Abstract:
PURPOSE OF REVIEW:African-Americans are more likely than Caucasians to develop hypertension-related end-stage renal disease. Elevations in blood pressure levels clearly potentiate pre-existing renal disease and also contribute to kidney injury independently of other primary renal diseases in this cohort. Until recently, data relevant to a full examination of the issue of blood pressure levels and end-stage renal disease in African-Americans have largely been from post-hoc analyses of clinical trials or from small, prospective, short-term studies. RECENT FINDINGS:The most recent United States Renal Data Systems data show hypertension as the primary cause of end-stage renal disease in African-Americans until 1997, diabetes now being the most prevalent etiology. Data from post-hoc analyses of the Modification of Diet in Renal Disease study demonstrated that African-Americans with a mean arterial pressure above 98 mmHg had a higher risk of end-stage renal disease than Caucasians. The African-American Study of Kidney Disease tested the hypothesis that a blood pressure well below the usual recommended level will further reduce renal disease progression in African-Americans. The study concluded that a blood pressure lower than that needed to reduce cardiovascular events, as defined by the Sixth Joint National Committee Report on the Detection, Evaluation and Treatment of High Blood Pressure, i.e. 135-140/80-85 mmHg, will not further slow renal disease progression in African-Americans with hypertensive nephrosclerosis. Moreover, a regimen of blood pressure lowering anchored on angiotensin-converting enzyme inhibitors, antihypertensive agents that are touted as ineffective in African-Americans, was more effective than one based on either beta-blockers or dihydropyridine calcium-channel blockers in slowing the progression of renal injury. SUMMARY:Systolic blood pressure reduction in the range 130-139 mmHg is appropriate to reduce risk of nephropathy progression and cardiovascular risk in African-Americans with hypertensive nephrosclerosis. Moreover, a regimen that is initiated with an angiotensin-converting enzyme inhibitor should be the antihypertensive treatment of choice in African-Americans with kidney disease.
journal_name
Curr Opin Nephrol Hypertensjournal_title
Current opinion in nephrology and hypertensionauthors
Kaperonis N,Bakris Gdoi
10.1097/00041552-200301000-00013keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
79-84issue
1eissn
1062-4821issn
1473-6543journal_volume
12pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Iron deficiency anaemia (IDA) is common and associated with fatigue, reduced quality of life and poorer clinical outcomes. Treatment with oral iron is often inadequate and international guidelines recommend intravenous (i.v.) iron as the preferred option for the treatment of IDA in certain clinical si...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0000000000000263
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abstract::Renal synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a pivotal step in calcium and phosphate homeostasis. Production of 1,25(OH)2D3 is catalyzed by the mitchondrial cytochrome P450, 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-HYD). As a consequence of the tight regulation of ...
journal_title:Current opinion in nephrology and hypertension
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abstract:PURPOSE OF REVIEW:In the last decade many attempts have been made to reduce the high residual risk of end-stage kidney disease and cardiovascular disease in patients with diabetic kidney disease by targeting a variety of risk markers. Subsequent analyses revealed that the variation in individual drug response to the te...
journal_title:Current opinion in nephrology and hypertension
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abstract:PURPOSE OF REVIEW:The analysis of renal tissue from kidney biopsies by histology, electron microscopy and immunohistology represents the current standards used to establish a specific diagnosis in nephrology. Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal b...
journal_title:Current opinion in nephrology and hypertension
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abstract:PURPOSE OF REVIEW:Defective transduction of the dopamine receptor signal in the kidney has been shown to be important in the pathogenesis of hypertension This review will discuss the genetic mechanism for the defective renal dopaminergic function and the interaction with other gene variant products in the pathogenesis ...
journal_title:Current opinion in nephrology and hypertension
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abstract::The signalling mechanisms and biological significance of the angiotensin II type 2 receptor have long been unknown. In recent years, studies, first in cell culture models but now increasingly also in vivo, have shed some light on the molecular events occurring after a stimulation of the receptor with its ligand as wel...
journal_title:Current opinion in nephrology and hypertension
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abstract::Magnesium is an important, predominantly intracellular cation that is required for a wide variety of cellular processes. The mammalian kidney plays a key role in whole-body magnesium homeostasis, but the molecular and cellular mechanisms that underlie renal epithelial magnesium reabsorption are poorly understood. Trad...
journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
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doi:10.1097/MNH.0b013e32832cb96a
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature. RECENT FINDINGS:In addition to the classical contact site between the macula densa plaque and the afferen...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0b013e32831daf54
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The discovery of the importance of proteins localized to cilia and basal bodies has provided novel insights into the pathogenesis of various human disorders including cystic kidney disease. The physiological role of cilium-generated signaling in most tissues including the kidney has remained elusive, ...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章
doi:10.1097/01.mnh.0000222690.53970.ca
更新日期:2006-05-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2005-05-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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doi:10.1097/MNH.0b013e32835dda01
更新日期:2013-03-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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doi:10.1097/MNH.0000000000000462
更新日期:2019-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0000000000000051
更新日期:2014-09-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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doi:10.1097/MNH.0b013e3280117fc7
更新日期:2007-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/01.mnh.0000222700.14960.18
更新日期:2006-05-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-199212000-00005
更新日期:1992-12-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-199212000-00016
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-200011000-00013
更新日期:2000-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0000000000000120
更新日期:2015-05-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 社论,评审
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更新日期:1999-07-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1993-07-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-200005000-00012
更新日期:2000-05-01 00:00:00