochemical techniques. In the last 2 years, thanks to the combination of laser microdissection of glomeruli and mass ...

journal_title：Current opinion in nephrology and hypertension

authors： Ronco P,Debiec H

更新日期：2021-01-21 00:00:00

abstract：:Because long-term results of kidney transplantation are still unsatisfactory, efforts are needed to improve them, particularly through the allocation of well-matched kidneys to recipients. In the past 7 years, the United Network of Organ Sharing 6-antigen match program has established that superior results can be obta...

journal_title：Current opinion in nephrology and hypertension

authors： Terasaki PI,Gjertson DW,Cecka JM,Takemoto S

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Autoregulation of renal blood flow has traditionally been considered to stabilize glomerular filtration, and thus tubular load, in the face of blood pressure fluctuations. This view arose because of the contribution of tubuloglomerular feedback, which senses distal tubular fluid composition, to regula...

journal_title：Current opinion in nephrology and hypertension

authors： Cupples WA

更新日期：2007-01-01 00:00:00

abstract：:The present review considers the role that bisphosphonates might have in patients with renal failure. Although bisphosphonates are widely used to reduce fracture risk in patients with osteoporosis, few studies have documented their effect in patients with renal osteodystrophy. The pathogenesis of bone loss after renal...

journal_title：Current opinion in nephrology and hypertension

authors： Fan SL,Cunningham J

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic allograft nephropathy has fallen into disfavor as a morphologic term to describe parenchymal scarring in the renal allograft, with a recommendation that this be replaced by the more descriptive term 'interstitial fibrosis and tubular atrophy'. However, neither term addresses the underlying cau...

journal_title：Current opinion in nephrology and hypertension

authors： Haas M

更新日期：2014-05-01 00:00:00

abstract：:Renal synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a pivotal step in calcium and phosphate homeostasis. Production of 1,25(OH)2D3 is catalyzed by the mitchondrial cytochrome P450, 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-HYD). As a consequence of the tight regulation of ...

journal_title：Current opinion in nephrology and hypertension

authors： Bland R,Zehnder D,Hewison M

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular endothelial growth factors (VEGFs) influence renal function through angiogenesis, with VEGF-A being the most potent inducer of vascular formation. In the normal glomerulus, tight homeostatic balance is maintained between the levels of VEGF-A isoforms produced by podocyte cells, and the VEGF r...

journal_title：Current opinion in nephrology and hypertension

authors： Logue OC,McGowan JW,George EM,Bidwell GL 3rd

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity, which has reached epidemic prevalence, is now recognized as an independent risk factor for increasing blood pressure. The complex mechanisms of obesity-related hypertension are unclear, but several studies have provided evidence of a hypertensive shift in pressure natriuresis. Excess sympathe...

journal_title：Current opinion in nephrology and hypertension

authors： Coatmellec-Taglioni G,Ribière C

更新日期：2003-05-01 00:00:00

abstract：:The L-arginine: nitric oxide pathway is widely recognized as an important regulator of cell function and communication in a variety of physiological and pathophysiological situations. Recent advances in the biochemistry and molecular biology of nitric oxide synthases have contributed significantly to our understanding...

journal_title：Current opinion in nephrology and hypertension

authors： Palmer RM

更新日期：1993-01-01 00:00:00

abstract：:Secondary hyperparathyroidism remains the predominant histologic lesion in pediatric patients undergoing regular dialysis, but recent evidence indicates that the regulation of parathyroid hormone secretion by calcium does not differ substantially between patients with osteitis fibrosa and subjects with normal renal fu...

journal_title：Current opinion in nephrology and hypertension

authors： Salusky IB,Ramirez JA,Goodman WG

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in hemodialysis technology, a stable and well functioning vascular access remains the bane of every hemodialysis patient. It is recognized that vascular access contributes to cardiovascular disease mortality through a number of mechanisms. This review describes the relationship betwee...

journal_title：Current opinion in nephrology and hypertension

authors： MacRae JM

更新日期：2006-11-01 00:00:00

abstract：:In spite of the popular belief that "nervous tension," "stress," and hypertension are causally related, it has been difficult to prove a role of autonomic dysfunction in the genesis of essential hypertension. There are three major reasons for this: 1) autonomic function cannot be assessed with one simple test, 2) the ...

journal_title：Current opinion in nephrology and hypertension

authors： Julius S

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Identification of the mechanisms of magnesium absorption and reabsorption has markedly enhanced our understanding of the causes of hypomagnesemia. RECENT FINDINGS:New gastrointestinal and renal causes of hypomagnesemia have been recently documented. SUMMARY:The recognition of new mechanisms and caus...

journal_title：Current opinion in nephrology and hypertension

authors： Agus ZS

更新日期：2016-07-01 00:00:00

abstract：:Recent investigations cast some doubts on the status of insulin resistance as a trigger in hyperinsulinemia-associated hypertension or obesity-related hypertension, or both. Major epidemiological studies have shown that central adiposity is a powerful risk factor for stroke or coronary artery disease when accompanied ...

journal_title：Current opinion in nephrology and hypertension

authors： Reisin E,Messerli FH

更新日期：1995-01-01 00:00:00

abstract：:Overexpression of the cytokine transforming growth factor-beta has been identified as the key mediator of chronic progressive kidney fibrosis in experimental and human kidney diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have recently been linked to downregulation of transformin...

journal_title：Current opinion in nephrology and hypertension

authors： Peters H,Noble NA,Border WA

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with chronic kidney disease (CKD) have an increased risk of hyperkalemia that increases both short-term and long-term mortality. Historically, managing hyperkalemia has relied upon dietary modifications, augmentation of urinary potassium excretion and enhanced enteral potassium elimination. T...

journal_title：Current opinion in nephrology and hypertension

authors： Cowan AC,Gharib EG,Weir MA

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Tubulointerstitial injury is characteristic of aging-associated renal injury and progressive renal disease. Salt-sensitive hypertension is also associated with tubulointerstitial inflammation, especially when accompanied by microvascular disease. Here we summarize recent studies on the pathogenesis an...

journal_title：Current opinion in nephrology and hypertension

authors： Nakagawa T,Kang DH,Ohashi R,Suga S,Herrera-Acosta J,Rodriguez-Iturbe B,Johnson RJ

更新日期：2003-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Sirtuins are a family of nicotinamide adenine dinucleotide+-dependent enzymes catalyzing target protein deacetylation to modulate cellular metabolism, response to oxidative stress and inflammation, senescence, autophagy and apoptosis. In this review, we provide an overview of recent studies regarding ...

journal_title：Current opinion in nephrology and hypertension

authors： Wang W,Li J,Cai L

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The majority of uric acid nephrolithiasis in humans occurs in the absence of frank hyperuricosuria and is primarily a disease of excessively low urinary pH. Uric acid is substantially less soluble than urate salts so in low urine pH urate is protonated, thus favoring precipitation even under what is c...

journal_title：Current opinion in nephrology and hypertension

authors： Moe OW

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Calciphylaxis remains a poorly understood vascular calcification disorder with predilection for patients with end-stage renal disease (ESRD). Recent data from large patient registries and databases have begun to provide information regarding incidence, risk factors, and outcomes in patients with calci...

journal_title：Current opinion in nephrology and hypertension

authors： Nigwekar SU

更新日期：2017-07-01 00:00:00

abstract：:Cells in renal medullas are exposed to a high concentration of salt during antidiuresis. They adapt in part by accumulating myo-inositol, glycine betaine, taurine, and other amino acids by transporting them from the interstitial fluid. This transport is osmotically regulated by changes in transcription of the transpor...

journal_title：Current opinion in nephrology and hypertension

authors： Burg MB

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an update on the current knowledge regarding the role of the intrarenal rennin-angiotensin system (RAS) in the regulation of glomerular function including glomerular dynamics and filtration rate, glomerular permeability and structural alterations during chronic...

journal_title：Current opinion in nephrology and hypertension

authors： Navar LG

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension is an important risk factor for adverse cardiovascular and renal outcomes particularly in patients with chronic kidney disease. This review compares blood pressure measurements obtained in the clinic with those obtained outside the clinic to predict cardiovascular and renal injury and out...

journal_title：Current opinion in nephrology and hypertension

authors： Agarwal R

更新日期：2006-05-01 00:00:00

abstract：:The cellular and molecular mechanisms whereby hypertension causes vascular and cardiac disease are beginning to be understood. Angiotensin II, perhaps because so many probes to explore its action are available, is emerging as a central pathogenetic factor in the development of both vascular and cardiac hypertrophy. It...

journal_title：Current opinion in nephrology and hypertension

authors： Oliver JA

更新日期：1993-03-01 00:00:00