Personalized medicine in diabetic kidney disease: a novel approach to improve trial design and patient outcomes.

abstract：:This review focuses on the role of two cytokines, platelet-derived growth factor and transforming growth factor-beta, in glomerular injury. The most recent in vitro and in vivo evidence for the role of platelet-derived growth factor and transforming growth factor-beta in glomerular hypercellularity and matrix expansio...

journal_title：Current opinion in nephrology and hypertension

authors： Abboud HE

更新日期：1994-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature. RECENT FINDINGS:In addition to the classical contact site between the macula densa plaque and the afferen...

journal_title：Current opinion in nephrology and hypertension

authors： Komlosi P,Bell PD,Zhang ZR

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To characterize the mechanism and clinical impact of the angiotensin-receptor blocker losartan on both renal uric acid handling and thereby serum uric acid. RECENT FINDINGS:Losartan effect on serum uric acid has been demonstrated at various stages of renal failure including most recently observations...

journal_title：Current opinion in nephrology and hypertension

authors： Sica DA,Schoolwerth AC

更新日期：2002-09-01 00:00:00

abstract：:Sodium restriction is the most commonly used lifestyle modification for control of hypertension. Nevertheless, there is no consensus on the relative importance of salt in the development of hypertension, nor is the physiological mechanism(s) responsible for salt-induced elevations of blood pressure clearly understood....

journal_title：Current opinion in nephrology and hypertension

authors： Hatton DC,McCarron DA

更新日期：1996-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The examination of urine sediment is a diagnostic test which is frequently neglected by nephrologists. With this review the authors wanted to demonstrate that it can provide useful and relevant information in a wide spectrum of clinical situations. RECENT FINDINGS:The authors reviewed the main contri...

journal_title：Current opinion in nephrology and hypertension

authors： Fogazzi GB,Garigali G

更新日期：2003-11-01 00:00:00

abstract：:Cells in renal medullas are exposed to a high concentration of salt during antidiuresis. They adapt in part by accumulating myo-inositol, glycine betaine, taurine, and other amino acids by transporting them from the interstitial fluid. This transport is osmotically regulated by changes in transcription of the transpor...

journal_title：Current opinion in nephrology and hypertension

authors： Burg MB

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent data have highlighted the shortcomings of the usual blood pressure hypothesis in posthoc analyses of randomized controlled trials led in populations at high cardiovascular risk and have emphasized the importance of an increased visit-to-visit variability of blood pressure in predicting cardiova...

journal_title：Current opinion in nephrology and hypertension

authors： Rossignol P,Kessler M,Zannad F

更新日期：2013-01-01 00:00:00

abstract：:An increasing number of population-based studies and clinical trials have examined the role of blood pressure in renal disease. Recent reports indicate that elevations of blood pressure, even within the normotensive range, may result in renal damage. The available evidence suggests that blood pressure reduction dimini...

journal_title：Current opinion in nephrology and hypertension

authors： Perneger TV,Whelton PK

更新日期：1993-05-01 00:00:00

abstract：PURPOSE OF REVIEW:MRI can noninvasively assess the structure and function of the kidney in a single MRI scan session. This review summarizes recent advancements in functional renal MRI techniques, with a particular focus on clinical applications. RECENT FINDINGS:A number of MRI techniques now provide measures of relev...

journal_title：Current opinion in nephrology and hypertension

authors： Mahmoud H,Buchanan C,Francis ST,Selby NM

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review addresses the recent literature demonstrating important differences in the rate of progression of kidney function decline between transplant recipients and patients with native kidney disease. It also highlights the need for prospective studies to determine the importance of nonimmu...

journal_title：Current opinion in nephrology and hypertension

authors： Woo YM,Pereira BJ,Gill JS

更新日期：2004-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension is an important risk factor for adverse cardiovascular and renal outcomes particularly in patients with chronic kidney disease. This review compares blood pressure measurements obtained in the clinic with those obtained outside the clinic to predict cardiovascular and renal injury and out...

journal_title：Current opinion in nephrology and hypertension

authors： Agarwal R

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin-aldosterone system is an important modulator of renal salt excretion and arterial pressure. An important body of evidence now supports that angiotensin II (AngII) modulates the function of the renal sodium-chloride cotransporter (NCC), independently of aldosterone. Here we summar...

journal_title：Current opinion in nephrology and hypertension

authors： Castañeda-Bueno M,Gamba G

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In light of the recent changes to the kidney allocation system (KAS) and the observed increase in the rate of transplantation of the highly sensitized kidney transplant candidate, the evaluation and care of this population is a timely topic. RECENT FINDINGS:In its first year, the new KAS has already ...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar V

更新日期：2015-11-01 00:00:00

abstract：:Dopamine is one of the major natriuretic hormone. It acts as an autocrine or paracrine factor to inhibit Na+ transport in several tubular segments. Na+,K(+)-ATPase is an important target protein for dopamine. Studies of the tubular effects of dopamine have provided new information about the coupling of dopamine to int...

journal_title：Current opinion in nephrology and hypertension

authors： Aperia A

更新日期：1994-01-01 00:00:00

abstract：:Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieske JC,Toback FG

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the article is to review studies on bone health and oxalate metabolism/therapeutics in the obese rodent model of Roux-en-Y gastric bypass (RYGB) and examine pathways to decrease procedural morbidity. RECENT FINDINGS:Compared with controls, RYGB rodents have up to 40-fold more fat in their ...

journal_title：Current opinion in nephrology and hypertension

authors： Kwenda EP,Rabley AK,Canales BK

更新日期：2020-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Hyperphosphatemia remains an important aspect in the management of end-stage renal disease patients. Consequently, there is a need for new, efficient and well-tolerated phosphate binders. In this review, a new phosphate-binding drug, lanthanum carbonate, with an attractive preclinical efficacy profile...

journal_title：Current opinion in nephrology and hypertension

authors： Behets GJ,Verberckmoes SC,D'Haese PC,De Broe ME

更新日期：2004-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The gut-kidney axis plays a critical role in oxalate homeostasis, and better understanding of oxalate transport regulatory mechanisms is essential for developing novel therapies. RECENT FINDINGS:Oxalate potentially contributes to chronic kidney disease (CKD) progression, CKD - and end stage renal dis...

journal_title：Current opinion in nephrology and hypertension

authors： Alshaikh AE,Hassan HA

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Endothelial nitric oxide synthase (eNOS) and nicotinamide adenine dinucleotide (phosphate) oxidase [NAD(P)H oxidase] are both expressed in tubular epithelial cells within the renal medulla, particularly the thick ascending limb of the loop of Henle (mTALH). Thick ascending limbs contribute to long-ter...

journal_title：Current opinion in nephrology and hypertension

authors： Evans RG,Fitzgerald SM

更新日期：2005-01-01 00:00:00

abstract：:Chronic renal disease evolves to end-stage renal failure through events, including enhanced intraglomerular pressure and plasma protein ultrafiltration, mediated at least in part by angiotensin II. Angiotensin-converting enzyme inhibitors reduce intracapillary pressure and ameliorate glomerular size-selective function...

journal_title：Current opinion in nephrology and hypertension

authors： Ruggenenti P,Remuzzi G

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in hemodialysis technology, a stable and well functioning vascular access remains the bane of every hemodialysis patient. It is recognized that vascular access contributes to cardiovascular disease mortality through a number of mechanisms. This review describes the relationship betwee...

journal_title：Current opinion in nephrology and hypertension

authors： MacRae JM

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review surveys the literature on the search for the genetic basis of hypertension during the 10 months since November 2003. The goals set forth by this search are defined and the highlights of the work accomplished are provided. RECENT FINDINGS:The search for the genetic basis of hypertension is...

journal_title：Current opinion in nephrology and hypertension

authors： Yagil Y,Yagil C

更新日期：2005-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Iron deficiency is a major contributory cause to the development of anaemia in chronic kidney disease (CKD), and thus, iron replacement therapy plays a critical role in the management of this condition. The two main routes for administering iron are oral and intravenous, and there have been a number o...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The analysis of renal tissue from kidney biopsies by histology, electron microscopy and immunohistology represents the current standards used to establish a specific diagnosis in nephrology. Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal b...

journal_title：Current opinion in nephrology and hypertension

authors： Henger A,Schmid H,Kretzler M

更新日期：2004-05-01 00:00:00

abstract：:In spite of the popular belief that "nervous tension," "stress," and hypertension are causally related, it has been difficult to prove a role of autonomic dysfunction in the genesis of essential hypertension. There are three major reasons for this: 1) autonomic function cannot be assessed with one simple test, 2) the ...

journal_title：Current opinion in nephrology and hypertension

authors： Julius S

更新日期：1992-12-01 00:00:00

abstract：:Our basic understanding of sodium mechanisms provides unique insights into epithelial transport processes, and unusual clinical syndromes can arise from mutations of these ion transporters. These genetic disorders affect sodium balance, with both sodium-retaining and sodium-wasting conditions being the consequence. A ...

journal_title：Current opinion in nephrology and hypertension

authors： Warnock DG

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:With the increasing incidence and prevalence of ESRD in the elderly, we are now transplanting more elderly patients. Although we know from previous reports that transplantation provides increased survival advantage and/or quality of life when compared to being on dialysis, we also know that transplant...

journal_title：Current opinion in nephrology and hypertension

authors： Kodali L,Turner A

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. PLA2R and THSD7A antigens were described in 2009 and 2014 using classical immunochemical techniques. In the last 2 years, thanks to the combination of laser microdissection of glomeruli and mass ...

journal_title：Current opinion in nephrology and hypertension

authors： Ronco P,Debiec H

更新日期：2021-01-21 00:00:00

abstract：PURPOSE OF REVIEW:Simultaneous liver kidney transplantation (SLK) has taken center stage since the initiation of the new kidney allocation system (KAS). This review places SLK in the context of the changing landscape of organ allocation. RECENT FINDINGS:The introduction of the Mayo End-Stage Liver Disease score into l...

journal_title：Current opinion in nephrology and hypertension

authors： Formica RN Jr

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors activated by nutrient molecules and their derivatives. Their role has been increasingly recognized to be important in hypertension, metabolic disorders and cardiovascular disease, including atherosclerosis. Control o...

journal_title：Current opinion in nephrology and hypertension

authors： Duan SZ,Usher MG,Mortensen RM

更新日期：2009-03-01 00:00:00