The tissue renin-angiotensin system and intracellular signalling.

abstract：:Ischemic nephropathy is a major cause of chronic renal failure in people over 50 years of age. In addition, renal artery stenosis is associated with increased mortality, particularly if renal or cardiac function is compromised. The diagnosis is made both by clinical characteristics and imaging studies. At present, dup...

journal_title：Current opinion in nephrology and hypertension

authors： Tuttle KR

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Emerging evidence supports an important role for the heme oxygenase system in the maintenance of a healthy pregnancy. This review attempts to collect these wide-ranging data and summarize the recent progress in the field. RECENT FINDINGS:New studies looking at heme oxygenase depletion in a variety of...

journal_title：Current opinion in nephrology and hypertension

authors： George EM,Granger JP

更新日期：2013-03-01 00:00:00

abstract：:Sodium restriction is the most commonly used lifestyle modification for control of hypertension. Nevertheless, there is no consensus on the relative importance of salt in the development of hypertension, nor is the physiological mechanism(s) responsible for salt-induced elevations of blood pressure clearly understood....

journal_title：Current opinion in nephrology and hypertension

authors： Hatton DC,McCarron DA

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Insulin resistance is a known complication of end-stage renal disease that also appears to be present in earlier stages of chronic kidney disease (CKD). It is a risk factor for cardiovascular disease and an important potential therapeutic target in this population. Measurement of insulin resistance is...

journal_title：Current opinion in nephrology and hypertension

authors： Pham H,Utzschneider KM,de Boer IH

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin system plays an important role in cardiovascular disease via the production of angiotensin II. Over the past decades, however, more and more evidence has accumulated suggesting an important role for another angiotensin: Angiotensin-(1-7) [Ang-(1-7)]. In this review, we discuss th...

journal_title：Current opinion in nephrology and hypertension

authors： van Twist DJ,Kroon AA,de Leeuw PW

更新日期：2014-09-01 00:00:00

abstract：:The immunosuppressants cyclosporine and FK506 (tacrolimus) are extremely potent inhibitors of T-lymphocyte activation. Recent studies have shown that these agents are actually prodrugs that become active only when bound to specific members of the cyclophilin or FK506 binding protein receptor gene families. The cyclosp...

journal_title：Current opinion in nephrology and hypertension

authors： Tocci MJ,Sigal NH

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin superfamily of carrier proteins. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. Here, we review the expression, siderophore-...

journal_title：Current opinion in nephrology and hypertension

authors： Schmidt-Ott KM,Mori K,Kalandadze A,Li JY,Paragas N,Nicholas T,Devarajan P,Barasch J

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial nitric oxide synthase (eNOS) and nicotinamide adenine dinucleotide (phosphate) oxidase [NAD(P)H oxidase] are both expressed in tubular epithelial cells within the renal medulla, particularly the thick ascending limb of the loop of Henle (mTALH). Thick ascending limbs contribute to long-ter...

journal_title：Current opinion in nephrology and hypertension

authors： Evans RG,Fitzgerald SM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The association between dysbiosis and CKD is well established. This review focuses on the current understanding of microbiome, in normal individuals and CKD patients, in order to hypothesize how to correct uremic toxins levels and preserve the renal function and reduce associated comorbidities. Here w...

journal_title：Current opinion in nephrology and hypertension

authors： Caggiano G,Cosola C,Di Leo V,Gesualdo M,Gesualdo L

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Nox-4 is a member of the NADPH oxidase (Nox) family of enzymes implicated in reactive oxygen species generation. Nox-4 is distributed in many tissues; however, its physiological functions remain poorly understood. In contrast to other Nox isoforms, it is unique in that it produces large amounts of hyd...

journal_title：Current opinion in nephrology and hypertension

authors： Thallas-Bonke V,Jandeleit-Dahm KA,Cooper ME

更新日期：2015-01-01 00:00:00

abstract：:The precise adaptation of renal sodium excretion to systemic needs is to a large extent achieved by the regulation of sodium re-absorption in the aldosterone-sensitive distal nephron. Transcellular sodium re-absorption by the segment-specific cells of the aldosterone-sensitive distal nephron (often called principal ce...

journal_title：Current opinion in nephrology and hypertension

authors： Verrey F

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature. RECENT FINDINGS:In addition to the classical contact site between the macula densa plaque and the afferen...

journal_title：Current opinion in nephrology and hypertension

authors： Komlosi P,Bell PD,Zhang ZR

更新日期：2009-01-01 00:00:00

abstract：:Chronic renal disease evolves to end-stage renal failure through events, including enhanced intraglomerular pressure and plasma protein ultrafiltration, mediated at least in part by angiotensin II. Angiotensin-converting enzyme inhibitors reduce intracapillary pressure and ameliorate glomerular size-selective function...

journal_title：Current opinion in nephrology and hypertension

authors： Ruggenenti P,Remuzzi G

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss how recent findings obtained in disorders of phosphate metabolism in humans and in animal models have provided insights into the pathogenesis of renal stone formation and bone demineralization. RECENT FINDINGS:Mice that are null for the sodium-phosphate cotransporter (NPT)2a gene (NPT2a(-/...

journal_title：Current opinion in nephrology and hypertension

authors： Prié D,Beck L,Friedlander G,Silve C

更新日期：2004-11-01 00:00:00

abstract：:The complex multifactorial inheritance pattern of systemic lupus erythematosus in various murine models has been dissected via both classic genetic analysis and the use of modern technologies in genomic manipulation. Current information suggests that lupus may be mediated by a multitude of genetic abnormalities that i...

journal_title：Current opinion in nephrology and hypertension

authors： Yim YS,Wakeland EK

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We aim to review the biological properties of novel molecules that are members of a kidney-bone axis involved in the regulation of phosphate homeostasis. In addition, we describe how an improved knowledge of the mechanisms leading to changes in renal phosphate handling may lead to the development of n...

journal_title：Current opinion in nephrology and hypertension

authors： Strom TM,Jüppner H

更新日期：2008-07-01 00:00:00

abstract：:The cellular and molecular mechanisms whereby hypertension causes vascular and cardiac disease are beginning to be understood. Angiotensin II, perhaps because so many probes to explore its action are available, is emerging as a central pathogenetic factor in the development of both vascular and cardiac hypertrophy. It...

journal_title：Current opinion in nephrology and hypertension

authors： Oliver JA

更新日期：1993-03-01 00:00:00

abstract：:Our basic understanding of sodium mechanisms provides unique insights into epithelial transport processes, and unusual clinical syndromes can arise from mutations of these ion transporters. These genetic disorders affect sodium balance, with both sodium-retaining and sodium-wasting conditions being the consequence. A ...

journal_title：Current opinion in nephrology and hypertension

authors： Warnock DG

更新日期：2001-07-01 00:00:00

abstract：:Tests have become available that not only give an index of iron stores and availability but also provide an integrated assessment of the efficacy of its utilization. This has allowed the revision of previously accepted criteria of iron deficiency as well as the most appropriate strategies for iron administration. By o...

journal_title：Current opinion in nephrology and hypertension

authors： van Zyl-Smit R

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors activated by nutrient molecules and their derivatives. Their role has been increasingly recognized to be important in hypertension, metabolic disorders and cardiovascular disease, including atherosclerosis. Control o...

journal_title：Current opinion in nephrology and hypertension

authors： Duan SZ,Usher MG,Mortensen RM

更新日期：2009-03-01 00:00:00

abstract：:Elevated serum uric acid is a frequent finding in patients with kidney disease and cardiovascular disease. Intrarenal ischaemia, induced by hypertension, increased sympathetic nervous system activity, and hyperinsulinaemia have all been implicated in reduced renal clearance of urate. This frequently results in elevate...

journal_title：Current opinion in nephrology and hypertension

authors： Culleton BF

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the role of restricting dietary sodium intake in chronic kidney disease (CKD) and its complications. RECENT FINDINGS:A consistent line of evidence shows that high dietary sodium intake is a determinant of therapy resistance to blockade of the renin-angiotensin-aldosterone system (RAAS). A...

journal_title：Current opinion in nephrology and hypertension

authors： Krikken JA,Laverman GD,Navis G

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Simultaneous liver kidney transplantation (SLK) has taken center stage since the initiation of the new kidney allocation system (KAS). This review places SLK in the context of the changing landscape of organ allocation. RECENT FINDINGS:The introduction of the Mayo End-Stage Liver Disease score into l...

journal_title：Current opinion in nephrology and hypertension

authors： Formica RN Jr

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Incretin mimetics, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as dipeptidyl peptidase-IV (DPP-IV) inhibitors, are used in the treatment of type 2 diabetes mellitus (T2DM). In addition to stimulating insulin secretion from pancreatic β cells,...

journal_title：Current opinion in nephrology and hypertension

authors： Tanaka T,Nangaku M,Nishiyama A

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the maturational changes that occur in renal tubules during postnatal development. RECENT FINDINGS:The ability to study transport in neonatal tubules and the use of molecular techniques have allowed studies that not only examine the mechanism of solute and water transport in neon...

journal_title：Current opinion in nephrology and hypertension

authors： Baum M,Quigley R,Satlin L

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Autonomic dysfunction is well recognized in chronic kidney disease. The baroreflex arc is an important component of the autonomic nervous system and influences vasodilatation and heart rate in response to information derived from baroreceptors located in the aorta and common carotid arteries. Appropri...

journal_title：Current opinion in nephrology and hypertension

authors： Chesterton LJ,McIntyre CW

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There is currently a major debate on the mechanisms of albuminuria, and this review appraises recent studies in this area. RECENT FINDINGS:The traditional view of albuminuria is that it is the result of damage to an essentially impermeable glomerular barrier. However, over the years, critical evidenc...

journal_title：Current opinion in nephrology and hypertension

authors： Comper WD,Russo LM

更新日期：2009-07-01 00:00:00

abstract：:The pathogenesis of acute renal failure has been attributed to persistent vasoconstriction and leukocyte-endothelial interactions, resulting in inflammation and compromise of local blood flow to the outer medulla, the loss of tubular epithelial cell polarity with multiple functional sequelae, necrosis or apoptosis of ...

journal_title：Current opinion in nephrology and hypertension

authors： Sheridan AM,Bonventre JV

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron deficiency anaemia (IDA) is common and associated with fatigue, reduced quality of life and poorer clinical outcomes. Treatment with oral iron is often inadequate and international guidelines recommend intravenous (i.v.) iron as the preferred option for the treatment of IDA in certain clinical si...

journal_title：Current opinion in nephrology and hypertension

authors： Kalra PA,Bhandari S

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To clarify misconceptions about the feasibility and risks of peritoneal dialysis that unnecessarily limit peritoneal dialysis uptake or continuation in patients for whom peritoneal dialysis is the preferred dialysis modality. The inappropriate choice of haemodialysis as a result of these misconception...

journal_title：Current opinion in nephrology and hypertension

authors： Lee MB,Bargman JM

更新日期：2016-11-01 00:00:00