Myocyte cell death and ventricular remodeling.

abstract：PURPOSE OF REVIEW:Obesity is becoming recognized as one of the most important risk factors for the development of hypertension. The purpose of the review is to examine the latest evidence linking hypertension to obesity, summarize the benefits of weight reduction and present results of recent clinical trials evaluating...

journal_title：Current opinion in nephrology and hypertension

authors： Chrostowska M,Szczech R,Narkiewicz K

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate homeostasis is tightly controlled by the coordinated activity of bone, kidney, intestine, and parathyroid gland. The renal phosphate transporters have emerged as key regulators of both total body phosphate homeostasis and serum phosphate concentration. This review focuses on the latest updat...

journal_title：Current opinion in nephrology and hypertension

authors： Lederer E

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic allograft nephropathy has fallen into disfavor as a morphologic term to describe parenchymal scarring in the renal allograft, with a recommendation that this be replaced by the more descriptive term 'interstitial fibrosis and tubular atrophy'. However, neither term addresses the underlying cau...

journal_title：Current opinion in nephrology and hypertension

authors： Haas M

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:MRI can noninvasively assess the structure and function of the kidney in a single MRI scan session. This review summarizes recent advancements in functional renal MRI techniques, with a particular focus on clinical applications. RECENT FINDINGS:A number of MRI techniques now provide measures of relev...

journal_title：Current opinion in nephrology and hypertension

authors： Mahmoud H,Buchanan C,Francis ST,Selby NM

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Assessment of fluid status to reach normovolemia in patients with chronic kidney disease (CKD) continues to be a tough task. Besides clinical observation, technological methods have been introduced, yet, the best approach is still uncertain. The present review looks at fluid overload in CKD from three...

journal_title：Current opinion in nephrology and hypertension

authors： de Ruiter A,Bello A,Braam B

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The glomerular filtration barrier is a unique structure characterized by a specialized three-dimensional framework of podocytes. This review is aimed at describing the latest advances made in the understanding of polarity signalling pathways regulating the formation and the maintenance of the complex ...

journal_title：Current opinion in nephrology and hypertension

authors： Simons M,Hartleben B,Huber TB

更新日期：2009-07-01 00:00:00

abstract：:The vasculature wall is an active, integrated organ composed of endothelial cells and vascular smooth muscle cells, as well as other cell types depending on the specific vascular segment (e.g. fibroblasts in many vascular regions). The vascular wall is not static; the vascular components (cells and extracellular matri...

journal_title：Current opinion in nephrology and hypertension

authors： Dubey RK,Jackson EK,Rupprecht HD,Sterzel RB

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim is to review data on the epidemiology of fibroblast growth factor 23 (FGF23) and adverse clinical outcomes in chronic kidney disease (CKD) and introduce recent insights into the pathophysiology behind the observed relationships. RECENT FINDINGS:End-stage renal disease and cardiovascular disea...

journal_title：Current opinion in nephrology and hypertension

authors： Isakova T

更新日期：2012-05-01 00:00:00

abstract：:Chronic renal disease evolves to end-stage renal failure through events, including enhanced intraglomerular pressure and plasma protein ultrafiltration, mediated at least in part by angiotensin II. Angiotensin-converting enzyme inhibitors reduce intracapillary pressure and ameliorate glomerular size-selective function...

journal_title：Current opinion in nephrology and hypertension

authors： Ruggenenti P,Remuzzi G

更新日期：1997-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Insulin resistance is a known complication of end-stage renal disease that also appears to be present in earlier stages of chronic kidney disease (CKD). It is a risk factor for cardiovascular disease and an important potential therapeutic target in this population. Measurement of insulin resistance is...

journal_title：Current opinion in nephrology and hypertension

authors： Pham H,Utzschneider KM,de Boer IH

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension is an important risk factor for adverse cardiovascular and renal outcomes particularly in patients with chronic kidney disease. This review compares blood pressure measurements obtained in the clinic with those obtained outside the clinic to predict cardiovascular and renal injury and out...

journal_title：Current opinion in nephrology and hypertension

authors： Agarwal R

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The renin-angiotensin system, traditionally viewed as a circulatory system, has significantly expanded in the last two decades to include independently regulated local systems in several tissues, newly identified active products of angiotensin II, and new receptors and functions of renin-angiotensin s...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar R,Singh VP,Baker KM

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of vitamin D beyond its importance for bone health is under much debate. In this article, we review recent evidence for genetic influences on 25-hydroxyvitamin D [25(OH)D] and discuss the uses of this information and its importance for public health. RECENT FINDINGS:Findings from large-scale...

journal_title：Current opinion in nephrology and hypertension

authors： Berry D,Hyppönen E

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Multiple studies have established the beneficial role of mesenchymal stem cell (MSC) therapy for kidney injury. In this review we will discuss the recent identification of Gli1 as a marker for perivascular MSC and the role of this cell population in kidney fibrosis. RECENT FINDINGS:Recent studies dem...

journal_title：Current opinion in nephrology and hypertension

authors： Kuppe C,Kramann R

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Incidence of end-stage renal disease has increased dramatically during the last 30 years and screening for early stages of chronic kidney disease is often suggested as a preventive measure. The relationship between chronic kidney disease and end-stage renal disease is complex, however, and recent stud...

journal_title：Current opinion in nephrology and hypertension

authors： Hallan SI,Vikse BE

更新日期：2008-05-01 00:00:00

abstract：:Tests have become available that not only give an index of iron stores and availability but also provide an integrated assessment of the efficacy of its utilization. This has allowed the revision of previously accepted criteria of iron deficiency as well as the most appropriate strategies for iron administration. By o...

journal_title：Current opinion in nephrology and hypertension

authors： van Zyl-Smit R

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The majority of uric acid nephrolithiasis in humans occurs in the absence of frank hyperuricosuria and is primarily a disease of excessively low urinary pH. Uric acid is substantially less soluble than urate salts so in low urine pH urate is protonated, thus favoring precipitation even under what is c...

journal_title：Current opinion in nephrology and hypertension

authors： Moe OW

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Emerging evidence supports an important role for the heme oxygenase system in the maintenance of a healthy pregnancy. This review attempts to collect these wide-ranging data and summarize the recent progress in the field. RECENT FINDINGS:New studies looking at heme oxygenase depletion in a variety of...

journal_title：Current opinion in nephrology and hypertension

authors： George EM,Granger JP

更新日期：2013-03-01 00:00:00

abstract：:The majority of hemodialysis patients die from cardiovascular disease. However, the contribution of myocardial infarction to mortality is relatively minor, despite the fact that coronary artery disease is common in uremic patients. Hypertension seems to be the major risk factor for the development of atherosclerosis i...

journal_title：Current opinion in nephrology and hypertension

authors： Kooman JP,Leunissen KM

更新日期：1993-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The current article reviews the available literature on the incidence, complications, outcomes, and management of pregnancies in kidney transplant recipients. RECENT FINDINGS:Pregnancy can be a reasonable option for women with a kidney transplant. More than 4700 successful pregnancies have been repor...

journal_title：Current opinion in nephrology and hypertension

authors： Vijayan M,Pavlakis M

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Klotho is a transmembrane protein that acts as a co-receptor for fibroblast growth factor 23 (FGF23). Recent investigations have discovered the presence of Klotho in bone-forming osteoblasts and osteocytes. This review summarizes emerging literature on the roles of bone Klotho in mineral and bone meta...

journal_title：Current opinion in nephrology and hypertension

authors： Komaba H,Lanske B

更新日期：2018-07-01 00:00:00

abstract：:Experimental animal models and cell culture techniques, highlighting the central role of glucose metabolism, have provided important insight into the pathogenesis of diabetic nephropathy. Microalbuminuria and other candidate phenotypic or genotypic markers for the early onset of disease are discussed. Management recom...

journal_title：Current opinion in nephrology and hypertension

authors： Mogyorósi A,Ziyadeh FN

更新日期：1996-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent evidence regarding the role of distal nephron segments other than the macula densa in sensing the tubular environment and transmitting this signal to the adjacent vasculature. RECENT FINDINGS:In addition to the classical contact site between the macula densa plaque and the afferen...

journal_title：Current opinion in nephrology and hypertension

authors： Komlosi P,Bell PD,Zhang ZR

更新日期：2009-01-01 00:00:00

abstract：:Proteinuria (protein excretion > 300 mg/d) is an independent risk factor for the development of cardiovascular disease and renal failure. The finding of persistent proteinuria in otherwise asymptomatic patients often precedes the development of arterial hypertension and renal failure. When proteinuria is accompanied b...

journal_title：Current opinion in nephrology and hypertension

authors： Ruilope LM,Rodicio JL

更新日期：1993-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Carboxyl-terminal parathyroid hormone (C-PTH) fragments constitute 80% of circulating PTH. Since the first 34 amino acids of the PTH structure are sufficient to explain PTH classical biological effects on the type I PTH/PTHrP receptor and since C-PTH fragments do not bind to this receptor, they have l...

journal_title：Current opinion in nephrology and hypertension

authors： D'Amour P,Brossard JH

更新日期：2005-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS:Sin...

journal_title：Current opinion in nephrology and hypertension

authors： Rubinstein M,Dvash E

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Frailty is highly prevalent in the dialysis population and is associated with mortality. Recent studies have suggested that other dialysis outcomes are compromised in frail individuals. While we do not yet have a consensus as to the best measure of frailty, identification of these poor outcomes and th...

journal_title：Current opinion in nephrology and hypertension

authors： Sy J,Johansen KL

更新日期：2017-11-01 00:00:00

abstract：:The L-arginine: nitric oxide pathway is widely recognized as an important regulator of cell function and communication in a variety of physiological and pathophysiological situations. Recent advances in the biochemistry and molecular biology of nitric oxide synthases have contributed significantly to our understanding...

journal_title：Current opinion in nephrology and hypertension

authors： Palmer RM

更新日期：1993-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The analysis of renal tissue from kidney biopsies by histology, electron microscopy and immunohistology represents the current standards used to establish a specific diagnosis in nephrology. Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal b...

journal_title：Current opinion in nephrology and hypertension

authors： Henger A,Schmid H,Kretzler M

更新日期：2004-05-01 00:00:00

abstract：PURPOSE OF REVIEW:While treating high blood pressure in middle age is beneficial in terms of reducing the occurrence of cardiovascular disease, treated and well controlled hypertensive adults still have a substantial excess mortality and reduced survival compared with normotensives. Therefore, identification of the mea...

journal_title：Current opinion in nephrology and hypertension

authors： Lawlor DA,Smith GD

更新日期：2005-05-01 00:00:00