The renal monoamine oxidases: pathophysiology and targets for therapeutic intervention.

abstract：:The ability to record sympathetic nerve activity in conscious human subjects using intraneural microelectrodes (microneurography) has proven to be a powerful clinical research tool, which has shed new light on the pathophysiology of important blood pressure problems as exemplified in studies of patients with chronic r...

journal_title：Current opinion in nephrology and hypertension

authors： Hansen J,Victor RG

更新日期：1994-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Identification of the mechanisms of magnesium absorption and reabsorption has markedly enhanced our understanding of the causes of hypomagnesemia. RECENT FINDINGS:New gastrointestinal and renal causes of hypomagnesemia have been recently documented. SUMMARY:The recognition of new mechanisms and caus...

journal_title：Current opinion in nephrology and hypertension

authors： Agus ZS

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Klotho is a transmembrane protein that acts as a co-receptor for fibroblast growth factor 23 (FGF23). Recent investigations have discovered the presence of Klotho in bone-forming osteoblasts and osteocytes. This review summarizes emerging literature on the roles of bone Klotho in mineral and bone meta...

journal_title：Current opinion in nephrology and hypertension

authors： Komaba H,Lanske B

更新日期：2018-07-01 00:00:00

abstract：:Renal tubular cells die by apoptosis as well as necrosis in experimental models of ischemic and toxic acute renal failure as well as in humans with acute tubular necrosis. It is not yet possible, however, to determine the relative contribution of these two forms of cell death to loss of renal tubular cells in acute tu...

journal_title：Current opinion in nephrology and hypertension

authors： Bonegio R,Lieberthal W

更新日期：2002-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Inflammatory cytokines contribute to the pathogenesis of hypertension through effects on renal blood flow and sodium handling. This review will update recent advances that explore the renal actions of immune cells and cytokines in the pathogenesis of hypertension. RECENT FINDINGS:Populations of cells...

journal_title：Current opinion in nephrology and hypertension

authors： Wen Y,Crowley SD

更新日期：2018-03-01 00:00:00

abstract：:The recognition that cell death in the myocardium is not only necrotic in nature but is also mediated by activation of the suicide program of myocytes has raised several questions concerning the magnitude of this phenomenon, and whether these two distinct forms of cell death are disease-dependent or coexist in the pat...

journal_title：Current opinion in nephrology and hypertension

authors： Anversa P,Olivetti G,Leri A,Liu Y,Kajstura J

更新日期：1997-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to describe the recent findings concerning novel Mg transporters as putative interesting players in renal transepithelial Mg transport. RECENT FINDINGS:So far, the best characterized Mg transport proteins are found in prokaryotes and yeast cells. In recent years, phylogenetic analysi...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrè S,Hoenderop JG,Bindels RJ

更新日期：2011-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Calcium is an essential ion for the maintenance of normal bone health and physiologic functions. The extracellular and intracellular levels of calcium are maintained through hormonal regulation called homeostasis. Balance, the net intake minus excretion of calcium, is maintained by hormonal regulation...

journal_title：Current opinion in nephrology and hypertension

authors： Moe SM

更新日期：2018-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The analysis of renal tissue from kidney biopsies by histology, electron microscopy and immunohistology represents the current standards used to establish a specific diagnosis in nephrology. Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal b...

journal_title：Current opinion in nephrology and hypertension

authors： Henger A,Schmid H,Kretzler M

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension (HTN) and chronic kidney disease (CKD) are significant problems. With recent advances in technologies, biosensors have shown a great potential to provide better home monitoring in hypertension (HTN), medication compliance, diagnostic device for kidney disease, CKD/end-stage renal disease ...

journal_title：Current opinion in nephrology and hypertension

authors： Park SH,Zhang Y,Rogers JA,Gallon L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS:Sin...

journal_title：Current opinion in nephrology and hypertension

authors： Rubinstein M,Dvash E

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin superfamily of carrier proteins. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. Here, we review the expression, siderophore-...

journal_title：Current opinion in nephrology and hypertension

authors： Schmidt-Ott KM,Mori K,Kalandadze A,Li JY,Paragas N,Nicholas T,Devarajan P,Barasch J

更新日期：2006-07-01 00:00:00

abstract：:Acute ischemic or toxic injury to the kidney induces alterations in the expression of many genes. Some of these molecular responses have been termed 'maladaptive' because they exacerbate the tubular damage induced by the initiating insult. Some maladaptive responses include alterations in the activity of nitric oxide ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieberthal W

更新日期：1998-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Ischemia reperfusion injury (IRI) is an inevitable complication in solid organ transplantation. Limiting this injury can increase patient and graft survival and can decrease complications associated with transplantation. We provide an extensive literature review analyzing the available evidence for is...

journal_title：Current opinion in nephrology and hypertension

authors： Nadarajah L,Yaqoob MM,McCafferty K

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Incidence of end-stage renal disease has increased dramatically during the last 30 years and screening for early stages of chronic kidney disease is often suggested as a preventive measure. The relationship between chronic kidney disease and end-stage renal disease is complex, however, and recent stud...

journal_title：Current opinion in nephrology and hypertension

authors： Hallan SI,Vikse BE

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we discuss how the genetic hypercalciuric stone-forming (GHS) rats, which closely model idiopathic hypercalciuria and stone formation in humans, provide insights into the pathophysiology and consequences of clinical hypercalciuria. RECENT FINDINGS:Hypercalciuria in the GHS rats is due...

journal_title：Current opinion in nephrology and hypertension

authors： Frick KK,Krieger NS,Bushinsky DA

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Carboxyl-terminal parathyroid hormone (C-PTH) fragments constitute 80% of circulating PTH. Since the first 34 amino acids of the PTH structure are sufficient to explain PTH classical biological effects on the type I PTH/PTHrP receptor and since C-PTH fragments do not bind to this receptor, they have l...

journal_title：Current opinion in nephrology and hypertension

authors： D'Amour P,Brossard JH

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There is increasing evidence that endothelin receptor blockade and, in particular, ET(A) receptor blockade not only confers protection against proteinuric renal disease in diabetes but also confers vasculoprotection. RECENT FINDINGS:Recent clinical trials using ET(A) receptor blockade in treating pro...

journal_title：Current opinion in nephrology and hypertension

authors： Jandeleit-Dahm KA,Watson AM

更新日期：2012-01-01 00:00:00

abstract：:Overexpression of the cytokine transforming growth factor-beta has been identified as the key mediator of chronic progressive kidney fibrosis in experimental and human kidney diseases. The renoprotective effects of angiotensin II blockade and low-protein diets have recently been linked to downregulation of transformin...

journal_title：Current opinion in nephrology and hypertension

authors： Peters H,Noble NA,Border WA

更新日期：1997-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular endothelial growth factors (VEGFs) influence renal function through angiogenesis, with VEGF-A being the most potent inducer of vascular formation. In the normal glomerulus, tight homeostatic balance is maintained between the levels of VEGF-A isoforms produced by podocyte cells, and the VEGF r...

journal_title：Current opinion in nephrology and hypertension

authors： Logue OC,McGowan JW,George EM,Bidwell GL 3rd

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin D has diverse biological actions, and consequently the mechanisms behind how it regulates gene transcription are diverse. Unlike its well described positive effects on gene transcription, little is known about how vitamin D induces transcriptional repression. RECENT FINDINGS:Vitamin D-induced...

journal_title：Current opinion in nephrology and hypertension

authors： Kato S,Kim MS,Yamaoka K,Fujiki R

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The sodium-hydrogen exchanger isoform-1 (NHE1) functions in intracellular pH and cell volume homeostasis by catalyzing an electroneutral exchange of extracellular sodium and intracellular hydrogen. Recent studies have revealed the structural functions of NHE1 as an anchor for actin filaments and a sca...

journal_title：Current opinion in nephrology and hypertension

authors： Meima ME,Mackley JR,Barber DL

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines the maturational changes that occur in renal tubules during postnatal development. RECENT FINDINGS:The ability to study transport in neonatal tubules and the use of molecular techniques have allowed studies that not only examine the mechanism of solute and water transport in neon...

journal_title：Current opinion in nephrology and hypertension

authors： Baum M,Quigley R,Satlin L

更新日期：2003-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Simultaneous liver kidney transplantation (SLK) has taken center stage since the initiation of the new kidney allocation system (KAS). This review places SLK in the context of the changing landscape of organ allocation. RECENT FINDINGS:The introduction of the Mayo End-Stage Liver Disease score into l...

journal_title：Current opinion in nephrology and hypertension

authors： Formica RN Jr

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic kidney disease (CKD) remains a serious diabetic complication despite the use of widely employed interventions such as angiotensin-converting enzyme inhibitors and glucose-lowering treatments. Accumulation of methylglyoxal, a highly reactive glucose metabolite and a major precursor in the forma...

journal_title：Current opinion in nephrology and hypertension

authors： Hanssen NMJ,Stehouwer CDA,Schalkwijk CG

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Epigenetic modifications are reversible changes to a cell's DNA or histones that alter gene expression but not DNA sequence. The present review will explore epigenomic profiling and bioinformatics techniques for the study of kidney development and disease. RECENT FINDINGS:Reversible DNA and histone m...

journal_title：Current opinion in nephrology and hypertension

authors： Wilson PC,Ledru N,Humphreys BD

更新日期：2020-05-01 00:00:00

abstract：:Mesangial cells possess Ca(2+)-activated Cl- channels, Ca(2+)-activated K+ channels, voltage-gated Ca2+ channels, ATP-sensitive K+ channels, and two types of nonselective cation channels. Angiotensin II and arginine vasopressin depolarize the membrane. This membrane depolarization is caused by the activation of Ca(2+)...

journal_title：Current opinion in nephrology and hypertension

authors： Matsunaga H,Yamashita N,Okuda T,Kurokawa K

更新日期：1994-09-01 00:00:00

abstract：:Recent investigations cast some doubts on the status of insulin resistance as a trigger in hyperinsulinemia-associated hypertension or obesity-related hypertension, or both. Major epidemiological studies have shown that central adiposity is a powerful risk factor for stroke or coronary artery disease when accompanied ...

journal_title：Current opinion in nephrology and hypertension

authors： Reisin E,Messerli FH

更新日期：1995-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To clarify misconceptions about the feasibility and risks of peritoneal dialysis that unnecessarily limit peritoneal dialysis uptake or continuation in patients for whom peritoneal dialysis is the preferred dialysis modality. The inappropriate choice of haemodialysis as a result of these misconception...

journal_title：Current opinion in nephrology and hypertension

authors： Lee MB,Bargman JM

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:African-Americans are more likely than Caucasians to develop hypertension-related end-stage renal disease. Elevations in blood pressure levels clearly potentiate pre-existing renal disease and also contribute to kidney injury independently of other primary renal diseases in this cohort. Until recently...

journal_title：Current opinion in nephrology and hypertension

authors： Kaperonis N,Bakris G

更新日期：2003-01-01 00:00:00