Glucose 6-phosphate dehydrogenase and the kidney.

abstract：PURPOSE OF REVIEW:Vascular endothelial growth factors (VEGFs) influence renal function through angiogenesis, with VEGF-A being the most potent inducer of vascular formation. In the normal glomerulus, tight homeostatic balance is maintained between the levels of VEGF-A isoforms produced by podocyte cells, and the VEGF r...

journal_title：Current opinion in nephrology and hypertension

authors： Logue OC,McGowan JW,George EM,Bidwell GL 3rd

更新日期：2016-09-01 00:00:00

abstract：:This article reviews the current state of knowledge concerning cyclosporine A-induced hypertension after heart transplantation, its pathophysiology and management. The hypothesis is presented that a common molecular mechanism mediates both the immunosuppressive and the hypertensive actions of cyclosporine. The calcium...

journal_title：Current opinion in nephrology and hypertension

authors： Sander M,Victor RG

更新日期：1995-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Epithelial sodium channels mediate Na+ transport across high resistance, Na+-transporting epithelia. This review describes recent findings that indicate that epithelial sodium channels are activated by the proteolytic release of inhibitory peptides from the alpha and gamma subunits. RECENT FINDINGS:N...

journal_title：Current opinion in nephrology and hypertension

authors： Hughey RP,Carattino MD,Kleyman TR

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:With the aging population of kidney transplant candidates, a history of malignancy is an increasingly prevalent finding. Tumors can constitute a contraindication for transplantation or can lead to a delay of acceptance to the waiting-list. Current waiting time guidelines mainly refer to early data col...

journal_title：Current opinion in nephrology and hypertension

authors： Bojic M,Watschinger C,Reiter T,Watschinger B

更新日期：2020-11-01 00:00:00

abstract：:Tests have become available that not only give an index of iron stores and availability but also provide an integrated assessment of the efficacy of its utilization. This has allowed the revision of previously accepted criteria of iron deficiency as well as the most appropriate strategies for iron administration. By o...

journal_title：Current opinion in nephrology and hypertension

authors： van Zyl-Smit R

更新日期：2000-11-01 00:00:00

abstract：:Recent insights into the etiopathogenesis of nephritogenic immune responses are derived primarily from experimental models of systemic and organ-specific autoimmunity. Genetic analyses and immune-related gene ablation studies indicate that multiple independent mechanisms determine disease susceptibility. However, full...

journal_title：Current opinion in nephrology and hypertension

authors： Fitzsimons MM,Foster MH

更新日期：1997-05-01 00:00:00

abstract：:Historically, studies in humans have not shown conclusively that low-protein diets ameloriate the progression of renal disease. However, recent trials have demonstrated that, in patients with advanced renal insufficiency, low-protein diets may slow the loss of renal function and defer the onset of end-stage renal dise...

journal_title：Current opinion in nephrology and hypertension

authors： Klahr S

更新日期：1996-07-01 00:00:00

abstract：:Renal synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a pivotal step in calcium and phosphate homeostasis. Production of 1,25(OH)2D3 is catalyzed by the mitchondrial cytochrome P450, 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-HYD). As a consequence of the tight regulation of ...

journal_title：Current opinion in nephrology and hypertension

authors： Bland R,Zehnder D,Hewison M

更新日期：2000-01-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:To discuss new insights regarding chronic antibody-mediated rejection (CAMR) and its progression to transplant glomerulopathy. We will describe the progression to transplant glomerulopathy from a histologic perspective and provide updates on what is known about its pathophysiology, prognosis, and...

journal_title：Current opinion in nephrology and hypertension

authors： Schinstock CA,Stegall M,Cosio F

更新日期：2014-11-01 00:00:00

abstract：:Elevated serum uric acid is a frequent finding in patients with kidney disease and cardiovascular disease. Intrarenal ischaemia, induced by hypertension, increased sympathetic nervous system activity, and hyperinsulinaemia have all been implicated in reduced renal clearance of urate. This frequently results in elevate...

journal_title：Current opinion in nephrology and hypertension

authors： Culleton BF

更新日期：2001-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Inadequately controlled blood pressure is considered an important risk factor for both chronic kidney disease (CKD) progression and cardiovascular disease progression in CKD patients. Patients with CKD and hypertension are typically followed in primary care practice settings and blood pressure is not ...

journal_title：Current opinion in nephrology and hypertension

authors： St Peter WL,Farley TM,Carter BL

更新日期：2011-09-01 00:00:00

abstract：:The vasculature wall is an active, integrated organ composed of endothelial cells and vascular smooth muscle cells, as well as other cell types depending on the specific vascular segment (e.g. fibroblasts in many vascular regions). The vascular wall is not static; the vascular components (cells and extracellular matri...

journal_title：Current opinion in nephrology and hypertension

authors： Dubey RK,Jackson EK,Rupprecht HD,Sterzel RB

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Membranous nephropathy is an autoimmune disease caused by antibodies mostly directed to podocyte antigens. PLA2R and THSD7A antigens were described in 2009 and 2014 using classical immunochemical techniques. In the last 2 years, thanks to the combination of laser microdissection of glomeruli and mass ...

journal_title：Current opinion in nephrology and hypertension

authors： Ronco P,Debiec H

更新日期：2021-01-21 00:00:00

abstract：PURPOSE OF REVIEW:Carboxyl-terminal parathyroid hormone (C-PTH) fragments constitute 80% of circulating PTH. Since the first 34 amino acids of the PTH structure are sufficient to explain PTH classical biological effects on the type I PTH/PTHrP receptor and since C-PTH fragments do not bind to this receptor, they have l...

journal_title：Current opinion in nephrology and hypertension

authors： D'Amour P,Brossard JH

更新日期：2005-07-01 00:00:00

abstract：:The cardinal feature of systemic lupus erythematosus is the formation of anti-nuclear antibodies. In recent years, it has become clear that the nucleosome is a major autoantigen that drives this T cell-dependent autoimmune response, as exemplified by the presence of nucleosome-specific T helper cells and the high prev...

journal_title：Current opinion in nephrology and hypertension

authors： Berden JH,Licht R,van Bruggen MC,Tax WJ

更新日期：1999-05-01 00:00:00

abstract：:Several lines of evidence indicate a significant association between insulin and cardiovascular disease. This association might be explained by direct (cardio) vascular effects of insulin. Two hemodynamic actions of insulin are discussed in this review; it induces direct vasodilation in skeletal muscle and stimulation...

journal_title：Current opinion in nephrology and hypertension

authors： Tack CJ,Lenders JW,Goldstein DS,Lutterman JA,Smits P,Thien T

更新日期：1998-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of the article is to review studies on bone health and oxalate metabolism/therapeutics in the obese rodent model of Roux-en-Y gastric bypass (RYGB) and examine pathways to decrease procedural morbidity. RECENT FINDINGS:Compared with controls, RYGB rodents have up to 40-fold more fat in their ...

journal_title：Current opinion in nephrology and hypertension

authors： Kwenda EP,Rabley AK,Canales BK

更新日期：2020-07-01 00:00:00

abstract：:There is substantial evidence to suggest that regular physical activity reduces the risk of heart disease. Less clear is the extent to which this is caused by blood pressure reduction. This review considers effects of exercise on blood pressure and overall cardiovascular risk in normotensive and hypertensive individua...

journal_title：Current opinion in nephrology and hypertension

authors： Puddey IB,Beilin LJ

更新日期：1995-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now a...

journal_title：Current opinion in nephrology and hypertension

authors： Nguyen Dinh Cat A,Jaisser F

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines recent advances in understanding of how clinical outcomes for hemodialysis patients may be improved by achieving longer or more frequent treatment times, lower ultrafiltration rates (UFRs), improving nutritional status, and individualizing dialysate composition. This review also d...

journal_title：Current opinion in nephrology and hypertension

authors： Fissell R,Hakim RM

更新日期：2013-11-01 00:00:00

abstract：:In spite of the popular belief that "nervous tension," "stress," and hypertension are causally related, it has been difficult to prove a role of autonomic dysfunction in the genesis of essential hypertension. There are three major reasons for this: 1) autonomic function cannot be assessed with one simple test, 2) the ...

journal_title：Current opinion in nephrology and hypertension

authors： Julius S

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The success of any given kidney transplant is closely tied to the ability to monitor patients and responsively change their medications. Transplant monitoring is still, however, dependent on relatively old technologies: serum creatinine levels, urine output, blood pressure, blood glucose and histopath...

journal_title：Current opinion in nephrology and hypertension

authors： Wishart DS

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Development of the mammalian kidney is a complex process involving numerous signals and signaling pathways. Other complex tissues have benefited enormously from studies in lower, simpler organisms. The present review provides an update on what we have learned from the fruitfly Drosophila melanogaster,...

journal_title：Current opinion in nephrology and hypertension

authors： Cagan R

更新日期：2003-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic kidney disease (CKD) remains a serious diabetic complication despite the use of widely employed interventions such as angiotensin-converting enzyme inhibitors and glucose-lowering treatments. Accumulation of methylglyoxal, a highly reactive glucose metabolite and a major precursor in the forma...

journal_title：Current opinion in nephrology and hypertension

authors： Hanssen NMJ,Stehouwer CDA,Schalkwijk CG

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To clarify misconceptions about the feasibility and risks of peritoneal dialysis that unnecessarily limit peritoneal dialysis uptake or continuation in patients for whom peritoneal dialysis is the preferred dialysis modality. The inappropriate choice of haemodialysis as a result of these misconception...

journal_title：Current opinion in nephrology and hypertension

authors： Lee MB,Bargman JM

更新日期：2016-11-01 00:00:00

abstract：:Our basic understanding of sodium mechanisms provides unique insights into epithelial transport processes, and unusual clinical syndromes can arise from mutations of these ion transporters. These genetic disorders affect sodium balance, with both sodium-retaining and sodium-wasting conditions being the consequence. A ...

journal_title：Current opinion in nephrology and hypertension

authors： Warnock DG

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The role of vitamin D beyond its importance for bone health is under much debate. In this article, we review recent evidence for genetic influences on 25-hydroxyvitamin D [25(OH)D] and discuss the uses of this information and its importance for public health. RECENT FINDINGS:Findings from large-scale...

journal_title：Current opinion in nephrology and hypertension

authors： Berry D,Hyppönen E

更新日期：2011-07-01 00:00:00

abstract：:After renal transplantation, acute allograft dysfunction secondary to acute rejection occurs in around 30-40% of patients. Although in the majority of patients these episodes are reversible, acute rejection remains a major risk factor for the development of chronic rejection. Remarkably, prior episodes of acute allogr...

journal_title：Current opinion in nephrology and hypertension

authors： Chandraker A

更新日期：1999-11-01 00:00:00

abstract：:Experimental animal models and cell culture techniques, highlighting the central role of glucose metabolism, have provided important insight into the pathogenesis of diabetic nephropathy. Microalbuminuria and other candidate phenotypic or genotypic markers for the early onset of disease are discussed. Management recom...

journal_title：Current opinion in nephrology and hypertension

authors： Mogyorósi A,Ziyadeh FN

更新日期：1996-05-01 00:00:00

abstract：:The present review considers the role that bisphosphonates might have in patients with renal failure. Although bisphosphonates are widely used to reduce fracture risk in patients with osteoporosis, few studies have documented their effect in patients with renal osteodystrophy. The pathogenesis of bone loss after renal...

journal_title：Current opinion in nephrology and hypertension

authors： Fan SL,Cunningham J

更新日期：2001-09-01 00:00:00