Hypertension diagnosis and prognosis in chronic kidney disease with out-of-office blood pressure monitoring.

abstract：:The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor belongs to a newly discovered family of G protein-coupled receptors. Members of this family, which have been isolated from mammals, include the receptors for PTH/PTHrP, calcitonin, secretin, growth hormone-releasing hormone, vasoactive ...

journal_title：Current opinion in nephrology and hypertension

authors： Jüppner H

更新日期：1994-07-01 00:00:00

abstract：:Sodium restriction is the most commonly used lifestyle modification for control of hypertension. Nevertheless, there is no consensus on the relative importance of salt in the development of hypertension, nor is the physiological mechanism(s) responsible for salt-induced elevations of blood pressure clearly understood....

journal_title：Current opinion in nephrology and hypertension

authors： Hatton DC,McCarron DA

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Autonomic dysfunction is well recognized in chronic kidney disease. The baroreflex arc is an important component of the autonomic nervous system and influences vasodilatation and heart rate in response to information derived from baroreceptors located in the aorta and common carotid arteries. Appropri...

journal_title：Current opinion in nephrology and hypertension

authors： Chesterton LJ,McIntyre CW

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss if there will still be a role for the originator ESAs after the already available biosimilars and the approval of HIF stabilizers in the near future. RECENT FINDINGS:Current treatment with erythropoiesis-simulating agents (ESAs) is effective and generally well tolerated, but requires paren...

journal_title：Current opinion in nephrology and hypertension

authors： Locatelli F,Del Vecchio L

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Insulin resistance is a known complication of end-stage renal disease that also appears to be present in earlier stages of chronic kidney disease (CKD). It is a risk factor for cardiovascular disease and an important potential therapeutic target in this population. Measurement of insulin resistance is...

journal_title：Current opinion in nephrology and hypertension

authors： Pham H,Utzschneider KM,de Boer IH

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Several genetic and acquired abnormalities leading to abnormal activation of the alternative pathway of complement have been identified in patients with atypical hemolytic uremic syndrome (aHUS). The purpose of this review is to shed light on how advances in the understanding of aHUS pathogenesis have...

journal_title：Current opinion in nephrology and hypertension

authors： Noris M,Remuzzi G

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The review describes studies investigating the role of microRNAs in the signaling pathway of the mineralocorticoid hormone, aldosterone. RECENT FINDINGS:Emerging evidence indicates that aldosterone alters the expression of microRNAs in target tissues thereby modulating the expression of key regulator...

journal_title：Current opinion in nephrology and hypertension

authors： Butterworth MB

更新日期：2018-09-01 00:00:00

abstract：:The complex multifactorial inheritance pattern of systemic lupus erythematosus in various murine models has been dissected via both classic genetic analysis and the use of modern technologies in genomic manipulation. Current information suggests that lupus may be mediated by a multitude of genetic abnormalities that i...

journal_title：Current opinion in nephrology and hypertension

authors： Yim YS,Wakeland EK

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Structural biology is one of the most informative disciplines available to biochemical research. It unites technologies that can reveal high-resolution (often atomic) details of the inner workings of biochemical systems. These insights are crucial for an understanding of basic life processes, such as ...

journal_title：Current opinion in nephrology and hypertension

authors： Machius M

更新日期：2003-07-01 00:00:00

abstract：:The cardinal feature of systemic lupus erythematosus is the formation of anti-nuclear antibodies. In recent years, it has become clear that the nucleosome is a major autoantigen that drives this T cell-dependent autoimmune response, as exemplified by the presence of nucleosome-specific T helper cells and the high prev...

journal_title：Current opinion in nephrology and hypertension

authors： Berden JH,Licht R,van Bruggen MC,Tax WJ

更新日期：1999-05-01 00:00:00

abstract：:Acute hypertension provokes a rapid decrease in proximal tubule salt and water reabsorption that increases the levels of sodium chloride at the macula densa, the error signal to increase arteriolar resistance to autoregulate renal blood flow and glomerular filtration rate, and contributes to pressure natriuresis. The ...

journal_title：Current opinion in nephrology and hypertension

authors： Magyar CE,McDonough AA

更新日期：2000-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Disturbances in mineral metabolism are common among individuals with chronic kidney disease and have consistently been associated with cardiovascular and bone disease. The current review aims to describe the current knowledge of the genetic aspects of mineral metabolism disturbances and to suggest dir...

journal_title：Current opinion in nephrology and hypertension

authors： Robinson-Cohen C

更新日期：2020-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an up-to-date understanding of how peroxisome proliferator activated receptor γ (PPARγ) exerts its cardioprotective effect in the vasculature through its activation of novel PPARγ target genes in endothelium and vascular smooth muscle. RECENT FINDINGS:In vascular endothelial cell...

journal_title：Current opinion in nephrology and hypertension

authors： Fang S,Sigmund CD

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:microRNAs (miRNAs) are short noncoding RNAs that function as sequence-specific inhibitors of gene expression. Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of end-stage kidney failure with limited treatment options. The realization that miRNA upregulation, and...

journal_title：Current opinion in nephrology and hypertension

authors： Yheskel M,Patel V

更新日期：2017-07-01 00:00:00

abstract：:Overexpression of the cytokine transforming growth factor-beta has been identified as the key mediator of chronic progressive kidney fibrosis in experimental and human kidney diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have recently been linked to downregulation of transformin...

journal_title：Current opinion in nephrology and hypertension

authors： Peters H,Noble NA,Border WA

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The discovery of the extracellular calcium-sensing receptor, CasR has broadened our understanding of calcium homeostasis and led to the development of new pharmacological agents, calcimimetics, for treating hyperparathyroidism. In the present review, I discuss the function of CasR as well as provide e...

journal_title：Current opinion in nephrology and hypertension

authors： Quarles LD

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The calcium-sensing receptor gene (CaSR, chr. 3q13.3-21) is a candidate to explain nephrolithiasis. This review analyzes the potential role of CaSR in lithogenesis according to findings of functional and genetic studies. RECENT FINDINGS:CaSR is a cation receptor located in the tubular cell plasma mem...

journal_title：Current opinion in nephrology and hypertension

authors： Vezzoli G,Terranegra A,Soldati L

更新日期：2012-07-01 00:00:00

abstract：:This article reviews the current state of knowledge concerning cyclosporine A-induced hypertension after heart transplantation, its pathophysiology and management. The hypothesis is presented that a common molecular mechanism mediates both the immunosuppressive and the hypertensive actions of cyclosporine. The calcium...

journal_title：Current opinion in nephrology and hypertension

authors： Sander M,Victor RG

更新日期：1995-09-01 00:00:00

abstract：:Recent insights into the etiopathogenesis of nephritogenic immune responses are derived primarily from experimental models of systemic and organ-specific autoimmunity. Genetic analyses and immune-related gene ablation studies indicate that multiple independent mechanisms determine disease susceptibility. However, full...

journal_title：Current opinion in nephrology and hypertension

authors： Fitzsimons MM,Foster MH

更新日期：1997-05-01 00:00:00

abstract：:There is ample evidence to support the recommendation of renin-angiotensin system blockade therapy as the standard of care for strategies aimed at preserving renal function in chronic renal disease. Nevertheless, despite the well established antihypertensive effects of these drugs, the use of renin-angiotensin system ...

journal_title：Current opinion in nephrology and hypertension

authors： Remuzzi G,Perico N

更新日期：2002-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex ...

journal_title：Current opinion in nephrology and hypertension

authors： Simons M,Hartleben B,Huber TB

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Fibrosis is an important biomarker of chronic kidney injury, and a powerful predictor of renal outcome. Currently, the only method for measuring fibrotic burden is histologic analysis, which requires a kidney biopsy in humans, or kidney removal in animal models. These requirements have not only hinder...

journal_title：Current opinion in nephrology and hypertension

authors： Hysi E,Yuen DA

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity, which has reached epidemic prevalence, is now recognized as an independent risk factor for increasing blood pressure. The complex mechanisms of obesity-related hypertension are unclear, but several studies have provided evidence of a hypertensive shift in pressure natriuresis. Excess sympathe...

journal_title：Current opinion in nephrology and hypertension

authors： Coatmellec-Taglioni G,Ribière C

更新日期：2003-05-01 00:00:00

abstract：:It has been suspected that abnormalities of the L-arginine-nitric oxide pathway could underlie certain forms of hypertension. In this review, we will consider the role of nitric oxide in primary and secondary models of experimental hypertension and discuss potential abnormalities of the L-arginine-nitric oxide pathway...

journal_title：Current opinion in nephrology and hypertension

authors： Arnal JF,Michel JB,Harrison DG

更新日期：1995-03-01 00:00:00

abstract：:Chronic renal disease evolves to end-stage renal failure through events, including enhanced intraglomerular pressure and plasma protein ultrafiltration, mediated at least in part by angiotensin II. Angiotensin-converting enzyme inhibitors reduce intracapillary pressure and ameliorate glomerular size-selective function...

journal_title：Current opinion in nephrology and hypertension

authors： Ruggenenti P,Remuzzi G

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Non-valvular atrial fibrillation is common in patients with severe chronic kidney disease (CKD) and historically patients have been treated with vitamin K antagonists (VKA). However, these agents have questionable efficacy and are associated with increased bleeding risk. Non-vitamin K oral anticoagula...

journal_title：Current opinion in nephrology and hypertension

authors： Kalra PA,Burlacu A,Ferro CJ,Covic A

更新日期：2018-11-01 00:00:00

abstract：:Our basic understanding of sodium mechanisms provides unique insights into epithelial transport processes, and unusual clinical syndromes can arise from mutations of these ion transporters. These genetic disorders affect sodium balance, with both sodium-retaining and sodium-wasting conditions being the consequence. A ...

journal_title：Current opinion in nephrology and hypertension

authors： Warnock DG

更新日期：2001-07-01 00:00:00

abstract：:The aquaporin water channels are expressed in various fluid-transporting epithelia. Physiological and genetic investigations have revealed that aquaporin channel-like intrinsic protein is expressed in numerous tissues, but its significance in water transport physiology is unclear. It has been shown that aquaporin-coll...

journal_title：Current opinion in nephrology and hypertension

authors： Fushimi K,Marumo F

更新日期：1995-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings on the relationship between congestive heart failure and renal failure are summarized in this review. RECENT FINDINGS:Congestive heart failure is found in about one-quarter of cases of chronic kidney disease. The most common cause of congestive heart failure is ischemic heart disease....

journal_title：Current opinion in nephrology and hypertension

authors： Silverberg D,Wexler D,Blum M,Schwartz D,Iaina A

更新日期：2004-03-01 00:00:00

abstract：:There is substantial evidence to suggest that regular physical activity reduces the risk of heart disease. Less clear is the extent to which this is caused by blood pressure reduction. This review considers effects of exercise on blood pressure and overall cardiovascular risk in normotensive and hypertensive individua...

journal_title：Current opinion in nephrology and hypertension

authors： Puddey IB,Beilin LJ

更新日期：1995-05-01 00:00:00