Dietary salt and hypertension.

abstract：PURPOSE OF REVIEW:Simultaneous liver kidney transplantation (SLK) has taken center stage since the initiation of the new kidney allocation system (KAS). This review places SLK in the context of the changing landscape of organ allocation. RECENT FINDINGS:The introduction of the Mayo End-Stage Liver Disease score into l...

journal_title：Current opinion in nephrology and hypertension

authors： Formica RN Jr

更新日期：2016-11-01 00:00:00

abstract：:An increasing number of population-based studies and clinical trials have examined the role of blood pressure in renal disease. Recent reports indicate that elevations of blood pressure, even within the normotensive range, may result in renal damage. The available evidence suggests that blood pressure reduction dimini...

journal_title：Current opinion in nephrology and hypertension

authors： Perneger TV,Whelton PK

更新日期：1993-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of vitamin D beyond its importance for bone health is under much debate. In this article, we review recent evidence for genetic influences on 25-hydroxyvitamin D [25(OH)D] and discuss the uses of this information and its importance for public health. RECENT FINDINGS:Findings from large-scale...

journal_title：Current opinion in nephrology and hypertension

authors： Berry D,Hyppönen E

更新日期：2011-07-01 00:00:00

abstract：:During the past 12 months additional evidence has emerged from several studies, indicating that hepatitis C virus infection is the most important liver disease after renal transplantation. A new, severe and rare entity called fibrosing cholestatic hepatitis can lead to early liver failure, although the most important ...

journal_title：Current opinion in nephrology and hypertension

authors： Morales JM,Campistol JM,Andrés A,Rodicio JL

更新日期：1998-03-01 00:00:00

abstract：:Proteinuria (protein excretion > 300 mg/d) is an independent risk factor for the development of cardiovascular disease and renal failure. The finding of persistent proteinuria in otherwise asymptomatic patients often precedes the development of arterial hypertension and renal failure. When proteinuria is accompanied b...

journal_title：Current opinion in nephrology and hypertension

authors： Ruilope LM,Rodicio JL

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:We aim to review the biological properties of novel molecules that are members of a kidney-bone axis involved in the regulation of phosphate homeostasis. In addition, we describe how an improved knowledge of the mechanisms leading to changes in renal phosphate handling may lead to the development of n...

journal_title：Current opinion in nephrology and hypertension

authors： Strom TM,Jüppner H

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:African-Americans are more likely than Caucasians to develop hypertension-related end-stage renal disease. Elevations in blood pressure levels clearly potentiate pre-existing renal disease and also contribute to kidney injury independently of other primary renal diseases in this cohort. Until recently...

journal_title：Current opinion in nephrology and hypertension

authors： Kaperonis N,Bakris G

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The sodium-hydrogen exchanger isoform-1 (NHE1) functions in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of extracellular sodium and intracellular hydrogen. Recent studies have revealed the structural functions of NHE1 as an anchor for actin filaments and a sca...

journal_title：Current opinion in nephrology and hypertension

authors： Meima ME,Mackley JR,Barber DL

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Several genetic and acquired abnormalities leading to abnormal activation of the alternative pathway of complement have been identified in patients with atypical hemolytic uremic syndrome (aHUS). The purpose of this review is to shed light on how advances in the understanding of aHUS pathogenesis have...

journal_title：Current opinion in nephrology and hypertension

authors： Noris M,Remuzzi G

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this mini-review is to highlight some unresolved questions and controversies in the evolving story of apolipoprotein L1 (APOL1) nephropathy. RECENT FINDINGS:We highlight studies that introduce complexity in unraveling the mechanisms whereby APOL1 risk variant alleles cause disease. The...

journal_title：Current opinion in nephrology and hypertension

authors： Kruzel-Davila E,Skorecki K

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:MRI can noninvasively assess the structure and function of the kidney in a single MRI scan session. This review summarizes recent advancements in functional renal MRI techniques, with a particular focus on clinical applications. RECENT FINDINGS:A number of MRI techniques now provide measures of relev...

journal_title：Current opinion in nephrology and hypertension

authors： Mahmoud H,Buchanan C,Francis ST,Selby NM

更新日期：2016-11-01 00:00:00

abstract：:It has been 6 years since the first reports of the use of recombinant human erythropoietin for the treatment of renal anemia appeared in the medical literature. During this period, erythropoietin has become established as a safe and highly effective therapy, and it is currently being evaluated for other nonrenal types...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：1992-12-01 00:00:00

abstract：:Several recently completed or ongoing large-scale clinical trials, including the Modification of Diet in Renal Disease Study, the Diabetes Control and Complications Trial, and the African-American Study of Kidney Disease and Hypertension, have all chosen the renal clearance of sodium 125I-iothalmate to monitor renal d...

journal_title：Current opinion in nephrology and hypertension

authors： Hall PM,Rolin H

更新日期：1995-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin-aldosterone system is an important modulator of renal salt excretion and arterial pressure. An important body of evidence now supports that angiotensin II (AngII) modulates the function of the renal sodium-chloride cotransporter (NCC), independently of aldosterone. Here we summar...

journal_title：Current opinion in nephrology and hypertension

authors： Castañeda-Bueno M,Gamba G

更新日期：2012-09-01 00:00:00

abstract：:The recognition that cell death in the myocardium is not only necrotic in nature but is also mediated by activation of the suicide program of myocytes has raised several questions concerning the magnitude of this phenomenon, and whether these two distinct forms of cell death are disease-dependent or coexist in the pat...

journal_title：Current opinion in nephrology and hypertension

authors： Anversa P,Olivetti G,Leri A,Liu Y,Kajstura J

更新日期：1997-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Several factors are now known to contribute to the development and progression of nephropathy, particularly in diabetes. In recent times, there has been surge of interest in the role of small noncoding RNA, with several reports focusing on the effects of microRNAs on their target genes that are of rel...

journal_title：Current opinion in nephrology and hypertension

authors： McClelland A,Hagiwara S,Kantharidis P

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The review will examine clinically relevant advances in the area of polycystic kidney disease (PKD), mainly focusing on autosomal dominant polycystic kidney disease (ADPKD). Discussion will focus on predicting the course of ADPKD, clinical trials and new research endeavors. RECENT FINDINGS:During the...

journal_title：Current opinion in nephrology and hypertension

authors： Steinman TI

更新日期：2012-03-01 00:00:00

abstract：:The target hematocrit to be achieved when treating anemia in hemodialysis patients with erythropoietin is controversial. Current evidence-based recommendations suggest a target hematocrit range of 33% to 36%. Small studies suggest that normalization of hematocrit with erythropoietin may benefit hemodialysis patients i...

journal_title：Current opinion in nephrology and hypertension

authors： Murphy ST,Parfrey PS

更新日期：1999-09-01 00:00:00

abstract：:Overexpression of the cytokine transforming growth factor-beta has been identified as the key mediator of chronic progressive kidney fibrosis in experimental and human kidney diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have recently been linked to downregulation of transformin...

journal_title：Current opinion in nephrology and hypertension

authors： Peters H,Noble NA,Border WA

更新日期：1997-07-01 00:00:00

abstract：:It has been suspected that abnormalities of the L-arginine-nitric oxide pathway could underlie certain forms of hypertension. In this review, we will consider the role of nitric oxide in primary and secondary models of experimental hypertension and discuss potential abnormalities of the L-arginine-nitric oxide pathway...

journal_title：Current opinion in nephrology and hypertension

authors： Arnal JF,Michel JB,Harrison DG

更新日期：1995-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Structural biology is one of the most informative disciplines available to biochemical research. It unites technologies that can reveal high-resolution (often atomic) details of the inner workings of biochemical systems. These insights are crucial for an understanding of basic life processes, such as ...

journal_title：Current opinion in nephrology and hypertension

authors： Machius M

更新日期：2003-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we will discuss (i) how the recent advancements in digital technology and computational engineering are currently applied to nephropathology in the setting of clinical research, trials, and practice; (ii) the benefits of the new digital environment; (iii) how recognizing its challenges...

journal_title：Current opinion in nephrology and hypertension

authors： Barisoni L,Hodgin JB

更新日期：2017-11-01 00:00:00

abstract：:Heat shock proteins, or stress proteins, are molecular chaperones responsible for protein processing and protection against cellular injury through the prevention of inappropriate peptide interactions. The distribution of individual stress proteins varies between regions of the kidney and within subcellular compartmen...

journal_title：Current opinion in nephrology and hypertension

authors： Van Why SK,Siegel NJ

更新日期：1998-07-01 00:00:00

abstract：:After renal transplantation, acute allograft dysfunction secondary to acute rejection occurs in around 30-40% of patients. Although in the majority of patients these episodes are reversible, acute rejection remains a major risk factor for the development of chronic rejection. Remarkably, prior episodes of acute allogr...

journal_title：Current opinion in nephrology and hypertension

authors： Chandraker A

更新日期：1999-11-01 00:00:00

abstract：:The characteristic structure of polarized proximal tubule cells is drastically altered by the onset of ischemic acute renal failure. Distinctive apical brush border microvilli disruption occurs rapidly and in a duration-dependent fashion. Microvillar membranes internalize into the cytosol of the cell or are shed into ...

journal_title：Current opinion in nephrology and hypertension

authors： Ashworth SL,Molitoris BA

更新日期：1999-07-01 00:00:00

abstract：:Elevated serum uric acid is a frequent finding in patients with kidney disease and cardiovascular disease. Intrarenal ischaemia, induced by hypertension, increased sympathetic nervous system activity, and hyperinsulinaemia have all been implicated in reduced renal clearance of urate. This frequently results in elevate...

journal_title：Current opinion in nephrology and hypertension

authors： Culleton BF

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin system, traditionally viewed as a circulatory system, has significantly expanded in the last two decades to include independently regulated local systems in several tissues, newly identified active products of angiotensin II, and new receptors and functions of renin-angiotensin s...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar R,Singh VP,Baker KM

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequately controlled blood pressure is considered an important risk factor for both chronic kidney disease (CKD) progression and cardiovascular disease progression in CKD patients. Patients with CKD and hypertension are typically followed in primary care practice settings and blood pressure is not ...

journal_title：Current opinion in nephrology and hypertension

authors： St Peter WL,Farley TM,Carter BL

更新日期：2011-09-01 00:00:00

abstract：:Vascular endothelial growth factor is a diffusible endothelial cell-specific mitogen and angiogenic factor that can also increase vascular permeability. The vascular endothelial growth factor receptors are specifically expressed on the cell surface of vascular endothelial cells. Recent studies point to vascular endoth...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrara N,Bunting S

更新日期：1996-01-01 00:00:00

abstract：:The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor belongs to a newly discovered family of G protein-coupled receptors. Members of this family, which have been isolated from mammals, include the receptors for PTH/PTHrP, calcitonin, secretin, growth hormone-releasing hormone, vasoactive ...

journal_title：Current opinion in nephrology and hypertension

authors： Jüppner H

更新日期：1994-07-01 00:00:00