Heme oxygenase in pregnancy and preeclampsia.

abstract：PURPOSE OF THIS REVIEW:The purpose of this review is to explain the rationale and limitations for use of mineralocorticoid receptor blockers (MRBs) for the treatment of chronic kidney disease (CKD) and its complications. RECENT FINDINGS:Recent studies in animal models of CKD demonstrate that blockade of the mineraloco...

journal_title：Current opinion in nephrology and hypertension

authors： Toto RD

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:To discuss new insights regarding chronic antibody-mediated rejection (CAMR) and its progression to transplant glomerulopathy. We will describe the progression to transplant glomerulopathy from a histologic perspective and provide updates on what is known about its pathophysiology, prognosis, and...

journal_title：Current opinion in nephrology and hypertension

authors： Schinstock CA,Stegall M,Cosio F

更新日期：2014-11-01 00:00:00

abstract：:Our basic understanding of sodium mechanisms provides unique insights into epithelial transport processes, and unusual clinical syndromes can arise from mutations of these ion transporters. These genetic disorders affect sodium balance, with both sodium-retaining and sodium-wasting conditions being the consequence. A ...

journal_title：Current opinion in nephrology and hypertension

authors： Warnock DG

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute kidney injury (AKI) is a serious problem. Understanding an individual patient's risk profile may offer opportunities for prevention or early intervention. The aim of this review is to describe novel nontraditional risk factors. RECENT FINDINGS:The risk of AKI is determined by patient factors an...

journal_title：Current opinion in nephrology and hypertension

authors： Varrier M,Ostermann M

更新日期：2014-11-01 00:00:00

abstract：:The precise adaptation of renal sodium excretion to systemic needs is to a large extent achieved by the regulation of sodium re-absorption in the aldosterone-sensitive distal nephron. Transcellular sodium re-absorption by the segment-specific cells of the aldosterone-sensitive distal nephron (often called principal ce...

journal_title：Current opinion in nephrology and hypertension

authors： Verrey F

更新日期：2001-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent findings on the relationship between congestive heart failure and renal failure are summarized in this review. RECENT FINDINGS:Congestive heart failure is found in about one-quarter of cases of chronic kidney disease. The most common cause of congestive heart failure is ischemic heart disease....

journal_title：Current opinion in nephrology and hypertension

authors： Silverberg D,Wexler D,Blum M,Schwartz D,Iaina A

更新日期：2004-03-01 00:00:00

abstract：:The proximal tubule in the kidney is a main organ for the metabolic clearance of small peptide hormones, and is intensively involved in reabsorption, storage and homeostatic regulation of different vitamins. Recently, the endocytic membrane protein megalin has been shown to bind several smaller peptides, including ins...

journal_title：Current opinion in nephrology and hypertension

authors： Christensen EI,Birn H

更新日期：1997-01-01 00:00:00

abstract：:Recent investigations cast some doubts on the status of insulin resistance as a trigger in hyperinsulinemia-associated hypertension or obesity-related hypertension, or both. Major epidemiological studies have shown that central adiposity is a powerful risk factor for stroke or coronary artery disease when accompanied ...

journal_title：Current opinion in nephrology and hypertension

authors： Reisin E,Messerli FH

更新日期：1995-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The majority of uric acid nephrolithiasis in humans occurs in the absence of frank hyperuricosuria and is primarily a disease of excessively low urinary pH. Uric acid is substantially less soluble than urate salts so in low urine pH urate is protonated, thus favoring precipitation even under what is c...

journal_title：Current opinion in nephrology and hypertension

authors： Moe OW

更新日期：2006-07-01 00:00:00

abstract：:The parathyroid normally has very few cells in mitosis but it retains the potential to proliferate. In-vivo studies in rats have demonstrated that hypocalcaemia and high serum phosphate both lead to an increase in the number of proliferating cells, which is relevant to the increased parathyroid cell proliferation in c...

journal_title：Current opinion in nephrology and hypertension

authors： Silver J,Sela SB,Naveh-Many T

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic allograft nephropathy has fallen into disfavor as a morphologic term to describe parenchymal scarring in the renal allograft, with a recommendation that this be replaced by the more descriptive term 'interstitial fibrosis and tubular atrophy'. However, neither term addresses the underlying cau...

journal_title：Current opinion in nephrology and hypertension

authors： Haas M

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the recent findings concerning novel Mg transporters as putative interesting players in renal transepithelial Mg transport. RECENT FINDINGS:So far, the best characterized Mg transport proteins are found in prokaryotes and yeast cells. In recent years, phylogenetic analysi...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrè S,Hoenderop JG,Bindels RJ

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade post-hoc analyses of clinical trials and observational studies have tended to show that participants treated with thiazide diuretics are at greater risk for newly diagnosed diabetes mellitus than those treated with other medication classes. We review the results of several recent ...

journal_title：Current opinion in nephrology and hypertension

authors： Barzilay JI,Cutler JA,Davis BR

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Disturbances in mineral metabolism are common among individuals with chronic kidney disease and have consistently been associated with cardiovascular and bone disease. The current review aims to describe the current knowledge of the genetic aspects of mineral metabolism disturbances and to suggest dir...

journal_title：Current opinion in nephrology and hypertension

authors： Robinson-Cohen C

更新日期：2020-07-01 00:00:00

abstract：:The immunosuppressants cyclosporine and FK506 (tacrolimus) are extremely potent inhibitors of T-lymphocyte activation. Recent studies have shown that these agents are actually prodrugs that become active only when bound to specific members of the cyclophilin or FK506 binding protein receptor gene families. The cyclosp...

journal_title：Current opinion in nephrology and hypertension

authors： Tocci MJ,Sigal NH

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Arterial stiffness due to alterations in extracellular matrix is one of the mechanisms responsible for increased peripheral resistance in hypertension. Recent evidence points to arterial stiffness as an independent predictor of cardiovascular events. This review focuses on recent advances in the biolo...

journal_title：Current opinion in nephrology and hypertension

authors： Briones AM,Arribas SM,Salaices M

更新日期：2010-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequately controlled blood pressure is considered an important risk factor for both chronic kidney disease (CKD) progression and cardiovascular disease progression in CKD patients. Patients with CKD and hypertension are typically followed in primary care practice settings and blood pressure is not ...

journal_title：Current opinion in nephrology and hypertension

authors： St Peter WL,Farley TM,Carter BL

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Assessment of fluid status to reach normovolemia in patients with chronic kidney disease (CKD) continues to be a tough task. Besides clinical observation, technological methods have been introduced, yet, the best approach is still uncertain. The present review looks at fluid overload in CKD from three...

journal_title：Current opinion in nephrology and hypertension

authors： de Ruiter A,Bello A,Braam B

更新日期：2020-11-01 00:00:00

abstract：:The complex multifactorial inheritance pattern of systemic lupus erythematosus in various murine models has been dissected via both classic genetic analysis and the use of modern technologies in genomic manipulation. Current information suggests that lupus may be mediated by a multitude of genetic abnormalities that i...

journal_title：Current opinion in nephrology and hypertension

authors： Yim YS,Wakeland EK

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Identification of the mechanisms of magnesium absorption and reabsorption has markedly enhanced our understanding of the causes of hypomagnesemia. RECENT FINDINGS:New gastrointestinal and renal causes of hypomagnesemia have been recently documented. SUMMARY:The recognition of new mechanisms and caus...

journal_title：Current opinion in nephrology and hypertension

authors： Agus ZS

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now a...

journal_title：Current opinion in nephrology and hypertension

authors： Nguyen Dinh Cat A,Jaisser F

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The amiloride-sensitive epithelial sodium channel (ENaC) plays a major role in the regulation of sodium transport in the collecting duct and hence sodium balance. This review describes recent findings in the regulation of ENaC function by serine proteases in particular and other regulatory aspects. R...

journal_title：Current opinion in nephrology and hypertension

authors： Hamm LL,Feng Z,Hering-Smith KS

更新日期：2010-01-01 00:00:00

abstract：:Secondary hyperparathyroidism remains the predominant histologic lesion in pediatric patients undergoing regular dialysis, but recent evidence indicates that the regulation of parathyroid hormone secretion by calcium does not differ substantially between patients with osteitis fibrosa and subjects with normal renal fu...

journal_title：Current opinion in nephrology and hypertension

authors： Salusky IB,Ramirez JA,Goodman WG

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In the last decade many attempts have been made to reduce the high residual risk of end-stage kidney disease and cardiovascular disease in patients with diabetic kidney disease by targeting a variety of risk markers. Subsequent analyses revealed that the variation in individual drug response to the te...

journal_title：Current opinion in nephrology and hypertension

authors： Idzerda NMA,Pena MJ,Heerspink HJL

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The nephrology community lacks a unified view of protein sieving through the glomerular capillary wall. The glomerular capillary wall consists of three distinct but closely interacting layers: the fenestrated endothelium, with its glycocalyx; the podocytes, with their interdigitated foot processes and...

journal_title：Current opinion in nephrology and hypertension

authors： Jarad G,Miner JH

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with chronic kidney disease (CKD) endure compromised health-related quality of life (HRQOL). Although the link between HRQOL and increased mortality in patients with end-stage renal disease (ESRD) is well documented, less is known about the relationship between CKD and HRQOL. This article rev...

journal_title：Current opinion in nephrology and hypertension

authors： Soni RK,Weisbord SD,Unruh ML

更新日期：2010-03-01 00:00:00

abstract：:There has been an increasing focus on renovascular disease, particularly in renal failure, and on the role of renal angioplasty and stenting. Significant improvements have occurred in non-invasive imaging techniques. This review concentrates on the recent developments in imaging that specifically targets the renal art...

journal_title：Current opinion in nephrology and hypertension

authors： Reidy JF

更新日期：2002-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To clarify misconceptions about the feasibility and risks of peritoneal dialysis that unnecessarily limit peritoneal dialysis uptake or continuation in patients for whom peritoneal dialysis is the preferred dialysis modality. The inappropriate choice of haemodialysis as a result of these misconception...

journal_title：Current opinion in nephrology and hypertension

authors： Lee MB,Bargman JM

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the role of restricting dietary sodium intake in chronic kidney disease (CKD) and its complications. RECENT FINDINGS:A consistent line of evidence shows that high dietary sodium intake is a determinant of therapy resistance to blockade of the renin-angiotensin-aldosterone system (RAAS). A...

journal_title：Current opinion in nephrology and hypertension

authors： Krikken JA,Laverman GD,Navis G

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension (HTN) and chronic kidney disease (CKD) are significant problems. With recent advances in technologies, biosensors have shown a great potential to provide better home monitoring in hypertension (HTN), medication compliance, diagnostic device for kidney disease, CKD/end-stage renal disease ...

journal_title：Current opinion in nephrology and hypertension

authors： Park SH,Zhang Y,Rogers JA,Gallon L

更新日期：2019-07-01 00:00:00