Abstract:
PURPOSE OF REVIEW:Defective transduction of the dopamine receptor signal in the kidney has been shown to be important in the pathogenesis of hypertension This review will discuss the genetic mechanism for the defective renal dopaminergic function and the interaction with other gene variant products in the pathogenesis of salt sensitivity and essential hypertension. RECENT FINDINGS:Single nucleotide polymorphisms of G protein-coupled receptor kinase type 4 (GRK4) phosphorylate, desensitize, and diminish the inhibitory action of D receptors on sodium transport in the kidney. Inhibition of GRK4 expression normalizes renal proximal tubule D receptor function in humans and rodents and ameliorates the hypertension in genetically hypertensive rats. Expression of the GRK4 variant, GRK4gammaA142V, produces hypertension and impairs the natriuretic effect of D receptor stimulation in mice. In humans, GRK4 single nucleotide polymorphisms are associated with essential hypertension, particularly salt sensitive hypertension. The prediction of the hypertensive phenotype is most accurate when elements of the renin-angiotensin system and GRK4 are included in the analysis. SUMMARY:GRK4 single nucleotide polymorphisms, by preventing the natriuretic function of the dopaminergic system and by allowing the antinatriuretic function of angiotensin II type 1 receptors to predominate, may be responsible for salt sensitivity. Hypertension develops with additional perturbations caused by the variants of other genes (e.g., alpha-adducin, angiotensin converting enzyme, angiotensinogen, angiotensin II type 1 receptor, aldosterone synthase, 11beta-hydroxysteroid dehydrogenase type 2), the quantitative interaction of which may vary depending upon the genetic background.
journal_name
Curr Opin Nephrol Hypertensjournal_title
Current opinion in nephrology and hypertensionauthors
Jose PA,Eisner GM,Felder RAdoi
10.1097/00041552-200303000-00010keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
189-94issue
2eissn
1062-4821issn
1473-6543journal_volume
12pub_type
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/01.mnh.0000437612.50040.ae
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Fibrosis is an important biomarker of chronic kidney injury, and a powerful predictor of renal outcome. Currently, the only method for measuring fibrotic burden is histologic analysis, which requires a kidney biopsy in humans, or kidney removal in animal models. These requirements have not only hinder...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章
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journal_title:Current opinion in nephrology and hypertension
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doi:10.1097/MNH.0b013e328335f939
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Structural biology is one of the most informative disciplines available to biochemical research. It unites technologies that can reveal high-resolution (often atomic) details of the inner workings of biochemical systems. These insights are crucial for an understanding of basic life processes, such as ...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-200307000-00012
更新日期:2003-07-01 00:00:00
abstract::There is ample evidence to support the recommendation of renin-angiotensin system blockade therapy as the standard of care for strategies aimed at preserving renal function in chronic renal disease. Nevertheless, despite the well established antihypertensive effects of these drugs, the use of renin-angiotensin system ...
journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
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更新日期:1998-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The amiloride-sensitive epithelial sodium channel (ENaC) plays a major role in the regulation of sodium transport in the collecting duct and hence sodium balance. This review describes recent findings in the regulation of ENaC function by serine proteases in particular and other regulatory aspects. R...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2014-05-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-200211000-00011
更新日期:2002-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-199301000-00010
更新日期:1993-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This review examines recent advances in understanding of how clinical outcomes for hemodialysis patients may be improved by achieving longer or more frequent treatment times, lower ultrafiltration rates (UFRs), improving nutritional status, and individualizing dialysate composition. This review also d...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0b013e328365b34c
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Vitamin D has diverse biological actions, and consequently the mechanisms behind how it regulates gene transcription are diverse. Unlike its well described positive effects on gene transcription, little is known about how vitamin D induces transcriptional repression. RECENT FINDINGS:Vitamin D-induced...
journal_title:Current opinion in nephrology and hypertension
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doi:10.1097/MNH.0b013e3281c55f16
更新日期:2007-07-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章
doi:10.1097/01.mnh.0000222690.53970.ca
更新日期:2006-05-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0000000000000473
更新日期:2019-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Cytochrome (CYP) P450 metabolites of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) contribute to the regulation of renal tubular and vascular function. This review highlights the results of the recent genetic studies in humans and rodent models, indic...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0000000000000088
更新日期:2015-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Autoregulation of renal blood flow has traditionally been considered to stabilize glomerular filtration, and thus tubular load, in the face of blood pressure fluctuations. This view arose because of the contribution of tubuloglomerular feedback, which senses distal tubular fluid composition, to regula...
journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/MNH.0b013e3280117fc7
更新日期:2007-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-199809000-00008
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更新日期:2012-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
doi:10.1097/00041552-199303000-00018
更新日期:1993-03-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1993-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2014-11-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:1996-05-01 00:00:00
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更新日期:2018-07-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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journal_title:Current opinion in nephrology and hypertension
pub_type: 杂志文章,评审
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更新日期:2001-03-01 00:00:00
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journal_title:Current opinion in nephrology and hypertension
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更新日期:2006-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-11-01 00:00:00