Abstract:
PURPOSE OF REVIEW:To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature. RECENT FINDINGS:In addition to the classical contact site between the macula densa plaque and the afferent arteriole, there is accumulating evidence suggesting a functional association between the distal nephron and the vasculature at three distinct additional sites: at the terminal cortical thick ascending limb, at the early distal tubule and also at the connecting tubule segment. The epithelial cells around the macula densa also sense and respond to changes in tubular flow and salt content and may transmit this signal to the adjacent afferent arteriole. SUMMARY:There are multiple sites of anatomical and functional contact between the distal nephron and the vasculature supplying the glomerulus, and these may contribute to the regulation of glomerular filtration rate and renal hemodynamics.
journal_name
Curr Opin Nephrol Hypertensjournal_title
Current opinion in nephrology and hypertensionauthors
Komlosi P,Bell PD,Zhang ZRdoi
10.1097/MNH.0b013e32831daf54subject
Has Abstractpub_date
2009-01-01 00:00:00pages
57-62issue
1eissn
1062-4821issn
1473-6543pii
00041552-200901000-00011journal_volume
18pub_type
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2009-09-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0b013e328057dea2
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0b013e32834b23c1
更新日期:2011-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-200307000-00012
更新日期:2003-07-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2002-07-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-200501000-00003
更新日期:2005-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2005-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1994-05-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2018-07-01 00:00:00