Abstract:
:The cells of the renal medulla osmotically adapt to chronic alterations in extracellular tonicity by appropriate changes in the intracellular contents of organic osmoeffectors. The major organic osmolytes are glycerophosphorylcholine, betaine, myo-inositol, sorbitol, and, possibly, taurine. When the concentrations of poorly permeant external solutes are acutely reduced, cells that have been adapted to high tonicities rapidly release organic osmolytes via specific transmembrane transport pathways. In contrast, when medullary cells are depleted of organic osmolytes, osmolyte accumulation on acute elevation of external tonicity is slow and involves stimulation of uptake, intracellular de novo synthesis, or inhibition of intracellular degradation, and is preceded by increased intracellular electrolyte concentrations. The available evidence suggests that this rise in intracellular ionic strength plays an important role in the initiation of those processes responsible for full adaptation of renal medullary cells to high tonicities. Recently, complementary DNAs encoding a myo-inositol and a betaine transporter have been isolated.
journal_name
Curr Opin Nephrol Hypertensjournal_title
Current opinion in nephrology and hypertensionauthors
Beck FX,Schmolke M,Guder WGdoi
10.1097/00041552-199210000-00007keywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
43-52issue
1eissn
1062-4821issn
1473-6543journal_volume
1pub_type
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:The analysis of renal tissue from kidney biopsies by histology, electron microscopy and immunohistology represents the current standards used to establish a specific diagnosis in nephrology. Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal b...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-200405000-00008
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2005-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease. RECENT FINDINGS:Reversible DNA and histone m...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章
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更新日期:2020-05-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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更新日期:1998-07-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2009-09-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-199603000-00012
更新日期:1996-03-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1993-03-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-199301000-00010
更新日期:1993-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1999-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2013-09-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2000-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate the role of restricting dietary sodium intake in chronic kidney disease (CKD) and its complications. RECENT FINDINGS:A consistent line of evidence shows that high dietary sodium intake is a determinant of therapy resistance to blockade of the renin-angiotensin-aldosterone system (RAAS). A...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2009-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2003-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-199501000-00010
更新日期:1995-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2018-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2012-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0b013e3282f8b177
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Both type 1 and type 2 diabetes are associated with severe complications including diabetic nephropathy. With the rapidly rising number of patients with diabetes worldwide, diabetic nephropathy is becoming one of the most common causes of renal disease. Much research effort is being put into how to id...
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pub_type: 杂志文章,评审
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更新日期:2011-05-01 00:00:00