Routine renin-angiotensin system blockade in renal transplantation?

abstract：:There is substantial evidence to suggest that regular physical activity reduces the risk of heart disease. Less clear is the extent to which this is caused by blood pressure reduction. This review considers effects of exercise on blood pressure and overall cardiovascular risk in normotensive and hypertensive individua...

journal_title：Current opinion in nephrology and hypertension

authors： Puddey IB,Beilin LJ

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial nitric oxide synthase (eNOS) and nicotinamide adenine dinucleotide (phosphate) oxidase [NAD(P)H oxidase] are both expressed in tubular epithelial cells within the renal medulla, particularly the thick ascending limb of the loop of Henle (mTALH). Thick ascending limbs contribute to long-ter...

journal_title：Current opinion in nephrology and hypertension

authors： Evans RG,Fitzgerald SM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Acid-base (H and HCO3) transport in the kidney is crucial for maintaining blood pH, cellular pH and excreting metabolic acid. HCO3 transport in the kidney is mediated by HCO3 transporter proteins which occur in two gene families in humans, vertebrates and invertebrates (SLC4 and SLC26). Since SLC26 tr...

journal_title：Current opinion in nephrology and hypertension

authors： Romero MF

更新日期：2005-09-01 00:00:00

abstract：:The immunosuppressants cyclosporine and FK506 (tacrolimus) are extremely potent inhibitors of T-lymphocyte activation. Recent studies have shown that these agents are actually prodrugs that become active only when bound to specific members of the cyclophilin or FK506 binding protein receptor gene families. The cyclosp...

journal_title：Current opinion in nephrology and hypertension

authors： Tocci MJ,Sigal NH

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron deficiency anaemia (IDA) is common and associated with fatigue, reduced quality of life and poorer clinical outcomes. Treatment with oral iron is often inadequate and international guidelines recommend intravenous (i.v.) iron as the preferred option for the treatment of IDA in certain clinical si...

journal_title：Current opinion in nephrology and hypertension

authors： Kalra PA,Bhandari S

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension (HTN) and chronic kidney disease (CKD) are significant problems. With recent advances in technologies, biosensors have shown a great potential to provide better home monitoring in hypertension (HTN), medication compliance, diagnostic device for kidney disease, CKD/end-stage renal disease ...

journal_title：Current opinion in nephrology and hypertension

authors： Park SH,Zhang Y,Rogers JA,Gallon L

更新日期：2019-07-01 00:00:00

abstract：:The present review considers the role that bisphosphonates might have in patients with renal failure. Although bisphosphonates are widely used to reduce fracture risk in patients with osteoporosis, few studies have documented their effect in patients with renal osteodystrophy. The pathogenesis of bone loss after renal...

journal_title：Current opinion in nephrology and hypertension

authors： Fan SL,Cunningham J

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review summarizes recent advances in the understanding of the molecular physiology and regulation of the thiazide-sensitive sodium-chloride cotransporter (NCC). RECENT FINDINGS:Mutations of with-no-lysine (WNK) kinases 1 and 4 result in hyperactivity of NCC and familial hyperkalemic hypertension...

journal_title：Current opinion in nephrology and hypertension

authors： Ko B,Hoover RS

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Arterial calcification in chronic kidney disease (CKD) is associated with increased cardiovascular risk. The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins. RECENT FINDINGS:Arterial calcification is similar to ...

journal_title：Current opinion in nephrology and hypertension

authors： London GM,Marchais SJ,Guérin AP,Métivier F

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity is becoming recognized as one of the most important risk factors for the development of hypertension. The purpose of the review is to examine the latest evidence linking hypertension to obesity, summarize the benefits of weight reduction and present results of recent clinical trials evaluating...

journal_title：Current opinion in nephrology and hypertension

authors： Chrostowska M,Szczech R,Narkiewicz K

更新日期：2006-09-01 00:00:00

abstract：:Acute ischemic or toxic injury to the kidney induces alterations in the expression of many genes. Some of these molecular responses have been termed 'maladaptive' because they exacerbate the tubular damage induced by the initiating insult. Some maladaptive responses include alterations in the activity of nitric oxide ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieberthal W

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Aldosterone and the mineralocorticoid receptor contribute to resistant hypertension and cardiovascular mortality, and mineralocorticoid receptor antagonists effectively reduce these complications. Their use is limited in certain populations with a higher risk of hyperkalemia or renal dysfunction. This...

journal_title：Current opinion in nephrology and hypertension

authors： Luther JM

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The pathogenesis and optimal therapy of renal bone disease remains poorly understood in chronic kidney disease (CKD) and dialysis patients. Bone biopsy is thus far the only window into cellular and molecular events in bone. This review will focus on recent insights into the pathophysiology of renal bo...

journal_title：Current opinion in nephrology and hypertension

authors： Christov M,Pereira R,Wesseling-Perry K

更新日期：2013-03-01 00:00:00

abstract：:Renal tubular cells die by apoptosis as well as necrosis in experimental models of ischemic and toxic acute renal failure as well as in humans with acute tubular necrosis. It is not yet possible, however, to determine the relative contribution of these two forms of cell death to loss of renal tubular cells in acute tu...

journal_title：Current opinion in nephrology and hypertension

authors： Bonegio R,Lieberthal W

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin-aldosterone system is an important modulator of renal salt excretion and arterial pressure. An important body of evidence now supports that angiotensin II (AngII) modulates the function of the renal sodium-chloride cotransporter (NCC), independently of aldosterone. Here we summar...

journal_title：Current opinion in nephrology and hypertension

authors： Castañeda-Bueno M,Gamba G

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now a...

journal_title：Current opinion in nephrology and hypertension

authors： Nguyen Dinh Cat A,Jaisser F

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension is an important risk factor for adverse cardiovascular and renal outcomes particularly in patients with chronic kidney disease. This review compares blood pressure measurements obtained in the clinic with those obtained outside the clinic to predict cardiovascular and renal injury and out...

journal_title：Current opinion in nephrology and hypertension

authors： Agarwal R

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Calcium is an essential ion for the maintenance of normal bone health and physiologic functions. The extracellular and intracellular levels of calcium are maintained through hormonal regulation called homeostasis. Balance, the net intake minus excretion of calcium, is maintained by hormonal regulation...

journal_title：Current opinion in nephrology and hypertension

authors： Moe SM

更新日期：2018-07-01 00:00:00

abstract：:The cells of the renal medulla osmotically adapt to chronic alterations in extracellular tonicity by appropriate changes in the intracellular contents of organic osmoeffectors. The major organic osmolytes are glycerophosphorylcholine, betaine, myo-inositol, sorbitol, and, possibly, taurine. When the concentrations of ...

journal_title：Current opinion in nephrology and hypertension

authors： Beck FX,Schmolke M,Guder WG

更新日期：1992-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Non-valvular atrial fibrillation is common in patients with severe chronic kidney disease (CKD) and historically patients have been treated with vitamin K antagonists (VKA). However, these agents have questionable efficacy and are associated with increased bleeding risk. Non-vitamin K oral anticoagula...

journal_title：Current opinion in nephrology and hypertension

authors： Kalra PA,Burlacu A,Ferro CJ,Covic A

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization. RECENT FINDINGS:Mice that are null for the sodium-phosphate cotransporter (NPT)2a gene (NPT2a(-/...

journal_title：Current opinion in nephrology and hypertension

authors： Prié D,Beck L,Friedlander G,Silve C

更新日期：2004-11-01 00:00:00

abstract：:Heat shock proteins, or stress proteins, are molecular chaperones responsible for protein processing and protection against cellular injury through the prevention of inappropriate peptide interactions. The distribution of individual stress proteins varies between regions of the kidney and within subcellular compartmen...

journal_title：Current opinion in nephrology and hypertension

authors： Van Why SK,Siegel NJ

更新日期：1998-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Carboxyl-terminal parathyroid hormone (C-PTH) fragments constitute 80% of circulating PTH. Since the first 34 amino acids of the PTH structure are sufficient to explain PTH classical biological effects on the type I PTH/PTHrP receptor and since C-PTH fragments do not bind to this receptor, they have l...

journal_title：Current opinion in nephrology and hypertension

authors： D'Amour P,Brossard JH

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Autonomic dysfunction is well recognized in chronic kidney disease. The baroreflex arc is an important component of the autonomic nervous system and influences vasodilatation and heart rate in response to information derived from baroreceptors located in the aorta and common carotid arteries. Appropri...

journal_title：Current opinion in nephrology and hypertension

authors： Chesterton LJ,McIntyre CW

更新日期：2005-11-01 00:00:00

abstract：:Ischemic heart disease is the major cause of death in dialysis patients. Efforts at coronary artery disease detection in end-stage renal disease patients have primarily focused on the cardiac evaluation of 'high-risk' renal transplant candidates. Despite their high cardiac risk, no data exist on the results of reperfu...

journal_title：Current opinion in nephrology and hypertension

authors： Herzog CA

更新日期：1997-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease. RECENT FINDINGS:Reversible DNA and histone m...

journal_title：Current opinion in nephrology and hypertension

authors： Wilson PC,Ledru N,Humphreys BD

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:With the aging population of kidney transplant candidates, a history of malignancy is an increasingly prevalent finding. Tumors can constitute a contraindication for transplantation or can lead to a delay of acceptance to the waiting-list. Current waiting time guidelines mainly refer to early data col...

journal_title：Current opinion in nephrology and hypertension

authors： Bojic M,Watschinger C,Reiter T,Watschinger B

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings on the relationship between congestive heart failure and renal failure are summarized in this review. RECENT FINDINGS:Congestive heart failure is found in about one-quarter of cases of chronic kidney disease. The most common cause of congestive heart failure is ischemic heart disease....

journal_title：Current opinion in nephrology and hypertension

authors： Silverberg D,Wexler D,Blum M,Schwartz D,Iaina A

更新日期：2004-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The association between dysbiosis and CKD is well established. This review focuses on the current understanding of microbiome, in normal individuals and CKD patients, in order to hypothesize how to correct uremic toxins levels and preserve the renal function and reduce associated comorbidities. Here w...

journal_title：Current opinion in nephrology and hypertension

authors： Caggiano G,Cosola C,Di Leo V,Gesualdo M,Gesualdo L

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in understanding of how clinical outcomes for hemodialysis patients may be improved by achieving longer or more frequent treatment times, lower ultrafiltration rates (UFRs), improving nutritional status, and individualizing dialysate composition. This review also d...

journal_title：Current opinion in nephrology and hypertension

authors： Fissell R,Hakim RM

更新日期：2013-11-01 00:00:00